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Malignancy-associated minor histocompatibility antigens:
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Name
| Gene of Origin |
Peptide sequence |
Variation type |
HLA restriction |
Reference |
HA-1a | KIAA0223/19p13 | VLHDDLLEA | SNP | A*0201 | "The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism."
den Haan JM, Meadows LM, Wang W, Pool J, Blokland E, Bishop TL, Reinhardus C, Shabanowitz J, Offringa R, Hunt DF, Engelhard VH, Goulmy E.
Science. 1998;279(5353):1054-7 |
HA-1b | KIAA0223/19p13 | KECVLHDDL | SNP | B*4001 | "Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus."
Mommaas B, Kamp J, Drijfhout JW, Beekman N, Ossendorp F, Van Veelen P, Den Haan J, Goulmy E, Mutis T.
J Immunol. 2002 Sep 15;169(6):3131-6. |
HA-2 | MYOG1/7p13-p11.2 | YIGEVLVSV | SNP | A*0201 | "Identification of a graft versus host disease-associated human minor histocompatibility antigen."
den Haan JM, Sherman NE, Blokland E, Huczko E, Koning F, Drijfhout JW, Skipper J, Shabanowitz J, Hunt DF, Engelhard VH, et al.
Science. 1995 Jun 9;268(5216):1476-80 |
HA-3 | LBC/15q24-25 | VTEPGTAQY | SNP | A*0101 | "The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein."
Spierings E, Brickner AG, Caldwell JA, Zegveld S, Tatsis N, Blokland E, Pool J, Pierce RA, Mollah S, Shabanowitz J, Eisenlohr LC, van Veelen P, Ossendorp F, Hunt DF, Goulmy E, Engelhard VH.
Blood. 2003 Jul 15;102(2):621-9. |
HA-8 | KIAA0020/9p24.2 | RTLDKVLEV | SNP | A*0201 | "The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing."
Brickner AG, Warren EH, Caldwell JA, Akatsuka Y, Golovina TN, Zarling AL, Shabanowitz J, Eisenlohr LC, Hunt DF, Engelhard VH, Riddell SR.
J Exp Med. 2001 Jan 15;193(2):195-206. |
HB-1 | HB-1/5q32 | EEKRGSLHVW | SNP | B*44 | "A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia."
Dolstra H, Fredrix H, Maas F, Coulie PG, Brasseur F, Mensink E, Adema GJ, de Witte TM, Figdor CG, van de Wiel-van Kemenade E.
J Exp Med. 1999 Jan 18;189(2):301-8. |
ACC-1 | BCL2A1/15q24.3 | DYLQYVLQI | SNP | A*2402 | "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens."
Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T.
J Exp Med. 2003 Jun 2;197(11):1489-500. |
ACC-2 | BCL2A1/15q24.3 | KEFEDDIINW | SNP | B*44 | "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens."
Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T.
J Exp Med. 2003 Jun 2;197(11):1489-500. |
LRH-1 | P2X5/17p13.2 | TPNQRQNVC | frameshift due to deletion | B*0702 | "A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia."
de Rijke B, van Horssen-Zoetbrood A, Beekman JM, Otterud B, Maas F, Woestenenk R, Kester M, Leppert M, Schattenberg AV, de Witte T, van de Wiel-van Kemenade E, Dolstra H.
J Clin Invest. 2005 Dec;115(12):3506-16. |
PANE1 | PANE1/22q13.2 | RVWDLPGVLK | variant exon due to stopcodon caused by SNP | A*0301 | "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL."
Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH.
Blood. 2006 May 1;107(9):3779-86. |
LB-ADIR-1F | ADIR | SVAPALALFPA | SNP in ARF before CDS | A*0201 | "Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene."
van Bergen CA, Kester MG, Jedema I, Heemskerk MH, van Luxemburg-Heijs SA, Kloosterboer FM, Marijt
WA, de Ru AH, Schaafsma MR, Willemze R, van Veelen PA, Falkenburg JH.
Blood. 2007 May 1;109(9):4089-96. |
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Alternative Reading Frame peptides:
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From: "Alternative Translational Products and Cryptic T Cell Epitopes: Expecting the Unexpected", On Ho and William R. Green
The Journal of Immunology, 2006, 177: 8283-8289.
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Disease System |
Gene of Origin |
Peptide sequence |
Melanoma | TRP-1/gp75 | MSLQRQFLR |
Melanoma | BING-4 | CQWGRLWQL MCQWGRLWQL |
Breast/prostate cancer | TCR{gamma} | FVFLRNFSL FLRNFSLML |
Colorectal cancer | O-linked N-acetylglucosamine transferase (OGT) | SLYKFSPFPL+ |
Renal cell carcinoma | Intestinal carboxyl esterase | SPRWWPTCL |
Melanoma | CDKN2A | AVCPWTWLR |
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+) not found in HSPVdb
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