LOCUS JAWXXO010000002 21341 bp DNA linear BCT 20-NOV-2023 DEFINITION Lactococcus lactis subsp. lactis strain ATCC 19435 contig_2_polypolish, whole genome shotgun sequence. ACCESSION JAWXXO010000002 VERSION JAWXXO010000002.1 KEYWORDS . SOURCE Lactococcus lactis subsp. lactis ORGANISM Lactococcus lactis subsp. lactis Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Lactococcus. COMMENT The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ ##rhizoSMASH-Data-START## Version :: 0.3.1-cb03db34 Run date :: 2025-03-15 23:19:40 ##rhizoSMASH-Data-END## ##antiSMASH-Data-START## Version :: 6.1.1-b1d0db06 ##rhizoSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..21341 /aStool="rule-based-clusters" /category="Amino-acid" /contig_edge="False" /core_location="[618603:619944]" /cutoff="6000" /detection_rule="(cds(Gln-synt_C and Gln-synt_N) and minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))" /neighbourhood="10000" /product="Glutamine_synthetase" /protocluster_number="1" /tool="antismash" proto_core 10001..11341 /aStool="rule-based-clusters" /tool="antismash" /cutoff="6000" /detection_rule="(cds(Gln-synt_C and Gln-synt_N) and minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))" /neighbourhood="10000" /product="Glutamine_synthetase" /protocluster_number="1" cand_cluster 1..21341 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(cds(Gln-synt_C and Gln-synt_N) and minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))" /kind="single" /product="Glutamine_synthetase" /protoclusters="1" /tool="antismash" region 1..21341 /candidate_cluster_numbers="1" /contig_edge="False" /product="Glutamine_synthetase" /region_number="2" /rules="(cds(Gln-synt_C and Gln-synt_N) and minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))" /tool="antismash" gene 599..1294 /locus_tag="SIL76_03575" CDS 599..1294 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012898700.1" /locus_tag="SIL76_03575" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="MDX6023571.1" /transl_table=11 /translation="MGNEKELKGQEIPETQVEPTEELNSENLASQEETTKSDISEWDAS EPVLDEPVVAKAEVSEGFVSEPVIAEPVIAASEPLDSKVEEKTSEQSAYADIPQNRSLE NQDEIKTKWNWGAFALTMWFGIANRAYLGLLILLTLVPWVGWIFGIVWMIVFGFNGEKW ALENRDNKYRDEEEFRKVMDGWNRAGFVAFIIGIVLFVIAILILIFVLVFAFNSYNNFD NGYRDFGNY" gene 1423..3393 /gene="mutL" /locus_tag="SIL76_03580" CDS 1423..3393 /codon_start=1 /gene="mutL" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011677256.1" /locus_tag="SIL76_03580" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0032300 - mismatch repair complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATP hydrolysis activity [Evidence IEA]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]" /product="DNA mismatch repair endonuclease MutL" /protein_id="MDX6023572.1" /transl_table=11 /translation="MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIII NVEEAGLRLIEVIDDGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIA SVSQMTIETSTAEEESGTKLVAKGGNIETLEPLAKRVGTKISVANLFYNTPARLKYIKS LQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMR QIKGSDLDFELTGYVSIPELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRF PFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEALSEGVLIPEALENLQ GRAKEKETLSVQTELPLQNNPLYYDNVRQDFYVREEATFKINKNQASNDSSEQTFDNFT ENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDNEAKISQSSTFPQLEYLA QLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQQILLAPYLFILAKNDF IVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSINEMIDIILSSKEFSLK KYRHDLAAMVACKSSIKANHPLDAESARALLAELATCKNPYSCAHGRPTIVHFSGDDIQ KMFRRIQETHRSKAASWKDFE" gene 3506..4099 /gene="ruvA" /locus_tag="SIL76_03585" CDS 3506..4099 /EC_number="3.6.4.12" /codon_start=1 /gene="ruvA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011836117.1" /locus_tag="SIL76_03585" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0009379 - Holliday junction helicase complex [Evidence IEA]; GO_function: GO:0009378 - four-way junction helicase activity [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]" /product="Holliday junction branch migration protein RuvA" /protein_id="MDX6023573.1" /transl_table=11 /translation="MFEYLNGKLVKISPTNIVIDVAGIGYLISVANPYAWSALMNTEVK IYVHQVIREDAHSLYGFVNEAEKALFLRLISVSGIGPKSALAIIAAADNEGLITAIDNS DIKYLTKFPGVGKKTAMQMVLDLAGKFDATGTVGISLLDAGPAGNLALEEAIEALQALG YKATELKKIEKKLAQETGLTSEEYIKSALKLMMK" gene 4226..5227 /gene="ruvB" /locus_tag="SIL76_03590" CDS 4226..5227 /EC_number="3.6.4.12" /codon_start=1 /gene="ruvB" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131994.1" /locus_tag="SIL76_03590" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0009378 - four-way junction helicase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]" /product="Holliday junction branch migration DNA helicase RuvB" /protein_id="MDX6023574.1" /transl_table=11 /translation="MNDILNKEPMEEDYGIEKSLRPQFFNQYIGQDKVKEQLEIFIKAA KMREEVLDHVLLFGPPGLGKTTMAFVIANELGVNIKQTAGPAIEKPGDLVAILNELEPG DVLFIDEIHRMPMQVEEVLYSAMEDFYIDIMLGSGDGSRSVHLDLPPFTLVGATTRAGM LSNPLRARFGISSHMEYYQERDLEEIVKRTADIFEVEVIDNAALEIALRSRGTPRIANR LLKRVRDFAQIMGDGRVDKAITDKALSILDVDAAGLDYIDQKILRTMIEMYHGGPVGIG TLAVNIAEDRETVEDMYEPYLIQKGFLMRTKQGRKVTQRAYEHLGYVYNEED" gene 5364..6248 /locus_tag="SIL76_03595" CDS 5364..6248 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012898698.1" /locus_tag="SIL76_03595" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="XRE/MutR family transcriptional regulator" /protein_id="MDX6023575.1" /transl_table=11 /translation="MVNQYYGLKLQELCEAKEITKNEIIKKTGIPKSSLSRFFSGEGYL NLDQIDALLEFLHLELSEYDYYLNNFKHSFYEELFSKIDQAATNNNIEELKDIAWQCEQ IGEHLIALCAKARLEKLPENEVVELSSFIFGIEIFSFYELLILSDTIEQFSSEMIKAII QDLSHHHQRLANRTRYRKIICQIACRGAVTCIQEGKEKEAQECLALVKAYCHEKDAYSR LIYRFTKGYYCIFYGQGEERLLGIDSMKKVIEIFDWEGSINLAKTYQKLYDKYVKNYNF PQWLSDILGKDSI" gene 6468..6758 /locus_tag="SIL76_03600" CDS 6468..6758 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131992.1" /locus_tag="SIL76_03600" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="MDX6023576.1" /transl_table=11 /translation="MKMNLKKQIFVLSTLLVTTGAIGVTSVSATQVTYVKTSSVTYYLN NVSTGTTDYYDYVNILHGGSYTTTTSTIYYTVVNSVGQSQPAKQVTTYYHY" gene 6825..8009 /locus_tag="SIL76_03605" CDS 6825..8009 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015427215.1" /locus_tag="SIL76_03605" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="ABC transporter permease" /protein_id="MDX6023577.1" /transl_table=11 /translation="MKYFKFELKKFILNKRNRYLLALISSLIIVYSVYNTISFTNIFKN NITSLVQEVQTNEKSVQDNIETTEESLKTTKVKAEDDNLNNTLSDLKQKDNIYQKQIAA IGVNDINEYYHLQKEIDQLYFKQNGNQSSSGQDKFLKAEIKYIKTVQERKLDFEAMPTM QSHAFGNFHQQFIPILTSSLFIVLFASMVSILVATSYESKENRFYRFAGIDLQKNLIIK VLSGTLATFAWIIISSIIYFLVIGVVNGFGAWNYPAYLGDSDLKTGFTLTNLTIPNGIL DLGSILYLFFVIFFLASLGALISVFVKRSMVVVGVIALFVMGYSMIGNVSWIISIRRFV PLSYLEPLKLFGNPSALFGKYSILIGAGYLLSLSVLFLLISVFIIKNQKTRRIS" gene 8006..8551 /locus_tag="SIL76_03610" CDS 8006..8551 /codon_start=1 /gene_functions="catabolic-additional (rule-based-clusters) ABC_tran" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 83.1; E-value: 4.2e-25)" /gene_kind="transport" /inference="COORDINATES: protein motif:HMM:NF012235.3" /locus_tag="SIL76_03610" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /product="AAA family ATPase" /protein_id="MDX6023578.1" /sec_met_domain="ABC_tran (E-value: 4.5e-14, bitscore: 50.4, seeds: 135, tool: rule-based-clusters)" /transl_table=11 /translation="MILKIKNLKIPDIAPLNFEISENGLYGLIGRNGIGKSTLFGILSG EIGFSQGEIENGRVAYLPDVESFEESLKMHDYFKILKNSEQDRARELSLTFGADKFAKK RIGQFSLGMKELFATILSFSIDCDILIIDELFSGLDVSKKALVYEEVKKIAQEKIVLLT SHNLKEIEHFCDQAYLLS" gene 8728..8892 /locus_tag="SIL76_03615" CDS 8728..8892 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131988.1" /locus_tag="SIL76_03615" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="MDX6023579.1" /transl_table=11 /translation="MSVITPAPQPKSDIFREVEQLQNSFKNNESKVLVDNNKIYKKLKE KKKKIKQKD" gene 9036..9473 /locus_tag="SIL76_03620" CDS 9036..9473 /EC_number="3.1.3.48" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010906378.1" /locus_tag="SIL76_03620" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]" /product="low molecular weight protein-tyrosine-phosphatase" /protein_id="MDX6023580.1" /transl_table=11 /translation="MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSW EHGNPIHSGTQTKLKEQKIAFDLQKGSQKISSEDFYEFDKIIAMDESNLENLRKMAPEG TSQKIAMLLEQGVPDPWFTGDFQETYQLVKTGCQRLLDEIV" gene 9574..9939 /locus_tag="SIL76_03625" CDS 9574..9939 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003133119.1" /locus_tag="SIL76_03625" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="MerR family transcriptional regulator" /protein_id="MDX6023581.1" /transl_table=11 /translation="MKERELRRSMAVLPIGTVMKLTDLSARQIRYYEEQELIFPERSDG NRRMYSLNDIDALFDIADLLQEGNNIADIKEIYAKRDAKKAQTLSIGEVHHALEREFAQ QGRFGTPDPTHFTQPRM" gene 10001..11341 /gene="glnA" /locus_tag="SIL76_03630" CDS 10001..11341 /EC_number="6.3.1.2" /codon_start=1 /gene="glnA" /gene_functions="catabolic (rule-based-clusters) Glutamine_synthetase: Gln-synt_N" /gene_functions="catabolic (rule-based-clusters) Glutamine_synthetase: Gln-synt_C" /gene_kind="catabolic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009854979.1" /locus_tag="SIL76_03630" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_function: GO:0004356 - glutamine synthetase activity [Evidence IEA]; GO_process: GO:0006542 - glutamine biosynthetic process [Evidence IEA]" /product="type I glutamate--ammonia ligase" /protein_id="MDX6023582.1" /sec_met_domain="Gln-synt_N (E-value: 1e-30, bitscore: 102.5, seeds: 83, tool: rule-based-clusters)" /sec_met_domain="Gln-synt_C (E-value: 1.1e-141, bitscore: 469.0, seeds: 345, tool: rule-based-clusters)" /transl_table=11 /translation="MTITAADIRRDVKEKDIKFLRLMFTDILGTLKNVEVPATDEQLDK LFENKMMFDGSSIEGFVRINESDMYLYPDLDTWIVFPWGDEYGKVAGVICDVYTPEGEP FAGDPRGVLKRNLKSMEKLGFKSFNLGPEPEFFLFKLNENDEPTLEVNDKGGYFDLAPT DLAGNTRREIVNVLTDLGFEVEASHHEVAIGQHEIDFKYANALKACDNIQIFKLVVKTI ARKHGLHATFMAKPVHGINGSGMHCNMSLFTEDGANAFADPTGDMGLSDVAHSFIAGLL KHAYNFTAITNPTVNSYKRLVPGYEAPVYVAWAGRNRSPLIRVPASRGLSTRVELRAVD PTANPYLALAVLLAAGLDGVEHKLEAPEAIESNIYVMTEEERKAHGITDLPSTLHNAVK ALREDTIVTEALGEHVLVNFVEAKRIEWASYAQFVSQWEIDNYLELY" gene complement(11400..11600) /locus_tag="SIL76_03635" CDS complement(11400..11600) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131983.1" /locus_tag="SIL76_03635" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="MDX6023583.1" /transl_table=11 /translation="MKFKFKGINYYEDSENNYVGATNTCSIVKEFADFQAAIDYVAEHK GFLIAEDGKTAFNVLTITENN" gene 11818..12264 /locus_tag="SIL76_03640" CDS 11818..12264 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015427212.1" /locus_tag="SIL76_03640" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="MDX6023584.1" /transl_table=11 /translation="MELNDLKDSLTALKYGEIATVAMIDRGAYAEIEESIEAESKDQKI NSGIFKELAATVKDENEDLVVVGRSDIDQALTPEDFSRFIGQMTKEKHIILVECLYLGT TEIKGFLNSLKENNLLENSKLVLLDLPQLEYMMLRDSLAGQFKL" gene complement(12353..12625) /locus_tag="SIL76_03645" CDS complement(12353..12625) /EC_number="5.4.99.5" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011677248.1" /locus_tag="SIL76_03645" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="chorismate mutase" /protein_id="MDX6023585.1" /transl_table=11 /translation="MNKLEELRNNIDHVDQEIVQLLEKRMTIVQEISQEKQAQKITILD NSREQAVLDLARQNIKNSAYQETIINTFKDIMKNSRLYQRENREQ" gene 13135..13623 /locus_tag="SIL76_03650" CDS 13135..13623 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131959.1" /locus_tag="SIL76_03650" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_function: GO:0005515 - protein binding [Evidence IEA]; GO_function: GO:0033745 - L-methionine-(R)-S-oxide reductase activity [Evidence IEA]" /product="GAF domain-containing protein" /protein_id="MDX6023586.1" /transl_table=11 /translation="MNKEEKIEGYELLNLQLKALLSEQNYTLSNLANASSLLWSFLPEQ VYTGFYLYNGEKLILGPFQGSVSCVEIIMGKGVCGESAQNRQTIIVENVKKHKNYISCD GRAMSEIVVPMVKDGKLVGVLDLDSSEIGFYDEIDQKYLEEFANILCEMTDFKFFEVG" gene 13655..14296 /locus_tag="SIL76_03655" CDS 13655..14296 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131958.1" /locus_tag="SIL76_03655" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="phosphotransferase" /protein_id="MDX6023587.1" /transl_table=11 /translation="MSEIVKKFIADRFGEKEGISVNPGNIGDVREFAQELGSFLYQLHR LPTTDAKSPSFENAFAGSDLIFFEAEMIELLKVYQKVVPADLLQEKFDFAAKTKWSKKP VWVLGQLLTQNLKVTDGKLVNVKITDKAVIGDPAFDLAIAWTIFDEKARKIFFAATEAD EATINRARMFALRQALRNYQSQDIDELIQSRDASTEILKDLNYSLGQDFY" gene 14345..16003 /gene="dnaX" /locus_tag="SIL76_03660" CDS 14345..16003 /EC_number="2.7.7.7" /codon_start=1 /gene="dnaX" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015427209.1" /locus_tag="SIL76_03660" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0009360 - DNA polymerase III complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]" /product="DNA polymerase III subunit gamma/tau" /protein_id="MDX6023588.1" /transl_table=11 /translation="MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSG PRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICDSITKGSLDDVIELDAASNNGVDEI REIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQKIP ATIISRVQRFAFKSITTGDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLD QALSFSSGKLEENDALLVTGSIAADALVTYVVALFEHDEAKALTELDKIFAEGKNMLRF TEDLLAYLRDLLLDKNSQYDRGQIFSWIDVAIESLKTIKETTQTKIAADVMTMRLAEIG QNNLLTASQGEIPNQLTAEIATLKTEINQLKAQISAGQIQVNSDSQNNLLTEKVKGSPK PIASKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTAPVAASE NFLVVTFPHENLAKRVSENEELQLFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNL KSENVQEDEEDEKEPDETVNLAKELFGEKVVEIND" gene complement(16038..17504) /locus_tag="SIL76_03665" CDS complement(16038..17504) /codon_start=1 /gene_functions="catabolic-additional (rule-based-clusters) AA_permease_2" /gene_functions="catabolic-additional (smcogs) SMCOG1038:phenylalanine-specific permease (Score: 416.4; E-value: 1.8e-126)" /gene_kind="catabolic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017865200.1" /locus_tag="SIL76_03665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]" /product="amino acid permease" /protein_id="MDX6023589.1" /sec_met_domain="AA_permease_2 (E-value: 7e-45, bitscore: 150.8, seeds: 399, tool: rule-based-clusters)" /transl_table=11 /translation="MENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDVIHT AGPFGALTAYVLIGAMVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWL NWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFAINALSVKTFGETEYWLSAIK ITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFS FQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGDS AAQSPFTIVFERVGLSIAASIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFS KTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTFLVSASGLTGFIAWIGIAISHFRFR RAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIP LFFILYLGYKFKNKTKLIPLKEVDLSRHKD" regulatory complement(17663..17845) /bound_moiety="lysine" /db_xref="RFAM:RF00168" /inference="COORDINATES: nucleotide motif:Rfam:14.4:RF00168" /inference="COORDINATES: profile:INFERNAL:1.1.4" /note="Lysine riboswitch is most abundant in Firmicutes and Gammaproteobacteria where they are found upstream of a number of genes involved in lysine biosynthesis, transport and catabolism; Derived by automated computational analysis using gene prediction method: cmsearch." /regulatory_class="riboswitch" gene 18028..18882 /locus_tag="SIL76_03670" CDS 18028..18882 /EC_number="3.6.1.27" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012898664.1" /locus_tag="SIL76_03670" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0050380 - undecaprenyl-diphosphatase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]" /product="undecaprenyl-diphosphate phosphatase" /protein_id="MDX6023590.1" /transl_table=11 /translation="MDFIRAIILGIIEGITEWLPISSTGHLIIADEFIRLNQSAAFKEM FDVVIQLGAILSVVVLYFHKLNPFNKLNPADKQKTPREIQLTWRLWLKVLIAALPAAII GLPLNDWLDKHFYHFVPVAFMLIIYGVAFIVIERRWVPNHEFSVMNIDRLPYRAALYIG LFQVLSLLPGTSRSGATIVGALLIGVSREVAAEFTFFLGIPVMFGASFIKILHFFKNGN SLSFEQFGVLLVACIVAFGVSMVAIKFLTDYVKKHDFTFFGKYRIVLGIILLIYAMFKA FLG" gene 19074..19367 /gene="rpsF" /locus_tag="SIL76_03675" CDS 19074..19367 /codon_start=1 /gene="rpsF" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018030687.1" /locus_tag="SIL76_03675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0000314 - organellar small ribosomal subunit [Evidence IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]" /product="30S ribosomal protein S6" /protein_id="MDX6023591.1" /transl_table=11 /translation="MTKYEILYIIRPNIDEEAKAALVERFDGILTDNGAANLESKDWEK RKLAYEINDFREGIYHIATFEAETTSEALSEFDRLAKINLDILRHMIVKVEA" gene 19397..19897 /locus_tag="SIL76_03680" CDS 19397..19897 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019778239.1" /locus_tag="SIL76_03680" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="single-stranded DNA-binding protein" /protein_id="MDX6023592.1" /transl_table=11 /translation="MINNVVLVGRITRDPELRYTPQNQAVATFSLAVNRQFKNANGERE ADFINCVIWRQQAENLANWAKKGALIGVTGRIQTRNYENQQGQRVYVTEVVADSFQMLE SRSAREGMGGGTSAGSYSAPSQSTNNTPRPQTNNNNATPNFGRDADPFGSSPMEISDDD LPF" gene 20071..20316 /gene="rpsR" /locus_tag="SIL76_03685" CDS 20071..20316 /codon_start=1 /gene="rpsR" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003131952.1" /locus_tag="SIL76_03685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology. GO_component: GO:0000314 - organellar small ribosomal subunit [Evidence IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]" /product="30S ribosomal protein S18" /protein_id="MDX6023593.1" /transl_table=11 /translation="MAQQRRGGFKRRKKVDFIAANKIEVVDYKDTELLKRFISERGKIL PRRVTGTSAKNQRKVVNAIKRARIMALLPFVAEDQN" gene 20516..21289 /locus_tag="SIL76_03690" CDS 20516..21289 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015427206.1" /locus_tag="SIL76_03690" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="metallophosphoesterase" /protein_id="MDX6023594.1" /transl_table=11 /translation="MIELIIGAVLLSLLIYGIFIEPHLMKVRHVKIAQKQNLKIAHFTD THFAWHTTSRRFKKFARNIANEQPDLIIFSGDLFDKVAWAKNRDWTDLLTILSELKAPL GKFAILGNHDFDDEKSSRFVEEFLEKAGFVLLKNSSVVKDNLSISGVDDWREGRPDFEL EPIDATFSLLALHEPDTILDMETIKEFDLILSGHSHGGQIRIGNWRLRNKGSSSADAGL YQLNDRTKLYVNRGIGLTFLPIRFGVPPEIVYYYI" ORIGIN 1 tgaattaggg cgaggaacgg caacttatga tgggatggct ctagctcaag caattattga 61 atatgttcat gaccatattg gggcaaagac cttgtttgct acgcattatc atgaattgac 121 agacttagat gaagcgctcg atcatcttga taatgtccat gttgctacct tggagcaaaa 181 tgggaatgtg acttttttgc ataaaataac agagggacca gctgataaat cctatgggat 241 tcatgtggcg aaaattgcag gtttaccaca gcctttgtta gagcgagcag atttgatttt 301 gcagaagtta gaaaataaac ctttgcctgc taaaaaagtt gctgatgaac aagaacaact 361 tagtttattt gattttaccg aaaattcttc agaaattatt gaaaagataa aaaggcaaaa 421 tgttgataat atgactgcaa gagaggcttt gaatttcttg tgggaactta aagattcact 481 ttgaacttgg tagcgaggct tattctgtaa ataagctaag aaaaaaggct ataattactt 541 aaaaagagat tcattgaaag atgaattgag tagaagctaa cataaaaagg agctaaacat 601 gggaaatgaa aaagaactta aagggcaaga aattccagag actcaagtgg agccaactga 661 agaattaaat tctgagaatc ttgcttctca agaagaaaca actaagagtg atattagtga 721 atgggatgcc tcagagcctg tacttgatga gccagtagtt gccaaggctg aagtttcaga 781 aggttttgta agtgaaccag tgattgcaga accagtaatt gctgctagtg aaccacttga 841 ttcaaaagtc gaagagaaaa cgagcgaaca atcagcttat gcagatattc ctcagaatcg 901 ttcactagaa aatcaagatg aaattaaaac taaatggaac tggggcgctt ttgctttaac 961 tatgtggttt gggattgcca atcgcgctta tttgggactt ttgattctac ttactttggt 1021 accgtgggta ggttggattt ttgggattgt atggatgatc gtttttggtt ttaatggcga 1081 aaaatgggca cttgaaaatc gagataataa atatcgtgat gaggaagagt tccgtaaggt 1141 catggacggt tggaatcgag caggtttcgt tgcattcatc attggaattg tattatttgt 1201 gattgcaatt ttgattctta ttttcgtatt agtctttgct tttaacagct ataataattt 1261 tgataatggt taccgcgatt ttggaaacta ctaattaatg taaaaatgat agacaatttt 1321 catcttgtct atcatttttt gtcagtaaaa aatgaaaagc gagcccttgc tttttgtgtt 1381 ataattagaa ttaatttaaa aaaacaagag agcgagatta ttgtgggaaa aattattgaa 1441 ctaaatgaag cgctcgccaa tcaaattgct gctggagagg tggttgagcg gcctgctagt 1501 gttgtcaaag aattagtcga aaactcaatt gatgctggaa gcagtaaaat tattatcaat 1561 gttgaagaag ctggtttgcg gttaattgaa gtcattgatg atggtttggg tttggaaaaa 1621 gaagatgtgg ctttggcttt acgtcgtcat gcaacaagta aaatcaagga ttcggcagat 1681 ttgtttcgga ttagaacact tggttttcgg ggggaggctc tgccatcaat cgcttctgtc 1741 agccagatga ccattgaaac aagtacggct gaggaagaat caggaacaaa actagttgct 1801 aaaggtggaa atatcgaaac tttagaacca cttgctaagc gagtggggac gaaaatttct 1861 gttgctaatc ttttttataa tacaccagca agactcaagt atatcaagtc cttgcaggct 1921 gaactttctc atatcacaga catcatcaac cgattgagtc tggctcatcc agagatttcc 1981 tttactttag ttaatgaggg taaagaattt ttgaaaacgg ctggaaatgg tgatttacgc 2041 caggttattg ctgcaattta tggcataggg acagcgaaaa aaatgcgtca aatcaagggc 2101 tcagacttag attttgaact aacaggttat gtcagcatac cagagctgac aagggctaat 2161 cgtaattata ttacgatttt aataaatggt cgatttatca aaaacttttt attgaatcgg 2221 gcaattttag aaggatatgg caatcgattg atggtgggac ggttcccttt tgctatttta 2281 tcgattaaaa ttgacccaac acttgctgat gttaatgttc atccgacaaa acaagaggtg 2341 cgtttgtcta aagagcgtga attgatggct ttaatttcta aagcaattga tgaggcttta 2401 tcagaaggtg ttttgattcc agaagctttg gaaaatttgc aaggaagagc taaagaaaag 2461 gaaactcttt ctgttcaaac ggaacttcct ttgcaaaata atcctttata ttatgataat 2521 gttcgccaag atttttatgt cagagaagag gcaactttta aaatcaataa aaatcaagct 2581 tcaaatgatt cgtctgaaca aacttttgat aattttacag aaaatcaact taatacagat 2641 gctgtcagtg aaaaaatgac tgacagaact gtggaaagta ctactgaaat tactgacaac 2701 agtctagaaa atactgtcag caactttgaa attgattttg ataatgaagc aaagataagt 2761 cagtcatcaa cttttccgca gcttgaatac ttggcacaat tgcatgcgac ttatttactt 2821 tgtcagtcca aagaaggact ttacttggtt gaccaacatg cggctcaaga gcgaatcaaa 2881 tatgagtatt ggaaagataa aattggtgag gtcagtatgg agcaacaaat tttacttgca 2941 ccatatttgt tcattttagc caaaaatgat tttattgttt tagccgagaa gaaagatttg 3001 ttgcatgaag ccggtgtttt cttagaagaa tacggagaaa atcaattcat tttaagagaa 3061 catccaatct ggttaaaaga aaccgagata gagaaatcaa ttaatgaaat gattgatatt 3121 attctctcat caaaagaatt ttcactcaaa aaatatcgtc atgatttagc tgcaatggtt 3181 gcttgtaaaa gttcaattaa agctaatcat ccccttgacg ccgagtcagc tagagcttta 3241 ctcgcagaat tagcaacttg taaaaatcct tatagttgtg cgcatggacg gccaacgatt 3301 gttcattttt caggggatga cattcaaaaa atgttccgga gaatccaaga aacgcatcgt 3361 tcaaaagcag cttcgtggaa agattttgag taaaaagtga ctaaacagat taatgatgaa 3421 gttggtcagt aaaaaaatag ataaaaacta ctgacagact tgaataaggg agtttgtcaa 3481 tcaaaaaaat tagaaaagta aaaaaatgtt tgaatatctt aatggaaaat tagtaaaaat 3541 ttccccaaca aatattgtaa ttgatgtagc aggaattggt tatcttatca gtgtagctaa 3601 cccttacgct tggtctgctt tgatgaacac agaagtaaaa atttatgttc atcaagtcat 3661 tcgcgaagat gcccacagcc tctatggttt tgttaacgag gccgaaaaag ctttattctt 3721 acgtctgatc agcgtttctg ggattgggcc aaaatcagct ctggccatca ttgcggcggc 3781 tgataacgaa ggtttaatca ctgctattga caatagtgat atcaagtatt taactaaatt 3841 tccaggagtt ggtaaaaaaa cagccatgca gatggtgctt gatttggctg ggaaatttga 3901 tgcgacagga actgtaggta tttctcttct tgatgctgga cctgctggca atcttgcttt 3961 ggaagaagcg attgaagcgc tgcaagcttt gggttataaa gcaacagaat tgaagaaaat 4021 tgagaaaaaa ttagctcaag aaacaggtct gaccagcgaa gaatatatca aatcagcctt 4081 aaaacttatg atgaaataaa aaagtttgaa gaaagaactg acagacatca aaaatagtca 4141 ttaaagtctt tctgtcagta aaatttactg acagcttctc ataagttatc aaaaatcatc 4201 tctaaaagga gaattacaag ataagatgaa cgatatatta aacaaagagc caatggaaga 4261 agattacggt attgaaaaat ctctacgtcc gcaatttttt aatcaatata ttggtcaaga 4321 taaagtcaaa gaacaattag aaatctttat taaagcagca aaaatgcgtg aagaagtttt 4381 ggaccacgtg ttactttttg gccctccggg acttggtaag acaacaatgg catttgtcat 4441 tgccaatgag ttgggggtta atattaaaca aacagcgggt cctgccattg aaaagccagg 4501 agatttagtt gcgattttga atgaattgga acctggcgat gtgctattta ttgatgaaat 4561 tcatcggatg ccaatgcaag ttgaagaagt tctttatagc gctatggaag atttctacat 4621 tgatattatg cttggttctg gtgatggttc acgctcggtt catttagatt tgccgccatt 4681 tactctagtt ggggcaacaa caagagctgg aatgctttcg aatccattgc gtgcccgttt 4741 tggaatttca agtcatatgg agtattatca agagcgtgat ttggaagaaa ttgttaaaag 4801 aacagctgat atttttgaag tcgaagttat tgataatgcc gctttagaga ttgctttacg 4861 tagtcgaggg actccgcgga ttgccaatcg tttacttaaa cgagtgcgtg attttgctca 4921 aataatgggg gatggccgag tggataaagc aattaccgat aaggccttgt ctattcttga 4981 tgttgatgcc gctggtttgg actatattga ccaaaaaatt ctccgcacaa tgattgaaat 5041 gtaccacggt ggtcctgttg ggattggaac tttggcggta aacattgccg aagaccgtga 5101 aacggtcgag gatatgtatg aaccttattt gattcaaaaa ggatttttga tgagaactaa 5161 acagggacgt aaggtgaccc aaagagccta tgaacaccta ggttatgttt acaatgaaga 5221 agattgacag ttagtatctg tcagtaaaaa ggtttgtcaa agcttgacgg gcttttttat 5281 attacataaa ttcctgccgt tgtaacaata atgaaaaaag tatataatat gaccataaag 5341 ttacgactgg agagacaaga caaatggtta atcaatacta tggtttaaaa cttcaagaac 5401 tctgtgaagc taaagaaatc acgaaaaatg aaattatcaa aaaaacagga attcctaaaa 5461 gtagtctctc tcgttttttt agtggagaag gttatttaaa tcttgatcaa attgatgctt 5521 tgcttgaatt tcttcacttg gaactttctg aatatgatta ttatctcaat aattttaaac 5581 atagttttta cgaagaatta tttagtaaaa tcgaccaagc ggcaacgaat aataatattg 5641 aagaactaaa agacattgcc tggcaatgtg agcaaattgg cgaacatttg attgctcttt 5701 gtgccaaagc acgcttagaa aagttgccag aaaacgaagt ggttgagtta agttctttta 5761 tttttggaat tgaaatattt agtttttatg aacttctcat tttgtcagat accattgagc 5821 aattttcgtc agaaatgata aaagcaatta ttcaagattt gagccatcat catcaaaggt 5881 tagccaatcg tacacgttat cgcaaaatta tttgtcaaat cgcctgtcgc ggagcagtga 5941 cttgtatcca agaagggaaa gaaaaggaag cgcaagaatg tctggctctg gtcaaagcat 6001 attgtcatga aaaagacgca tattctagat tgatttatcg ctttactaaa ggttattatt 6061 gtatttttta tggtcaaggc gaagaacgac ttctgggaat tgatagcatg aaaaaggtca 6121 tcgaaatttt tgattgggaa ggaagtataa atttagcaaa aacctaccaa aaactctatg 6181 ataaatatgt gaaaaactat aattttcctc aatggttaag tgatattcta ggaaaagatt 6241 caatttgaat cttttttttg tgctttcgaa atcggtgcta caataaagtt aaggagacaa 6301 aaataaaaac aaacgaggaa aaaccaatgg acaaattcgc aagctactga gcgcagccaa 6361 gaaaacaaag taaaaaatga aaggaagctc tcaacatgag aaaaatatca tcagcttgat 6421 tcagaaaaga taatttcttt ctgaatttgg gcagaaagag gtaaattatg aaaatgaatt 6481 tgaaaaaaca aatctttgtc ttatcaactt tacttgttac gacaggtgcg ataggggtaa 6541 cttctgtatc tgcgactcaa gtcacctatg taaaaacaag ttcagttact tactatctaa 6601 ataatgtttc tacaggaaca acggattatt atgattatgt gaatatcctt catggaggtt 6661 cttatacaac caccacaagt acaatttact acacggtagt aaattctgtc ggacaaagtc 6721 aaccggcaaa acaagtaact acttattatc attattgatg gaataggagt aagctacctc 6781 acttactcct atttaatgat tatttttgat tgagaggtga ttaaatgaaa tacttcaaat 6841 ttgaattaaa aaagtttatt ctaaacaaaa gaaacagata cttattagct ttgatttctt 6901 ccttaatcat agtttatagt gtatataata caatttcttt tactaatatt tttaaaaata 6961 acatcactag ccttgttcaa gaggtacaga ctaatgaaaa atcagttcag gataacattg 7021 aaactactga agaaagccta aaaaccacaa aagtgaaggc agaagatgat aatctaaata 7081 atacattgag tgacttaaag caaaaagata acatctatca aaaacaaatc gcagctatag 7141 gcgtcaatga cattaatgaa tattatcatt tacaaaaaga aattgaccag ttgtatttta 7201 aacaaaatgg taaccaatca tcatctggtc aagataaatt cctgaaagca gaaattaagt 7261 atatcaagac agttcaagag agaaagttag attttgaagc aatgcctacc atgcaatctc 7321 atgcttttgg aaattttcat cagcagttca ttccaatttt aacgagtagt ctattcattg 7381 tcttatttgc ttccatggtt tcaatccttg tcgccactag ttatgaatca aaagaaaaca 7441 gattttatcg atttgcggga attgatttgc agaaaaattt aattataaaa gttttatctg 7501 gaactttagc gacctttgct tggattatta tttctagtat catttatttt ctggtaattg 7561 gggtggtgaa tggttttgga gcatggaatt atcccgccta tcttggtgat tcggatttga 7621 aaacaggatt tactttgact aatctcacaa ttccaaatgg aattttggat ttaggaagta 7681 tcctctatct gttttttgtc atctttttct tggcttcatt aggtgccttg atttctgttt 7741 ttgtaaaacg gagtatggtt gttgttgggg ttatagctct atttgtcatg ggatattcga 7801 tgataggaaa tgtttcttgg ataatttcaa ttagacgttt tgtgccactt tcttatcttg 7861 aacctctaaa actttttgga aatcctagtg ctctttttgg aaaatattct atattaatcg 7921 gggctggcta tctactttct ttaagtgtat tatttttgct catctctgtc ttcattatta 7981 aaaatcaaaa aacaaggaga atctcatgat attaaaaata aaaaatttaa agataccaga 8041 cattgctccg cttaattttg agatttctga aaatggtttg tacggtctga ttggacgaaa 8101 tgggattggg aaaagtacac ttttcggcat tctttcagga gaaattggat tttctcaagg 8161 agaaatagaa aatgggcgtg tcgcttatct tcccgatgta gaatcttttg aagaaagttt 8221 aaaaatgcat gattatttta aaattttgaa aaatagtgaa caggatagag caagagagtt 8281 aagtcttact tttggtgcag ataaatttgc gaaaaagaga attggccaat tttctttagg 8341 aatgaaagag ctttttgcga caattttatc attttctatc gactgtgata ttttaatcat 8401 tgacgagcta ttcagtgggc ttgacgtttc caaaaaagcc ctagtttatg aagaagtgaa 8461 aaaaatcgct caagaaaaaa ttgttttatt aacctcacac aatctcaagg aaattgaaca 8521 tttctgtgac caagcttatc tattgtccta aaaaggactg actttggtga caaattttga 8581 tgaagcggca aaagaaatcg gttatatgga tgtatttttt tagtgaaagg gaattaatgc 8641 gaaataatac tacattattt ggtttatata ttttctaata attgtttccg attaagagat 8701 aagtcgaatg aaagataagg agaacttatg tcagtaatta cacctgcccc tcaacctaaa 8761 agtgatattt ttcgggaggt tgaacaactc caaaattctt ttaaaaataa tgaaagtaaa 8821 gttttggtag ataacaataa aatttataaa aaattgaagg aaaaaaagaa aaaaattaag 8881 cagaaagatt agttcgtctg tcagtaaaaa agtttgtcaa attttggcag actttttcat 8941 tttagaattc tgtcagtaat atcttgtgaa atagggtata atagaataaa tgctcaaaat 9001 tagttaattt ataaatgata taaagtaagg aagtcatgga aaagattgtt tttgtctgtt 9061 taggaaatat ttgtcgtagc ccaatggcag aatttgtcat gaaagattta gttgaaaagg 9121 caggaaatga atcaaatttt ttgattgaaa gtcgagcaac ttcttcttgg gagcatggaa 9181 atccaattca ttctggaacc caaacaaaac taaaagaaca aaagattgct tttgaccttc 9241 aaaaaggaag tcaaaaaatc agtagtgaag atttttatga atttgataaa attatcgcaa 9301 tggatgaatc caatttagaa aatcttagaa aaatggcacc agaaggaacg agtcaaaaaa 9361 tcgcgatgct tttagaacaa ggtgttccag atccatggtt tacgggcgat ttccaagaaa 9421 cttatcaact tgttaagacg ggttgtcaaa gattattgga tgaaattgta taaaatattt 9481 caaataaaat aaaccgatgt gagaaaatct cacattaaaa cttgactttg ctaataacaa 9541 ggtctataat gaaaggcatg gaggcgagat ttggtgaaag aacgtgaatt aagacgctct 9601 atggcggtac ttccaatagg aactgtcatg aaactcactg acctaagcgc aaggcagatt 9661 cgttattacg aagagcaaga gcttattttc ccggagcgaa gtgacggtaa tcgtcgcatg 9721 tattcgctca atgacataga tgctctattt gatattgctg acttattgca agaaggtaat 9781 aatattgcag atatcaaaga aatttatgcc aaaagggatg ctaagaaggc tcaaacttta 9841 tctatcggag aagtccacca tgcacttgaa cgcgaatttg cccaacaagg tagattcgga 9901 actcctgatc ccactcattt tacccaaccg cggatgtaag tttagtttac tttatttgtc 9961 aactaagttt acagcgaaaa tttaactagg agagtaaagc atgacaatca cagcagcaga 10021 cattcgtcgc gacgtcaaag aaaaggatat taaattcttg cgtttgatgt ttacagacat 10081 tcttggaaca cttaaaaacg ttgaagttcc agctacagat gaacaattgg acaaattgtt 10141 tgaaaacaaa atgatgtttg acggttcatc aatcgaagga ttcgttcgta tcaatgaatc 10201 agacatgtat ctttatccag accttgacac ttggattgtt tttccttggg gagatgagta 10261 tggtaaagtg gcaggtgtaa tttgtgatgt ttacactcca gaaggtgaac ctttcgctgg 10321 agacccacgc ggtgtcttga aacgtaacct taaatcaatg gaaaaattgg gcttcaagag 10381 ctttaacctt ggacctgaac cagagttctt ccttttcaaa cttaatgaaa atgatgaacc 10441 aacacttgaa gtgaatgata aaggtggtta ttttgacctt gcaccaactg acctcgctgg 10501 aaacacaaga cgtgaaatcg taaatgtatt gacagacctt ggttttgaag ttgaagcttc 10561 tcaccacgaa gtagcaatcg gtcaacacga aattgacttt aaatatgcca atgctttgaa 10621 agcttgtgat aatattcaaa tctttaagct tgttgttaaa acaattgcgc gtaaacatgg 10681 tttacatgca acgtttatgg caaaaccagt tcacggaatc aacggttctg ggatgcattg 10741 taacatgtct ttatttacag aagatggtgc caatgccttt gctgatccaa caggagatat 10801 gggactttca gatgttgcac atagctttat tgctggactt ttgaaacatg cttataactt 10861 tacagcaatt acaaacccaa ctgttaactc atataaacgt ttggttcctg gttatgaagc 10921 acccgtttat gtcgcttggg ctggacgtaa cagatcacct ttgattcgcg tacctgcttc 10981 acgtggtttg tcaactcgtg ttgaacttcg tgcggttgac ccaacagcaa atccatatct 11041 tgcattggct gttctattgg cagctggtct tgacggtgtt gaacataaat tggaagcgcc 11101 agaagcaatc gaatcaaata tttacgtaat gacagaagaa gaacgtaaag cacatggtat 11161 tacagatttg ccatctactt tgcacaatgc cgttaaagca ttgcgtgaag atacaattgt 11221 gactgaagcg cttggagaac atgttttggt taactttgtt gaagcaaaac gcattgaatg 11281 ggcaagctat gcacaattcg tatcgcaatg ggaaattgat aactatttag aactttatta 11341 attgatataa aaaatcactg acaaagcctg tcagtgattt tttggaccat ttaaatattt 11401 tagttgtttt cagtaattgt caaaacgttg aaggcagttt ttccgtcttc ggcaatcaag 11461 aatcctttgt gttcagcaac atagtcaata gctgcttgga aatcagcgaa ttctttgacg 11521 attgagcaag tgtttgtggc accgacataa ttgttttctg agtcctcgta ataattgatt 11581 cctttaaatt taaatttcat aataaaaagt cctttctttg ttatagtttt attatagcaa 11641 atggcactta ttttttactg ataaaacttt aaatcaaagt tgaaatcaca aaaagagcca 11701 tattttttga aaaattcaca aagtcagtgt aaacttgaga taggttttat gaatttaatg 11761 cgagaaagga agcgaatctt aatacttttt actaaaagta gatttgcata ggaaaatatg 11821 gaactcaatg atttgaaaga ttcactgact gctttaaaat atggtgaaat tgcaactgtc 11881 gcgatgattg accgaggcgc atatgctgaa attgaagagt ctattgaagc ggaaagtaaa 11941 gatcaaaaga taaattctgg aatctttaaa gagcttgctg ctacagttaa agatgaaaac 12001 gaggatttag tggtagttgg tcgttcagat attgatcagg cactgactcc agaagatttt 12061 tcgcgattta tcggtcagat gaccaaggaa aaacatatta ttcttgttga gtgtctctat 12121 ttgggaacaa cagaaattaa aggttttctt aacagcttga aagaaaataa tcttttagaa 12181 aatagtaaat tggttctgct tgatttgccg caattagaat acatgatgtt gcgagacagt 12241 ttagctggac aatttaaatt ataaaaaaag ttactgacaa aattatcgct cagtctgtaa 12301 gttgcgtaag caagcagata ggagtgatag aatttttgtc agtaactttt tcttattgtt 12361 cacggttttc tctttgataa aggcgagaat ttttcataat atctttaaaa gtattaatga 12421 ttgtttcttg ataagcagaa tttttaatat tttggcgagc caaatctaat acggcttgtt 12481 cgcgagagtt atctaaaata gtaatttttt gtgcttgttt ttcttggcta atttcttgaa 12541 caattgtcat acgtttctca agaagctgaa cgatttcttg gtccacgtgg tcaatgttgt 12601 tccgaagttc ttctagttta ttcatggttt ttattatatc atagccagta acacgaaaca 12661 acgtttcatg ttgctgactt ctttctctca ttatgaccga actcagcggg acgataattt 12721 tccgccgagt gagtgcggct cgacttgttg ctttagcaac gtagcgtaga gaagtaataa 12781 ggtatctact ttgtttcact acgttgtcca taccacaggt gtccattttg tcagcattgc 12841 taaagcaacg gacaaaaggg ctcgatctaa gccagcaagg tgaaaaggca ggaaggacgc 12901 catagctgga agcgactgaa aagggagctt tcagggtgca gattagaaaa gtatagcttt 12961 tcaccttttc gtctgcgcgt tcacgcttta gcgtgttgcc tttttggcag ttgcttgagc 13021 agctagtcaa aacggacagc gtagtagaag caagaatgct tatatcaaaa ctaatctaaa 13081 atttgccttt aaaaaatgat ataatggatt atattatttt tgaggagcaa caagatgaat 13141 aaagaagaaa aaatcgaagg ttatgagttg cttaatttgc aactaaaagc gcttcttagt 13201 gaacaaaatt atacactttc aaacttagcc aatgcaagta gtttactttg gagctttttg 13261 cctgagcaag tttatacagg tttctacctc tacaatggtg aaaaattaat tttagggcca 13321 tttcaagggt ctgtgtcttg cgttgaaatt ataatgggca aaggggtttg tggggaatca 13381 gctcaaaatc gccaaaccat tattgttgaa aatgtaaaga aacacaaaaa ttatatttct 13441 tgtgacggtc gagcaatgtc tgaaattgtt gttccgatgg ttaaagacgg taaattagtt 13501 ggggttcttg acttagatag ttcagaaatt ggtttttacg atgaaatcga ccaaaaatat 13561 cttgaagaat ttgctaacat tttatgtgaa atgactgatt ttaaattttt tgaagtaggt 13621 taaatcaaaa ttttaaaggg tatcggagaa aaaaatgagt gaaatagtaa aaaaatttat 13681 tgctgaccgt tttggggaaa aagaaggaat atctgtaaat ccaggtaata ttggagatgt 13741 tcgtgaattt gcgcaagaat taggaagttt tctctatcaa ttacatcggc taccaacaac 13801 agatgcaaag tcacctagtt ttgaaaatgc ttttgctggc tctgatttga ttttctttga 13861 agctgagatg atagaacttt tgaaagtcta tcaaaaagtt gttcctgctg accttttgca 13921 agaaaaattt gattttgcag caaaaacaaa atggtccaag aaacctgttt gggttttggg 13981 acaattgctt acgcaaaatt taaaagttac tgacggaaag ttagttaacg tcaaaattac 14041 tgacaaagct gttattggtg atccagcttt tgatttagca attgcttgga cgatttttga 14101 tgaaaaagca cgtaaaatat tttttgcggc aaccgaagca gatgaggcaa cgattaatcg 14161 agcaagaatg ttcgccctca gacaggccct cagaaattat caatcacaag atattgatga 14221 attgattcaa tcacgtgatg cttcaactga aattttaaaa gacttaaact atagtcttgg 14281 gcaagatttc tattgaaaca agcggatatg aaaagaatac taagtaaaaa attggaagag 14341 aaaaatggca tatcaagcat tatatagaaa atatcgaagt caaagatttg atgaaatggt 14401 ggggcaagaa gttgtagcaa caacattaaa aaatgcgatt gtcaatcatc aaatttcaca 14461 tgcttatctt ttttctggtc caagagggac agggaaaacc tcagcagcta aaatttttgc 14521 taaggcaata aattgtccta atcaagtgga tggagagccc tgcaataatt gctttatttg 14581 tgactcaatc accaaaggaa gcttagatga tgtcattgaa cttgatgcgg catcaaataa 14641 tggggttgac gaaattcgag aaattcgaga taaatcaact tacgcagcta gtcaagccac 14701 ttacaaggtt tatattattg atgaagtgca tatgctttca acaggggctt ttaatgcact 14761 tttgaaaaca ctagaagaac ctacagaaaa tgttgttttc gtcctggcta ctactgaatt 14821 acaaaaaatt ccagcaacca ttatctcgcg tgttcaacgt tttgctttta aatcaatcac 14881 aacaggagac attcggactt atttagcaaa aataatggct gatgaaggac ttgaattcga 14941 cggtaaagca ctcgatgtta ttgctaaagc agctgaaggt ggaatgcgtg atgccctctc 15001 tttattagac caagctttat cgttttcatc aggaaaatta gaagaaaatg atgcactact 15061 tgtcacaggg tcgattgctg cagatgcttt agtaacatat gttgtagcac tttttgagca 15121 tgatgaagca aaagcgctga cggaacttga taagattttt gctgaaggaa aaaatatgct 15181 tcgatttacg gaagatttat tagcatacct tcgggattta ctcttggata aaaattctca 15241 gtatgaccgg ggtcaaattt tttcatggat tgatgttgca attgaaagtt tgaaaacgat 15301 aaaggaaacg actcaaacaa aaattgcggc agacgtcatg accatgcgtt tggctgaaat 15361 tggacaaaat aatttactga cagcttcgca aggagaaatt ccaaatcagc tgacagccga 15421 aattgctact ttaaaaaccg aaattaatca attgaaagct caaatttcag ctggtcaaat 15481 tcaggtaaat tcagattcac aaaataattt actgacagaa aaagttaaag gcagtccgaa 15541 accaatagca tctaaaaaac gccaaattaa caaagattta atttataaag ctttggctga 15601 ggcgacaaat gaagctagaa aagctgctct aagtgcgtgg ccagaacttg ttgcttcggt 15661 aactaaaccg gcagaccgag ctttacttaa taatacagcc cctgtcgctg cgtcagaaaa 15721 tttccttgtg gtgacttttc ctcatgagaa tcttgctaaa agagtcagtg aaaatgaaga 15781 attgcaactt ttttgtggga atctcttgag ttcaattgtt ggatttgcgc cagaaattat 15841 ctctcttgct gaacaagact ggcaagaagt tcgagcagaa tatgtttcta atttaaaatc 15901 tgaaaatgtt caagaagatg aagaagatga aaaagagccg gatgaaacgg taaacttagc 15961 taaagaactc tttggtgaaa aagtagttga aattaatgat taaaataata aaaaagccgc 16021 tcattgagcg acttttttta atctttatga cgacttaaat caacctcttt aagggggata 16081 agtttcgttt tgtttttaaa tttataaccc aagtaaagga tgaagaagag tggaattgcg 16141 gcatacatga tgacaccttg cacccaagtt ttaccaaaaa gaagcattgg gtcttggccg 16201 agtgtgacta aaacggtcat aattaaggct aagattggac caaatgggaa tagttttgca 16261 tgataaggta attttttaac atcttttcct tgagcgacat aggcgcggcg gaagcggaag 16321 tggctaattg caatcccaat ccaagcaata aatcctgtta aaccagaggc tgagacgagg 16381 aatgtaaaga agctaactcc gtaaattgat gtcaagaatg tgagtaaagc aacagcagtt 16441 gtagctaata aagcaatgaa aggaatcccg ttttttgaag tttttgagaa aatctttggt 16501 gcgccaccat ctttagctag tgaataaagc atccgagtag aggcatacat tccagagttt 16561 gctgctgaaa cgacagaagt taaaacaacg gcgttcatga tagaagctgc aatagagaga 16621 ccaacacgtt caaatacaat tgtgaaaggg ctttgagcag ctgaatctcc tccaactaag 16681 tgggggtcgg taaatggaat gatagccgcc atcacgaaga tagataagat ataaaagaca 16741 agaatacgcc agaagataga gttcatagct ttaggaattg atttttcagg attttcagct 16801 tcaccagctg taattccgag caattctgtt ccttggaaag agaaaccagc gactaagagt 16861 acgccgagaa tccctccgcc ggtagtgaaa ctaccaagtc ctccgacaaa accatgatta 16921 ccaactgaaa gatttttagc gacgtcaata tgaccgccca taattccaaa aatagataag 16981 aaaccaataa tcaagaataa aacaacaaca gtaattttaa tggctgacaa ccaatattca 17041 gtttcgccaa aagttttaac tgataaggca ttgattgcaa agacaataat taaggcaatc 17101 agtgaaaaaa tccaacttgg aacatctggt aaccagaatt tgatacaaag ggcaacggct 17161 gttaaatcaa ccgctacggt aattgcccag ttcaaccaat aattccaacc tagagcaaaa 17221 ccaaaagctg ggtcaacata acgtgttcca tagtctgaaa aagaaccaga agtgggtaaa 17281 taagtggcca tttcaccaag tgatgtcatg aggaagtaaa ccattgctcc gataagaaca 17341 taggcagtca gtgcaccaaa tggtcctgcc gtgtgaatga catcgcctga agtcagaaac 17401 aatccagttc cgattgttcc gccaagggca atcatggaaa catggcgtga ttttaagccg 17461 cgttttactt gcgtctcagt agttgagttt gaagaatttt ccaaaattct ctccctaata 17521 aaatttattc tacaccgact tgtttgactc agactcaacc ttactcctgt ttagtttaga 17581 aaagtctgag aaaaacaaaa aaagcaatcc tactaggata gaatagattg ctaaaggtcc 17641 gacaaaattt taaaaatttt cttgaacgaa tagccctccg catggttatt aaccatttgc 17701 gacagtctag tgagtttttc tcactagccc aagaactttg ctgagcaaca aaattctttc 17761 ggcaacctct cctcctctat atacgcgtct ttgttgtgct ccaactcggc gtagattcat 17821 atcagttgcg acctctatcg atgtgttatt tgtaattcta gcgcaatttt aagatgatgt 17881 caaggaagag aatgtaaaat taattacaaa taatcacttt ctttgtaagt ttattcattt 17941 gtcatttatg atatacttat gaggatagga ctgctatgtc agtcaataaa aatcagtctt 18001 tttactgaaa ttttctagga gcaaaatatg gattttattc gtgccattat tttaggtatt 18061 attgaaggaa tcactgagtg gttacctatt tcctcaacag gacatttgat tattgctgat 18121 gaatttattc gtcttaatca atcagcagct tttaaagaaa tgtttgatgt tgtgattcag 18181 ctaggagcaa ttttgtcagt tgttgttctt tattttcata aactgaatcc atttaataag 18241 ttaaatccag ctgacaaaca aaaaacccca cgtgaaattc aattaacttg gcgtttgtgg 18301 ttgaaagttt tgattgcggc tttaccagca gcgattattg gtttaccact taatgactgg 18361 ttggacaaac atttttacca ttttgttcct gttgccttca tgttaattat ttatggggta 18421 gcatttattg tcattgagcg tcggtgggta ccaaaccatg aattttccgt aatgaatatt 18481 gaccgtttgc cttatcgtgc cgctctttat attggattat tccaagtgct gtctttactt 18541 ccagggacat cgcgttcagg tgcgacaatt gtcggtgctt tattaattgg tgtaagtcgt 18601 gaagttgccg cagaatttac ctttttcttg ggtattccag ttatgtttgg ggctagtttc 18661 atcaaaatac ttcacttttt caaaaatggg aattctttaa gttttgaaca atttggggtc 18721 ttgttagtag cttgtatagt tgcctttggg gtatcaatgg ttgccatcaa gttcttgacc 18781 gattatgtga aaaaacatga ttttactttc tttgggaaat atcggattgt gttagggatt 18841 atccttctta tttatgcaat gtttaaagcc tttttgggct aagaatgaga taaattatgc 18901 caactctctt tagttggtat tttttatttt aaaatagttc tctttgctga gggaaagttt 18961 aaatgtattc ttgctaaaaa tagaaaaaag tgatagaata taactctgtg ggaaaaactc 19021 acaacttacg caggactcaa cctgcgtcat tagtccaaaa ggaggaaaaa tcaatgacta 19081 aatacgaaat tctttatatt attcgcccaa acattgatga agaagcaaaa gctgccctcg 19141 ttgaacgttt cgatggaatc ttgactgaca acggtgctgc aaatcttgag tctaaagact 19201 gggaaaaacg taaacttgct tacgaaatca atgatttccg cgaaggtatc taccacatcg 19261 caacttttga agctgaaaca acttcagaag ctttgagcga atttgaccgt cttgctaaga 19321 tcaaccttga cattcttcgt catatgatcg ttaaagttga agcttaagag ctttcatttc 19381 taaggagaag ttcatcatga ttaacaatgt tgtattagta ggacgcatta ctcgcgatcc 19441 tgaacttcga tacacccctc aaaatcaagc tgtcgcaaca ttttcattgg ctgtaaaccg 19501 tcaatttaaa aatgcgaatg gcgaacgtga ggctgatttc attaactgcg ttatttggcg 19561 ccaacaagct gagaatttgg cgaattgggc taaaaaagga gctttgattg gggtaactgg 19621 tcgaattcaa acacgtaact atgaaaatca acaaggtcaa cgcgtttatg tgactgaggt 19681 tgtggctgac agtttccaaa tgttggaaag tagatctgct cgtgaaggta tgggaggcgg 19741 aacttctgct ggttcatatt ctgcacctag ccaatctaca aataatactc cacgtccaca 19801 aacgaataac aataatgcaa caccgaattt cggtcgtgat gctgatccgt ttggtagctc 19861 accgatggaa atttcggatg atgaccttcc attctaatag ggtgaaataa ttgacgctaa 19921 agcgcctaat tatttcacgg aaaccgctat ggcggatttc ctaaccctct tactagttat 19981 tatgaaaagc agaatcggct tttcataata acgtcgtaat cctaagaaag ctttaaacag 20041 acatctaaaa ataatataag gagaaataaa atggcacaac aacgtcgtgg cggcttcaaa 20101 cgccgtaaaa aagttgactt catcgctgca aacaaaatcg aagtcgttga ctacaaagac 20161 actgaacttt tgaaacgttt catctcagaa cgtggtaaaa tcttgccacg tcgcgtgact 20221 ggtacatctg ctaaaaacca acgtaaagtg gttaacgcaa tcaaacgcgc gcgcataatg 20281 gctttgcttc cattcgtagc tgaagaccaa aactaataaa tgaaaggctg cttcggtggt 20341 ctttttttgt ataaaaattt gataattaga gttgatattt actgacagaa agctcggttc 20401 cgtccgaatt tactgaccag aaatttgtca gaaaaagaga atagattgat aacttcatca 20461 agtatttttg attaatacta tgtttttgtc agtgaattta tgataaaatg gacaaatgat 20521 tgaattgata ataggagcag tgctcttaag tttgttaatt tatggaattt ttatagagcc 20581 tcatttgatg aaagtgagac atgtaaaaat cgctcaaaaa caaaatttaa aaattgctca 20641 ttttaccgat acccactttg cttggcacac gactagtcgt cgttttaaaa aatttgctcg 20701 aaatattgct aatgaacagc cagatttaat tattttttct ggagatttat ttgacaaggt 20761 tgcttgggca aaaaatcgag attggactga tttactgacg atattgtcag aacttaaagc 20821 tcctcttggg aaatttgcga tacttggtaa tcatgatttt gatgatgaaa aatcgtcaag 20881 gtttgttgaa gagtttctag aaaaagctgg ttttgttctg ttgaaaaatt catcagttgt 20941 caaagataat ttatctattt ctggggttga tgactggcgt gagggacggc ctgattttga 21001 acttgagcct attgatgcaa cattttcgct tttagccctt cacgaaccgg atactatttt 21061 agacatggaa acaattaagg aatttgattt aattctttct ggtcatagtc acggagggca 21121 aattcggata ggaaattggc gtttacgcaa taaggggtca agtagtgctg atgctggttt 21181 gtatcagctc aatgaccgaa caaaattgta tgttaatcgt ggaattggtt tgactttctt 21241 acctattcgt tttggggtgc ctccagaaat tgtgtattac tacatctaaa aaaatctgtc 21301 agtaattttg acagattttt ttatttaaaa atttactgac a //