LOCUS       JAWXXO010000002        21341 bp    DNA     linear   BCT 20-NOV-2023
DEFINITION  Lactococcus lactis subsp. lactis strain ATCC 19435
            contig_2_polypolish, whole genome shotgun sequence.
ACCESSION   JAWXXO010000002
VERSION     JAWXXO010000002.1
KEYWORDS    .
SOURCE      Lactococcus lactis subsp. lactis
  ORGANISM  Lactococcus lactis subsp. lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
COMMENT     The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##rhizoSMASH-Data-START##
            Version      :: 0.3.1-cb03db34
            Run date     :: 2025-03-15 23:19:40
            ##rhizoSMASH-Data-END##
            ##antiSMASH-Data-START##
            Version      :: 6.1.1-b1d0db06
            ##rhizoSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21341
                     /aStool="rule-based-clusters"
                     /category="Amino-acid"
                     /contig_edge="False"
                     /core_location="[618603:619944]"
                     /cutoff="6000"
                     /detection_rule="(cds(Gln-synt_C and Gln-synt_N) and
                     minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))"
                     /neighbourhood="10000"
                     /product="Glutamine_synthetase"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11341
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="6000"
                     /detection_rule="(cds(Gln-synt_C and Gln-synt_N) and
                     minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))"
                     /neighbourhood="10000"
                     /product="Glutamine_synthetase"
                     /protocluster_number="1"
     cand_cluster    1..21341
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(Gln-synt_C and Gln-synt_N) and
                     minimum(1, [Gln-synt_C, HATPase_c, Response_reg]))"
                     /kind="single"
                     /product="Glutamine_synthetase"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21341
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Glutamine_synthetase"
                     /region_number="2"
                     /rules="(cds(Gln-synt_C and Gln-synt_N) and minimum(1,
                     [Gln-synt_C, HATPase_c, Response_reg]))"
                     /tool="antismash"
     gene            599..1294
                     /locus_tag="SIL76_03575"
     CDS             599..1294
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898700.1"
                     /locus_tag="SIL76_03575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="MDX6023571.1"
                     /transl_table=11
                     /translation="MGNEKELKGQEIPETQVEPTEELNSENLASQEETTKSDISEWDAS
                     EPVLDEPVVAKAEVSEGFVSEPVIAEPVIAASEPLDSKVEEKTSEQSAYADIPQNRSLE
                     NQDEIKTKWNWGAFALTMWFGIANRAYLGLLILLTLVPWVGWIFGIVWMIVFGFNGEKW
                     ALENRDNKYRDEEEFRKVMDGWNRAGFVAFIIGIVLFVIAILILIFVLVFAFNSYNNFD
                     NGYRDFGNY"
     gene            1423..3393
                     /gene="mutL"
                     /locus_tag="SIL76_03580"
     CDS             1423..3393
                     /codon_start=1
                     /gene="mutL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011677256.1"
                     /locus_tag="SIL76_03580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0032300 - mismatch repair complex [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity [Evidence
                     IEA]; GO_function: GO:0030983 - mismatched DNA binding
                     [Evidence IEA]; GO_process: GO:0006298 - mismatch repair
                     [Evidence IEA]"
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="MDX6023572.1"
                     /transl_table=11
                     /translation="MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIII
                     NVEEAGLRLIEVIDDGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIA
                     SVSQMTIETSTAEEESGTKLVAKGGNIETLEPLAKRVGTKISVANLFYNTPARLKYIKS
                     LQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMR
                     QIKGSDLDFELTGYVSIPELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRF
                     PFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEALSEGVLIPEALENLQ
                     GRAKEKETLSVQTELPLQNNPLYYDNVRQDFYVREEATFKINKNQASNDSSEQTFDNFT
                     ENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDNEAKISQSSTFPQLEYLA
                     QLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQQILLAPYLFILAKNDF
                     IVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSINEMIDIILSSKEFSLK
                     KYRHDLAAMVACKSSIKANHPLDAESARALLAELATCKNPYSCAHGRPTIVHFSGDDIQ
                     KMFRRIQETHRSKAASWKDFE"
     gene            3506..4099
                     /gene="ruvA"
                     /locus_tag="SIL76_03585"
     CDS             3506..4099
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /gene="ruvA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836117.1"
                     /locus_tag="SIL76_03585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0009379 - Holliday junction helicase complex [Evidence
                     IEA]; GO_function: GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]; GO_process: GO:0006310 - DNA
                     recombination [Evidence IEA]"
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="MDX6023573.1"
                     /transl_table=11
                     /translation="MFEYLNGKLVKISPTNIVIDVAGIGYLISVANPYAWSALMNTEVK
                     IYVHQVIREDAHSLYGFVNEAEKALFLRLISVSGIGPKSALAIIAAADNEGLITAIDNS
                     DIKYLTKFPGVGKKTAMQMVLDLAGKFDATGTVGISLLDAGPAGNLALEEAIEALQALG
                     YKATELKKIEKKLAQETGLTSEEYIKSALKLMMK"
     gene            4226..5227
                     /gene="ruvB"
                     /locus_tag="SIL76_03590"
     CDS             4226..5227
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /gene="ruvB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131994.1"
                     /locus_tag="SIL76_03590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_function:
                     GO:0009378 - four-way junction helicase activity [Evidence
                     IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="MDX6023574.1"
                     /transl_table=11
                     /translation="MNDILNKEPMEEDYGIEKSLRPQFFNQYIGQDKVKEQLEIFIKAA
                     KMREEVLDHVLLFGPPGLGKTTMAFVIANELGVNIKQTAGPAIEKPGDLVAILNELEPG
                     DVLFIDEIHRMPMQVEEVLYSAMEDFYIDIMLGSGDGSRSVHLDLPPFTLVGATTRAGM
                     LSNPLRARFGISSHMEYYQERDLEEIVKRTADIFEVEVIDNAALEIALRSRGTPRIANR
                     LLKRVRDFAQIMGDGRVDKAITDKALSILDVDAAGLDYIDQKILRTMIEMYHGGPVGIG
                     TLAVNIAEDRETVEDMYEPYLIQKGFLMRTKQGRKVTQRAYEHLGYVYNEED"
     gene            5364..6248
                     /locus_tag="SIL76_03595"
     CDS             5364..6248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898698.1"
                     /locus_tag="SIL76_03595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="MDX6023575.1"
                     /transl_table=11
                     /translation="MVNQYYGLKLQELCEAKEITKNEIIKKTGIPKSSLSRFFSGEGYL
                     NLDQIDALLEFLHLELSEYDYYLNNFKHSFYEELFSKIDQAATNNNIEELKDIAWQCEQ
                     IGEHLIALCAKARLEKLPENEVVELSSFIFGIEIFSFYELLILSDTIEQFSSEMIKAII
                     QDLSHHHQRLANRTRYRKIICQIACRGAVTCIQEGKEKEAQECLALVKAYCHEKDAYSR
                     LIYRFTKGYYCIFYGQGEERLLGIDSMKKVIEIFDWEGSINLAKTYQKLYDKYVKNYNF
                     PQWLSDILGKDSI"
     gene            6468..6758
                     /locus_tag="SIL76_03600"
     CDS             6468..6758
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131992.1"
                     /locus_tag="SIL76_03600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="MDX6023576.1"
                     /transl_table=11
                     /translation="MKMNLKKQIFVLSTLLVTTGAIGVTSVSATQVTYVKTSSVTYYLN
                     NVSTGTTDYYDYVNILHGGSYTTTTSTIYYTVVNSVGQSQPAKQVTTYYHY"
     gene            6825..8009
                     /locus_tag="SIL76_03605"
     CDS             6825..8009
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427215.1"
                     /locus_tag="SIL76_03605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="MDX6023577.1"
                     /transl_table=11
                     /translation="MKYFKFELKKFILNKRNRYLLALISSLIIVYSVYNTISFTNIFKN
                     NITSLVQEVQTNEKSVQDNIETTEESLKTTKVKAEDDNLNNTLSDLKQKDNIYQKQIAA
                     IGVNDINEYYHLQKEIDQLYFKQNGNQSSSGQDKFLKAEIKYIKTVQERKLDFEAMPTM
                     QSHAFGNFHQQFIPILTSSLFIVLFASMVSILVATSYESKENRFYRFAGIDLQKNLIIK
                     VLSGTLATFAWIIISSIIYFLVIGVVNGFGAWNYPAYLGDSDLKTGFTLTNLTIPNGIL
                     DLGSILYLFFVIFFLASLGALISVFVKRSMVVVGVIALFVMGYSMIGNVSWIISIRRFV
                     PLSYLEPLKLFGNPSALFGKYSILIGAGYLLSLSVLFLLISVFIIKNQKTRRIS"
     gene            8006..8551
                     /locus_tag="SIL76_03610"
     CDS             8006..8551
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     ABC_tran"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 83.1; E-value:
                     4.2e-25)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.3"
                     /locus_tag="SIL76_03610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_function:
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /product="AAA family ATPase"
                     /protein_id="MDX6023578.1"
                     /sec_met_domain="ABC_tran (E-value: 4.5e-14, bitscore:
                     50.4, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILKIKNLKIPDIAPLNFEISENGLYGLIGRNGIGKSTLFGILSG
                     EIGFSQGEIENGRVAYLPDVESFEESLKMHDYFKILKNSEQDRARELSLTFGADKFAKK
                     RIGQFSLGMKELFATILSFSIDCDILIIDELFSGLDVSKKALVYEEVKKIAQEKIVLLT
                     SHNLKEIEHFCDQAYLLS"
     gene            8728..8892
                     /locus_tag="SIL76_03615"
     CDS             8728..8892
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131988.1"
                     /locus_tag="SIL76_03615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="MDX6023579.1"
                     /transl_table=11
                     /translation="MSVITPAPQPKSDIFREVEQLQNSFKNNESKVLVDNNKIYKKLKE
                     KKKKIKQKD"
     gene            9036..9473
                     /locus_tag="SIL76_03620"
     CDS             9036..9473
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906378.1"
                     /locus_tag="SIL76_03620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004725 - protein tyrosine phosphatase activity
                     [Evidence IEA]; GO_process: GO:0006470 - protein
                     dephosphorylation [Evidence IEA]"
                     /product="low molecular weight
                     protein-tyrosine-phosphatase"
                     /protein_id="MDX6023580.1"
                     /transl_table=11
                     /translation="MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSW
                     EHGNPIHSGTQTKLKEQKIAFDLQKGSQKISSEDFYEFDKIIAMDESNLENLRKMAPEG
                     TSQKIAMLLEQGVPDPWFTGDFQETYQLVKTGCQRLLDEIV"
     gene            9574..9939
                     /locus_tag="SIL76_03625"
     CDS             9574..9939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003133119.1"
                     /locus_tag="SIL76_03625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="MDX6023581.1"
                     /transl_table=11
                     /translation="MKERELRRSMAVLPIGTVMKLTDLSARQIRYYEEQELIFPERSDG
                     NRRMYSLNDIDALFDIADLLQEGNNIADIKEIYAKRDAKKAQTLSIGEVHHALEREFAQ
                     QGRFGTPDPTHFTQPRM"
     gene            10001..11341
                     /gene="glnA"
                     /locus_tag="SIL76_03630"
     CDS             10001..11341
                     /EC_number="6.3.1.2"
                     /codon_start=1
                     /gene="glnA"
                     /gene_functions="catabolic (rule-based-clusters)
                     Glutamine_synthetase: Gln-synt_N"
                     /gene_functions="catabolic (rule-based-clusters)
                     Glutamine_synthetase: Gln-synt_C"
                     /gene_kind="catabolic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009854979.1"
                     /locus_tag="SIL76_03630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004356 - glutamine synthetase activity [Evidence IEA];
                     GO_process: GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="MDX6023582.1"
                     /sec_met_domain="Gln-synt_N (E-value: 1e-30, bitscore:
                     102.5, seeds: 83, tool: rule-based-clusters)"
                     /sec_met_domain="Gln-synt_C (E-value: 1.1e-141, bitscore:
                     469.0, seeds: 345, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITAADIRRDVKEKDIKFLRLMFTDILGTLKNVEVPATDEQLDK
                     LFENKMMFDGSSIEGFVRINESDMYLYPDLDTWIVFPWGDEYGKVAGVICDVYTPEGEP
                     FAGDPRGVLKRNLKSMEKLGFKSFNLGPEPEFFLFKLNENDEPTLEVNDKGGYFDLAPT
                     DLAGNTRREIVNVLTDLGFEVEASHHEVAIGQHEIDFKYANALKACDNIQIFKLVVKTI
                     ARKHGLHATFMAKPVHGINGSGMHCNMSLFTEDGANAFADPTGDMGLSDVAHSFIAGLL
                     KHAYNFTAITNPTVNSYKRLVPGYEAPVYVAWAGRNRSPLIRVPASRGLSTRVELRAVD
                     PTANPYLALAVLLAAGLDGVEHKLEAPEAIESNIYVMTEEERKAHGITDLPSTLHNAVK
                     ALREDTIVTEALGEHVLVNFVEAKRIEWASYAQFVSQWEIDNYLELY"
     gene            complement(11400..11600)
                     /locus_tag="SIL76_03635"
     CDS             complement(11400..11600)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131983.1"
                     /locus_tag="SIL76_03635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="MDX6023583.1"
                     /transl_table=11
                     /translation="MKFKFKGINYYEDSENNYVGATNTCSIVKEFADFQAAIDYVAEHK
                     GFLIAEDGKTAFNVLTITENN"
     gene            11818..12264
                     /locus_tag="SIL76_03640"
     CDS             11818..12264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427212.1"
                     /locus_tag="SIL76_03640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="MDX6023584.1"
                     /transl_table=11
                     /translation="MELNDLKDSLTALKYGEIATVAMIDRGAYAEIEESIEAESKDQKI
                     NSGIFKELAATVKDENEDLVVVGRSDIDQALTPEDFSRFIGQMTKEKHIILVECLYLGT
                     TEIKGFLNSLKENNLLENSKLVLLDLPQLEYMMLRDSLAGQFKL"
     gene            complement(12353..12625)
                     /locus_tag="SIL76_03645"
     CDS             complement(12353..12625)
                     /EC_number="5.4.99.5"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011677248.1"
                     /locus_tag="SIL76_03645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chorismate mutase"
                     /protein_id="MDX6023585.1"
                     /transl_table=11
                     /translation="MNKLEELRNNIDHVDQEIVQLLEKRMTIVQEISQEKQAQKITILD
                     NSREQAVLDLARQNIKNSAYQETIINTFKDIMKNSRLYQRENREQ"
     gene            13135..13623
                     /locus_tag="SIL76_03650"
     CDS             13135..13623
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131959.1"
                     /locus_tag="SIL76_03650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0005515 - protein binding [Evidence IEA]; GO_function:
                     GO:0033745 - L-methionine-(R)-S-oxide reductase activity
                     [Evidence IEA]"
                     /product="GAF domain-containing protein"
                     /protein_id="MDX6023586.1"
                     /transl_table=11
                     /translation="MNKEEKIEGYELLNLQLKALLSEQNYTLSNLANASSLLWSFLPEQ
                     VYTGFYLYNGEKLILGPFQGSVSCVEIIMGKGVCGESAQNRQTIIVENVKKHKNYISCD
                     GRAMSEIVVPMVKDGKLVGVLDLDSSEIGFYDEIDQKYLEEFANILCEMTDFKFFEVG"
     gene            13655..14296
                     /locus_tag="SIL76_03655"
     CDS             13655..14296
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131958.1"
                     /locus_tag="SIL76_03655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphotransferase"
                     /protein_id="MDX6023587.1"
                     /transl_table=11
                     /translation="MSEIVKKFIADRFGEKEGISVNPGNIGDVREFAQELGSFLYQLHR
                     LPTTDAKSPSFENAFAGSDLIFFEAEMIELLKVYQKVVPADLLQEKFDFAAKTKWSKKP
                     VWVLGQLLTQNLKVTDGKLVNVKITDKAVIGDPAFDLAIAWTIFDEKARKIFFAATEAD
                     EATINRARMFALRQALRNYQSQDIDELIQSRDASTEILKDLNYSLGQDFY"
     gene            14345..16003
                     /gene="dnaX"
                     /locus_tag="SIL76_03660"
     CDS             14345..16003
                     /EC_number="2.7.7.7"
                     /codon_start=1
                     /gene="dnaX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427209.1"
                     /locus_tag="SIL76_03660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0009360 - DNA polymerase III complex [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]; GO_function: GO:0005524 - ATP
                     binding [Evidence IEA]; GO_process: GO:0006260 - DNA
                     replication [Evidence IEA]"
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="MDX6023588.1"
                     /transl_table=11
                     /translation="MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSG
                     PRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICDSITKGSLDDVIELDAASNNGVDEI
                     REIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQKIP
                     ATIISRVQRFAFKSITTGDIRTYLAKIMADEGLEFDGKALDVIAKAAEGGMRDALSLLD
                     QALSFSSGKLEENDALLVTGSIAADALVTYVVALFEHDEAKALTELDKIFAEGKNMLRF
                     TEDLLAYLRDLLLDKNSQYDRGQIFSWIDVAIESLKTIKETTQTKIAADVMTMRLAEIG
                     QNNLLTASQGEIPNQLTAEIATLKTEINQLKAQISAGQIQVNSDSQNNLLTEKVKGSPK
                     PIASKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTAPVAASE
                     NFLVVTFPHENLAKRVSENEELQLFCGNLLSSIVGFAPEIISLAEQDWQEVRAEYVSNL
                     KSENVQEDEEDEKEPDETVNLAKELFGEKVVEIND"
     gene            complement(16038..17504)
                     /locus_tag="SIL76_03665"
     CDS             complement(16038..17504)
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     AA_permease_2"
                     /gene_functions="catabolic-additional (smcogs)
                     SMCOG1038:phenylalanine-specific permease (Score: 416.4;
                     E-value: 1.8e-126)"
                     /gene_kind="catabolic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017865200.1"
                     /locus_tag="SIL76_03665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0016020 - membrane [Evidence IEA]; GO_function:
                     GO:0015171 - amino acid transmembrane transporter activity
                     [Evidence IEA]; GO_process: GO:0003333 - amino acid
                     transmembrane transport [Evidence IEA]"
                     /product="amino acid permease"
                     /protein_id="MDX6023589.1"
                     /sec_met_domain="AA_permease_2 (E-value: 7e-45, bitscore:
                     150.8, seeds: 399, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSSNSTTETQVKRGLKSRHVSMIALGGTIGTGLFLTSGDVIHT
                     AGPFGALTAYVLIGAMVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWL
                     NWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFAINALSVKTFGETEYWLSAIK
                     ITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAGFS
                     FQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGDS
                     AAQSPFTIVFERVGLSIAASIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFS
                     KTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTFLVSASGLTGFIAWIGIAISHFRFR
                     RAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVIMYAAIP
                     LFFILYLGYKFKNKTKLIPLKEVDLSRHKD"
     regulatory      complement(17663..17845)
                     /bound_moiety="lysine"
                     /db_xref="RFAM:RF00168"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00168"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="Lysine riboswitch is most abundant in Firmicutes and
                     Gammaproteobacteria where they are found upstream of a
                     number of genes involved in lysine biosynthesis, transport
                     and catabolism; Derived by automated computational analysis
                     using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            18028..18882
                     /locus_tag="SIL76_03670"
     CDS             18028..18882
                     /EC_number="3.6.1.27"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898664.1"
                     /locus_tag="SIL76_03670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0016020 - membrane [Evidence IEA]; GO_function:
                     GO:0050380 - undecaprenyl-diphosphatase activity [Evidence
                     IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence
                     IEA]"
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="MDX6023590.1"
                     /transl_table=11
                     /translation="MDFIRAIILGIIEGITEWLPISSTGHLIIADEFIRLNQSAAFKEM
                     FDVVIQLGAILSVVVLYFHKLNPFNKLNPADKQKTPREIQLTWRLWLKVLIAALPAAII
                     GLPLNDWLDKHFYHFVPVAFMLIIYGVAFIVIERRWVPNHEFSVMNIDRLPYRAALYIG
                     LFQVLSLLPGTSRSGATIVGALLIGVSREVAAEFTFFLGIPVMFGASFIKILHFFKNGN
                     SLSFEQFGVLLVACIVAFGVSMVAIKFLTDYVKKHDFTFFGKYRIVLGIILLIYAMFKA
                     FLG"
     gene            19074..19367
                     /gene="rpsF"
                     /locus_tag="SIL76_03675"
     CDS             19074..19367
                     /codon_start=1
                     /gene="rpsF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /locus_tag="SIL76_03675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0000314 - organellar small ribosomal subunit [Evidence
                     IEA]; GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]; GO_function: GO:0003735 -
                     structural constituent of ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /product="30S ribosomal protein S6"
                     /protein_id="MDX6023591.1"
                     /transl_table=11
                     /translation="MTKYEILYIIRPNIDEEAKAALVERFDGILTDNGAANLESKDWEK
                     RKLAYEINDFREGIYHIATFEAETTSEALSEFDRLAKINLDILRHMIVKVEA"
     gene            19397..19897
                     /locus_tag="SIL76_03680"
     CDS             19397..19897
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019778239.1"
                     /locus_tag="SIL76_03680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="single-stranded DNA-binding protein"
                     /protein_id="MDX6023592.1"
                     /transl_table=11
                     /translation="MINNVVLVGRITRDPELRYTPQNQAVATFSLAVNRQFKNANGERE
                     ADFINCVIWRQQAENLANWAKKGALIGVTGRIQTRNYENQQGQRVYVTEVVADSFQMLE
                     SRSAREGMGGGTSAGSYSAPSQSTNNTPRPQTNNNNATPNFGRDADPFGSSPMEISDDD
                     LPF"
     gene            20071..20316
                     /gene="rpsR"
                     /locus_tag="SIL76_03685"
     CDS             20071..20316
                     /codon_start=1
                     /gene="rpsR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131952.1"
                     /locus_tag="SIL76_03685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0000314 - organellar small ribosomal subunit [Evidence
                     IEA]; GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]; GO_function: GO:0003735 -
                     structural constituent of ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /product="30S ribosomal protein S18"
                     /protein_id="MDX6023593.1"
                     /transl_table=11
                     /translation="MAQQRRGGFKRRKKVDFIAANKIEVVDYKDTELLKRFISERGKIL
                     PRRVTGTSAKNQRKVVNAIKRARIMALLPFVAEDQN"
     gene            20516..21289
                     /locus_tag="SIL76_03690"
     CDS             20516..21289
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015427206.1"
                     /locus_tag="SIL76_03690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="MDX6023594.1"
                     /transl_table=11
                     /translation="MIELIIGAVLLSLLIYGIFIEPHLMKVRHVKIAQKQNLKIAHFTD
                     THFAWHTTSRRFKKFARNIANEQPDLIIFSGDLFDKVAWAKNRDWTDLLTILSELKAPL
                     GKFAILGNHDFDDEKSSRFVEEFLEKAGFVLLKNSSVVKDNLSISGVDDWREGRPDFEL
                     EPIDATFSLLALHEPDTILDMETIKEFDLILSGHSHGGQIRIGNWRLRNKGSSSADAGL
                     YQLNDRTKLYVNRGIGLTFLPIRFGVPPEIVYYYI"
ORIGIN
        1 tgaattaggg cgaggaacgg caacttatga tgggatggct ctagctcaag caattattga
       61 atatgttcat gaccatattg gggcaaagac cttgtttgct acgcattatc atgaattgac
      121 agacttagat gaagcgctcg atcatcttga taatgtccat gttgctacct tggagcaaaa
      181 tgggaatgtg acttttttgc ataaaataac agagggacca gctgataaat cctatgggat
      241 tcatgtggcg aaaattgcag gtttaccaca gcctttgtta gagcgagcag atttgatttt
      301 gcagaagtta gaaaataaac ctttgcctgc taaaaaagtt gctgatgaac aagaacaact
      361 tagtttattt gattttaccg aaaattcttc agaaattatt gaaaagataa aaaggcaaaa
      421 tgttgataat atgactgcaa gagaggcttt gaatttcttg tgggaactta aagattcact
      481 ttgaacttgg tagcgaggct tattctgtaa ataagctaag aaaaaaggct ataattactt
      541 aaaaagagat tcattgaaag atgaattgag tagaagctaa cataaaaagg agctaaacat
      601 gggaaatgaa aaagaactta aagggcaaga aattccagag actcaagtgg agccaactga
      661 agaattaaat tctgagaatc ttgcttctca agaagaaaca actaagagtg atattagtga
      721 atgggatgcc tcagagcctg tacttgatga gccagtagtt gccaaggctg aagtttcaga
      781 aggttttgta agtgaaccag tgattgcaga accagtaatt gctgctagtg aaccacttga
      841 ttcaaaagtc gaagagaaaa cgagcgaaca atcagcttat gcagatattc ctcagaatcg
      901 ttcactagaa aatcaagatg aaattaaaac taaatggaac tggggcgctt ttgctttaac
      961 tatgtggttt gggattgcca atcgcgctta tttgggactt ttgattctac ttactttggt
     1021 accgtgggta ggttggattt ttgggattgt atggatgatc gtttttggtt ttaatggcga
     1081 aaaatgggca cttgaaaatc gagataataa atatcgtgat gaggaagagt tccgtaaggt
     1141 catggacggt tggaatcgag caggtttcgt tgcattcatc attggaattg tattatttgt
     1201 gattgcaatt ttgattctta ttttcgtatt agtctttgct tttaacagct ataataattt
     1261 tgataatggt taccgcgatt ttggaaacta ctaattaatg taaaaatgat agacaatttt
     1321 catcttgtct atcatttttt gtcagtaaaa aatgaaaagc gagcccttgc tttttgtgtt
     1381 ataattagaa ttaatttaaa aaaacaagag agcgagatta ttgtgggaaa aattattgaa
     1441 ctaaatgaag cgctcgccaa tcaaattgct gctggagagg tggttgagcg gcctgctagt
     1501 gttgtcaaag aattagtcga aaactcaatt gatgctggaa gcagtaaaat tattatcaat
     1561 gttgaagaag ctggtttgcg gttaattgaa gtcattgatg atggtttggg tttggaaaaa
     1621 gaagatgtgg ctttggcttt acgtcgtcat gcaacaagta aaatcaagga ttcggcagat
     1681 ttgtttcgga ttagaacact tggttttcgg ggggaggctc tgccatcaat cgcttctgtc
     1741 agccagatga ccattgaaac aagtacggct gaggaagaat caggaacaaa actagttgct
     1801 aaaggtggaa atatcgaaac tttagaacca cttgctaagc gagtggggac gaaaatttct
     1861 gttgctaatc ttttttataa tacaccagca agactcaagt atatcaagtc cttgcaggct
     1921 gaactttctc atatcacaga catcatcaac cgattgagtc tggctcatcc agagatttcc
     1981 tttactttag ttaatgaggg taaagaattt ttgaaaacgg ctggaaatgg tgatttacgc
     2041 caggttattg ctgcaattta tggcataggg acagcgaaaa aaatgcgtca aatcaagggc
     2101 tcagacttag attttgaact aacaggttat gtcagcatac cagagctgac aagggctaat
     2161 cgtaattata ttacgatttt aataaatggt cgatttatca aaaacttttt attgaatcgg
     2221 gcaattttag aaggatatgg caatcgattg atggtgggac ggttcccttt tgctatttta
     2281 tcgattaaaa ttgacccaac acttgctgat gttaatgttc atccgacaaa acaagaggtg
     2341 cgtttgtcta aagagcgtga attgatggct ttaatttcta aagcaattga tgaggcttta
     2401 tcagaaggtg ttttgattcc agaagctttg gaaaatttgc aaggaagagc taaagaaaag
     2461 gaaactcttt ctgttcaaac ggaacttcct ttgcaaaata atcctttata ttatgataat
     2521 gttcgccaag atttttatgt cagagaagag gcaactttta aaatcaataa aaatcaagct
     2581 tcaaatgatt cgtctgaaca aacttttgat aattttacag aaaatcaact taatacagat
     2641 gctgtcagtg aaaaaatgac tgacagaact gtggaaagta ctactgaaat tactgacaac
     2701 agtctagaaa atactgtcag caactttgaa attgattttg ataatgaagc aaagataagt
     2761 cagtcatcaa cttttccgca gcttgaatac ttggcacaat tgcatgcgac ttatttactt
     2821 tgtcagtcca aagaaggact ttacttggtt gaccaacatg cggctcaaga gcgaatcaaa
     2881 tatgagtatt ggaaagataa aattggtgag gtcagtatgg agcaacaaat tttacttgca
     2941 ccatatttgt tcattttagc caaaaatgat tttattgttt tagccgagaa gaaagatttg
     3001 ttgcatgaag ccggtgtttt cttagaagaa tacggagaaa atcaattcat tttaagagaa
     3061 catccaatct ggttaaaaga aaccgagata gagaaatcaa ttaatgaaat gattgatatt
     3121 attctctcat caaaagaatt ttcactcaaa aaatatcgtc atgatttagc tgcaatggtt
     3181 gcttgtaaaa gttcaattaa agctaatcat ccccttgacg ccgagtcagc tagagcttta
     3241 ctcgcagaat tagcaacttg taaaaatcct tatagttgtg cgcatggacg gccaacgatt
     3301 gttcattttt caggggatga cattcaaaaa atgttccgga gaatccaaga aacgcatcgt
     3361 tcaaaagcag cttcgtggaa agattttgag taaaaagtga ctaaacagat taatgatgaa
     3421 gttggtcagt aaaaaaatag ataaaaacta ctgacagact tgaataaggg agtttgtcaa
     3481 tcaaaaaaat tagaaaagta aaaaaatgtt tgaatatctt aatggaaaat tagtaaaaat
     3541 ttccccaaca aatattgtaa ttgatgtagc aggaattggt tatcttatca gtgtagctaa
     3601 cccttacgct tggtctgctt tgatgaacac agaagtaaaa atttatgttc atcaagtcat
     3661 tcgcgaagat gcccacagcc tctatggttt tgttaacgag gccgaaaaag ctttattctt
     3721 acgtctgatc agcgtttctg ggattgggcc aaaatcagct ctggccatca ttgcggcggc
     3781 tgataacgaa ggtttaatca ctgctattga caatagtgat atcaagtatt taactaaatt
     3841 tccaggagtt ggtaaaaaaa cagccatgca gatggtgctt gatttggctg ggaaatttga
     3901 tgcgacagga actgtaggta tttctcttct tgatgctgga cctgctggca atcttgcttt
     3961 ggaagaagcg attgaagcgc tgcaagcttt gggttataaa gcaacagaat tgaagaaaat
     4021 tgagaaaaaa ttagctcaag aaacaggtct gaccagcgaa gaatatatca aatcagcctt
     4081 aaaacttatg atgaaataaa aaagtttgaa gaaagaactg acagacatca aaaatagtca
     4141 ttaaagtctt tctgtcagta aaatttactg acagcttctc ataagttatc aaaaatcatc
     4201 tctaaaagga gaattacaag ataagatgaa cgatatatta aacaaagagc caatggaaga
     4261 agattacggt attgaaaaat ctctacgtcc gcaatttttt aatcaatata ttggtcaaga
     4321 taaagtcaaa gaacaattag aaatctttat taaagcagca aaaatgcgtg aagaagtttt
     4381 ggaccacgtg ttactttttg gccctccggg acttggtaag acaacaatgg catttgtcat
     4441 tgccaatgag ttgggggtta atattaaaca aacagcgggt cctgccattg aaaagccagg
     4501 agatttagtt gcgattttga atgaattgga acctggcgat gtgctattta ttgatgaaat
     4561 tcatcggatg ccaatgcaag ttgaagaagt tctttatagc gctatggaag atttctacat
     4621 tgatattatg cttggttctg gtgatggttc acgctcggtt catttagatt tgccgccatt
     4681 tactctagtt ggggcaacaa caagagctgg aatgctttcg aatccattgc gtgcccgttt
     4741 tggaatttca agtcatatgg agtattatca agagcgtgat ttggaagaaa ttgttaaaag
     4801 aacagctgat atttttgaag tcgaagttat tgataatgcc gctttagaga ttgctttacg
     4861 tagtcgaggg actccgcgga ttgccaatcg tttacttaaa cgagtgcgtg attttgctca
     4921 aataatgggg gatggccgag tggataaagc aattaccgat aaggccttgt ctattcttga
     4981 tgttgatgcc gctggtttgg actatattga ccaaaaaatt ctccgcacaa tgattgaaat
     5041 gtaccacggt ggtcctgttg ggattggaac tttggcggta aacattgccg aagaccgtga
     5101 aacggtcgag gatatgtatg aaccttattt gattcaaaaa ggatttttga tgagaactaa
     5161 acagggacgt aaggtgaccc aaagagccta tgaacaccta ggttatgttt acaatgaaga
     5221 agattgacag ttagtatctg tcagtaaaaa ggtttgtcaa agcttgacgg gcttttttat
     5281 attacataaa ttcctgccgt tgtaacaata atgaaaaaag tatataatat gaccataaag
     5341 ttacgactgg agagacaaga caaatggtta atcaatacta tggtttaaaa cttcaagaac
     5401 tctgtgaagc taaagaaatc acgaaaaatg aaattatcaa aaaaacagga attcctaaaa
     5461 gtagtctctc tcgttttttt agtggagaag gttatttaaa tcttgatcaa attgatgctt
     5521 tgcttgaatt tcttcacttg gaactttctg aatatgatta ttatctcaat aattttaaac
     5581 atagttttta cgaagaatta tttagtaaaa tcgaccaagc ggcaacgaat aataatattg
     5641 aagaactaaa agacattgcc tggcaatgtg agcaaattgg cgaacatttg attgctcttt
     5701 gtgccaaagc acgcttagaa aagttgccag aaaacgaagt ggttgagtta agttctttta
     5761 tttttggaat tgaaatattt agtttttatg aacttctcat tttgtcagat accattgagc
     5821 aattttcgtc agaaatgata aaagcaatta ttcaagattt gagccatcat catcaaaggt
     5881 tagccaatcg tacacgttat cgcaaaatta tttgtcaaat cgcctgtcgc ggagcagtga
     5941 cttgtatcca agaagggaaa gaaaaggaag cgcaagaatg tctggctctg gtcaaagcat
     6001 attgtcatga aaaagacgca tattctagat tgatttatcg ctttactaaa ggttattatt
     6061 gtatttttta tggtcaaggc gaagaacgac ttctgggaat tgatagcatg aaaaaggtca
     6121 tcgaaatttt tgattgggaa ggaagtataa atttagcaaa aacctaccaa aaactctatg
     6181 ataaatatgt gaaaaactat aattttcctc aatggttaag tgatattcta ggaaaagatt
     6241 caatttgaat cttttttttg tgctttcgaa atcggtgcta caataaagtt aaggagacaa
     6301 aaataaaaac aaacgaggaa aaaccaatgg acaaattcgc aagctactga gcgcagccaa
     6361 gaaaacaaag taaaaaatga aaggaagctc tcaacatgag aaaaatatca tcagcttgat
     6421 tcagaaaaga taatttcttt ctgaatttgg gcagaaagag gtaaattatg aaaatgaatt
     6481 tgaaaaaaca aatctttgtc ttatcaactt tacttgttac gacaggtgcg ataggggtaa
     6541 cttctgtatc tgcgactcaa gtcacctatg taaaaacaag ttcagttact tactatctaa
     6601 ataatgtttc tacaggaaca acggattatt atgattatgt gaatatcctt catggaggtt
     6661 cttatacaac caccacaagt acaatttact acacggtagt aaattctgtc ggacaaagtc
     6721 aaccggcaaa acaagtaact acttattatc attattgatg gaataggagt aagctacctc
     6781 acttactcct atttaatgat tatttttgat tgagaggtga ttaaatgaaa tacttcaaat
     6841 ttgaattaaa aaagtttatt ctaaacaaaa gaaacagata cttattagct ttgatttctt
     6901 ccttaatcat agtttatagt gtatataata caatttcttt tactaatatt tttaaaaata
     6961 acatcactag ccttgttcaa gaggtacaga ctaatgaaaa atcagttcag gataacattg
     7021 aaactactga agaaagccta aaaaccacaa aagtgaaggc agaagatgat aatctaaata
     7081 atacattgag tgacttaaag caaaaagata acatctatca aaaacaaatc gcagctatag
     7141 gcgtcaatga cattaatgaa tattatcatt tacaaaaaga aattgaccag ttgtatttta
     7201 aacaaaatgg taaccaatca tcatctggtc aagataaatt cctgaaagca gaaattaagt
     7261 atatcaagac agttcaagag agaaagttag attttgaagc aatgcctacc atgcaatctc
     7321 atgcttttgg aaattttcat cagcagttca ttccaatttt aacgagtagt ctattcattg
     7381 tcttatttgc ttccatggtt tcaatccttg tcgccactag ttatgaatca aaagaaaaca
     7441 gattttatcg atttgcggga attgatttgc agaaaaattt aattataaaa gttttatctg
     7501 gaactttagc gacctttgct tggattatta tttctagtat catttatttt ctggtaattg
     7561 gggtggtgaa tggttttgga gcatggaatt atcccgccta tcttggtgat tcggatttga
     7621 aaacaggatt tactttgact aatctcacaa ttccaaatgg aattttggat ttaggaagta
     7681 tcctctatct gttttttgtc atctttttct tggcttcatt aggtgccttg atttctgttt
     7741 ttgtaaaacg gagtatggtt gttgttgggg ttatagctct atttgtcatg ggatattcga
     7801 tgataggaaa tgtttcttgg ataatttcaa ttagacgttt tgtgccactt tcttatcttg
     7861 aacctctaaa actttttgga aatcctagtg ctctttttgg aaaatattct atattaatcg
     7921 gggctggcta tctactttct ttaagtgtat tatttttgct catctctgtc ttcattatta
     7981 aaaatcaaaa aacaaggaga atctcatgat attaaaaata aaaaatttaa agataccaga
     8041 cattgctccg cttaattttg agatttctga aaatggtttg tacggtctga ttggacgaaa
     8101 tgggattggg aaaagtacac ttttcggcat tctttcagga gaaattggat tttctcaagg
     8161 agaaatagaa aatgggcgtg tcgcttatct tcccgatgta gaatcttttg aagaaagttt
     8221 aaaaatgcat gattatttta aaattttgaa aaatagtgaa caggatagag caagagagtt
     8281 aagtcttact tttggtgcag ataaatttgc gaaaaagaga attggccaat tttctttagg
     8341 aatgaaagag ctttttgcga caattttatc attttctatc gactgtgata ttttaatcat
     8401 tgacgagcta ttcagtgggc ttgacgtttc caaaaaagcc ctagtttatg aagaagtgaa
     8461 aaaaatcgct caagaaaaaa ttgttttatt aacctcacac aatctcaagg aaattgaaca
     8521 tttctgtgac caagcttatc tattgtccta aaaaggactg actttggtga caaattttga
     8581 tgaagcggca aaagaaatcg gttatatgga tgtatttttt tagtgaaagg gaattaatgc
     8641 gaaataatac tacattattt ggtttatata ttttctaata attgtttccg attaagagat
     8701 aagtcgaatg aaagataagg agaacttatg tcagtaatta cacctgcccc tcaacctaaa
     8761 agtgatattt ttcgggaggt tgaacaactc caaaattctt ttaaaaataa tgaaagtaaa
     8821 gttttggtag ataacaataa aatttataaa aaattgaagg aaaaaaagaa aaaaattaag
     8881 cagaaagatt agttcgtctg tcagtaaaaa agtttgtcaa attttggcag actttttcat
     8941 tttagaattc tgtcagtaat atcttgtgaa atagggtata atagaataaa tgctcaaaat
     9001 tagttaattt ataaatgata taaagtaagg aagtcatgga aaagattgtt tttgtctgtt
     9061 taggaaatat ttgtcgtagc ccaatggcag aatttgtcat gaaagattta gttgaaaagg
     9121 caggaaatga atcaaatttt ttgattgaaa gtcgagcaac ttcttcttgg gagcatggaa
     9181 atccaattca ttctggaacc caaacaaaac taaaagaaca aaagattgct tttgaccttc
     9241 aaaaaggaag tcaaaaaatc agtagtgaag atttttatga atttgataaa attatcgcaa
     9301 tggatgaatc caatttagaa aatcttagaa aaatggcacc agaaggaacg agtcaaaaaa
     9361 tcgcgatgct tttagaacaa ggtgttccag atccatggtt tacgggcgat ttccaagaaa
     9421 cttatcaact tgttaagacg ggttgtcaaa gattattgga tgaaattgta taaaatattt
     9481 caaataaaat aaaccgatgt gagaaaatct cacattaaaa cttgactttg ctaataacaa
     9541 ggtctataat gaaaggcatg gaggcgagat ttggtgaaag aacgtgaatt aagacgctct
     9601 atggcggtac ttccaatagg aactgtcatg aaactcactg acctaagcgc aaggcagatt
     9661 cgttattacg aagagcaaga gcttattttc ccggagcgaa gtgacggtaa tcgtcgcatg
     9721 tattcgctca atgacataga tgctctattt gatattgctg acttattgca agaaggtaat
     9781 aatattgcag atatcaaaga aatttatgcc aaaagggatg ctaagaaggc tcaaacttta
     9841 tctatcggag aagtccacca tgcacttgaa cgcgaatttg cccaacaagg tagattcgga
     9901 actcctgatc ccactcattt tacccaaccg cggatgtaag tttagtttac tttatttgtc
     9961 aactaagttt acagcgaaaa tttaactagg agagtaaagc atgacaatca cagcagcaga
    10021 cattcgtcgc gacgtcaaag aaaaggatat taaattcttg cgtttgatgt ttacagacat
    10081 tcttggaaca cttaaaaacg ttgaagttcc agctacagat gaacaattgg acaaattgtt
    10141 tgaaaacaaa atgatgtttg acggttcatc aatcgaagga ttcgttcgta tcaatgaatc
    10201 agacatgtat ctttatccag accttgacac ttggattgtt tttccttggg gagatgagta
    10261 tggtaaagtg gcaggtgtaa tttgtgatgt ttacactcca gaaggtgaac ctttcgctgg
    10321 agacccacgc ggtgtcttga aacgtaacct taaatcaatg gaaaaattgg gcttcaagag
    10381 ctttaacctt ggacctgaac cagagttctt ccttttcaaa cttaatgaaa atgatgaacc
    10441 aacacttgaa gtgaatgata aaggtggtta ttttgacctt gcaccaactg acctcgctgg
    10501 aaacacaaga cgtgaaatcg taaatgtatt gacagacctt ggttttgaag ttgaagcttc
    10561 tcaccacgaa gtagcaatcg gtcaacacga aattgacttt aaatatgcca atgctttgaa
    10621 agcttgtgat aatattcaaa tctttaagct tgttgttaaa acaattgcgc gtaaacatgg
    10681 tttacatgca acgtttatgg caaaaccagt tcacggaatc aacggttctg ggatgcattg
    10741 taacatgtct ttatttacag aagatggtgc caatgccttt gctgatccaa caggagatat
    10801 gggactttca gatgttgcac atagctttat tgctggactt ttgaaacatg cttataactt
    10861 tacagcaatt acaaacccaa ctgttaactc atataaacgt ttggttcctg gttatgaagc
    10921 acccgtttat gtcgcttggg ctggacgtaa cagatcacct ttgattcgcg tacctgcttc
    10981 acgtggtttg tcaactcgtg ttgaacttcg tgcggttgac ccaacagcaa atccatatct
    11041 tgcattggct gttctattgg cagctggtct tgacggtgtt gaacataaat tggaagcgcc
    11101 agaagcaatc gaatcaaata tttacgtaat gacagaagaa gaacgtaaag cacatggtat
    11161 tacagatttg ccatctactt tgcacaatgc cgttaaagca ttgcgtgaag atacaattgt
    11221 gactgaagcg cttggagaac atgttttggt taactttgtt gaagcaaaac gcattgaatg
    11281 ggcaagctat gcacaattcg tatcgcaatg ggaaattgat aactatttag aactttatta
    11341 attgatataa aaaatcactg acaaagcctg tcagtgattt tttggaccat ttaaatattt
    11401 tagttgtttt cagtaattgt caaaacgttg aaggcagttt ttccgtcttc ggcaatcaag
    11461 aatcctttgt gttcagcaac atagtcaata gctgcttgga aatcagcgaa ttctttgacg
    11521 attgagcaag tgtttgtggc accgacataa ttgttttctg agtcctcgta ataattgatt
    11581 cctttaaatt taaatttcat aataaaaagt cctttctttg ttatagtttt attatagcaa
    11641 atggcactta ttttttactg ataaaacttt aaatcaaagt tgaaatcaca aaaagagcca
    11701 tattttttga aaaattcaca aagtcagtgt aaacttgaga taggttttat gaatttaatg
    11761 cgagaaagga agcgaatctt aatacttttt actaaaagta gatttgcata ggaaaatatg
    11821 gaactcaatg atttgaaaga ttcactgact gctttaaaat atggtgaaat tgcaactgtc
    11881 gcgatgattg accgaggcgc atatgctgaa attgaagagt ctattgaagc ggaaagtaaa
    11941 gatcaaaaga taaattctgg aatctttaaa gagcttgctg ctacagttaa agatgaaaac
    12001 gaggatttag tggtagttgg tcgttcagat attgatcagg cactgactcc agaagatttt
    12061 tcgcgattta tcggtcagat gaccaaggaa aaacatatta ttcttgttga gtgtctctat
    12121 ttgggaacaa cagaaattaa aggttttctt aacagcttga aagaaaataa tcttttagaa
    12181 aatagtaaat tggttctgct tgatttgccg caattagaat acatgatgtt gcgagacagt
    12241 ttagctggac aatttaaatt ataaaaaaag ttactgacaa aattatcgct cagtctgtaa
    12301 gttgcgtaag caagcagata ggagtgatag aatttttgtc agtaactttt tcttattgtt
    12361 cacggttttc tctttgataa aggcgagaat ttttcataat atctttaaaa gtattaatga
    12421 ttgtttcttg ataagcagaa tttttaatat tttggcgagc caaatctaat acggcttgtt
    12481 cgcgagagtt atctaaaata gtaatttttt gtgcttgttt ttcttggcta atttcttgaa
    12541 caattgtcat acgtttctca agaagctgaa cgatttcttg gtccacgtgg tcaatgttgt
    12601 tccgaagttc ttctagttta ttcatggttt ttattatatc atagccagta acacgaaaca
    12661 acgtttcatg ttgctgactt ctttctctca ttatgaccga actcagcggg acgataattt
    12721 tccgccgagt gagtgcggct cgacttgttg ctttagcaac gtagcgtaga gaagtaataa
    12781 ggtatctact ttgtttcact acgttgtcca taccacaggt gtccattttg tcagcattgc
    12841 taaagcaacg gacaaaaggg ctcgatctaa gccagcaagg tgaaaaggca ggaaggacgc
    12901 catagctgga agcgactgaa aagggagctt tcagggtgca gattagaaaa gtatagcttt
    12961 tcaccttttc gtctgcgcgt tcacgcttta gcgtgttgcc tttttggcag ttgcttgagc
    13021 agctagtcaa aacggacagc gtagtagaag caagaatgct tatatcaaaa ctaatctaaa
    13081 atttgccttt aaaaaatgat ataatggatt atattatttt tgaggagcaa caagatgaat
    13141 aaagaagaaa aaatcgaagg ttatgagttg cttaatttgc aactaaaagc gcttcttagt
    13201 gaacaaaatt atacactttc aaacttagcc aatgcaagta gtttactttg gagctttttg
    13261 cctgagcaag tttatacagg tttctacctc tacaatggtg aaaaattaat tttagggcca
    13321 tttcaagggt ctgtgtcttg cgttgaaatt ataatgggca aaggggtttg tggggaatca
    13381 gctcaaaatc gccaaaccat tattgttgaa aatgtaaaga aacacaaaaa ttatatttct
    13441 tgtgacggtc gagcaatgtc tgaaattgtt gttccgatgg ttaaagacgg taaattagtt
    13501 ggggttcttg acttagatag ttcagaaatt ggtttttacg atgaaatcga ccaaaaatat
    13561 cttgaagaat ttgctaacat tttatgtgaa atgactgatt ttaaattttt tgaagtaggt
    13621 taaatcaaaa ttttaaaggg tatcggagaa aaaaatgagt gaaatagtaa aaaaatttat
    13681 tgctgaccgt tttggggaaa aagaaggaat atctgtaaat ccaggtaata ttggagatgt
    13741 tcgtgaattt gcgcaagaat taggaagttt tctctatcaa ttacatcggc taccaacaac
    13801 agatgcaaag tcacctagtt ttgaaaatgc ttttgctggc tctgatttga ttttctttga
    13861 agctgagatg atagaacttt tgaaagtcta tcaaaaagtt gttcctgctg accttttgca
    13921 agaaaaattt gattttgcag caaaaacaaa atggtccaag aaacctgttt gggttttggg
    13981 acaattgctt acgcaaaatt taaaagttac tgacggaaag ttagttaacg tcaaaattac
    14041 tgacaaagct gttattggtg atccagcttt tgatttagca attgcttgga cgatttttga
    14101 tgaaaaagca cgtaaaatat tttttgcggc aaccgaagca gatgaggcaa cgattaatcg
    14161 agcaagaatg ttcgccctca gacaggccct cagaaattat caatcacaag atattgatga
    14221 attgattcaa tcacgtgatg cttcaactga aattttaaaa gacttaaact atagtcttgg
    14281 gcaagatttc tattgaaaca agcggatatg aaaagaatac taagtaaaaa attggaagag
    14341 aaaaatggca tatcaagcat tatatagaaa atatcgaagt caaagatttg atgaaatggt
    14401 ggggcaagaa gttgtagcaa caacattaaa aaatgcgatt gtcaatcatc aaatttcaca
    14461 tgcttatctt ttttctggtc caagagggac agggaaaacc tcagcagcta aaatttttgc
    14521 taaggcaata aattgtccta atcaagtgga tggagagccc tgcaataatt gctttatttg
    14581 tgactcaatc accaaaggaa gcttagatga tgtcattgaa cttgatgcgg catcaaataa
    14641 tggggttgac gaaattcgag aaattcgaga taaatcaact tacgcagcta gtcaagccac
    14701 ttacaaggtt tatattattg atgaagtgca tatgctttca acaggggctt ttaatgcact
    14761 tttgaaaaca ctagaagaac ctacagaaaa tgttgttttc gtcctggcta ctactgaatt
    14821 acaaaaaatt ccagcaacca ttatctcgcg tgttcaacgt tttgctttta aatcaatcac
    14881 aacaggagac attcggactt atttagcaaa aataatggct gatgaaggac ttgaattcga
    14941 cggtaaagca ctcgatgtta ttgctaaagc agctgaaggt ggaatgcgtg atgccctctc
    15001 tttattagac caagctttat cgttttcatc aggaaaatta gaagaaaatg atgcactact
    15061 tgtcacaggg tcgattgctg cagatgcttt agtaacatat gttgtagcac tttttgagca
    15121 tgatgaagca aaagcgctga cggaacttga taagattttt gctgaaggaa aaaatatgct
    15181 tcgatttacg gaagatttat tagcatacct tcgggattta ctcttggata aaaattctca
    15241 gtatgaccgg ggtcaaattt tttcatggat tgatgttgca attgaaagtt tgaaaacgat
    15301 aaaggaaacg actcaaacaa aaattgcggc agacgtcatg accatgcgtt tggctgaaat
    15361 tggacaaaat aatttactga cagcttcgca aggagaaatt ccaaatcagc tgacagccga
    15421 aattgctact ttaaaaaccg aaattaatca attgaaagct caaatttcag ctggtcaaat
    15481 tcaggtaaat tcagattcac aaaataattt actgacagaa aaagttaaag gcagtccgaa
    15541 accaatagca tctaaaaaac gccaaattaa caaagattta atttataaag ctttggctga
    15601 ggcgacaaat gaagctagaa aagctgctct aagtgcgtgg ccagaacttg ttgcttcggt
    15661 aactaaaccg gcagaccgag ctttacttaa taatacagcc cctgtcgctg cgtcagaaaa
    15721 tttccttgtg gtgacttttc ctcatgagaa tcttgctaaa agagtcagtg aaaatgaaga
    15781 attgcaactt ttttgtggga atctcttgag ttcaattgtt ggatttgcgc cagaaattat
    15841 ctctcttgct gaacaagact ggcaagaagt tcgagcagaa tatgtttcta atttaaaatc
    15901 tgaaaatgtt caagaagatg aagaagatga aaaagagccg gatgaaacgg taaacttagc
    15961 taaagaactc tttggtgaaa aagtagttga aattaatgat taaaataata aaaaagccgc
    16021 tcattgagcg acttttttta atctttatga cgacttaaat caacctcttt aagggggata
    16081 agtttcgttt tgtttttaaa tttataaccc aagtaaagga tgaagaagag tggaattgcg
    16141 gcatacatga tgacaccttg cacccaagtt ttaccaaaaa gaagcattgg gtcttggccg
    16201 agtgtgacta aaacggtcat aattaaggct aagattggac caaatgggaa tagttttgca
    16261 tgataaggta attttttaac atcttttcct tgagcgacat aggcgcggcg gaagcggaag
    16321 tggctaattg caatcccaat ccaagcaata aatcctgtta aaccagaggc tgagacgagg
    16381 aatgtaaaga agctaactcc gtaaattgat gtcaagaatg tgagtaaagc aacagcagtt
    16441 gtagctaata aagcaatgaa aggaatcccg ttttttgaag tttttgagaa aatctttggt
    16501 gcgccaccat ctttagctag tgaataaagc atccgagtag aggcatacat tccagagttt
    16561 gctgctgaaa cgacagaagt taaaacaacg gcgttcatga tagaagctgc aatagagaga
    16621 ccaacacgtt caaatacaat tgtgaaaggg ctttgagcag ctgaatctcc tccaactaag
    16681 tgggggtcgg taaatggaat gatagccgcc atcacgaaga tagataagat ataaaagaca
    16741 agaatacgcc agaagataga gttcatagct ttaggaattg atttttcagg attttcagct
    16801 tcaccagctg taattccgag caattctgtt ccttggaaag agaaaccagc gactaagagt
    16861 acgccgagaa tccctccgcc ggtagtgaaa ctaccaagtc ctccgacaaa accatgatta
    16921 ccaactgaaa gatttttagc gacgtcaata tgaccgccca taattccaaa aatagataag
    16981 aaaccaataa tcaagaataa aacaacaaca gtaattttaa tggctgacaa ccaatattca
    17041 gtttcgccaa aagttttaac tgataaggca ttgattgcaa agacaataat taaggcaatc
    17101 agtgaaaaaa tccaacttgg aacatctggt aaccagaatt tgatacaaag ggcaacggct
    17161 gttaaatcaa ccgctacggt aattgcccag ttcaaccaat aattccaacc tagagcaaaa
    17221 ccaaaagctg ggtcaacata acgtgttcca tagtctgaaa aagaaccaga agtgggtaaa
    17281 taagtggcca tttcaccaag tgatgtcatg aggaagtaaa ccattgctcc gataagaaca
    17341 taggcagtca gtgcaccaaa tggtcctgcc gtgtgaatga catcgcctga agtcagaaac
    17401 aatccagttc cgattgttcc gccaagggca atcatggaaa catggcgtga ttttaagccg
    17461 cgttttactt gcgtctcagt agttgagttt gaagaatttt ccaaaattct ctccctaata
    17521 aaatttattc tacaccgact tgtttgactc agactcaacc ttactcctgt ttagtttaga
    17581 aaagtctgag aaaaacaaaa aaagcaatcc tactaggata gaatagattg ctaaaggtcc
    17641 gacaaaattt taaaaatttt cttgaacgaa tagccctccg catggttatt aaccatttgc
    17701 gacagtctag tgagtttttc tcactagccc aagaactttg ctgagcaaca aaattctttc
    17761 ggcaacctct cctcctctat atacgcgtct ttgttgtgct ccaactcggc gtagattcat
    17821 atcagttgcg acctctatcg atgtgttatt tgtaattcta gcgcaatttt aagatgatgt
    17881 caaggaagag aatgtaaaat taattacaaa taatcacttt ctttgtaagt ttattcattt
    17941 gtcatttatg atatacttat gaggatagga ctgctatgtc agtcaataaa aatcagtctt
    18001 tttactgaaa ttttctagga gcaaaatatg gattttattc gtgccattat tttaggtatt
    18061 attgaaggaa tcactgagtg gttacctatt tcctcaacag gacatttgat tattgctgat
    18121 gaatttattc gtcttaatca atcagcagct tttaaagaaa tgtttgatgt tgtgattcag
    18181 ctaggagcaa ttttgtcagt tgttgttctt tattttcata aactgaatcc atttaataag
    18241 ttaaatccag ctgacaaaca aaaaacccca cgtgaaattc aattaacttg gcgtttgtgg
    18301 ttgaaagttt tgattgcggc tttaccagca gcgattattg gtttaccact taatgactgg
    18361 ttggacaaac atttttacca ttttgttcct gttgccttca tgttaattat ttatggggta
    18421 gcatttattg tcattgagcg tcggtgggta ccaaaccatg aattttccgt aatgaatatt
    18481 gaccgtttgc cttatcgtgc cgctctttat attggattat tccaagtgct gtctttactt
    18541 ccagggacat cgcgttcagg tgcgacaatt gtcggtgctt tattaattgg tgtaagtcgt
    18601 gaagttgccg cagaatttac ctttttcttg ggtattccag ttatgtttgg ggctagtttc
    18661 atcaaaatac ttcacttttt caaaaatggg aattctttaa gttttgaaca atttggggtc
    18721 ttgttagtag cttgtatagt tgcctttggg gtatcaatgg ttgccatcaa gttcttgacc
    18781 gattatgtga aaaaacatga ttttactttc tttgggaaat atcggattgt gttagggatt
    18841 atccttctta tttatgcaat gtttaaagcc tttttgggct aagaatgaga taaattatgc
    18901 caactctctt tagttggtat tttttatttt aaaatagttc tctttgctga gggaaagttt
    18961 aaatgtattc ttgctaaaaa tagaaaaaag tgatagaata taactctgtg ggaaaaactc
    19021 acaacttacg caggactcaa cctgcgtcat tagtccaaaa ggaggaaaaa tcaatgacta
    19081 aatacgaaat tctttatatt attcgcccaa acattgatga agaagcaaaa gctgccctcg
    19141 ttgaacgttt cgatggaatc ttgactgaca acggtgctgc aaatcttgag tctaaagact
    19201 gggaaaaacg taaacttgct tacgaaatca atgatttccg cgaaggtatc taccacatcg
    19261 caacttttga agctgaaaca acttcagaag ctttgagcga atttgaccgt cttgctaaga
    19321 tcaaccttga cattcttcgt catatgatcg ttaaagttga agcttaagag ctttcatttc
    19381 taaggagaag ttcatcatga ttaacaatgt tgtattagta ggacgcatta ctcgcgatcc
    19441 tgaacttcga tacacccctc aaaatcaagc tgtcgcaaca ttttcattgg ctgtaaaccg
    19501 tcaatttaaa aatgcgaatg gcgaacgtga ggctgatttc attaactgcg ttatttggcg
    19561 ccaacaagct gagaatttgg cgaattgggc taaaaaagga gctttgattg gggtaactgg
    19621 tcgaattcaa acacgtaact atgaaaatca acaaggtcaa cgcgtttatg tgactgaggt
    19681 tgtggctgac agtttccaaa tgttggaaag tagatctgct cgtgaaggta tgggaggcgg
    19741 aacttctgct ggttcatatt ctgcacctag ccaatctaca aataatactc cacgtccaca
    19801 aacgaataac aataatgcaa caccgaattt cggtcgtgat gctgatccgt ttggtagctc
    19861 accgatggaa atttcggatg atgaccttcc attctaatag ggtgaaataa ttgacgctaa
    19921 agcgcctaat tatttcacgg aaaccgctat ggcggatttc ctaaccctct tactagttat
    19981 tatgaaaagc agaatcggct tttcataata acgtcgtaat cctaagaaag ctttaaacag
    20041 acatctaaaa ataatataag gagaaataaa atggcacaac aacgtcgtgg cggcttcaaa
    20101 cgccgtaaaa aagttgactt catcgctgca aacaaaatcg aagtcgttga ctacaaagac
    20161 actgaacttt tgaaacgttt catctcagaa cgtggtaaaa tcttgccacg tcgcgtgact
    20221 ggtacatctg ctaaaaacca acgtaaagtg gttaacgcaa tcaaacgcgc gcgcataatg
    20281 gctttgcttc cattcgtagc tgaagaccaa aactaataaa tgaaaggctg cttcggtggt
    20341 ctttttttgt ataaaaattt gataattaga gttgatattt actgacagaa agctcggttc
    20401 cgtccgaatt tactgaccag aaatttgtca gaaaaagaga atagattgat aacttcatca
    20461 agtatttttg attaatacta tgtttttgtc agtgaattta tgataaaatg gacaaatgat
    20521 tgaattgata ataggagcag tgctcttaag tttgttaatt tatggaattt ttatagagcc
    20581 tcatttgatg aaagtgagac atgtaaaaat cgctcaaaaa caaaatttaa aaattgctca
    20641 ttttaccgat acccactttg cttggcacac gactagtcgt cgttttaaaa aatttgctcg
    20701 aaatattgct aatgaacagc cagatttaat tattttttct ggagatttat ttgacaaggt
    20761 tgcttgggca aaaaatcgag attggactga tttactgacg atattgtcag aacttaaagc
    20821 tcctcttggg aaatttgcga tacttggtaa tcatgatttt gatgatgaaa aatcgtcaag
    20881 gtttgttgaa gagtttctag aaaaagctgg ttttgttctg ttgaaaaatt catcagttgt
    20941 caaagataat ttatctattt ctggggttga tgactggcgt gagggacggc ctgattttga
    21001 acttgagcct attgatgcaa cattttcgct tttagccctt cacgaaccgg atactatttt
    21061 agacatggaa acaattaagg aatttgattt aattctttct ggtcatagtc acggagggca
    21121 aattcggata ggaaattggc gtttacgcaa taaggggtca agtagtgctg atgctggttt
    21181 gtatcagctc aatgaccgaa caaaattgta tgttaatcgt ggaattggtt tgactttctt
    21241 acctattcgt tttggggtgc ctccagaaat tgtgtattac tacatctaaa aaaatctgtc
    21301 agtaattttg acagattttt ttatttaaaa atttactgac a
//
