LOCUS       JAWXXO010000002        27148 bp    DNA     linear   BCT 20-NOV-2023
DEFINITION  Lactococcus lactis subsp. lactis strain ATCC 19435
            contig_2_polypolish, whole genome shotgun sequence.
ACCESSION   JAWXXO010000002
VERSION     JAWXXO010000002.1
KEYWORDS    .
SOURCE      Lactococcus lactis subsp. lactis
  ORGANISM  Lactococcus lactis subsp. lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
COMMENT     The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##rhizoSMASH-Data-START##
            Version      :: 0.3.1-cb03db34
            Run date     :: 2025-03-15 23:19:40
            ##rhizoSMASH-Data-END##
            ##antiSMASH-Data-START##
            Version      :: 6.1.1-b1d0db06
            ##rhizoSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..27148
                     /aStool="rule-based-clusters"
                     /category="Carbohydrate"
                     /contig_edge="False"
                     /core_location="[2124887:2132035]"
                     /cutoff="5000"
                     /detection_rule="((Glyco_hydro_10 or Glyco_hydro_11 or
                     cds(Glyco_hydro_30 and Glyco_hydro_30C) or
                     cds(Glyco_hydro_3 and Glyco_hydro_3_C) or
                     cds(Glyco_hydro_43 and GH43_C2) or Glyco_hydro_39) and
                     (minimum(2, [Glyco_hydro_10, Glyco_hydro_11, Glyco_hydro_3,
                     Glyco_hydro_30, Glyco_hydro_39, Glyco_hydro_43]) or
                     (Alpha-L-AF_C or cds(Glyco_hydro_67M and Glyco_hydro_67C)
                     or cds(Glyco_hydro_115 and GH115_C)) or (xylose_isom_A or
                     XylB or gph)) and minimum(1, [AXE1, BD-FAE, CE2_N,
                     Esterase_PHB, Glyco_hydro_10, Glyco_hydro_11,
                     Glyco_hydro_3, Glyco_hydro_30, Glyco_hydro_39,
                     Glyco_hydro_43, UxaC]))"
                     /neighbourhood="10000"
                     /product="Xylan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17148
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((Glyco_hydro_10 or Glyco_hydro_11 or
                     cds(Glyco_hydro_30 and Glyco_hydro_30C) or
                     cds(Glyco_hydro_3 and Glyco_hydro_3_C) or
                     cds(Glyco_hydro_43 and GH43_C2) or Glyco_hydro_39) and
                     (minimum(2, [Glyco_hydro_10, Glyco_hydro_11, Glyco_hydro_3,
                     Glyco_hydro_30, Glyco_hydro_39, Glyco_hydro_43]) or
                     (Alpha-L-AF_C or cds(Glyco_hydro_67M and Glyco_hydro_67C)
                     or cds(Glyco_hydro_115 and GH115_C)) or (xylose_isom_A or
                     XylB or gph)) and minimum(1, [AXE1, BD-FAE, CE2_N,
                     Esterase_PHB, Glyco_hydro_10, Glyco_hydro_11,
                     Glyco_hydro_3, Glyco_hydro_30, Glyco_hydro_39,
                     Glyco_hydro_43, UxaC]))"
                     /neighbourhood="10000"
                     /product="Xylan"
                     /protocluster_number="1"
     cand_cluster    1..27148
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((Glyco_hydro_10 or Glyco_hydro_11 or
                     cds(Glyco_hydro_30 and Glyco_hydro_30C) or
                     cds(Glyco_hydro_3 and Glyco_hydro_3_C) or
                     cds(Glyco_hydro_43 and GH43_C2) or Glyco_hydro_39) and
                     (minimum(2, [Glyco_hydro_10, Glyco_hydro_11, Glyco_hydro_3,
                     Glyco_hydro_30, Glyco_hydro_39, Glyco_hydro_43]) or
                     (Alpha-L-AF_C or cds(Glyco_hydro_67M and Glyco_hydro_67C)
                     or cds(Glyco_hydro_115 and GH115_C)) or (xylose_isom_A or
                     XylB or gph)) and minimum(1, [AXE1, BD-FAE, CE2_N,
                     Esterase_PHB, Glyco_hydro_10, Glyco_hydro_11,
                     Glyco_hydro_3, Glyco_hydro_30, Glyco_hydro_39,
                     Glyco_hydro_43, UxaC]))"
                     /detection_rules="(xylose_isom_A and minimum(1, [XylB,
                     xylose_isom_A]))"
                     /kind="chemical_hybrid"
                     /product="Xylan"
                     /product="Xylose"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..27148
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Xylan"
                     /product="Xylose"
                     /region_number="5"
                     /rules="((Glyco_hydro_10 or Glyco_hydro_11 or
                     cds(Glyco_hydro_30 and Glyco_hydro_30C) or
                     cds(Glyco_hydro_3 and Glyco_hydro_3_C) or
                     cds(Glyco_hydro_43 and GH43_C2) or Glyco_hydro_39) and
                     (minimum(2, [Glyco_hydro_10, Glyco_hydro_11, Glyco_hydro_3,
                     Glyco_hydro_30, Glyco_hydro_39, Glyco_hydro_43]) or
                     (Alpha-L-AF_C or cds(Glyco_hydro_67M and Glyco_hydro_67C)
                     or cds(Glyco_hydro_115 and GH115_C)) or (xylose_isom_A or
                     XylB or gph)) and minimum(1, [AXE1, BD-FAE, CE2_N,
                     Esterase_PHB, Glyco_hydro_10, Glyco_hydro_11,
                     Glyco_hydro_3, Glyco_hydro_30, Glyco_hydro_39,
                     Glyco_hydro_43, UxaC]))"
                     /rules="(xylose_isom_A and minimum(1, [XylB,
                     xylose_isom_A]))"
                     /tool="antismash"
     gene            complement(1263..2687)
                     /gene="araA"
                     /locus_tag="SIL76_11215"
     CDS             complement(1263..2687)
                     /EC_number="5.3.1.4"
                     /codon_start=1
                     /gene="araA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898114.1"
                     /locus_tag="SIL76_11215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0008733 - L-arabinose isomerase activity [Evidence IEA];
                     GO_process: GO:0005996 - monosaccharide metabolic process
                     [Evidence IEA]"
                     /product="L-arabinose isomerase"
                     /protein_id="MDX6025012.1"
                     /transl_table=11
                     /translation="MLENTQKEFWFVTGSQFLYGPEALATVEKNARKVVDEMNYSGSLP
                     YPIIFKIVATTAENITQIMKEANYQDEVAGVITWMHTFSPAKNWIRGTQLLNKPLLHLA
                     TQFLNHIPYKTIDFDYMNVNQSAHGDREYAFINARLKKNNKIIFGHWEDDEIRQQIAKW
                     MNVAVAYNESYKIKIVTFADKMRDVAVTDGDKVEAQIKFGWTVDYWGVGDLVEYVNAVA
                     ESDINQLYKDLQSKYDYIEGNNSPEKFEKNVKYQLREYLGIKKFMDDKGYSAFTTNFED
                     LVGLEQLPGLAAQLLLADGYGFAGEGDWKTAALVRLFKIMAHNKETVFMEDYTLDLRQG
                     HEAILGSHMLEVDPSIASDKPRVEVHPLDIGGKSDPARLVFTGMIGEAVDITMADYGNE
                     FKLISYEVTGNKPEEETPFLPVAKQLWTPKQGLKVGAEQWLKAGGGHHTVLSFVVDSEQ
                     IGDLCAMFGLTYINLG"
     gene            complement(2718..3419)
                     /locus_tag="SIL76_11220"
     CDS             complement(2718..3419)
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     Aldolase_II"
                     /gene_kind="catabolic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005873905.1"
                     /locus_tag="SIL76_11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="MDX6025013.1"
                     /sec_met_domain="Aldolase_II (E-value: 5.8e-49, bitscore:
                     163.7, seeds: 185, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEDLKEKVLKANLELPEHHLVEFTWGNASAFDKETGYFVIKPSG
                     VDYGSLKASDMVVVDLEGKVIEGELNPSSDTPTHAVLYKKYPELGGIVHTHSNWATAWA
                     ESGVDVSAMGTTHADTFYGPVPCTRYLTKEEIDKGYEYETGKLIIETFEERGIDILDIP
                     AVLLHGHGPFTWGGDVEAAVYNAVVLENVCKMNIFARQINSYAADLPQRILDKHYLRKH
                     GKDAYYGQKNK"
     gene            complement(3435..5017)
                     /locus_tag="SIL76_11225"
                     /pseudo=""
     CDS             complement(3435..5017)
                     /codon_start=1
                     /gene_functions="catabolic-additional (smcogs)
                     SMCOG1210:glycerol kinase (Score: 126.6; E-value: 1.8e-38)"
                     /gene_kind="catabolic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898116.1"
                     /locus_tag="SIL76_11225"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]; GO_process: GO:0016310 - phosphorylation
                     [Evidence IEA]"
                     /product="FGGY-family carbohydrate kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVSLRAGEMLDIVDVRTNLGIEFGSTRIKAVLIDSKFQTIASGSY
                     EWENKLVDGYWTYSTEEVWKGLRRSYRELATEVYKKYGLILEKVASIGFSAMMHGYMAF
                     DKTDKLLIPFRTWRNSTTSEASRMLTELFDFNIPERWTIAHYYQAILNREKHINQVEYL
                     TTLAGYVHWQLTGEKVLGIGDASGMFPIDSATKTYNKKFINLFEKETSTSLENIFPKVL
                     RAGEKAGTLTEQGAFLIDPTGALKAGIPLCPPEGDAGTGMVATNSIEVRTGNVSVGTSA
                     FAMIVLEKSLSKVYPEIDIVTTPDGELVGMVHANNSTSDINAWIKLFEEYTTSLGIAVN
                     REKIFSILFNKALEADNDLGGLLSYGYFSGENITKVSAGRPLFVRLPDGNFNLANFMRT
                     HIYSAFGAMRIGMDLLKQEKIEISGLVGHGGIFKTPEVGQQILAAALQKPVTVMETAGE
                     GGAWGMAVLGHSVRVKIII"
     protocluster    4257..27148
                     /aStool="rule-based-clusters"
                     /category="Carbohydrate"
                     /contig_edge="False"
                     /core_location="[2129143:2132035]"
                     /cutoff="5000"
                     /detection_rule="(xylose_isom_A and minimum(1, [XylB,
                     xylose_isom_A]))"
                     /neighbourhood="10000"
                     /product="Xylose"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14257..17148
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(xylose_isom_A and minimum(1, [XylB,
                     xylose_isom_A]))"
                     /neighbourhood="10000"
                     /product="Xylose"
                     /protocluster_number="2"
     gene            5098..6465
                     /locus_tag="SIL76_11230"
     CDS             5098..6465
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 392; E-value: 5.7e-119)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898117.1"
                     /locus_tag="SIL76_11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0005886 - plasma membrane [Evidence IEA]; GO_function:
                     GO:0051119 - sugar transmembrane transporter activity
                     [Evidence IEA]; GO_process: GO:0008643 - carbohydrate
                     transport [Evidence IEA]"
                     /product="sugar porter family MFS transporter"
                     /protein_id="MDX6025014.1"
                     /sec_met_domain="MFS_1 (E-value: 1.8e-35, bitscore: 119.7,
                     seeds: 321, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNKKISASFIYFFGAFGGILFGYDIGVMTGALPFLQTSWGLTN
                     NATIIGWITSSVMFGAIFGGAAAGLLSDRLGRRKMILISSLIFMVGSLLSSISPHDGQY
                     YLIVVRILLGLAVGAASALVPSYMSEMSPANIRGRLSGINQVMIVSGMLLSYIADYFLK
                     NLSTDIAWRIMLGAAAIPALILFFGVLALPESPRFLIKSGKINEAKQVLSFIRKPDEIE
                     NEIKSIQDTAKQESAALSSTSWGTLFKSRYRYLVVAGLGVAAFQQFQGANAIFYYIPLI
                     VEKATGHSASEALMWPIIQGIILVIGALFFLVIADRFDRRTLLRLGGSIMGLSFILPAI
                     INFIIPNSSPMMIVFFLCIYVALYSCTWAPLTWVLVGEVFPLAIRGRASGLASSFNWIG
                     SFLVGLLFPIMTASMSQEAVFAIFGVICLLGVLFVQFFVPETRGRTLEEIEKHIKN"
     gene            6651..7736
                     /locus_tag="SIL76_11235"
     CDS             6651..7736
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 179.3; E-value: 1.9e-54)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898120.1"
                     /locus_tag="SIL76_11235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="MDX6025015.1"
                     /transl_table=11
                     /translation="MKPKYQVIADSLRDKIISTEYVVGGVIPTELQLQEAYHASRYTVR
                     QAVSVLVSEGYLRKEKGSGTYVNEPPTSTSEISPKKTIGVITTYISDYIFPTIIRGIEK
                     ELKADGYSLLLSSTNNDYLQEKECLDRMIEFGVDGLIVEPTKSNQYNPNLATYVTLREH
                     NIPIVMINATYEELSTPSIHVDDVETGYLATKELIDNNHQRLLLITKIDDLQGKYRMKG
                     FIKACEEKEIKLSSNSIITYTTENEVSIYDKIISHLKEFTDISGIVCYNDKIAKTLIGK
                     LSSLGYKIPDDFSIVGNDDSTLSQMGEVSLTTTVHTKEKMGIDAAKWIVNTIKNGKFEK
                     DILYPPKLIRRNSVKKLKTED"
     gene            complement(7794..9170)
                     /locus_tag="SIL76_11240"
     CDS             complement(7794..9170)
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 374.7; E-value: 1e-113)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898121.1"
                     /locus_tag="SIL76_11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0022857 - transmembrane transporter activity [Evidence
                     IEA]; GO_process: GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /product="sugar porter family MFS transporter"
                     /protein_id="MDX6025016.1"
                     /sec_met_domain="MFS_1 (E-value: 1.5e-28, bitscore: 96.9,
                     seeds: 290, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKLSPTFIYFFGALGGLLFGYDTGVISGALLFIEKESWQVSSWA
                     WMEGWITAAVLMGAVIGAVVIGPMSDRFGRKRLLLLSAVIFFVGALGSGLSNSAELLII
                     SRVILGMAVGSASALVPTYLSELSPAKIRGGVSTMFQLMIMTGILLAYISNYALKGVSG
                     NWHWMLGLATVPAALLFIGGLFLPESPRFLVRHDNEAGAREILGMINDDPNSIEAEISD
                     IQLMAKEEKQGGLQELFGQMSRPVLIMAIGLAIFQQVMGCNTVLYFVPSIFVAVGFGAS
                     AALLAHIGIGIFNVIVTYIAMRVMDKVNRRWMLNFGAWGMGISLVLMSVGMILAENAHI
                     GFGKYLAVIALTVYIAFFSATWGPVMWVMIGESFPLKIRGLGNSFGAAVNWAANWVVSL
                     TFLPLLSFFGTGKIFLIYAACCFLSIWFTSKKVIETRGKTLEQIEAELLHRVHHLEEEG
                     "
     gene            complement(9340..9942)
                     /locus_tag="SIL76_11245"
     CDS             complement(9340..9942)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     Hexapep"
                     /gene_functions="catabolic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 88.2;
                     E-value: 9.7e-27)"
                     /gene_kind="catabolic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130078.1"
                     /locus_tag="SIL76_11245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0016407 - acetyltransferase activity [Evidence IEA]"
                     /product="sugar O-acetyltransferase"
                     /protein_id="MDX6025017.1"
                     /sec_met_domain="Hexapep (E-value: 2e-10, bitscore: 37.2,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRMLDEAEKLRLAKLSIFDKINNGDWYQYSKEVELQKIVKNSSQK
                     ISEINDKAKENIDEARKLLEDFLPNLPQSSEIYFPIIALEYPNRFKVGENTFINSGLQI
                     ISAGKVKIGKNCFIGPNCQLFTPNHHARDVFLRREGWQYDGPIVIGNDCWLGGSVILLP
                     GVSLGDDVVVGAGSVVTKSFPSHCIIAGNPARLIKNE"
     gene            complement(10001..11680)
                     /locus_tag="SIL76_11250"
     CDS             complement(10001..11680)
                     /codon_start=1
                     /gene_functions="catabolic (rule-based-clusters) Xylan:
                     Glyco_hydro_43"
                     /gene_functions="catabolic (rule-based-clusters) Xylan:
                     GH43_C2"
                     /gene_kind="catabolic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898123.1"
                     /locus_tag="SIL76_11250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 43 protein"
                     /protein_id="MDX6025018.1"
                     /sec_met_domain="Glyco_hydro_43 (E-value: 5.7e-98,
                     bitscore: 325.0, seeds: 288, tool: rule-based-clusters)"
                     /sec_met_domain="GH43_C2 (E-value: 1.9e-51, bitscore:
                     171.9, seeds: 202, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIQNPILTGFNADPSIIRVEDTYYIANSTFEWFPGVRLHESKD
                     LEHWNLLPSPLSTITLLDMRGNSASGGIWAPDLSYADGKFWLVYTDVKVVNGAFKDMTN
                     YLTTATDIKGPWTDPIKLNGLGFDASLFHDKDGRKYLVQQTWDHREYKHPFDGITLTEF
                     DVTTMKLQPKTAKTIYNGTNVKLVEGPHLYQINDYYYLFAAQGGTVFTHQEVVARSKTL
                     DTLSFETEPGDPFITNFDTPDNYIQKQGHGGLVSTPKGEWYYASLCARPWNHKNESSTD
                     PRGWSSLGRETSIQKVEWDEEGWPRIVGGHGGTTFVEVPKDAIQTNAPADHSQKDDFAS
                     STLDINWNTLRVPFTEKMGSVGNGKLTLIGQGSLANNFDLSLIARRWQAFYFDAEVKVK
                     FDPFSYQQMAGLTNYYNDRHWSFAFITWNEINGAVIEVAENNRGNYTSYLKDNAIKIPD
                     RTEYVWFRTKVRKESYSYEYSFDGKKFIEIPVVLDAAVLSDDYVLQTYGGFFTGAFVGL
                     AAVDYSGYDRVAEFYNFDYKELGDKVLPDGSYTWKASESRFD"
     gene            complement(11705..13188)
                     /locus_tag="SIL76_11255"
                     /pseudo=""
     CDS             complement(11705..13188)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906009.1"
                     /locus_tag="SIL76_11255"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]; GO_process: GO:0055085 -
                     transmembrane transport [Evidence IEA]"
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYSKMSNEIKQVQHDEYHELTLGERIGYGMGDFAQNLVFGTVGGF
                     LALYMTTVNAIGTATAGFIFLFVRIINVFWDPMVGTFIDKRTSKAGKYRPWLLRAGIPL
                     VILAALLFAPLPGVKGSVPFAFIVYFALDLVYSVVNIPYGSLNASLTRNPESVDKLTST
                     RMMLANGANLLVYTLFPMFVQMAAPKGRSLKDTGLFGLKLHMGNYTDPSVGHAWFGVYS
                     VYMIIGAIALFLCYKLTKERVVATAEQSAEVKTTDLFLELKNNRPLVILGIFFMLAFTF
                     MFL"
     gene            complement(13250..14254)
                     /locus_tag="SIL76_11260"
     CDS             complement(13250..14254)
                     /EC_number="5.1.3.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906010.1"
                     /locus_tag="SIL76_11260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0016857 - racemase and epimerase activity, acting on
                     carbohydrates and derivatives [Evidence IEA]; GO_function:
                     GO:0030246 - carbohydrate binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /product="aldose epimerase family protein"
                     /protein_id="MDX6025019.1"
                     /transl_table=11
                     /translation="MTFTISKESLPFRADKSISQITLSNERLTIVVHDYGARVHQLLTP
                     DKNGTFENILLSKNNSETYANDGGYYGVICGPVAGRISGATYDSVSLEANEGKNNLHSG
                     SHGWERQFWSYETFETASSLGIKLSLRDEESSFPGQIQAEVTYKLTDNKLEVTISGLSV
                     TDTVFNPAWHPYFNLSAELSTTHEHFIQANVDFLVETNQENIPTGRLLTVDDSSYSIKE
                     SVSIKKLLKDNPEGLDDCFVFNPKGDKSLMLYDPLSGRKLVAQTDRQAVVIYTATNPEI
                     ESMINGRPMSKNRGIAIEFQEIPDLVHHPEWGTIELKAGQKKTFITEYLFTTN"
     gene            complement(14257..15762)
                     /gene="xylB"
                     /locus_tag="SIL76_11265"
     CDS             complement(14257..15762)
                     /EC_number="2.7.1.17"
                     /codon_start=1
                     /gene="xylB"
                     /gene_functions="catabolic (rule-based-clusters) Xylose:
                     XylB"
                     /gene_functions="catabolic (rule-based-clusters) Xylan:
                     XylB"
                     /gene_functions="catabolic-additional (smcogs)
                     SMCOG1210:glycerol kinase (Score: 475.4; E-value: 3e-144)"
                     /gene_kind="catabolic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898126.1"
                     /locus_tag="SIL76_11265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004856 - xylulokinase activity [Evidence IEA];
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_process: GO:0005997 - xylulose metabolic process
                     [Evidence IEA]; GO_process: GO:0042732 - D-xylose metabolic
                     process [Evidence IEA]"
                     /product="xylulokinase"
                     /protein_id="MDX6025020.1"
                     /sec_met_domain="XylB (E-value: 7.2e-178, bitscore: 589.1,
                     seeds: 481, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYVLGIDLGTSSLKGILMDEVGNLITTKSAEYQIDTPKQGYSEQ
                     RPEYWIVALESVLTDLSVEISDFGQQLAGISFSGQMHSLVVLDDNNKPVYPAILWNDVR
                     TSKQCQEITDRLGQRLLEITKNIALEGFTLPKILWLQENEPEVWSRVKKIMLPKDYLSL
                     WLTGNIYTEFSDAAGTLLLDIEKKQWSEEITDAFNIDRGILPELIESTDRTGFVKAEIA
                     ERYKLTNEVKVFAGGADNAAAALGVGLINEEVGLISMGTSGVVSAYEPKIADYKGKLHF
                     FNHTVPGAYYSMGVTLAAGNSLNWYKETFGKGLSFNELLSEVYTVSPGSEGLLFTPYIV
                     GERTPHFDSKIRGSFIGISAHHEQKHFSRAVLEGITFSLRDSKDIMEKTKNKKFKRLIS
                     VGGGAQNPDIMQMQADIFNSEMIRLTVEQGPGLGACMIAAFGCGLFDSLEAVTKAFVHY
                     KEASFIPNPKNVARYEQIYQIWKQVYKNTSEISHQLVEFNDEG"
     gene            complement(15829..17148)
                     /gene="xylA"
                     /locus_tag="SIL76_11270"
     CDS             complement(15829..17148)
                     /EC_number="5.3.1.5"
                     /codon_start=1
                     /gene="xylA"
                     /gene_functions="catabolic (rule-based-clusters) Xylose:
                     xylose_isom_A"
                     /gene_functions="catabolic (rule-based-clusters) Xylan:
                     xylose_isom_A"
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     AP_endonuc_2"
                     /gene_kind="catabolic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014572399.1"
                     /locus_tag="SIL76_11270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0000287 - magnesium ion binding [Evidence IEA];
                     GO_function: GO:0009045 - xylose isomerase activity
                     [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate
                     shunt [Evidence IEA]; GO_process: GO:0042732 - D-xylose
                     metabolic process [Evidence IEA]"
                     /product="xylose isomerase"
                     /protein_id="MDX6025021.1"
                     /sec_met_domain="xylose_isom_A (E-value: 1.8e-216,
                     bitscore: 716.2, seeds: 435, tool: rule-based-clusters)"
                     /sec_met_domain="AP_endonuc_2 (E-value: 8.7e-11, bitscore:
                     39.2, seeds: 169, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYFNDIAPIKYEGTKTKNMFAFRHYNPEEVVAGKTMEEQLHFAL
                     AFWHTITMDGSDPFGGATMERPWDLEGGSELDRAHRRVDAFFEIAEKLGVKYYCFHDID
                     IVPTGNSLKEFYANLDEITDHLLEKQKATGIKLLWNTANMFSNPRYMNGVSTSNRAEVF
                     AYGAAQVKKGLELSKKLGGENYVFWGGREGYESLLNTDMGLEMDHMAKFFHLAIDYAKS
                     INHLPIFLIEPKPKEPMTHQYDFDAATALAFLQKYDLDKYFKLNLETNHAWLAGHTFEH
                     ELNTARTFNALGSIDANQGNYLLGWDTDEFPTLVIDITLAMHQILLNGGLGKGGINFDA
                     KVRRTSFKAEDLILAHIAGMDTYARALKGAAAIIEDKFLSDIVDERYSSYKNTEVGQSI
                     ENGTATFESLAAFALEHGDDIELDSNHLEYIKSVLNDYLV"
     gene            17259..18212
                     /locus_tag="SIL76_11275"
     CDS             17259..18212
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     Cupin_2"
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 63.3; E-value: 3.5e-19)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898128.1"
                     /locus_tag="SIL76_11275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AraC family transcriptional regulator"
                     /protein_id="MDX6025022.1"
                     /sec_met_domain="Cupin_2 (E-value: 2.4e-07, bitscore: 27.6,
                     seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNELENIYHSKINNLNFLLVDITYRKPHLHFDIELAFVLEGAGQ
                     VITQEQCFEIKAGQAIIFNSCQVHELSSSDSMKLLILQFSSEIFKIIFPQLDKIYFESH
                     PFNLKNQPETLKLLLQAALSYFADDKNNSLRTHGYTSLLLDRLLSISEYSILSSSEQNK
                     LMDLQERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIR
                     SEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFVKSYGVLPKEFRKNSVLFPNLNYMT
                     FNQDKIDNQVFYSDRGSFDILQYYLEKNFEKTSSHF"
     gene            complement(18357..19463)
                     /gene="purK"
                     /locus_tag="SIL76_11280"
     CDS             complement(18357..19463)
                     /EC_number="6.3.4.18"
                     /codon_start=1
                     /gene="purK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011676458.1"
                     /locus_tag="SIL76_11280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004638 - phosphoribosylaminoimidazole carboxylase
                     activity [Evidence IEA]; GO_function: GO:0005524 - ATP
                     binding [Evidence IEA]; GO_function: GO:0046872 - metal ion
                     binding [Evidence IEA]; GO_process: GO:0006189 - 'de novo'
                     IMP biosynthetic process [Evidence IEA]"
                     /product="5-(carboxyamino)imidazole ribonucleotide
                     synthase"
                     /protein_id="MDX6025023.1"
                     /transl_table=11
                     /translation="MIKNTKQTIGIIGGGQLGQMMAIAAQYMGHKVITLDPNPNCSAAK
                     VSDELIVAPYDDVDNLLRLAYACDVITYEFENVSAKALHEIEGCVRIPQGIRLLEITQN
                     RRFEKEFLTNEAKVNVAPWQLVDSAEKLPETVTRKQVLKTTTGGYDGHGQVVLNADKDL
                     SAAKSLTELSECVLEDFISFEREISVIISGNGHEYVVFPLAENEHRENILHQTISPARI
                     SAEITENAYKIATSIAEKLELSGVLCVEMFLTADGQIYVNELAPRPHNSGHFTIEACDF
                     NQFDLHIKGILGEDLPEPKLLKPAIMLNVLGQHVEAVKKLNHEHADWHQHDYGKADAKH
                     NRKMGHVTILTNDFDQTINEIKATKIWD"
     gene            complement(19514..19999)
                     /gene="purE"
                     /locus_tag="SIL76_11285"
     CDS             complement(19514..19999)
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /codon_start=1
                     /gene="purE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010906015.1"
                     /locus_tag="SIL76_11285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_component:
                     GO:0009320 - phosphoribosylaminoimidazole carboxylase
                     complex [Evidence IEA]; GO_function: GO:0004638 -
                     phosphoribosylaminoimidazole carboxylase activity [Evidence
                     IEA]; GO_process: GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="MDX6025024.1"
                     /transl_table=11
                     /translation="MAEVAIIMGSSSDWATMKETAKILDDFGLAYEKKVVSAHRTPALM
                     AEFSSQAREAGYKVIIAGAGGAAHLPGMVAAQTLVPVIGVPIKSRALSGLDSLYSIVQM
                     PAGVPVATMAIGEAGAKNAALFALQLLANTNENLYQKLLVYRAAAQEMVEESNKALL"
     gene            complement(20032..21270)
                     /gene="purD"
                     /locus_tag="SIL76_11290"
     CDS             complement(20032..21270)
                     /EC_number="6.3.4.13"
                     /codon_start=1
                     /gene="purD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019292352.1"
                     /locus_tag="SIL76_11290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0004637 - phosphoribosylamine-glycine ligase activity
                     [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP
                     biosynthetic process [Evidence IEA]; GO_process: GO:0009152
                     - purine ribonucleotide biosynthetic process [Evidence
                     IEA]"
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="MDX6025025.1"
                     /transl_table=11
                     /translation="MKILVIGSGGREHALAKKFMESPQVEEVFVAPGNSGMEKDGIQIV
                     DISELSNDKLVKFAQNQNIGLTFVGPETALMNGVVDAFIKAELPIFGPNKMAAELEGSK
                     DFAKSIMKKYGVPTADYATFDSLEPALAYLDEKGVPLVIKADGLAAGKGVTVAFDIETA
                     KSALADIFSGSQGKVVIEEFLDGEEFSLFSFIHDGKIYPMPIAQDHKRAFDGDKGPNTG
                     GMGAYSPVLHISKEVVNEALEKVVKPTVAGMIEEGKSFTGVLYAGLILTEDGVKTIEFN
                     ARFGDPETQVVLPRLKSDLAQAIIDILAGNEPTLEWLESGVTLGVVVAAEGYPSQAKLG
                     LILPEIPEGLNVYYAGVSKNENNQLISSGGRVYLVSETGEDVKSTQKLLYEKLDKLEND
                     GFFYRHDIGSRAI"
     gene            21626..22252
                     /locus_tag="SIL76_11295"
     CDS             21626..22252
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239:TetR family
                     transcriptional regulator (Score: 99.6; E-value: 3.9e-30)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130063.1"
                     /locus_tag="SIL76_11295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="MDX6025026.1"
                     /transl_table=11
                     /translation="MATQPTKDKIISSSWELLEELPLTEFSMRKLASRLGMTVSSLYYH
                     FSSKEALFAELIDKASLEIIFPANEKTWQDRLFVYGKNIYAVLESYPNLAQLMMDYPPE
                     SENYLRLFDKLLMIVDDLKLSDDHKFYTINLFLNFIYTSKIDSDRLVEQPEKPLSTVKI
                     PLVQLAPFLDKYWRTESLTSLGSSESFEFGLQLIISGIEKMLKIN"
     gene            22356..23753
                     /locus_tag="SIL76_11300"
     CDS             22356..23753
                     /codon_start=1
                     /gene_functions="catabolic-additional (rule-based-clusters)
                     MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 324.9; E-value:
                     1.1e-98)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864722.1"
                     /locus_tag="SIL76_11300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0022857 - transmembrane transporter activity [Evidence
                     IEA]; GO_process: GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /product="MDR family MFS transporter"
                     /protein_id="MDX6025027.1"
                     /sec_met_domain="MFS_1 (E-value: 1.2e-50, bitscore: 169.6,
                     seeds: 347, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTNDFNLKKVLPAVLTIAIGMLLVMMDTTIMNVTLPHIQSAFH
                     QNLSNSQWVITAYTLAMATVIPFAGFLGDRFSDKKVFALAIIFFTIASFLAANAHSLQS
                     LIIWRIAQGLTGGVVAPIGIGMSFKIIPMEKRGSMMGLLGLPMLLAPTIGPALSGFLVK
                     HFNWSTVFLINLPVGVLALIFVLLFLPNFPANKASKIDLKGALLSPFAFPILIYGVHVG
                     TDKGWSNPTALSFVVLGIIMLLLFIIVELRVENPLLHLRAFAISEFTKGISLMWLNQIV
                     VFGAMLLVPLYLQNVVGLSSENTGLIMVPQAIASFLGMTIGGRIFDKFGTKAAVLPGFT
                     LGALSLSLFSQIKPSSSLAFTLCAIVLLGLSQGLVNMQVNNHALQSVPMKNISRVTPLT
                     NEMMQVVNSFAIAFLTAFLSGQIKKQTGLSPLQANLTAFHHTFYLLLIFVSFGFILSLF
                     LRKKVKA"
     gene            complement(23789..24481)
                     /locus_tag="SIL76_11305"
     CDS             complement(23789..24481)
                     /codon_start=1
                     /gene_functions="catabolic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 75.7; E-value: 6.9e-23)"
                     /gene_kind="catabolic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130060.1"
                     /locus_tag="SIL76_11305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0008253 - 5'-nucleotidase activity [Evidence IEA]"
                     /product="YjjG family noncanonical pyrimidine nucleotidase"
                     /protein_id="MDX6025028.1"
                     /transl_table=11
                     /translation="MTVLLFDIDNTLLDFDKAEYDALGKIFTHYQIEDNQENRATYSRE
                     NKALWRLHESEKLSREELLSTRFDHAFRALNVSVNYNPVAVDDEYQLYLSQGHELINHA
                     KELLTELSAKEAEMYVVSNGTSRVSRPRIFESGISDHFREIFISEEVGHHKPSLAFFDY
                     VFDHIEAANQKEFTIVGDSLATDILGGNRAGIKTIWYNPKQLEVSGEAQPDVQIQDLLE
                     IPALVKNW"
     gene            complement(24658..26214)
                     /gene="purH"
                     /locus_tag="SIL76_11310"
     CDS             complement(24658..26214)
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /codon_start=1
                     /gene="purH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898135.1"
                     /locus_tag="SIL76_11310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_function:
                     GO:0003824 - catalytic activity [Evidence IEA];
                     GO_function: GO:0003937 - IMP cyclohydrolase activity
                     [Evidence IEA]; GO_function: GO:0004643 -
                     phosphoribosylaminoimidazolecarboxamide formyltransferase
                     activity [Evidence IEA]; GO_process: GO:0006164 - purine
                     nucleotide biosynthetic process [Evidence IEA]; GO_process:
                     GO:0006189 - 'de novo' IMP biosynthetic process [Evidence
                     IEA]"
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="MDX6025029.1"
                     /transl_table=11
                     /translation="MSKRALISVSDKEGIVEFAKKIREFGWEIISTGGTKAVLDQEEIP
                     NIAIDEVTGFPEMMDGRLKTLHPLIHGALLGRRDLESHMESMTEHHISPIDLVVVNLYP
                     FKETLLAGGSQAEMIEKIDIGGPSMLRSAAKNHASVTVVCDPNDYEKVLTELSVKGETS
                     LSFRQQLAAKVFRHTASYDALIAQYLTEEFPVENVKPEKLTLTYDLKQGMRYGENPQQN
                     ADFYESGIPTTYSIAQSKQIHGKELSYNNVRDADAALQIARDFEEPTVVALKHMNPCGI
                     GRATDIEKAWDYAYEADPVSIFGGIIVLNREVTLATAQKMSKIFLEIIIAPSYSKEALE
                     VLSKKKNIRLLTVDFSKKEASEKEVHVTGVLGGLLVQNQDVIVENPKEWTVATKVQPTD
                     RQMEAMEFAWKAVKFVKSNGIIVTNDHQTLGVGPGQTNRVGSVKIALEATADKSLELQE
                     NAVLGSDAFFPFADNIDEIAKAGIKAIVQPGGSVRDQEVIDACDKYGIAMVFTGLRHFR
                     H"
     gene            complement(26390..26932)
                     /gene="hpt"
                     /locus_tag="SIL76_11315"
     CDS             complement(26390..26932)
                     /EC_number="2.4.2.8"
                     /codon_start=1
                     /gene="hpt.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012898136.1"
                     /locus_tag="SIL76_11315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology. GO_process:
                     GO:0006166 - purine ribonucleoside salvage [Evidence IEA]"
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="MDX6025030.1"
                     /transl_table=11
                     /translation="MHPHLKEVLFTREQIAERVKELAEVVSRDYEGKNPLVVGILKGSI
                     MFTVDLLKELSIDAEVDFMDVTSYGYGISSSGEVRILKDLSTVAHGRDILIVEDIIDTG
                     NTLLYLKKLLTGRQAHSVKIISLLDKPSGRKVDIDADYVGFEVPDAFIVGYGIDYAERY
                     RQLPYIGIFNEEFLIKD"
ORIGIN
        1 tctcaccttt tggtgcaaaa tcacgcaact cttctttcaa acttccatca gcattaaata
       61 aagtttccgg ttgataagaa gtcatccatt ttacaaattc tggtaaagtt cccatatttt
      121 tagaagataa cggaagtgga acttgatgcg cacggaaact atgttcaatc ggcattcctc
      181 ttccgtcaaa tttaggacct gaccaatcat tataacgtgg accaccccaa ccttttggta
      241 aacgtgcgat aacaattggc caagctggaa tctctccatt ttgataacga ttatcttcac
      301 gcgcatcttt ctgaatttga tgaatgtctt caatcgcttt atcaaaaact tcagctgcta
      361 atttatgata agccatgtaa tcatgaatat catcattttc aatataacga ggtgagtaac
      421 ccagtccttc aaagaattta cgaatatcaa catctgaagt tcgagcgaac aaagtaggat
      481 ttgaaatttt aaaaccattt aaatcaagaa ttggtaaaat cgccccatca ttcttaggat
      541 taatgaattt aatagagtgc caacttgtca tcaacggtcc agtttcagct tctccatccc
      601 caacaacagc aaaagcaatt tgttcaggtt gatcaagaat agcccctgtt gcatgtgata
      661 gcacataacc taactcacct ccttcatgaa gtgaaccagg ggtttgcgcc gtcatatgtg
      721 accctattcc tccaggaaat gagaaacgtt taaacaaacg tgacatccct tccaaatctt
      781 gggtaatctc tggataaact tctgtatatg agccatcaag ataagaagga acaaccatgg
      841 cttgtccacc atgtccgggc ccccccatgt aaaacatctt ttgattatat ttattgatta
      901 aacgattggc atgagcatag aggaaagttt gtcctgatac cgtcccccag tgcccaatag
      961 gattggcttt aaggttttct gctttaattg gagttcctgt cacagagaac aaaggatttt
     1021 ctttcaagaa aatcattcct gctccaagat aagttgctgc tcgccaccat ttatcaagct
     1081 ttttcaaata agattctgaa ttatattctg tcattttttc ctcctgattt tccttcatta
     1141 taggtcaatt atgcttaata ttctaataat ttgttcatat atccactagg aaacattgct
     1201 atatattttt gtttattgaa attagcgaat acgaaaagag agagaattct ctctcaaatt
     1261 tttcatccaa gattaatata agttagtcca aacattgcac acaaatcacc aatttgttct
     1321 gaatcaacca caaaagataa aacagtatga tgtccccctc ctgcttttaa ccattgttca
     1381 gccccaactt ttaatccttg tttaggcgtc cagagctgct tagcaactgg taaaaacgga
     1441 gtttcttctt ctggtttatt tccagtaacc tcataagaaa ttaacttaaa ttcatttcca
     1501 taatctgcca tagtaatatc aacagcttca ccaatcatac ctgtgaatac taagcgtgct
     1561 ggatctgact taccaccaat atctaacgga tggacctcaa ctcgtggctt gtctgatgct
     1621 attgaaggat caacttcaag catgtgtgac ccaagaattg cttcgtgtcc ttgacgcaaa
     1681 tccaaagtat aatcttccat aaagactgtt tctttattat gcgccataat tttgaacaga
     1741 cggacaagtg ctgctgtttt ccaatctcct tctccagcga atccataacc atcagccaaa
     1801 agtaattgtg ctgcaagtcc aggtaattgt tctaagccta ccaagtcttc aaagttagta
     1861 gtaaaggcac tatagccttt atcgtccata aatttcttaa ttcctaaata ttcacgtaat
     1921 tgatatttaa catttttttc gaatttttcc ggactattgt ttccttcaat ataatcatat
     1981 ttactttgta aatctttata aagctgatta atatcactct ctgctacagc attaacatat
     2041 tctactaaat cacctactcc ccaataatca accgtccagc caaatttaat ttgcgcttca
     2101 actttatctc cgtccgtaac agcgacatct cgcattttat cagcaaatgt aacgattttt
     2161 attttatagg attcattgta agccaccgca acattcatcc atttagcgat ttgttgtcta
     2221 atttcatcat cttcccaatg gccaaatata atcttattat tttttttcaa acgtgcattg
     2281 ataaaagcat attctcggtc accatgagct gattgattta cattcatata atcaaaatca
     2341 atcgttttgt aaggaatatg gttcaaaaat tgagtagcta agtgtagtaa gggtttattt
     2401 aaaagttgtg tcccacgaat ccagtttttg gctggagaaa aggtgtgcat ccatgtaatc
     2461 acgcccgcaa cttcatcctg ataatttgct tccttcataa tttgagtaat attttcagca
     2521 gttgttgcaa ctattttaaa aataattgga taagggaggc taccagaata attcatttcg
     2581 tcaactactt ttcgagcatt tttttcaaca gtcgccaaag cttctggacc atataaaaat
     2641 tgagaccctg taacaaacca aaattctttt tgagtatttt ctaacatttt tctaccaact
     2701 ttcttcatat tatttattta tttatttttt tgtccataat aagcatcttt accatgttta
     2761 cgtaagtaat gcttatctaa aattctttga ggtaaatccg ctgcataact gttaatttga
     2821 cgagcaaaaa tattcatctt acaaacattt tctaaaacta ctgcattata tacagcagct
     2881 tcaacatccc ccccccatgt aaagggacca tgcccatgga gtaaaacagc tggtatatct
     2941 aagatatcaa tccctctttc ttcaaaagtt tcaataataa gtttaccagt ttcatactcg
     3001 tatcctttat caatttcctc ctttgtcaag tagcgagtac aaggaaccgg accgtagaag
     3061 gtatccgcat gagttgtacc catagccgaa acatctacac ctgactctgc ccatgcagtt
     3121 gcccaattcg aatgtgtatg gacaatacca cctaattccg gatatttttt gtagagtacg
     3181 gcgtgcgttg gagtatctga cgatgggttt aattctcctt caataacttt cccttccaaa
     3241 tcaaccacta ccatgtcaga tgcttttaag ctcccataat ctaccccact tggcttaatg
     3301 acaaaatagc ctgtttcctt atcaaaagca ctcgcatttc cccaagtaaa ttcaacaaga
     3361 tgatgttcag gaagttcaag atttgctttt aatacctttt cttttaagtc ttctaacatt
     3421 tttttcctta ctatttaatt tattttttca gcagcttgac gctccagatc aagcccttca
     3481 cgataacgtt taatgaacaa gttataactt gtttcgtctt caggattagg atttattgta
     3541 atacttttaa cagctgcaaa aactttttct tttaagaatt catttaaatt attattttca
     3601 ctcgaactga atgccccaag acagccattc cccaagcacc accttctcct gccgtttcca
     3661 taaccgtgac aggcttttgc agtgcagcag ctaaaatctg ctgcccaact tctggagttt
     3721 tgaaaatccc tccatgtcct actaaaccgc tgatttcgat tttttcctgc tttagaagat
     3781 ccataccaat acgcattgcg ccaaaagcgc tataaatatg cgttctcata aaattcgcta
     3841 agttaaaatt accatcgggt aatcgaacaa ataaaggacg tcctgcactt acctttgtta
     3901 tattttcacc agaaaaataa ccataactta atagccctcc tagatcatta tccgcttcca
     3961 aagctttatt aaaaagtatt gaaaatattt tctcacgatt aacagcaatt cctaaacttg
     4021 tcgtatattc ttcaaaaagc tttatccagg cattgatatc tgaagtagag ttgttggcat
     4081 gaaccatacc aacaagttct ccgtcaggag tggtcacaat atctatttca ggatagacct
     4141 ttgaaagaga cttctcaaga acaatcatcg caaatgctga agtcccaaca gaaacatttc
     4201 ccgtgcgaac ttctatacta tttgtcgcta ccatcccggt tcctgcatct ccttctggcg
     4261 gacaaagagg aattccagct ttaagagctc cggtaggatc aatcaaaaat gctccttgct
     4321 ctgttaatgt acctgctttt tcacctgctc gtaaaacttt cggaaaaata ttttctaaac
     4381 tcgttgaagt ctctttttca aaaagattaa taaatttttt attatatgtt tttgttgcac
     4441 tgtcaatcgg gaacattcca gaagcatcac caattcccaa aactttttcc cctgtcaatt
     4501 gccaatggac atagccagct aaagttgtta aatattcaac ttgattgata tgcttttctc
     4561 gatttagtat cgcttgatag taatgagcaa tagtccatcg ttcaggaata ttaaaatcaa
     4621 aaagttctgt caacattctt gaggcttctg atgtcgttga atttctccaa gttctaaaag
     4681 ggattagaag tttatcagtt ttatcaaagg ccatatagcc gtgcatcatt gcgctaaatc
     4741 caatcgaagc aaccttttca agtattagtc catatttttt atagacttcc gttgctagtt
     4801 ctctatagct ccttcgcagc cctttccata cttcttctgt cgaataagtc cagtaaccat
     4861 caactaactt gttttcccat tcatagcttc cagatgcaat tgtctgaaat ttggaatcaa
     4921 ttaataccgc ttttattcgc gtggacccaa actcaatccc caaatttgtg cggacatcaa
     4981 caatatctaa catttctccc gctcttaaag agaccatttt ttctcctttt tcttaattat
     5041 tcgctaatgc gtagcgctta cataattaca taattttata aggagatttt caatagcatg
     5101 aaaactaata aaaaaatttc tgcttctttt atctactttt ttggggcatt tggcggaata
     5161 ctattcggtt acgatatagg agttatgact ggagccctcc cttttttaca aactagttgg
     5221 ggcttaacca acaatgcaac aattataggg tggatcactt catcagtaat gtttggcgcg
     5281 atctttggtg gtgcagcagc tggacttttg tccgatcgtc tgggtcgacg aaaaatgatt
     5341 ctgatttcct cactaatttt tatggtaggt tcgttacttt cttccatctc ccctcatgat
     5401 ggtcaatatt atttaatcgt tgtccgaatt ttattgggac tagcagtggg agccgcttct
     5461 gcccttgtac catcatatat gtctgaaatg tcacccgcta atattagagg acggctgtca
     5521 ggtattaatc aagtgatgat cgtttctggt atgcttttat cttatatcgc cgattatttt
     5581 ctaaaaaatt tatccacgga tattgcttgg cgtattatgc ttggtgctgc tgcaattcca
     5641 gcattaattc ttttctttgg ggtattagct ttgccagagt cccctcgatt cctcattaaa
     5701 tctggaaaaa taaatgaagc taaacaagtt cttagcttca tacgtaaacc tgacgaaatt
     5761 gaaaacgaaa taaaatcaat ccaagataca gctaaacaag aatcagctgc attgtcttct
     5821 accagctggg gaaccctctt caaaagtcgc tataggtatt tagtagtagc tggcctaggt
     5881 gttgctgctt ttcaacaatt tcaaggtgct aatgcaattt tctactacat tccactgatt
     5941 gtagaaaaag caacaggaca ctctgctagt gaagcattga tgtggccgat tattcaggga
     6001 attatcctcg tgattggtgc acttttcttc ttggtaattg ctgatcgctt tgatagacgt
     6061 actctcctcc gattgggtgg aagtatcatg gggctctcct ttattcttcc agccatcatc
     6121 aatttcatca tacccaattc gagtcctatg atgattgttt tctttttgtg tatttacgtc
     6181 gccctttatt catgtacctg ggctccatta acttgggtgc ttgtaggtga ggtattccct
     6241 ttagctattc gaggacgtgc ctctggatta gcctcatcct ttaactggat tggttccttc
     6301 ctcgttggac ttctatttcc aattatgacc gcatcaatga gccaagaagc tgtttttgct
     6361 atatttggtg taatttgtct attaggagtg ctctttgtcc aattcttcgt ccctgaaacc
     6421 cgtggccgta cacttgaaga aattgaaaaa catataaaaa attaaattcc tacatggaaa
     6481 atgaaaataa ttgggtttaa aaaggccaaa ttttaacacc aatagatttt ttgaacttga
     6541 tgcaacttca ctacaactta tatgatataa tatattacaa tagtaaatat ttgaagtagg
     6601 ttaaaatctt taaatatcgc taaaaaataa gtaagaaagg ggatctttcc atgaaaccaa
     6661 aataccaagt aattgctgac tcacttcgag ataagattat ttctactgaa tatgtcgttg
     6721 gtggagtcat tccaacagag ttgcaattgc aagaagcata tcatgctagt cgatataccg
     6781 taagacaagc ggtatcggta ttagtaagtg aaggatatct ccgcaaagaa aaaggttctg
     6841 gaacctatgt caatgaaccc ccaacttcaa ctagtgaaat atctcccaaa aaaacaattg
     6901 gcgtaataac aacttacatc tctgattata tcttcccaac aattatccgg ggaattgaaa
     6961 aagaactgaa agctgatggc tattctcttc ttctttcgag cactaataat gattatcttc
     7021 aagagaaaga gtgcttggat agaatgattg aatttggtgt agatggatta atcgttgagc
     7081 caacaaaaag taatcaatat aaccctaatc tggcaaccta tgtcacttta cgagaacata
     7141 atattccaat cgttatgatt aatgcaactt atgaagaact aagtactcca tcgatccatg
     7201 ttgatgatgt tgaaactggc tatttagcaa caaaggaact tattgataat aatcaccaac
     7261 gcctcttatt aataactaaa attgacgact tacaaggtaa ataccgcatg aaaggtttta
     7321 taaaggcatg cgaagaaaaa gaaattaaac tttcttcaaa ttccattatt acttatacta
     7381 ctgaaaacga agtgtcaatc tatgacaaaa taatttctca cttaaaagaa tttaccgaca
     7441 tcagtggaat tgtttgttac aatgataaga ttgctaaaac gctaattgga aaactttcta
     7501 gtcttggcta taaaattcct gatgattttt caattgttgg aaacgatgac tctaccctaa
     7561 gtcaaatggg agaagttagt ttaacaacaa ctgtccatac taaagaaaaa atgggaatag
     7621 acgctgcaaa atggattgtt aataccataa aaaatgggaa atttgagaaa gatattcttt
     7681 acccaccaaa attaattcgt agaaattctg taaaaaaact aaaaactgaa gattgatacc
     7741 aagttatata aaagaactcc tcgcctctta tgcaaggagt tcttttaaat cttttatccc
     7801 tcttcttcta aatgatgcac acgatgcagt aattctgctt cgatttgttc gagtgttttg
     7861 cctcttgttt caataacttt tttactagta aaccaaattg agaggaaaca acaagccgca
     7921 taaatcagga aaattttacc tgttccaaaa aatgataata atggtaagaa tgttaatgac
     7981 accacccagt tagcagccca gttgacagca gcaccaaatg aatttcctaa gccacggatt
     8041 ttaagtggga aagattcacc aatcatcacc cacattactg gtccccatgt tgctgagaag
     8101 aaggcaatat ataccgttaa agcgataact gctaaatatt taccaaagcc aatatgagca
     8161 ttttctgcta aaatcatccc tactgacatc aatactagag aaattcccat tccccaagca
     8221 ccaaaattaa gcatccaccg acgattaact ttatccatta ctctcatagc aatataagtt
     8281 acaataacat tgaaaatacc aatcccaata tgagcaagta aagctgcgct tgccccaaat
     8341 cctaccgcaa caaaaattga tggtacaaag tataatactg tattacagcc cataacctgt
     8401 tgaaaaattg ccagaccaat tgccataatt aaaactggac gtgacatttg accaaataat
     8461 tcttgtaagc caccttgttt ttcttcctta gccatcaatt gaatatcaga aatttctgct
     8521 tcaatcgagt ttggatcatc atttatcatc cctaatattt cacgggcccc tgcttcatta
     8581 tcatgacgaa caagaaatct tggagattct ggcaaaaaga gtccaccgat gaaaagaagg
     8641 gctgctggaa cagtggccaa accaagcatc caatgccaat ttcctgaaac tccttttaaa
     8701 gcatagtttg agatataggc taataaaatc ccagtcataa tcatcaattg aaacatagtt
     8761 gaaactccac cacgaatttt agcgggtgaa agttctgata aataagtcgg caccaaagct
     8821 gaagctgacc caacagccat cccgagaata acccgagaaa taattagtaa ctcagcgcta
     8881 tttgaaagcc ctgaacctaa agctccaaca aaaaagatga ccgctgacaa aagtaacaaa
     8941 cgtttccgac caaaacggtc actcattggt ccaatcacga ccgcgccaat tacagctccc
     9001 attaagactg ccgctgtaat ccatccttcc atccaagccc aagaactcac ctgccagctc
     9061 tctttttcaa taaaaagtag cgctcccgat atgacgcctg tgtcatatcc aaataataag
     9121 ccacctaaag caccaaaaaa atagatgaaa gtgggagaaa gttttctcat gatagtaact
     9181 ccttaatttt tatttgcaag tcttcttgcc tttttttact acccacaaat gataccgctt
     9241 tccacactta ctttcttgta atccttgata ttttaaaatg gaaatgttgc tcataataaa
     9301 gctaaaaact actcttatgt aagagcagtt ttaattagtt tattcatttt ttattaagcg
     9361 tgccggattt ccagcaatta tgcagtggct aggaaatgat ttggtcacca cagagccagc
     9421 accaacgaca acatcatctc ctaaagaaac tccaggcaaa agaatcactg aaccgccaag
     9481 ccaacaatca ttaccaatta ctattggccc atcatattgc cagccttcac gtcttaaaaa
     9541 cacatccctg gcatgatgat taggtgtaaa taattgacaa tttggtccaa taaaacagtt
     9601 tttcccaatc ttaaccttac ccgcactaat aatctgaagt ccactattaa taaaagtatt
     9661 ttctccgact ttaaaacgat tgggatattc caaagcaatt attggaaaat atatttctga
     9721 actttgaggt aaatttggaa gaaaatcctc caagagtttt cttgcttcat caatattttc
     9781 ttttgcctta tcattaattt cagaaatttt ttgactagaa tttttgacta ttttttgtag
     9841 ttctacttct ttgctatatt ggtaccaatc accattattt attttatcaa aaatagatag
     9901 ctttgctaaa cgtaattttt ctgcttcatc taacattctc atcgactttt tcctttacta
     9961 aaaatccctt actacaaata tgtaggtaag ggattgtaga ctaatcaaat cttgattcac
    10021 ttgctttcca agtataagaa ccgtctggta agaccttgtc tcctaattct ttatagtcaa
    10081 agttataaaa ttctgcaact ctatcatatc cagaataatc aacggcagca agcccaacaa
    10141 atgctccagt gaagaatccg ccataagttt gtaaaacata atcatctgaa aggacagccg
    10201 catctaagac tacaggaatt tctatgaatt ttttgccgtc aaaactatat tcataagaat
    10261 atgattcttt acggacttta gtgcggaacc aaacatattc agttctgtca ggaattttaa
    10321 tggcattatc ttttaaataa gaagtatagt ttcctctgtt attttcagca acttcaatga
    10381 cagctccatt gatttcattc catgtgataa aagcgaagga ccaatgacgg tcattgtaat
    10441 agttggttaa tccagccatt tgttggtaag aaaatgggtc aaattttact ttgacttctg
    10501 cgtcaaaata gaaagcttgc caacgtctag caatcaaaga taaatcaaaa ttatttgcca
    10561 aagagccctg accaattaat gttaacttgc catttccaac tgaacccatt ttctcagtaa
    10621 atgggacacg caatgtattc cagttaatat ccaaagtaga acttgcaaaa tcgtcttttt
    10681 gactgtggtc agcaggtgca ttagtttgaa ttgcatcttt tggtacttca acaaaagttg
    10741 tcccaccatg accaccaaca atacgtggcc aaccttcttc gtcccattcc actttttgga
    10801 tagaagtttc acgacctaaa gagctccagc cacgagggtc tgtgcttgat tcatttttat
    10861 gattccatgg tcgagcgcat aaggaagcat aataccactc acctttgggt gtagatacaa
    10921 gacctccgtg tccttgcttt tgaatataat tatcaggagt atcgaagttt gtaataaatg
    10981 gatcgccggg ttcagtttca aaagataaag tatccaatgt tttagagcga gccacgactt
    11041 cttggtgtgt aaagactgtt ccaccttgag ccgcaaaaag ataataataa tcattaattt
    11101 ggtagaggtg tggaccttca accaatttaa catttgtacc attgtaaatc gttttagctg
    11161 ttttaggttg tagtttcatt gttgtcacat caaactcagt caatgtgatt ccgtcaaatg
    11221 gatgcttgta ttcacgatga tcccatgttt gttgaactaa gtatttccgt ccgtctttat
    11281 catggaaaag tgaagcgtca aagccaagac cattgagctt gattgggtct gtccatggtc
    11341 ctttgatgtc tgtagctgtt gttaaataat tggtcatatc tttgaaagca ccattgacaa
    11401 ccttaacatc tgtataaaca agccaaaatt taccatccgc ataagataaa tcaggggccc
    11461 agatcccacc tgaagctgag tttcctctca tatccaacaa agtgattgtt gacaatggac
    11521 ttggaagtag gttccaatgt tctaaatctt ttgattcatg taaacgaaca ccggggaacc
    11581 attcaaaagt ggagttcgcg atgtaataag tatcttctac gcgaataatg cttgggtctg
    11641 cattaaagcc ggtaagaatt gggttttgaa taagtgacat gattttgtct ccttttaata
    11701 taaattattc cgcttcctta agttgagcac gtttttcatc aagctgttga ttaatctctg
    11761 ctacatcctt atcagaaatt ggatagagtt gcataataat cattgataca agagcaagaa
    11821 cggctggaat ccaaattgct gtgagattta taccagctaa ggcattagca tgttgatgtg
    11881 ctgctgtctc attgaaacca taagctgcta agaaccaaag tggaatcgct ccacctaatg
    11941 taaaaccaat tttgaagaaa agtcccatga ttgcgttaat aatcgcagca tttcttttac
    12001 ccgatttgag ttctccataa gcgacaactt caggaactaa tgcccacatg aatcctgttg
    12061 ctgaagttaa gccccattgt ttaataaagg ttgcaacata agctaaccag agggcatcat
    12121 gcattccatt aagggaccaa atatatgtca aaatttctcc aacaatgaac attccgataa
    12181 aaagatgaaa gaaacctttt ttaccgaaaa ttttctttaa acgaggccaa aagattggga
    12241 aaacaattcc tggaattgaa gcaatgaggc caatggctcc catccattct gaatgtccaa
    12301 caacaaattg attaaagaaa ccatttacag tattcataaa aacatgaaag taaaagctaa
    12361 catgaagaaa atccctagaa tcacaagtgg acgattgttc tttaattcaa ggaagaggtc
    12421 agttgtttta acttctgccg attgttctgc tgttgcaacc acacgttctt tggtcaattt
    12481 ataacatagg aataaagcta ttgcaccaat aatcatataa actgagtaaa ctccaaacca
    12541 agcatgtccc actgaagggt cagtataatt ccccatatga agtttaaggc caaataatcc
    12601 agtatcttta agacttcttc ctttcggtgc tgccatttgg acaaacattg gaaagagggt
    12661 atagactagg agattggctc catttgccaa catcatccgt gtacttgtca gcttatcaac
    12721 ggattccgga ttacgagtta atgatgcatt aagtgaacca taaggaatat taacaactga
    12781 atatactaag tctaaggcaa aataaacgat aaaagcaaag ggaacagacc ctttaacacc
    12841 tggtagaggt gcaaaaagta aggcagctaa aatcactaga ggaatacctg ctcttaaaag
    12901 ccaaggacga tattttcctg cttttgatgt tcttttatca ataaaagtcc caaccattgg
    12961 gtcccaaaat acattaataa ttcggacaaa cagaaaaata aaaccggctg ttgcagtacc
    13021 aatcgcattg actgtcgtca tataaagtgc taaaaagcca ccaacagtcc caaagacaag
    13081 gttttgtgca aaatccccca ttccataacc aatacgttct ccaagcgtta attcatgata
    13141 ttcatcatgt tgaacttgtt tgatttcatt actcattttc gaatacattc ctcctattat
    13201 tttattaaaa ttatttttac tgatttactg atgagtctgt cagtaaattt taattcgttg
    13261 taaatagata ttctgttata aaagtctttt tttgacctgc tttaagctca atcgttcccc
    13321 attcaggatg atgaacaagg tcaggtattt cttgaaattc aatagcaatt ccgcgatttt
    13381 tggacattgg tctgccatta atcattgact ctatttctgg atttgtggct gtgtaaatca
    13441 cgaccgcttg tctatcagtt tgagctacta gtttccgacc agataaaggg tcataaagca
    13501 ttaaactttt atctcctttg ggattaaaaa caaagcaatc atctagtcct tcgggattat
    13561 cttttaaaag ctttttgatt gaaacgcttt ctttaattga ataagaactg tcgtcaacag
    13621 ttagaagacg accagttggt atattctctt gattggtttc aactagaaag tcaacatttg
    13681 cttgaatgaa atgctcatga gtcgttgata attctgctga cagattaaaa taaggatgcc
    13741 aagccggatt aaagactgtg tcagttactg acagacctga tattgtcact tctaacttat
    13801 tgtcagttaa tttataagtg acttctgctt ggatttgacc tggaaaactg gactcctcat
    13861 ctcttaaact tagtttaatg ccaagagatg atgctgtttc aaaagtttca taagaccaaa
    13921 attgtctttc ccagccatgg cttcctgaat gtaaattatt ttttccttca tttgcctcta
    13981 aactgacaga atcataagta gcacctgaaa tacgcccggc aactggaccg caaattacac
    14041 cataatatcc tccatcattt gcataggttt cggaattgtt tttggataaa agaatatttt
    14101 caaatgttcc atttttgtca ggagtgagga gttgatggac tcttgctcca taatcatgga
    14161 caacgatggt gagtcgttca tttgataatg taatctgact aattgatttg tcagctctaa
    14221 aaggcaaaga ttctttggaa atggtaaatg tcataattaa ccttcgtcat tgaattctac
    14281 taattgatga gaaatttcag aggtattttt ataaacttgt ttccaaattt gataaatttg
    14341 ctcataacgt gctacatttt ttggatttgg tatgaaactg gcttccttgt aatgaacaaa
    14401 agctttagtg accgcttcta agctatcaaa aagtccgcaa ccaaaagcag caatcataca
    14461 agcaccaagt cccggtccct gctcaaccgt taagcgaatc atttcagaat taaaaatatc
    14521 tgcttgcatt tgcataatgt cgggattttg cgcaccccca cctacggaaa tcaaacgttt
    14581 aaacttcttg tttttcgttt tttccatgat atctttagaa tcacgcaatg aaaaggtaat
    14641 tccttcaagc actgctcttg aaaaatgttt ttgttcatga tgagcagaaa ttcctataaa
    14701 acttccgcga atttttgaat caaaatgtgg tgttctttca cctacaatat atggcgtaaa
    14761 gagcaatcct tctgaaccag gagaaactgt gtaaacttct gacaaaagtt cattgaaact
    14821 caagcctttt ccaaaagttt ccttatacca gtttaaagaa tttccggcag ccaaggttac
    14881 tcccattgag taataagcac ccggaaccgt gtgattaaag aaatgaagtt ttcctttata
    14941 atctgcaatt ttaggttcat aagcggaaac gactccggag gttcccattg aaatcaagcc
    15001 cacttcttca ttgattaaac caacacccag agcggcggca gcattatcgg ctccaccagc
    15061 aaatactttt acttcatttg tcagtttata gcgttcagct atttctgctt tgacaaatcc
    15121 tgttcggtca gtggattcaa tcaattcagg tagaattccc ctatcaatat tgaatgcgtc
    15181 agtaatttcc tctgaccatt gttttttctc aatatctaaa agtaaagttc ctgctgcgtc
    15241 agaaaattcg gtataaatat ttcctgtcag ccaaaggctc aagtaatctt ttggcaacat
    15301 tatttttttt actcttgacc aaacctctgg ttcattttct tggagccaaa gaatttttgg
    15361 taaggtaaat ccttcaagag caatattttt tgtaatctct aaaagtcgct gaccaagtct
    15421 gtcagtaatt tcttgacatt gtttgcttgt tctcacatca ttccaaagaa ttgctggata
    15481 aactggttta ttattgtcat ctaaaacgac taatgaatgc atttgccccg aaaaactaat
    15541 gcctgcaagt tgctgaccaa aatctgaaat ttctactgac aaatcggtca gtactgattc
    15601 aagtgccaca atccaatatt ctggacgttg ttcagaatag ccttgtttgg gcgtatcaat
    15661 ttggtattca gcagattttg ttgtaattaa attaccaact tcatccatca aaattccttt
    15721 aagacttgat gttcctaagt caattcctaa cacgtaagtc attattattc ctcataataa
    15781 aagagaagga cgaggaggaa ttcctcgccc tcttttaagt tctaaatttt aaacaagata
    15841 gtcattcaat actgatttga tgtattccaa gtgattagaa tcaagttcaa tatcgtcacc
    15901 atgttcaagt gcaaatgcgg caagactttc aaaagttgct gttccatttt caatggattg
    15961 accaacttct gtatttttgt atgaactata acgttcgtca acaatatcag acaagaattt
    16021 atcttcaatg attgctgctg cacctttcaa agcacgcgca taagtatcca tccctgcaat
    16081 atgagcaaga attaaatcct ctgctttgaa acttgtacga cgtactttcg catcaaagtt
    16141 aattccacct ttgccaagtc caccgttcaa aagaatttgg tgcatcgcaa gtgtgatatc
    16201 aataacaagt gttgggaatt catctgtatc ccaaccaagc aagtaatttc cttgattggc
    16261 atcaatagaa cccaaagcat tgaaagtacg tgcagtattt aattcgtgtt caaaagtgtg
    16321 cccagccagc caagcatgat ttgtttcaag attgagtttg aagtatttgt ccaagtcata
    16381 tttttgcaag aaagcaagag ctgttgctgc gtcaaaatca tattggtgag tcattggttc
    16441 ttttggtttt ggttcaatca agaaaatagg caagtggttg attgattttg cataatcaat
    16501 tgccaaatgg aagaattttg ccatgtggtc catttcaaga cccatatctg tgttcaaaag
    16561 tgattcataa ccttcacgac caccccagaa gacataattt tcgccaccaa gttttttaga
    16621 aagttcaaga ccttttttaa cttgtgcagc accataagca aagacttcag cacggttaga
    16681 agttgaaaca ccattcatat agcggggatt tgaaaacatg tttgctgtat tccaaagtaa
    16741 tttaatccct gttgcttttt gtttttcaag aaggtggtca gtaatttcgt ccaaattagc
    16801 ataaaattct ttcaaagaat ttccagtagg tacaatatca atatcatgga aacaataata
    16861 tttaacacct aatttttcag caatttcaaa gaaagcatct actcgacggt gagcacggtc
    16921 aagttcagaa ccaccttcca aatcccaagg acgttccatt gttgctcccc caaagggatc
    16981 tgacccatcc attgtaattg tatgccaaaa tgcaagggca aaatgaagtt gttcttccat
    17041 tgttttacca gcaactactt cttctggatt ataatggcga aaggcaaaca tatttttagt
    17101 ttttgtacct tcgtatttga taggtgcgat gtcgttaaag taagccattt ttatagctcc
    17161 tcctctttat gatattaata ttattttcaa actcgtaatt actactatac atttcttgta
    17221 atatatgtca taataatagt gattaggaga gaatgaacat gaaaaacgaa ttagagaata
    17281 tttatcactc aaaaataaat aatcttaatt ttctacttgt cgatattact tacagaaaac
    17341 ctcaccttca ttttgacatt gaattagctt ttgtcttaga aggggctggt caggtaataa
    17401 cacaagagca atgctttgaa atcaaagctg gacaggcaat tatctttaat agttgccaag
    17461 ttcacgaact atcttcaagc gactctatga aacttttgat tctacagttt tcatcagaaa
    17521 tttttaaaat tatcttccct cagcttgata aaatttattt tgaaagccat cctttcaatc
    17581 taaaaaatca acctgaaact ttaaaattac tcttacaagc ggctttaagt tattttgctg
    17641 atgataagaa taattccttg cgtactcacg gatacacttc ccttttatta gatcgcttat
    17701 taagtatttc tgaatacagt attttaagca gttctgaaca aaataaatta atggatctcc
    17761 aagagcgaat ggaaagaatt tcttcttaca ttcatgaaaa ctacgaccat aaaatttctt
    17821 tagaaatgat tgcttcgcat gaaggacttt ccagaacgta tttttcccat ttctttaaaa
    17881 gtaattttgg gattaatttc aacgagtatt taaataagat tcgttctgaa aaagcaagaa
    17941 cattactttc ttcttctaaa gataatttat taaatattgc ttacatgtgt ggtttctcag
    18001 atatcagaac gctcaacacc gctttcgtta aatcttatgg tgttctaccg aaagaattta
    18061 gaaaaaatag tgtactcttt ccaaatctca actacatgac tttcaatcaa gataaaattg
    18121 ataatcaagt tttttattct gatagaggct cttttgatat tctgcaatat tatttagaaa
    18181 aaaactttga aaaaacaagt agtcattttt agactcttta tttttaacaa gttaatgata
    18241 tcgctttcta agaatcttat cttactgttt tgttctattt ttcaggggaa atgttgtcat
    18301 tttatcatac ctaaatcaaa taaaaaaaat acttggcttt taccaagtat tttttattaa
    18361 tcccaaattt tagttgcttt aatttcatta atcgtttggt caaaatcatt tgttaagatt
    18421 gtcacatgtc ccatttttcg gttatgttta gcatctgctt ttccataatc atgttgatgc
    18481 caatcggcat gctcatgatt aagtttctta actgcctcaa cgtgttgccc taaaacgttc
    18541 aacataatgg caggtttcaa aagtttaggt tctggtaggt cttctcctaa aatcccttta
    18601 atatgcaaat caaattggtt gaaatcacaa gcttcaattg taaagtggcc actattatgt
    18661 ggtcttggag ctagttcatt gacatagatt tgaccatctg ctgttaagaa catttccaca
    18721 caaagcacgc cagatagctc taatttttcc gcaattgagg tcgcaatttt ataagcattc
    18781 tctgtaattt cagcagatat acgagccgga gaaatcgttt gatgtaagat gttttctcta
    18841 tgttcgtttt cagctagagg aaaaaccaca tattcgtgac catttccact aataataaca
    18901 gaaatttcac gttcaaaaga aataaaatct tctaaaacac attctgaaag ttctgtcagt
    18961 gattttgcag ctgacaagtc tttatcagca tttaaaacca cttgtccatg accgtcatag
    19021 cctccagttg ttgtttttaa aacttgtttt ctagttactg tttctgggag tttttccgct
    19081 gaatctacga gttgccaagg tgcaacatta actttagctt cgttggtcaa aaattctttt
    19141 tcaaagcgac ggttttgcgt aatctctaac agacgtattc cttgaggaat ccttacacag
    19201 ccttcaattt cgtgcaaagc ttttgctgat acattttcaa actcataagt aatgacgtca
    19261 caagcatagg cgagtcttaa taaattgtca acgtcatcat aaggtgcaac aatcagttca
    19321 tcagatactt ttgccgcaga acagtttgga tttgggtcaa gtgtaatgac tttatgtccc
    19381 atgtattgag cagcaattgc catcatctgt ccaagctgac ctccaccaat aataccaatt
    19441 gtttgctttg tattctttat cacaagtctt cctacccttc attatttgaa atccgacaac
    19501 ttttgaactc tttttaaagt aatgctttgt ttgattcctc aaccatttct tgcgcagcag
    19561 cccgatagac caacaatttt tggtataaat tctcgtttgt attcgccaaa agttgcaaag
    19621 caaataaagc agcatttttt gctccagcct ctccaattgc cattgtcgct acaggaaccc
    19681 ctgccggcat ttgaacaatt gaataaagtg aatccaaacc agataaagcg cgtgatttta
    19741 ttggaacgcc aatgactgga acgagagtct gagcagctac cattcctggc aaatgagcag
    19801 ctccaccagc acctgcgatg atcactttat aacctgcctc acgggcttgg ctcgaaaatt
    19861 cagccatcaa agctggtgtt cggtgtgctg atacgacctt tttttcataa gctaaaccaa
    19921 agtcatctaa aatttttgct gtttctttca ttgtcgccca atctgagctc gaacccatga
    19981 taattgctac ttctgccatt tttcctcttc tttttttctt aaccaaaatt tttatattgc
    20041 tcgtgaacca atatcatgac gataaaagaa accatcattt tccaatttat caagtttttc
    20101 ataaagcaat ttttgtgtac tttttacatc ttctcccgtt tcagaaacaa gataaactcg
    20161 gcctccacta gagattaatt gattattttc atttttggaa actcctgcat aataaacatt
    20221 taaaccttca ggaatttctg gaagaataag tcctagtttt gcttgactag gatagccttc
    20281 tgcagcaaca accacaccca aagtcacacc agactcaagc cattctaatg ttggctcatt
    20341 tccagctaaa atatcaataa ttgcttgagc taagtcactt tttaaacggg ggagaacaac
    20401 ttgggtttca ggatccccaa agcgtgcatt aaattcaatt gttttgactc cgtcttctgt
    20461 caaaattaaa cctgcataaa gaacgcctgt aaatgacttg ccttcttcta tcattccagc
    20521 tactgttggt ttaacaactt tttccagagc ctcatttaca acctccttag aaatatgtag
    20581 gaccggtgag taagccccca ttccccctgt gttagggcct ttatctccat caaaagctcg
    20641 tttgtggtct tgagcaatcg gcatcggata tattttcccg tcatggataa aactaaataa
    20701 agaaaattct tcaccatcaa gaaattcctc aatcacaact tttccttgac taccagaaaa
    20761 aatatcggcc agagctgact tagcggtctc aatatcaaag gcaaccgtca caccctttcc
    20821 agcagcgagc ccatcagctt taatcacaag aggaactcct ttttcatcta gatatgcaag
    20881 agcaggctct aagctatcaa aagtagcata atcagccgtc ggaaccccat attttttcat
    20941 aattgatttt gcaaaatctt tagaaccttc tagctctgcg gccattttat ttggcccaaa
    21001 aattggtaat tctgctttta taaaagcatc gacgacgcca ttcatcaaag ctgtttctgg
    21061 gccaacaaat gttagtccaa tgttttgatt ttgagcaaat ttaactaatt tatcattaga
    21121 tagttcggaa atatcaacta tttgaattcc atctttttcc attcctgaat tgcctggagc
    21181 tacaaagact tcttcaactt gaggactttc cataaatttt tttgctaagg catgttcgcg
    21241 gccgccagaa ccaattacca aaattttcat catttctccg atattcccaa acgtttttta
    21301 tatacacaaa cttgtgtatt cagctatttt atttattatt caacaaatct tgaacgaata
    21361 ataaaagtca aagtgacgat agctcatcta tcttttcttg cattataaat cttataattc
    21421 tatcttaaaa gatttgtgat aaaagaaaaa gcctgaacaa aagtttcaag aaataagaag
    21481 agagattgtt cggtatttac tcaattatag ctagagtttt ccccttacaa tatttaaatg
    21541 acaaatttgt ttatcagctt ttctatcgca attttcatta aaaacatgta aaataaatct
    21601 aagtagaaaa agaaagcgaa aacttatggc gactcaacca accaaagata aaattattag
    21661 tagcagctgg gaacttttag aagaacttcc tctcacagaa ttttcaatgc gtaagttagc
    21721 tagtcggcta ggaatgacag tgtcttctct ttactaccat ttttcaagta aagaagcact
    21781 ttttgcagaa cttattgata aagcaagcct tgaaattatt tttccagcaa atgagaaaac
    21841 gtggcaagac cgccttttcg tctatggtaa aaatatttat gctgttttag aatcttatcc
    21901 aaacctcgca caattgatga tggattatcc accagaatct gagaactatc ttcggctctt
    21961 tgataaactt ttaatgattg tagatgatct caagctttct gatgatcata aattttacac
    22021 cattaacctt tttctaaatt ttatttacac cagtaaaata gatagtgatc gtttagtaga
    22081 gcaacccgaa aaacctcttt ctactgtcaa aattcctctg gtacaactgg ctccttttct
    22141 cgataaatat tggcgaactg aaagcctcac cagtcttggc tcttctgaaa gttttgagtt
    22201 tggtttacag cttattattt caggaattga aaaaatgctt aaaattaatt aatttataaa
    22261 aaacttcctg aggaagtttt tttcttgact ttatttcaga acaatggtat tatttttacc
    22321 gaacagtgtt ctaaaaatat aaaagaaggt tctttatgaa taatactaat gattttaatt
    22381 taaaaaaagt cttacctgcg gttctaacaa ttgcaattgg aatgctttta gtaatgatgg
    22441 atacaaccat tatgaatgtc actcttccgc atattcagtc tgctttccat caaaatctct
    22501 caaatagtca gtgggtcatt actgcttata ctttagctat ggccacagtt attccatttg
    22561 ctggattttt gggagaccgc ttttcagata aaaaagtttt tgctttagca atcatttttt
    22621 tcactatcgc ttcatttctt gcagctaacg ctcactcact gcaaagtctt attatttggc
    22681 gaattgctca aggcttaact ggtggcgttg ttgctccaat cggaattggg atgtctttta
    22741 aaattattcc aatggaaaaa cgaggttcaa tgatgggcct tctagggtta ccaatgttgc
    22801 tcgctccaac aataggacct gcactttcag gtttcttagt taaacacttc aattggtcaa
    22861 ctgtcttttt gattaatctt ccggttggag ttctagccct aatctttgtt ctcctctttc
    22921 tccccaattt tcctgcaaat aaagcaagta aaattgattt aaaaggggct cttctttctc
    22981 catttgcctt tccaatttta atttatggtg tacacgttgg gacagataaa ggctggtcaa
    23041 atcctactgc cctctctttt gtagtccttg gtataatcat gttgctttta ttcattattg
    23101 ttgaactacg tgttgagaat cctcttttac accttcgagc ttttgcaatt tctgaattta
    23161 caaaaggaat ttcgctcatg tggctcaatc aaatcgttgt ttttggggcc atgcttcttg
    23221 tcccacttta cttacaaaat gtcgttggac tttcttctga aaatacaggg ctaatcatgg
    23281 ttccgcaggc aattgctagt tttttaggaa tgacaatcgg tgggcgtatt tttgataaat
    23341 ttgggacgaa agccgcagtt ctgccgggtt ttactctggg agctctaagt cttagtcttt
    23401 ttagtcaaat taaacctagt tcttctttag ctttcacact ttgtgctatt gttttacttg
    23461 gtttaagtca aggtttagtc aatatgcaag ttaataatca cgcccttcaa tctgttccaa
    23521 tgaaaaatat cagtcgagtt actccactaa caaatgaaat gatgcaagta gtcaactcat
    23581 ttgccattgc ctttttgaca gcatttttaa gtggtcaaat caaaaaacag actggacttt
    23641 ctcctttaca agcgaattta actgccttcc atcatacttt ctacttactt cttatttttg
    23701 taagcttcgg tttcatttta agtctatttt tgagaaaaaa agtgaaggca taataaaaaa
    23761 acactgttaa aataaacagt gttttttatt accaattttt aaccaaagct ggaatttcta
    23821 ataggtcttg gatttgcaca tctggttgtg cttctccact aacttccaat tgttttggat
    23881 tataccaaat tgtctttatt ccagctctat tccctcctaa aatatcagtt gctagggagt
    23941 ccccaacgat tgtaaattcc ttttgattgg ccgcttcaat gtggtcaaag acataatcga
    24001 agaaagcaag cgaaggctta tgatgaccca cttcttcact aataaagatt tctctaaagt
    24061 gatcagaaat tccagactca aatattcgcg gacgagaaac acgtgaagtt ccattactaa
    24121 ccacatacat ttctgcctct tttgctgaca gctctgtcag taattctttg gcatgattaa
    24181 tcagttcatg cccttgtgat aagtaaagtt gatattcatc atcaacagca actggattat
    24241 aatttactga cacatttaaa gctctaaaag catggtcaaa tcgagtagat agaagttctt
    24301 cacgtgaaag tttttctgat tcgtgtaaac gccaaagcgc tttgttttca cgagagtaag
    24361 tcgcacgatt ttcctgatta tcttcaattt gatagtgggt aaaaattttt cccaaagcat
    24421 catattctgc tttatcaaaa tcaagtaagg tgttatcaat atcaaaaagt agtacagtca
    24481 tttcttttcc tttgctaaat gtattctttg cattccctac attatatcag aaaaggagat
    24541 aaagatgaat gttctgaaac ttgaaaattt tttcaatgac aatatacaga tgattttaca
    24601 atagaaattt taatattaaa ttagtgaaaa aaatctaccc taaaggtaga ctttttatta
    24661 atgtctaaaa tgacgaagtc ctgtgaaaac catcgcaatt ccatatttat cacaggcatc
    24721 aatcacttct tggtcacgta cagagccacc tggttgaacg attgctttaa ttcctgcctt
    24781 agcaatttca tcaatattgt cagcaaacgg gaagaaggca tccgaaccaa gaaccgcatt
    24841 ttcttgaagt tctaatgatt tatcagcggt tgcctctaag gcaattttta ctgagcccac
    24901 acggttagtt tggccaggac caacaccaag cgtctggtgg tcattggtca caataatccc
    24961 atttgatttg acaaacttaa ctgctttcca agcaaactcc atggcctcca tttgtctgtc
    25021 agttggttga actttagtcg ccactgtcca ttcttttgga ttttcaacaa tgacatcttg
    25081 attttgaaca agtagtcctc caagaacccc tgttacatgc acttcttttt ctgaggcttc
    25141 ttttttagaa aaatcaacgg ttaaaagtcg aatatttttc tttttactta aaacttccaa
    25201 ggcttctttg ctataagagg gtgcgataat aatttcaagg aaaatcttac tcattttttg
    25261 cgcagttgcc aaagttactt ctcgatttaa aacaataatt ccaccgaaaa ttgaaactgg
    25321 gtctgcttca taggcataat cccaagcttt ttcgatatcc gttgctcttc caatcccaca
    25381 tggattcata tgtttgaggg ctacaactgt tggttcttca aaatctcttg caatctgtaa
    25441 agcagcatct gcatcacgaa cattgttata gcttagttct ttaccatgaa tttgcttact
    25501 ttgggcaatt gaataagtcg taggtattcc tgactcataa aaatctgcat tttgttgcgg
    25561 attttcacca taacgcattc cttgtttaag gtcgtaagtc aaggttaatt tttctggttt
    25621 tacattttct accggaaatt cttctgtcaa atattgtgca attaaagcat cataacttgc
    25681 agtgtggcga aatacttttg ctgcaagttg ctgacgaaaa cttaaacttg tttcaccttt
    25741 tactgacagc tctgtcagta ctttttcata atcatttggg tcacaaacga ctgtgactga
    25801 cgcatgattt ttagctgctg aacgcaacat tgaaggacca ccaatatcaa tcttctcaat
    25861 catttctgct tgactgcccc cagcaagcaa agtttctttg aagggatata agttcacaac
    25921 aaccaaatca attggagaaa tatgatgttc tgtcattgat tccatgtgac tttccaaatc
    25981 tctacgtcca agaagggctc catgaattag tggatgcaat gttttaaggc gcccatccat
    26041 catttctgga aatcctgtta cttcatcgat tgcaatattc ggaatttctt cttggtccaa
    26101 aacggctttc gttccacccg ttgagataat ttcccaacca aattctcgaa ttttcttagc
    26161 aaattctaca ataccttctt tgtctgaaac actgataagt gcacgttttg acatgatttc
    26221 ctccaagttt tctgctgaca attctgtcag taatattttt cttataaaag aactgacaga
    26281 actgtcagta aatatttatc atgtctttat tttacattta tcgtttggaa ataaaaagca
    26341 ccagttttaa aactgggctt tttttattat aattgttcgg aaattacttt tagtctttaa
    26401 ttaaaaactc ttcattgaaa attccaatat atggcaactg acggtaacgt tcggcataat
    26461 caattccata gcccacaata aaggcatccg gtacttcaaa gccaacataa tcagcgtcaa
    26521 tatcaacttt acgaccactt ggtttatcta ataaagagat aatttttact gaatgtgctt
    26581 gacgtcctgt cagcaatttt ttaagataga gcaaagtatt tccagtgtca atgatatctt
    26641 caacaatcaa aatatcacgt ccatgagcca cggttgataa atctttcaaa attctaactt
    26701 ctccagaaga tgaaatccca taaccataac tggtaacatc cataaaatca acttcagcat
    26761 caattgataa ttctttaagc aaatcaaccg taaacatgat tgaccctttt aatattccaa
    26821 caacaagtgg attttttcct tcataatcgc gtgaaacaac ttccgcaagc tctttgacac
    26881 gttcggcaat ttgttctctg gtaaataaaa cttcttttaa atgtggatgc atttttctct
    26941 ccaatttttt tcacaatatg tttctatttt agactttttt agagagaaga aaaagatcag
    27001 aagtctgact ttggtctttt ttagcttaca acgttcggaa atagaaaatt ttcaaaacta
    27061 taattttctt aatcaacttt aataactccc aaatccaaca tcgtttgtgc cgtttgaata
    27121 atcgctgctt cacctgaacg tggtttcc
//
