LOCUS       LN831790               20981 bp    DNA     linear   BCT 17-JUN-2020
DEFINITION  Streptomyces leeuwenhoekii strain C34 (= DSM 42122 = NRRL B-24963)
            genome assembly, chromosome: chromosome.
ACCESSION   LN831790
VERSION     LN831790.1
KEYWORDS    .
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-02-26 04:50:55
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 562081
            Orig. end    :: 583062
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20981
                     /aStool="rule-based-clusters"
                     /category="saccharide"
                     /contig_edge="False"
                     /core_location="[10000:10981]"
                     /cutoff="20000"
                     /detection_rule="minimum(2, [Alpha-amylase,
                     Alpha-amylase_C, Bac_transf, CBM_48, Capsule_synth,
                     DegT_DnrJ_EryC1, Epimerase_2, Glyco_tran_28_C,
                     Glyco_transf_28, Glyco_transf_8, Glyco_transf_8C,
                     Glyco_transf_9, Glycos_transf_1, Glycos_transf_2,
                     Glycos_transf_4, MannoseP_isomer, PIG-L, Poly_export,
                     Polysacc_synt, Polysacc_synt_2, RmlD_sub_bind, Wzy_C,
                     dTDP_sugar_isom])"
                     /neighbourhood="10000"
                     /product="saccharide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10981
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="minimum(2, [Alpha-amylase,
                     Alpha-amylase_C, Bac_transf, CBM_48, Capsule_synth,
                     DegT_DnrJ_EryC1, Epimerase_2, Glyco_tran_28_C,
                     Glyco_transf_28, Glyco_transf_8, Glyco_transf_8C,
                     Glyco_transf_9, Glycos_transf_1, Glycos_transf_2,
                     Glycos_transf_4, MannoseP_isomer, PIG-L, Poly_export,
                     Polysacc_synt, Polysacc_synt_2, RmlD_sub_bind, Wzy_C,
                     dTDP_sugar_isom])"
                     /neighbourhood="10000"
                     /product="saccharide"
                     /protocluster_number="1"
     cand_cluster    1..20981
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(2, [Alpha-amylase,
                     Alpha-amylase_C, Bac_transf, CBM_48, Capsule_synth,
                     DegT_DnrJ_EryC1, Epimerase_2, Glyco_tran_28_C,
                     Glyco_transf_28, Glyco_transf_8, Glyco_transf_8C,
                     Glyco_transf_9, Glycos_transf_1, Glycos_transf_2,
                     Glycos_transf_4, MannoseP_isomer, PIG-L, Poly_export,
                     Polysacc_synt, Polysacc_synt_2, RmlD_sub_bind, Wzy_C,
                     dTDP_sugar_isom])"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="saccharide"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..20981
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="saccharide"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="minimum(2, [Alpha-amylase, Alpha-amylase_C,
                     Bac_transf, CBM_48, Capsule_synth, DegT_DnrJ_EryC1,
                     Epimerase_2, Glyco_tran_28_C, Glyco_transf_28,
                     Glyco_transf_8, Glyco_transf_8C, Glyco_transf_9,
                     Glycos_transf_1, Glycos_transf_2, Glycos_transf_4,
                     MannoseP_isomer, PIG-L, Poly_export, Polysacc_synt,
                     Polysacc_synt_2, RmlD_sub_bind, Wzy_C, dTDP_sugar_isom])"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     gene            296..1048
                     /gene="sle_05020"
     CDS             296..1048
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VL14"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR023772"
                     /db_xref="InterPro:IPR041347"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VL14"
                     /gene="sle_05020"
                     /gene_functions="regulatory (smcogs) SMCOG1215:TetR family
                     transcriptional regulator (Score: 184.5; E-value: 3.9e-56)"
                     /gene_kind="regulatory"
                     /product="TetR Family Transcriptional Regulator"
                     /protein_id="CQR59964.1"
                     /transl_table=11
                     /translation="MSSSSAAPRRDGKAEAVAGGKPPMREALVAAAFRLFVERGYERTT
                     VDDIVALAGVGRRSFFRYFPSKEDVVFPDHERCLADMTAFLAASSQGDEPVRRVCDAAR
                     LVLRMYAENPAFSVQRYRLTTQVPGLRAYELSVVWRYERALAAYLRGRFAGQPDGTLRA
                     DVIAAAVVAAHNNALRSWLRSGAQGDAATAVDHALGLVQSAFGPPAGVIGPGEPGPGEP
                     DDVMVVVSRRGAPLWRVVQEIETALGRP"
     gene            1169..1582
                     /gene="sle_05030"
     CDS             1169..1582
                     /codon_start=1
                     /db_xref="InterPro:IPR012340"
                     /db_xref="InterPro:IPR022002"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VLW1"
                     /gene="sle_05030"
                     /product="Conserved Hypothetical Protein"
                     /protein_id="CQR59965.1"
                     /transl_table=11
                     /translation="MYHHSGTAVQQAAGSATGVLEPGVPDTEAILFQRCTWCGTAMYHR
                     VLCPVCRGSDLRTERSDGTGTVRHSTVVHRNTPAARNVSLIEMAEGFVVRGRVMGPPIG
                     IHSGDRVRLSTAKDAVRGEPVFQLVDEPYRAWT"
     gene            complement(1672..2850)
                     /gene="sle_05040"
     CDS             complement(1672..2850)
                     /NRPS_PKS="Domain: Aminotran_1_2 (74-386). E-value:
                     4.9e-33. Score: 106.6. Matches aSDomain:
                     nrpspksdomains_sle_05040_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VST8"
                     /db_xref="InterPro:IPR004839"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VST8"
                     /gene="sle_05040"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 184; E-value: 7.4e-56)"
                     /gene_kind="biosynthetic-additional"
                     /product="Putative cystathionine beta-lyase"
                     /protein_id="CQR59966.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.6e-31, bitscore:
                     106.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTPQDRSGEPNPLRVLTLDRLKRRTSMKWRTYPEDVLPLWVAE
                     MDVPLAEPVVRAVTDALHLGDTGYPAGTDYAEALAAFAGKRWGWSGLAVERTAVVPDVM
                     LGVVEMLKLVTGPGDPVVVNPPVYPPFYQFVEHLDRRVVEAPLGAGLRIDPEVLEDAFR
                     RATGAGGRAAYLLCSPHNPTGTVHTATELAAVAALAERYGVRVVADEIHAPLVTGEARF
                     VPYLSVPGAERGLALMSASKGWNLAGLKAALALAGPGAAADLARMPEEVGHGPSHLGVI
                     AHTAALRDGTAWLDALLAGLADNRRLLTGLLAEHLPGIAHLPGEATYLAWLDCRALGLG
                     DDPAEVFLSRGRVALSSGIPFGTGGAGHARLNLATSPEVLSEGVRRMAAALR"
     aSDomain        complement(1693..2628)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sle_05040_Aminotran_1_2.1"
                     /evalue="4.90E-33"
                     /label="sle_05040_Aminotran_1_2.1"
                     /locus_tag="sle_05040"
                     /protein_end="386"
                     /protein_start="74"
                     /score="106.6"
                     /tool="antismash"
                     /translation="YAEALAAFAGKRWGWSGLAVERTAVVPDVMLGVVEMLKLVTGPGD
                     PVVVNPPVYPPFYQFVEHLDRRVVEAPLGAGLRIDPEVLEDAFRRATGAGGRAAYLLCS
                     PHNPTGTVHTATELAAVAALAERYGVRVVADEIHAPLVTGEARFVPYLSVPGAERGLAL
                     MSASKGWNLAGLKAALALAGPGAAADLARMPEEVGHGPSHLGVIAHTAALRDGTAWLDA
                     LLAGLADNRRLLTGLLAEHLPGIAHLPGEATYLAWLDCRALGLGDDPAEVFLSRGRVAL
                     SSGIPFGTGGAGHARLNLATSPEVLSEGVRR"
     gene            complement(2847..3104)
                     /gene="sle_05050"
     CDS             complement(2847..3104)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VR55"
                     /gene="sle_05050"
                     /product="Hypothetical Protein sle_05050"
                     /protein_id="CQR59967.1"
                     /transl_table=11
                     /translation="MVLASLYPALPVVPGVVLPRDSVTPRQEAGLLGAGAATVLLTLGR
                     PGRPYAAERAARAPPRRKKAPRRWHSPRFPGPAQPLSCAP"
     misc_feature    complement(2862..2864)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3525..3710)
                     /gene="sle_05060"
     CDS             complement(3525..3710)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VNQ7"
                     /gene="sle_05060"
                     /product="Conserved Hypothetical Protein"
                     /protein_id="CQR59968.1"
                     /transl_table=11
                     /translation="MLHSMSTTVEPSSERSAAEVNEEIRALWLRSGGTLSVEQREEYQR
                     LVMEWAAAAPDSEQAA"
     gene            complement(3843..4820)
                     /gene="sle_05070"
     CDS             complement(3843..4820)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VL22"
                     /db_xref="InterPro:IPR004136"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VL22"
                     /gene="sle_05070"
                     /product="Probable nitronate monooxygenase"
                     /protein_id="CQR59969.1"
                     /transl_table=11
                     /translation="MLRTRLCDVLGVELPVIGAPYGPYEQVELAAAVCRAGALGSLGTA
                     VRPLADLRRQWARMRELTGRPFAVNHTLRPLNEEAFRATLEERPAAISFHLGVPGDLVA
                     RAHDAGIRWIQQVMDVRQAEQAVRAGADVIVAQGGEAGGQGGEVATMVLVPQVVDIAGD
                     IPVVAAGGIADGRGLAAALALGAQGVALGTRLLASAEMNIAEEWKNRIVAAEARDTIKL
                     AHSDRFMPPFSRPDAYGLPRSLRTPFLEEAEEHPERVRPAEAGPRIVEAMLSGHGHEFL
                     PFTGQSAALVHDILPAAEIVRGIVEEAEAILRRTADACTRGAPR"
     gene            complement(4979..5893)
                     /gene="sle_05080"
     CDS             complement(4979..5893)
                     /codon_start=1
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VLW3"
                     /gene="sle_05080"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     95.5; E-value: 6.1e-29)"
                     /gene_kind="biosynthetic-additional"
                     /product="Uncharacterized oxidoreductase yxjF"
                     /protein_id="CQR59970.1"
                     /transl_table=11
                     /translation="MSGPLEGKVAWVAGATRGAGRGIAVELGAAGATVYVTGRSTRARR
                     SEYDRPEAIEDTADLVTEAGGHGIAVPADHLDPRQVRAVADRVAREQGRLDVLVNDIWG
                     GETLFEWDTPVWEHDLDKGLRLLRLAVDTHAITSHHALPLLLRRPGGLVVEVTDGTAEY
                     NREHYRNSFFYDLAKVSVLRMAFALGHEVGPRGATAVALTPGWLRSEIMLDVYGVREDN
                     WRDALDRVPHFAISETPRFVGRAVSALAADPDVARWNGQSLSSGGLAQVYGFTDVDGSR
                     PDAWRYIVEVQDAGKPADVTGYR"
     gene            complement(6049..6678)
                     /gene="sle_05090"
     CDS             complement(6049..6678)
                     /codon_start=1
                     /db_xref="InterPro:IPR001279"
                     /db_xref="InterPro:IPR036866"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VSU2"
                     /gene="sle_05090"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     151.1; E-value: 4.6e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="Uncharacterized protein aq_2135"
                     /protein_id="CQR59971.1"
                     /transl_table=11
                     /translation="MTARVERLVTSGQFTLDGGTWDVDNNVWIVGDDHEAVVIDAAHDA
                     DAIARAVGDRRLTAIVCTHAHNDHVNAAPALADRTGAVIWLHRDDLPLWQRTHPDRLPD
                     AWLSDGQVIEAAGADLTVLHTPGHAPGAVCLYDPGLGTVFTGDTLFSGGPGATGRSYSH
                     FPTIIDSIRDRLLTLPPETEVLTGHGDSTTVGAEAPHLDEWIKRGH"
     gene            complement(6678..7763)
                     /gene="sle_05100"
     CDS             complement(6678..7763)
                     /NRPS_PKS="Domain: PKS_ER (24-256). E-value: 2e-11. Score:
                     35.4. Matches aSDomain: nrpspksdomains_sle_05100_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VR56"
                     /db_xref="InterPro:IPR002328"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR017816"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VR56"
                     /gene="sle_05100"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 324.8; E-value:
                     9e-99)"
                     /gene_kind="biosynthetic-additional"
                     /product="S-(hydroxymethyl)mycothiol dehydrogenase"
                     /protein_id="CQR59972.1"
                     /sec_met_domain="ADH_N (E-value: 1.1e-26, bitscore: 91.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.1e-30, bitscore:
                     103.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQEVRGVIAPGKDEPVRIETIVVPDPGPGEAVVRVQACGVCHTD
                     LHYKQGGISDDFPFLLGHEAAGVVESVGQGVTDVAPGDFVILNWRAVCGKCRACLRGRP
                     WYCFDTHNAEQRMTLLDGTELSPALGIGAFAEKTLVAAGQCTKVDPAVSPQVAGLLGCG
                     VMAGIGAAINTGGVGRGDTVAVIGCGGVGDAAVAGSRLAGAAKIIAVDIDDRKLETARA
                     MGATHTVNSRESDPVEAIRELTGGFGADVVIEAVGRPETYRQAFYARDLAGTVVLVGVP
                     TPEMKLELPLLDVFGRGGSLKSSWYGDCLPSRDFPMLIDLHLQGRLDLAAFVTETIALD
                     EVEKAFERMHAGDVLRSVVVL"
     CDS_motif       complement(6927..6959)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sle_05100_0002"
                     /evalue="1.00E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="sle_05100"
                     /protein_end="279"
                     /protein_start="268"
                     /score="3.0"
                     /tool="antismash"
                     /translation="RDLAGTVVLVG"
     aSDomain        complement(6996..7691)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sle_05100_PKS_ER.1"
                     /evalue="2.00E-11"
                     /label="sle_05100_PKS_ER.1"
                     /locus_tag="sle_05100"
                     /protein_end="256"
                     /protein_start="24"
                     /score="35.4"
                     /tool="antismash"
                     /translation="PDPGPGEAVVRVQACGVCHTDLHYKQGGISDDFPFLLGHEAAGVV
                     ESVGQGVTDVAPGDFVILNWRAVCGKCRACLRGRPWYCFDTHNAEQRMTLLDGTELSPA
                     LGIGAFAEKTLVAAGQCTKVDPAVSPQVAGLLGCGVMAGIGAAINTGGVGRGDTVAVIG
                     CGGVGDAAVAGSRLAGAAKIIAVDIDDRKLETARAMGATHTVNSRESDPVEAIRELTGG
                     FGADVVIEAV"
     CDS_motif       complement(7545..7583)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sle_05100_0001"
                     /evalue="3.00E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="sle_05100"
                     /protein_end="73"
                     /protein_start="60"
                     /score="10.6"
                     /tool="antismash"
                     /translation="LGHEAAGVVESVG"
     gene            8058..9329
                     /gene="sle_05110"
     CDS             8058..9329
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VNQ8"
                     /db_xref="InterPro:IPR002372"
                     /db_xref="InterPro:IPR011045"
                     /db_xref="InterPro:IPR015943"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VNQ8"
                     /gene="sle_05110"
                     /product="Serine/Threonine Protein Kinase"
                     /protein_id="CQR59973.1"
                     /transl_table=11
                     /translation="MPATGPRHLRSVTATAAATLALGLAGPAHASPGTADALSPAGLRE
                     VLFVGNNWDGTADVIESTGDFRRIGRIDVVPDKEERLAEIKADPLRLIYFLGIRSSVGE
                     GHDQLVDDMYATPDGSSVVVSRPSFADVVSIDLATGRVEWRFPVDGYRSDHMAVSPDGK
                     RVAVSASTANTVHVLDIETGKELGSVATGDKPHENVFSKDGKYLWNMSIGEVNTSLDAP
                     WLDWTKGDRRITVADATTYQRVKVIDMRERLDAAGLRNHSDAVRPAVFSPDESRLYFQV
                     SFFNGFFEYDVATDRITRTKTLPKNPATSEDRTTWVNDSRHHGITMSPDGAKLCVAGTM
                     DDYAAVVDRATLEEGPLVTAAKPYWATVSGDGRHCVVSESGSDQVTAIDFATGRKTVSV
                     PVGDHPQRVRLGRVAADWTGPSAG"
     gene            complement(9432..10004)
                     /gene="sle_05120"
     CDS             complement(9432..10004)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VL23"
                     /db_xref="InterPro:IPR000979"
                     /db_xref="InterPro:IPR024654"
                     /db_xref="InterPro:IPR029052"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VL23"
                     /gene="sle_05120"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /product="Putative metallophosphoesterase MJ0623"
                     /protein_id="CQR59974.1"
                     /sec_met_domain="Metallophos_2 (E-value: 1.5e-25, bitscore:
                     88.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPAPPGPARPDAQAGGDRARPVRLLLMSDTHLPRRARELPAPLL
                     AELPQADVVVHAGDWVDTATLDLLESRSRRLVAVYGNNDGPGLRARLPEVAYADIGGLR
                     FGVVHETGPARGREARCAERFPGLDVLVFGHSHIPWDTTAPTGLRLLNPGSPTDRRRQP
                     YCTYMTASVAGGRLVDVALHRLPPRRT"
     gene            complement(10001..10981)
                     /gene="sle_05130"
     CDS             complement(10001..10981)
                     /NRPS_PKS="Domain: NAD_binding_4 (4-178). E-value: 6.4e-21.
                     Score: 66.4. Matches aSDomain:
                     nrpspksdomains_sle_05130_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VLW5"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VLW5"
                     /gene="sle_05130"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     saccharide: RmlD_sub_bind"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     saccharide: Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     343.1; E-value: 2.6e-104)"
                     /gene_kind="biosynthetic"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="CQR59975.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.4e-17, bitscore:
                     60.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 7.6e-21,
                     bitscore: 73.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 7.7e-19, bitscore:
                     66.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLLVTGAAGFIGSHYVRALLASDAPGAPRITVLDKLTYAGNPDN
                     LELGHPRLDFVQGDIRDAALVDKLMADADQVVHFAAESHVDRSIHTATDFVTTNVVGTQ
                     TLLDAALRHGVEPFVHVSTDEVYGSLESGSATEGDPLRPSSPYSASKAAADLLALAHHR
                     THGLDVRITRCSNNYGPRQFPEKIIPLFVTRLLDGENVPLYGDGRNVRDWLHVEDHCRG
                     VELVRTRGRAGEVYNIGGGTELSNRELTDLLLRACGAGWDRVEYVDDRKGHDLRYSVDW
                     SKARDELGYRPRRDFAESLAETVAWYRDNRGWWERSGQRAARERA"
     protocluster    10383..20598
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[15382:15598]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      15383..15598
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     cand_cluster    10383..20598
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     aSDomain        complement(10448..10969)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sle_05130_NAD_binding_4.1"
                     /evalue="6.40E-21"
                     /label="sle_05130_NAD_binding_4.1"
                     /locus_tag="sle_05130"
                     /protein_end="178"
                     /protein_start="4"
                     /score="66.4"
                     /tool="antismash"
                     /translation="VTGAAGFIGSHYVRALLASDAPGAPRITVLDKLTYAGNPDNLELG
                     HPRLDFVQGDIRDAALVDKLMADADQVVHFAAESHVDRSIHTATDFVTTNVVGTQTLLD
                     AALRHGVEPFVHVSTDEVYGSLESGSATEGDPLRPSSPYSASKAAADLLALAHHRTHGL
                     DVRITRCSNNY"
     misc_feature    10976..10987
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            complement(11126..11305)
                     /gene="sle_05140"
     CDS             complement(11126..11305)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VSU5"
                     /gene="sle_05140"
                     /product="Hypothetical Protein sle_05140"
                     /protein_id="CQR59976.1"
                     /transl_table=11
                     /translation="MTTDTGDKPATRRPETGWSTARRLRGHVAPRTWIPAVEDGDPPRT
                     PQPGPDPHIVRGED"
     gene            complement(11608..12027)
                     /gene="sle_05150"
     CDS             complement(11608..12027)
                     /codon_start=1
                     /db_xref="InterPro:IPR000644"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VR58"
                     /gene="sle_05150"
                     /product="CBS domain-containing protein yhcV"
                     /protein_id="CQR59977.1"
                     /transl_table=11
                     /translation="MVQYVRDIMTSEPVTVEPQASVVDVARIMRDEDLGAVLVTEGDRL
                     RGLVTDRDLVIRALAEGGDPQQTTVAGACSDDVVTVRPDEELDHVVELMREHAVRRIPV
                     VDEGHPVGIVSLGDMAMERDPESALGDISVARPNT"
     gene            complement(12145..12588)
                     /gene="sle_05160"
     CDS             complement(12145..12588)
                     /codon_start=1
                     /db_xref="InterPro:IPR036890"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VNR0"
                     /gene="sle_05160"
                     /product="Regulatory Protein"
                     /protein_id="CQR59978.1"
                     /transl_table=11
                     /translation="MPDVLCLVESAGVPGSLYGLREGYPVTGHSPVADAHRDGRPVRLG
                     PGDVAGRAESRRAPCGEFSLEALPVRRDGGGCLLSVTEDPGGFGPDARACLERIAEAVK
                     PTGIGWEATGGRGVLLVEAVSAAWGTLPAGGGKQVWCEIPLSR"
     gene            12700..14868
                     /gene="sle_05170"
     CDS             12700..14868
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VL25"
                     /db_xref="InterPro:IPR000014"
                     /db_xref="InterPro:IPR001932"
                     /db_xref="InterPro:IPR003018"
                     /db_xref="InterPro:IPR013656"
                     /db_xref="InterPro:IPR029016"
                     /db_xref="InterPro:IPR035965"
                     /db_xref="InterPro:IPR036457"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VL25"
                     /gene="sle_05170"
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 256.8; E-value: 8.1e-78)"
                     /gene_kind="other"
                     /product="Uncharacterized protein Rv1364c/MT1410"
                     /protein_id="CQR59979.1"
                     /transl_table=11
                     /translation="MVTDRQSTPGEPAGSGPVVGRSALSLALASMMEEVHAHAGAVYLL
                     SADRRVLEMAVIAGLPRSFAAPWERVPMTARIPVADAVRERRLIWVGGEEEMARRYPRV
                     AVVLPYPFALAALPVAAGSTVYGGVFLTWPGTRPADLSEREREQLAAACDRLALRLKRG
                     AGTRPPAPHQPEPAAAPAVGGVAGSLGALEAVRMAGRLPYGLCSLDAHGRVGFVNPAAA
                     ELLGVPADRLLGTPLWAAVPWLNDPVYEDRYRAALLSQHTASFVALRPPGEWLSFRLYP
                     SRNGVSVRIGLARGMSGAGRAGAEAGAGPGRAPAETPSRLVTIAQVLSLAGALTEAAGV
                     QDVVQLVADEIAPTLGSQALVLLGSRAGRMHVLGHRGYPDPYVVERFDGMPLTEHTPGT
                     QVLRTGVPAFLESAEQLEHLYPVRRATPDGFAAWAYLPLIASGRPVGTWVLAYARPHPF
                     PAEERAVLTSLAGLVAQALDRALLFDAKHRLAHGLQEALLPHSLPSLPGIEAAARYLPA
                     TRGMDIGGDFYDLMPVEGMAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTAVGQTPEEVM
                     RRTNRLLIDLGSDLFASCLYLRIDPARRRAVLARAGHPPPLLRRPDGRVRVLDLAGGPL
                     LGIDASAAYPASEVDLSPGSLLVLYTDGLVESPGVDFEDALADLGRRLGQAGDLPLDAL
                     ADALVRHVAKAEERIDDIALLLLRTREG"
     gene            15383..15598
                     /gene="sle_05180"
     CDS             15383..15598
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VLW7"
                     /gene="sle_05180"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /note="putative Bacteriocin gene cluster"
                     /product="Conserved Hypothetical Protein"
                     /protein_id="CQR59980.1"
                     /sec_met_domain="strepbact (E-value: 1.4e-32, bitscore:
                     110.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETVEIADTELDNVSGGLAINALNTVTGVVDSVAPVTGL
                     VNGVVDTVEGVTGLNTAPVTGLVAGL"
     gene            15719..16525
                     /gene="sle_05190"
     CDS             15719..16525
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VSV0"
                     /db_xref="InterPro:IPR011053"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VSV0"
                     /gene="sle_05190"
                     /note="putative Bacteriocin gene cluster"
                     /product="Secreted Protein"
                     /protein_id="CQR59981.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPDELDLPVRFARPQGWLVLSVTVVAMAAASVW
                     AVTGSVASTVSAPAVLTHGQGSYVLQSPVSGQVTAVLAEQGERLPAGAPVLKVRTAEGE
                     TVVRALDAGRVSALAATVGQIVQTGANVAAVEKVAHARDPLYATVYVPAENAAEIRAGA
                     AVDLTVQSVPSQEYGVLRGHVKSVDRSAQSAQQIGAFLGDSQLGEQFTKEGRPVAVTVR
                     LDTSSATKSGYEWSTAGGPPYALTSMTLATGSIRLADQRPVDWLLP"
     gene            16522..18744
                     /gene="sle_05200"
     CDS             16522..18744
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VR60"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR005074"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR022514"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="InterPro:IPR039421"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VR60"
                     /gene="sle_05200"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 313.2; E-value:
                     5.9e-95)"
                     /gene_kind="transport"
                     /note="putative Bacteriocin gene cluster"
                     /product="Transport/processing ATP-binding protein ComA"
                     /protein_id="CQR59982.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.2e-38, bitscore:
                     128.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDLKTRGRRRAAPPKRTVPKARAKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARGYGLTAKGMQMDLAALAEVTA
                     PAILFWEFNHYVVYDGMGRRFGRRGVYINDPGKGRRFVPLEEFDGSFTGVVLVMEPGEG
                     FTRGGRRPGVLGAMPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDEFLIGHQT
                     SLLGVLFTSMAACVLLTVVLTWLQQANLLRGRLISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAVVVVLYAVLLYTYDPQLTFVGIGVALLNIV
                     AMRVVIRLRATRTAKLRADSARLTNTSYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATFNSALILWIGGMRAVEGHISVGLLVAFQALVARFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFQADPLYGRPDAGDSTRRLQGHVELENITFGYNP
                     LDKPLLSGFDLIVGPGQQVALVGGSGSGKSTVSRLISGLYTPWEGVIRIDGRRIEDIPR
                     GALAASVSFVDQEVFLFEGTVRDNVALWDPSIPDDAVVEALRDAALYDVVMRRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQVVMDNLRKRGCACV
                     VIAHRLSTVRDSDEIVVLQHGTVVERGRHEELVARGGAYAALVRER"
ORIGIN
        1 cggtgaggta caggatgcgg gggcgggcgg gcggcatacg ggactcctcg ggacgaacgg
       61 ctcggcgacg acggcgcatg atcgtatgcg atcggcaagt gccggcccgc gaccggtcgg
      121 tgagcggccc ggtggcggca ctcccggcgt cgggacacgg cttcgcccgt gcccgcgcgg
      181 acaaggcggg cagcacgtcc ccaccggagg catcccatcc cccgccggaa gcaccgagtt
      241 ccctgccggg agcaccgagt gccgtccggg tcggccgggt gctacgttcc ccaccatgag
      301 ctccagcagt gcggcgcccc gccgcgacgg gaaggcggag gcggtggcgg gcgggaagcc
      361 gccgatgcgg gaggccctgg tcgcggcggc cttccggctg ttcgtggagc gggggtacga
      421 acggacgacc gtggacgaca tcgtggcgct ggccggtgtc ggacggcggt cgttcttccg
      481 ctacttcccc tcgaaggagg acgtggtctt ccccgaccac gagcggtgcc tggccgacat
      541 gacggccttt ctggccgcct cctcgcaggg cgacgaaccg gtgcggcggg tgtgcgacgc
      601 ggcccggctg gtcctgcgga tgtacgcgga gaacccggcg ttctcggtgc agcgctaccg
      661 tctgaccaca caggtgcccg ggctgcgggc atacgaactg tcggtcgtct ggcgctacga
      721 gcgcgccctg gccgcgtacc tgcgggggcg gttcgccgga cagccggacg gcaccctgag
      781 ggccgacgtg atcgcggcgg cggtggtggc cgcgcacaac aacgcgctgc gctcgtggct
      841 gcgttccggc gcccaggggg acgcggcaac cgcggtggac cacgcgctgg gcctggtgca
      901 gtccgctttc ggtccccccg ccggggtgat agggcccggg gagcccgggc ccggggagcc
      961 cgacgacgtg atggtcgtcg tctcccggcg cggcgcgccc ctgtggcggg tggtgcagga
     1021 gatcgagacc gcgctcggcc ggccctgagg ccctcagggt acggagtgcc tttacgcgtg
     1081 gcactgagtg ccatactctg tcagcgtgca cggtggcacg gtgaccgcgc acgtgtggga
     1141 ttccggccga gcgcagggag ttgacagcgt gtaccaccac tcaggaaccg ccgttcagca
     1201 ggcagccggc tccgcgacag gcgtcctcga acccggggtc ccggacaccg aggccatcct
     1261 gttccagcgc tgcacctggt gcggcaccgc catgtaccac cgggtgctgt gtccggtctg
     1321 ccggggcagc gacctgcgga ccgagcgcag cgacggcacg ggtacggtgc gccactccac
     1381 ggtggtgcac cgcaacaccc ccgccgcgcg caatgtgtcc ctgatcgaga tggccgaggg
     1441 gttcgtggtg cggggcaggg tgatgggccc gcccatcggg atccacagcg gggaccgggt
     1501 acggctgtcc acggccaagg acgcggtccg gggcgagccg gtgttccagt tggtcgacga
     1561 gccgtaccgg gcctggacct gacgagcggg cggccgcagc cggccgccgg ggagggtgag
     1621 cggtcgtggc cggtcggcgg ccggggcctc gcggggctgc cgcgccctgt tctaccgcag
     1681 cgccgccgcc atccgccgta cgccctccga gagcacctcc ggcgaggtcg ccaggttgag
     1741 ccgcgcatgg ccggctccgc ccgtgccgaa cgggatcccg gaactgagcg ccactcgccc
     1801 gcggctgagg aacacctccg ccgggtcgtc gccgaggccg agcgcacggc agtccagcca
     1861 ggccaggtag gtcgcctcgc cgggcaggtg cgcgatgccg ggcagatgct cggccaacag
     1921 gccggtgagc agccgccggt tgtcggcgag accggccagc agcgcgtcca gccaggcggt
     1981 gccgtcgcgc agcgcggcgg tgtgggcgat gacgccgaga tgactcgggc cgtggccgac
     2041 ctcctcgggc atccgggcca ggtcggcggc ggccccgggt ccggcgaggg cgagcgcggc
     2101 cttgagtccg gcgagattcc agcccttgga cgccgacatc agcgccaggc cccgttccgc
     2161 gccgggcacg ctcaggtacg gcacgaaccg cgcctcgccg gtgacgagcg gcgcgtggat
     2221 ctcgtcggcg acgacccgga cgccgtaccg ctcggcgagg gcggcgacgg cggcgagttc
     2281 ggtggcggtg tggacggttc cggtcgggtt gtgcgggctg cacagcaagt aggcggcgcg
     2341 tccgccggct ccggtggcgc gccggaaggc gtcctcgagc acctccgggt cgatgcgcag
     2401 gccggcgccg agcggcgcct cgaccacccg ccggtccagg tgctccacga actggtagaa
     2461 cggcggatac accggcgggt tgaccaccac cgggtcgccg ggcccggtga ccagcttgag
     2521 catctccacc acgcccagca tgacgtcggg cacgaccgcg gtgcgctcca cggcgagccc
     2581 gctccatccc caccgcttcc cggcgaaggc ggcgagcgcc tcggcgtagt cggtgccggc
     2641 gggatagccg gtgtcgccga ggtggagggc gtcggtgacg gcgcgtacga cgggctcggc
     2701 gagcggtacg tccatttcgg cgacccacag cggcaggacg tcctcggggt aggtgcgcca
     2761 tttcatgctc gtgcggcgct tgagccggtc gagggtgagg acgcgcaggg ggttcggttc
     2821 gccgctccgg tcctgcgggg tacgggtcat ggggcacaag ataagggctg cgcggggccg
     2881 gggaaacggg gcgagtgcca ccgccggggc gccttcttcc ggcgcggcgg ggcgcgggcg
     2941 gcacgctccg ccgcgtacgg ccgccccggt cggcccagcg tcagcagcac cgtggccgcc
     3001 cccgcgccca gcaggccggc ctcctgccga ggagtgaccg agtcgcgcgg caggaccacc
     3061 ccgggtacga cgggcaaggc cggatagagg gaggcgagca ccacggcgac cgcaggagct
     3121 gtcgctgcgc ggcgagcagg cagaggatca ggcccagcgc ggcgcccgcc ccggccagga
     3181 gggcctggac ggaccgccgg ggcggcagcc gcaggcgccc ggggtggcgc accgcgccgg
     3241 ggagcagcag tacggcggcg acgcgtccgg cggccaccgg ccacagcccg ctgccggggt
     3301 cggcccggcc gagggcgagg tactggacgg cgacaccggc gccggcgagc gggccgtcgg
     3361 tgacggccgg gcccgggccg ccggggccgc agaccagcca gagcgcgggg acggtgacgg
     3421 cgtgcccgcc caggcgggag gccgggatca gtgcgaggag ggcgcccgct cgatgcctgg
     3481 tgccccggag cgggttcggg atgcgccggg cagggacggc cgagtcaggc ggcctgctcc
     3541 gagtccgggg ccgcggcggc ccactccatc acgaggcgct ggtactcctc gcgctgctcg
     3601 acgctcagtg tcccgcccga ccggagccac agggcccgga tctcctcgtt gacctcggca
     3661 gccgatcgct cggaggaggg ttcaacagtg gtggacatgc tgtgaagcat acggcgctga
     3721 aagtgaaggc ggtgtgagta atcgcgaacc aatcggacat atcagaccgt gttgctgatc
     3781 acgtccttcg gcgacaccgg tgcggccgct gacatgtggt cccgagccgg gggccggacc
     3841 ggtcagcgcg gggcgccgcg ggtgcaggcg tcggcggtcc ggcgcaggat cgcctccgct
     3901 tcctcgacga tcccccgcac gatctcggcc gccggaagga tgtcgtggac gagggcggcg
     3961 gactgcccgg tgaaggggag gaactcgtgc ccgtgtccgc tgagcatggc ctccacgatg
     4021 cggggaccgg cttcggccgg ccgcacccgc tcggggtgct cttccgcctc ctcgaggaag
     4081 ggcgtccgca gcgaccgggg aaggccgtag gcgtcgggcc gtgagaacgg cggcatgaac
     4141 ctgtcgctgt gggccagctt gatcgtgtcg cgcgcctcgg cggcgacgat ccggttcttc
     4201 cactcctcgg cgatgttcat ctccgccgac gccagcaggc gggtgccgag ggccacgccc
     4261 tgggcgccca gggccagcgc cgccgccagc ccccggccgt cggcgatccc gcccgcggcg
     4321 acgacgggga tgtctcccgc gatgtccacg acctgcggga ccagcaccat ggtggccacc
     4381 tcaccgccct ggccgcccgc ctcgccgccc tgggcgacga tgacgtccgc acccgcgcgg
     4441 acggcctgct cggcctgccg gacgtccatg acctgctgga tccagcggat gcccgcgtca
     4501 tgggcgcgcg cgaccaagtc gccgggaacg ccgaggtgga acgagatggc ggccggccgc
     4561 tcctccagcg tcgcgcggaa cgcctcctcg ttcagggggc gcagggtgtg gttgacggcg
     4621 aagggccggc cggtgagctc ccgcatccgg gcccattggc gccgcaggtc ggcgagggga
     4681 cgcaccgccg tgcccaggct gccgagggcc cccgcacgac acacggcggc ggcgagctcc
     4741 acctgctcgt acggcccgta cggagcgccg atgacgggga gctcgacgcc gagcacatcg
     4801 cacagccgcg tccgcagcat cgtcgcctcc ttccggcacc gcgatcgggc ggagcggagc
     4861 cgctgccgcc atcctccccc gccggccgcg tcggtgcacg gcggccgggc cgcgccgccg
     4921 gaccctggcg gagcccgcgg acggccggcg gtgcggcgag gtccggcacc cgcggccgtc
     4981 agcggtagcc ggtcacgtcc gccggcttgc ccgcgtcctg cacctcgacg atgtagcgcc
     5041 aggcgtccgg gcggctgccg tcgacatcgg tgaagccgta cacctgggcg agaccgccgc
     5101 tggagaggga ctgcccgttc cagcgggcca cgtccggatc ggcggcgagg gcgctgacgg
     5161 cacggcccac gaagcggggc gtctcggaga tggcgaagtg ggggacgcgg tccagggcgt
     5221 cacgccagtt gtcctcgcgt acgccgtaga cgtcgagcat gatctccgag cggagccagc
     5281 ccggggtgag cgcgacggcc gtggcgccgc gcggccccac ttcgtggccg agggcgaagg
     5341 ccatgcgcag cacggacacc ttggcgaggt cgtagaagaa ggagttgcgg tagtgctcgc
     5401 ggttgtactc ggcggtgccg tcggtgacct ccacgaccag gccgccgggg cgccgcagca
     5461 acaacggcag ggcgtggtgg ctggtgatgg cgtgggtgtc caccgcgagg cgcagcagtc
     5521 tgagtccctt gtcgaggtcg tgctcccaga ccggggtgtc ccattcgaac agcgtctcgc
     5581 cgccccagat gtcgttgacc aggacgtcca ggcggccctg ttcgcgggcg acgcgatcgg
     5641 ccaccgcgcg gacctgccgc gggtcgaggt ggtcggcggg cacggcgatg ccgtggccgc
     5701 cggcctcggt gacgaggtcg gcggtgtcct cgatggcctc ggggcggtcg tactccgatc
     5761 gccgggcgcg cgtgctgcgc ccggtgacgt agacggtggc cccggccgcc ccgagttcca
     5821 cggcgatgcc gcgtccggct ccccgggtcg cccccgcgac ccatgcgacc ttgccctcca
     5881 gcggacctga catgtccggt ctcccgtcgt tcggtgcgtg atctctcacc gaggaggttg
     5941 ccggggaaac cggacatctt ctggcacctt taaccgacgt tccgtccgcg cgccgtgtgg
     6001 gacgtgcggg gtgacgggtg tggacgggga ctgtcggtgg cgccggggtc agtggccgcg
     6061 tttgatccac tcgtccagat ggggtgcctc ggcgccgacg gtggtggagt cgccgtggcc
     6121 ggtgaggacc tcggtctcgg gcggcagggt gagcagccgg tcgcggatgg agtcgatgat
     6181 cgtcgggaag tgggagtagg agcgtccggt ggcgcccggg ccgccggaga agagggtgtc
     6241 gccggtgaag acggtgccga ggccggggtc gtacaggcag accgcgccgg gcgcgtgccc
     6301 cggggtgtgc aggacggtca gatcggcgcc cgcggcctcg atcacctggc cgtcggagag
     6361 ccaggcgtcg ggcagccggt ccgggtgggt ccgctgccac agcggcaggt cgtcgcggtg
     6421 cagccagatg accgcgccgg tgcggtcggc cagggccggg gcggcgttca catggtcgtt
     6481 gtgggcgtgg gtgcacacga tggcggtcag gcggcggtcg ccgacggccc gggcgatggc
     6541 gtcggcgtcg tgggcggcgt cgatgacgac ggcctcgtgg tcgtcgccga cgatccagac
     6601 gttgttgtcg acgtcccagg tgccgccgtc gagggtgaac tggccggagg tgacgaggcg
     6661 ttcgacgcgg gcggtcatca cagcaccacc accgagcgca ggacgtcgcc tgcgtgcatc
     6721 cgctcgaacg ccttctccac ctcgtccagc gcgatcgtct cggtgacgaa cgcggcgagg
     6781 tcgaggcggc cctgcagatg caggtcgatc agcatgggga agtcgcggga gggcaggcag
     6841 tcgccgtacc aggaggactt cagggagccg ccgcgcccga agacgtcgag gaggggcagt
     6901 tcgagcttca tctcgggggt ggggacgccg acgaggacga cggtgccggc caggtcgcgg
     6961 gcgtagaacg cctgccggta ggtctccgga cggccgaccg cctcgatgac gacatcggcg
     7021 ccgaagccgc cggtcagttc gcggatggcc tcgaccgggt cgctctcgcg ggagttgacg
     7081 gtgtgggtgg cgcccatggc gcgggcggtc tccagcttgc ggtcgtcgat gtcgacagcg
     7141 atgatcttcg ccgcgccggc caggcgggag ccggcgacgg ccgcgtcccc gacgccgccg
     7201 cagccgatga cggcgaccgt gtcgccccgg ccgacaccgc cggtgttgat cgccgcgccg
     7261 atgccggcca tcacaccgca gcccagcagc ccggcgacct gcggggagac ggccgggtcg
     7321 accttggtgc actgcccggc ggcgacgagg gtcttctcgg cgaaggcgcc gatgccgagg
     7381 gcgggcgaga gttccgtgcc gtccaggagg gtcatcctct gctcggcgtt gtgggtgtcg
     7441 aagcagtacc agggccggcc gcgcagacac gcgcggcact tcccgcagac cgcgcgccag
     7501 ttcaggatca cgaagtcgcc gggggcgacg tccgtgacgc cctggcccac cgactccacc
     7561 acgcccgcgg cctcgtgacc gagcaggaag gggaagtcgt cgctgatgcc gccctgtttg
     7621 tagtgcaggt cggtgtggca caccccgcat gcctggacgc gcaccacggc ctcgccgggc
     7681 cccgggtccg gcacgacgat cgtctcgatg cgcaccggct cgtccttgcc cggtgcgatc
     7741 acgccgcgta cttcctgcgc catggtgctg cccctttcat cgaccgctct tcatcccttc
     7801 cgaccctatg cgtgactgat cggtaaggga tccggatcac gccattccgg cgtgccggtg
     7861 ccgggggcct cggtgtccgg cgttccggcc gtgccccggc ggtccaccgc gttccgcgcc
     7921 gctgccggcc cgatttttgt cgcgtacgca gtcttgtgga gaagtacgac cgatctttac
     7981 tttccagtaa gtaactggag ttgaacaagg ctcatgtccg atgtcgtatt ggcatgccca
     8041 caccagagga ggcagtcatg cctgccaccg gcccccggca cctccgctcc gtgaccgcca
     8101 ccgcggccgc caccctggcc ctcggcctcg ccggccccgc gcacgcgtcc cccggcacgg
     8161 cggacgcgct ctcccccgcc gggctgcggg aggtgctgtt cgtcggcaac aactgggacg
     8221 gcaccgccga tgtcatcgag tccaccggcg acttccgcag gatcgggcgg atcgacgtcg
     8281 tccccgacaa ggaggagcgg ctggccgaga tcaaggccga ccccctccgg ctgatctact
     8341 tcctggggat ccgcagcagc gtcggcgagg gccacgatca gttggtcgac gacatgtacg
     8401 cgaccccgga cgggtcgtcg gtggtcgtct cgcggcccag tttcgccgac gtggtctcca
     8461 tcgacctggc caccggccgg gtcgaatggc gtttcccggt ggacggctac cgctccgacc
     8521 acatggccgt ctcccccgac ggcaagcggg tcgcggtgtc ggcctcgacc gcgaacaccg
     8581 tgcatgtgct ggacatcgag accggcaagg agctcggctc ggtcgccacc ggcgacaagc
     8641 cgcacgagaa cgtcttcagc aaggacggca agtacctctg gaacatgtcc atcggcgagg
     8701 tgaacacctc cctggacgcc ccatggctgg actggaccaa gggtgaccgg cgcatcacgg
     8761 tcgcggacgc cacgacgtac cagcgggtca aggtgatcga catgcgcgag cggctcgacg
     8821 ccgccgggct gaggaaccat tccgacgcgg tgcggcccgc cgtcttctcg cccgacgagt
     8881 cccggctgta cttccaggtc tccttcttca acggcttctt cgagtacgac gtcgccaccg
     8941 accggatcac ccggaccaag acgctgccga agaacccggc gaccagcgag gaccgcacga
     9001 cctgggtcaa cgactcacgc caccacggca tcacgatgag cccggacggc gccaagctgt
     9061 gcgtcgcggg gaccatggac gactacgccg cggtggtcga ccgcgccacg ctggaggagg
     9121 gcccgctggt caccgccgcc aagccctact gggccaccgt cagcggggac ggcaggcact
     9181 gcgtcgtctc cgagagcggc tccgaccagg tgacggccat cgacttcgcc accggccgga
     9241 agacggtgtc cgtcccggtc ggcgaccatc cccagcgggt gcggctgggc cgcgtggcgg
     9301 cggactggac cgggccgtcg gccggctgac gccaccgggt gcggcgcggg cggtacgccg
     9361 ggaccgcgcc gcacccggcg gggcggaccg ccctcacggc accgggaccg agcggtcgca
     9421 ggaaccggtg atcaggtgcg gcggggcggc agccggtgca gggcgacgtc gacgaggcgg
     9481 ccgccggcca cggaggcggt catgtaggtg cagtacggct ggcggcggcg gtcggtcggg
     9541 gaaccgggat tgagcaggcg cagcccggtg ggcgcggtgg tgtcccaggg gatgtggctg
     9601 tgcccgaaga ccaggacgtc caggccggga aagcgctcgg cgcagcgggc ctcccggccc
     9661 cgggccgggc cggtctcgtg gaccaccccg aagcgcaggc cgccgatgtc ggcgtaggcc
     9721 acctcgggca gccgggcgcg caggccgggc ccgtcgttgt tgccgtacac ggcgacgagc
     9781 cggcggctgc ggctctccag caggtcgagg gtggcggtgt cgacccagtc ccccgcgtgg
     9841 acgacgacgt cggcctgcgg cagttcggcc aggagcgggg cgggcagttc ccgggcccgc
     9901 cggggcagat gggtgtcgga catgagcagc aggcgcaccg ggcgggcccg gtcgcccccg
     9961 gcctgggcgt ccgggcgggc gggcccgggc ggtgcgggcc tcacgcccgc tcccgcgcgg
    10021 cgcgctgccc ggaccgctcc caccagccgc ggttgtcccg gtaccaggcg acggtctcgg
    10081 cgagggactc ggcgaagtcg cgccgggggc ggtagcccag ttcgtcgcgg gccttgctcc
    10141 agtcgacgga gtaccgcagg tcgtggcctt tgcggtcgtc gacgtactcc acacggtccc
    10201 agccggcgcc gcaggcccgc aggagcaggt cggtcagctc ccggttgctc agttcggtgc
    10261 cgccgccgat gttgtagacc tcacccgccc tgccccgggt gcggaccagt tcgacgcccc
    10321 ggcagtggtc ctcgacgtgc agccagtcgc ggacgttgcg tccgtccccg tagagcggga
    10381 cgttctcccc gtcgaggagg cgggtgacga acaacgggat gatcttctcg gggaactggc
    10441 ggggaccgta gttgttggag cagcgggtga tccgcacgtc caggccgtgg gtccggtggt
    10501 gggcgagggc gagcaggtcg gcggcggcct tggaggcgga gtacggggag ctgggccgca
    10561 gcgggtcccc ctccgtcgcc gagccggact ccagggagcc gtacacctcg tcggtggaga
    10621 cgtgcacgaa cggttccacg ccgtgccgca gcgccgcgtc gaggagcgtc tgggtgccca
    10681 cgacgttggt ggtgacgaag tcggtggcgg tgtggatgga gcggtccaca tgggattccg
    10741 cggcgaagtg caccacctgg tcggcgtcgg ccatcagctt gtcgaccagt gcggcgtcgc
    10801 ggatgtcgcc ctgcacgaag tccaggcggg ggtggccgag ttcgaggttg tccgggttcc
    10861 cggcgtacgt cagcttgtcc agcaccgtga tccgcggcgc tccgggcgcg tcggaggcga
    10921 gcagcgcgcg gacgtagtgg gaaccgatga atccggcggc gccggtgacg aggaggttca
    10981 tgaacgcgtg tgcaccttgc tgtgtcctgc tgccggcatg ccggcgacgt taccagtgag
    11041 ccgcgggtgg cctgcgcgtc ctcccgtgac cgtcacccgt ccgccgggcc gtggcgcgcg
    11101 gcggcacggt gcgcggtgcg ggccgtcagt cctcgcccct gacgatgtgc gggtcggggc
    11161 ccggctgggg cgtgcgcggc gggtcgccgt cctcgacggc cgggatccag gtgcgcgggg
    11221 cgacgtggcc gcgcaggcgg cgcgcggtcg accagcctgt ctccggtcgg cgggtggcgg
    11281 gtttgtcacc ggtgtccgtg gtcacggggc atcgtcttcc ttccgggtgc gggcgaggga
    11341 cgcccgtgcg gtgccggcgt cgcggcgcgg cacggggaac cggcgccggg ttcccaggga
    11401 tcgccggtgt caaacgtcag accgccgccc ggccgcgcct cgcccgcacg cgcgcggggc
    11461 cccgccggtg gttcgggccg cgacgtgcga ccggcctcgc ggcaccgtcc gttccggtgc
    11521 gcgcgaggcc ggcgggccgc gtgcggccgg gcccgtgggc ccggggcggc gcggccccgg
    11581 gggcgtggct ctgccgccgt gtcgccgtta cgtgttcggc cgggccacgc tgatgtcgcc
    11641 gagcgccgac tccgggtcac gctccatggc catgtcgccg agggagacga tgcccaccgg
    11701 atgtccctcg tcgacgaccg ggatgcggcg caccgcgtgc tcgcgcatca gctccaccac
    11761 gtggtccagc tcctcgtcgg gccggacggt caccacgtcg tcgctgcacg cgccggccac
    11821 ggtggtctgc tgcgggtcgc cgccctccgc gagcgcccgg atcaccaggt cccggtcggt
    11881 gaccagcccg cgcagccggt ccccctcggt caccaggacg gctccgaggt cctcgtcccg
    11941 catgatgcgg gccacgtcga cgacggaggc ctgcggctcg acggtcaccg gttcactcgt
    12001 catgatgtcg cggacgtact ggaccatgac gcacctcttt cctcgccttc tcggcgctgt
    12061 gtgctctgcc ggtccgggta cccgcggacg cggttccggc acgccggggc gggcgggaac
    12121 cgggccggtg gcggccggcg gcgttcaccg ggacagcggg atctcgcacc acacctgctt
    12181 ccccccgccg gccgggaggg tcccccaggc cgccgacacc gcctcgacga gcaggacacc
    12241 gcggcccccg gtggcctccc agccgatgcc ggtgggtttg acggcctcgg cgatccgttc
    12301 caggcacgcc cgggcgtcgg ggccgaagcc gcccgggtcc tcggtgacgg agaggaggca
    12361 tccgccgccg tcccgccgca cgggcagggc ctccaggctg aactccccgc acggcgcgcg
    12421 ccgcgactcg gcgcgtccgg cgacgtcccc ggggccgagc cggaccggcc gcccgtcgcg
    12481 gtgggcgtcg gccacgggcg agtggccggt gacgggatag ccctcgcgca gcccgtacag
    12541 cgacccgggc acaccggccg actccaccag gcacagcacg tccggcacgc ccgcgctgcg
    12601 gccggagccg ggggcttcga gcggctcgcc gtgcgccccg ggccgtcgcg agggagattt
    12661 gtccctggga ccgtcgcccg gccgtgcgag gaggtggtcg tggtgaccga ccggcagtcg
    12721 acccccgggg agcccgcggg ctccggaccg gtggtcggcc ggtccgcgct ctccctggcg
    12781 ctggcctcga tgatggagga ggtccacgcg cacgccggtg cggtgtatct gctctccgcg
    12841 gaccggcggg tgctggagat ggcggtgata gcggggcttc cccggtcgtt cgcggccccc
    12901 tgggaacggg tcccgatgac cgcgcggatc ccggtggccg acgccgtgcg cgaacggcgg
    12961 ctgatctggg tcggcggcga ggaggagatg gcccggcgct atccgcgggt cgcggtggtc
    13021 ctgccctacc cgttcgccct ggccgcgctc ccggtggcgg ccgggtccac cgtgtacggc
    13081 ggggtgttcc tgacctggcc gggcacgcgc cccgcggatc tgtccgagcg ggagcgggag
    13141 cagctggcgg ccgcctgtga ccggctggcg ctccggctga agcgcggggc ggggacgcgt
    13201 ccgcccgcgc cgcaccagcc ggagccggcc gccgcgccgg ccgtgggggg agtcgccggg
    13261 tcgctcggtg ccctggaggc cgtgcggatg gcgggccggc tgccgtacgg actgtgctcg
    13321 ctggacgcgc acgggcgcgt cggcttcgtc aatccggcgg cggccgaact gctgggcgta
    13381 ccggccgaca gactgctcgg caccccgctg tgggcggccg tgccgtggct gaacgacccg
    13441 gtgtacgagg accgttaccg ggcggcgctg ctcagccagc acacggcctc gttcgtggcg
    13501 ctgcgcccgc ccggcgagtg gctgtcgttc cggctgtacc cgagccggaa cggggtgagc
    13561 gtccgcatcg gcctggcccg ggggatgtcc ggggccggac gggccggtgc cgaggccggc
    13621 gccgggcccg gccgggcacc ggccgagacg ccgtcccgcc tggtgaccat cgcgcaggtg
    13681 ctgagcctgg ccggggcgct gaccgaggcg gcgggcgtgc aggacgtggt gcagctcgtc
    13741 gcggacgaga tcgccccgac gctgggcagc caggcgctgg tgctcctcgg ctcacgggcg
    13801 ggccggatgc acgtgctggg gcaccggggc tatccggatc cctacgtcgt ggagcggttc
    13861 gacgggatgc cgctgaccga gcacactccc ggcacccagg tcctgcggac gggggtgccc
    13921 gccttcctgg agtccgcgga gcagctcgag cacctgtatc cggtccggcg agccaccccg
    13981 gacggcttcg cggcctgggc ctatctgccg ctgatcgcct ccggccgccc ggtgggcacc
    14041 tgggtgctgg cctacgcccg gccgcatccg ttcccggcgg aggagcgggc ggtgctgacc
    14101 agcctggccg ggctggtcgc ccaggccctg gaccgcgccc tgctgttcga cgccaagcac
    14161 cgcctggccc acgggctcca ggaggccctg ctgccgcact cgctgccgtc cctgccgggc
    14221 atcgaggcgg ccgcccgcta tctgccggcc acccggggca tggacatcgg cggcgacttc
    14281 tacgatctga tgccggtcga gggcatggcc gccgcggtga tcggggacgt gcagggccac
    14341 aacgtgaccg cggccgggct gatggggcag atccgcaccg ccgtccgcgc gtacacggcc
    14401 gtcggccaga cgccggagga ggtcatgcgc cggaccaacc ggctcctgat cgacctgggc
    14461 agtgatctgt tcgcgagctg tctgtacctg cggatcgacc cggcccgccg acgggccgtg
    14521 ctggcccgcg cggggcaccc cccgcccctg ctgcggcggc cggacgggcg ggtgcgggtc
    14581 ctcgatctgg ccggcggtcc gctgctgggc atcgacgcgt cggcggcgta ccccgcgtcg
    14641 gaggtcgacc tctcccccgg gtccctgctc gtcctctaca ccgacggcct ggtggagtcg
    14701 cccggcgtcg acttcgagga cgccctcgcc gacctggggc ggcggctcgg gcaggccggg
    14761 gacctgccgc tggacgcgct cgccgacgcc ctggtgcggc atgtcgcgaa agcggaggag
    14821 cgcatcgacg acatcgccct gttgctgctg aggacgcggg aagggtgaga aggcggcgac
    14881 acggctgttt cctgcggata tgtcagtatc gatctactcc gaatcactga cacacagcaa
    14941 ttgatcggtg acgttctgtc gagaacaccg agcggaatcc tcgcttcagc gaatctgcac
    15001 atcggctgcc caacccggtc accgcccacg ggggatctgc acaagcgccc ggccccgctc
    15061 acgcctttgg gacccaagtg ccggattcgc cgaccgagcc gcgcggccct cggcgccccg
    15121 gcaccgcgcc gcatgtgaag aagtcgccag caagccgtgc gcgcacctgc accaaaaggt
    15181 ggccgggcgg ttcgaaaggc ctggtgggag gcggtggttg agtggaacgg cgggctggcg
    15241 ccgtgctttg atccatcgca ccgcgggggc cgcgaacggt tccccggacc gggcgcccgg
    15301 cacccgcggc cgcggccgtc catctgtccc cagagggggc cgctcccccc ttgtgaatat
    15361 ccatatgaag ggaagttcca tcatgaactc caccccccag gtcgagaccg tcgagatcgc
    15421 cgacaccgag ctggacaacg tctccggtgg tctcgccatc aacgccctga acaccgtcac
    15481 cggcgtggtg gacagcgtcg ccccggtcac cggcctggtg aacggcgtcg tcgacacggt
    15541 cgagggtgtc acgggcctga acaccgcccc ggtcaccggc ctggtcgccg gtctctgatc
    15601 gcgcccacgc gctaccgaag tcccggagcc gctccccggc tccgggactc tcgggtgccg
    15661 tcacagcccc ggcccgcccg gggcggttcc gtcaagttcc gcaggtgagg gaaggtccgt
    15721 gcagttccgc cagcaggccc tcgccaagct gcagtcgccg gacgagctcg atctgccggt
    15781 gcggttcgcc cgcccgcagg gctggctcgt cctctccgtc accgtcgtcg cgatggccgc
    15841 cgcgtccgtg tgggcggtga ccggttcggt cgcctccacc gtcagcgcgc ccgccgtcct
    15901 cacccacggg cagggcagct atgtgctgca gagcccggtc tccggccagg tcaccgccgt
    15961 cctcgccgaa cagggcgagc ggctgcccgc cggcgcgccg gtgctgaagg tccgtaccgc
    16021 cgagggcgag acggtcgtcc gcgccctcga cgcgggccgg gtcagcgcgc tcgccgccac
    16081 cgtcggccag atcgtccaga ccggtgcgaa cgtcgccgcc gtcgagaagg tcgcccacgc
    16141 ccgggacccc ctgtacgcca ccgtgtacgt ccccgccgag aacgccgccg agatccgggc
    16201 gggcgccgcc gtggacctga ccgtgcagtc ggtgccctcc caggagtacg gcgtcctgcg
    16261 cggccatgtg aagtcggtgg accgctcggc ccagtccgcg cagcagatcg gcgcgttcct
    16321 cggcgacagc cagctcggcg agcagttcac caaggagggc aggccggtcg cggtgacggt
    16381 ccgcctcgac acctcctccg ccaccaagag cggttacgag tggtcgacgg cggggggacc
    16441 tccgtacgcc ctcacctcca tgactctggc cacgggctcg atccggctgg ccgaccagcg
    16501 tcccgtcgat tggctgctgc cgtgaccacc gacctgaaga cccggggcag acgccgtgcc
    16561 gccccgccca agcgcacggt gcccaaggcg cgggcgaaga ccgtccgcac cccgaccgtg
    16621 ctgcagatgg aggccgtcga gtgcggcgcc gcctccctgg cgatggtgct cggccactac
    16681 ggccgccatg tcccgctgga ggaactgcgc atcgcctgcg gtgtctcccg cgacggctcg
    16741 cgcgccagca acctgctcaa ggcggcccgc ggttacggcc tgaccgccaa gggcatgcag
    16801 atggacctgg ccgccctcgc cgaggtgacc gcgccggcca tcctgttctg ggagttcaac
    16861 cactacgtcg tctacgacgg catgggccgc cgcttcggcc gccgcggggt gtacatcaac
    16921 gaccccggca aggggcgccg gttcgtgccg ctggaggagt tcgacggcag cttcaccggc
    16981 gtcgtgctgg tcatggagcc cggcgagggc ttcacccgcg gtgggcgcag gccgggcgtg
    17041 ctgggcgcga tgccggcccg gctgcgcggc acggcgggca ccctgcccgc cgcggtgctg
    17101 gcgagcctgc tgctggtggc cgtcggcgcg gcggtgcccg cgctcagccg cacctacatc
    17161 gacgagttcc tcatcggcca ccagacctcg ctgctgggtg tgctgttcac ctcgatggcg
    17221 gcgtgcgtgc tgctcaccgt cgtcctgacc tggctccagc aggccaacct gctgcgcggc
    17281 cggctcatct cctccaccct gtccagcgcc cgcttcctgc gccatctgct acggctgccg
    17341 gtgaccttct tctcccagcg cagcccggcc gacctggtgc agcggctcca gtccaacgac
    17401 gcggtggccg agaccctggc ccgcgacctg gcggcggcgg gcgtggacgc ggtggtggtc
    17461 gtcctgtacg cggtgctgct gtacacctac gacccccagc tcaccttcgt cggcatcggc
    17521 gtggccctgc tgaacatcgt ggcgatgcgg gtcgtcatcc ggctgcgcgc cacccgcacc
    17581 gcgaaattgc gggcggacag cgcgcggctc accaacacct cgtacaccgg tctgcagttg
    17641 atcgagacga tgaaggcgac cggcggcgag gacggctact tccgcaagtg ggccgggcag
    17701 cacgccacga ccctggagga acagcagcgg ctcggcgtgc cgagcgcctg gctgggcgtg
    17761 gtggcgccga cgctcgccac cttcaacagc gcgctgatcc tgtggatcgg cggcatgcgc
    17821 gcggtggagg gccacatctc ggtcgggctg ctggtcgcct tccaggcgct ggtggcccgc
    17881 ttcaccgccc cgctgacccg tctgaacggc gtcgcgggtc gcatccagga cttcgcggcc
    17941 gacgtggccc gcctgaagga cgtggagaac ttccaggccg acccgctcta cggccgcccc
    18001 gacgccggcg actccacgcg ccgcctgcag ggccatgtcg agctggagaa catcaccttc
    18061 ggctacaacc ccctcgacaa gcccctgctc agcggcttcg acctgatcgt cgggccgggg
    18121 cagcaggtgg cgctggtcgg cggctcgggc agcggcaagt ccaccgtgtc ccggctgatc
    18181 tcgggcctgt acacgccgtg ggaaggcgtg atccgcatcg acggccggcg gatcgaggac
    18241 atcccgcgcg gggcgctggc ggcctccgtc tccttcgtcg accaggaggt gttcctcttc
    18301 gagggcacgg tccgcgacaa cgtggcgctg tgggacccgt ccatccccga cgacgcggtg
    18361 gtggaggcgc tgcgggacgc ggccctgtac gacgtggtca tgcgccgccc cggcggcatc
    18421 cacagccggg tcgagcagga cggccgcaac ttctccggcg ggcagcgcca gcgcctggag
    18481 atcgcgcggg cgctggtgcg ccggcccagc atcctcgtcc tggacgaggt gacgagcgca
    18541 ctggacgccg agaccgaaca ggtggtcatg gacaacctgc gcaagcgggg ctgcgcctgc
    18601 gtggtgatcg cgcaccggct cagcaccgtg cgcgacagcg acgagatcgt cgtgctccag
    18661 cacggcacgg tcgtggagcg cgggcggcac gaggagctgg tggcgcgcgg cggcgcgtac
    18721 gcggcactgg tcagggagcg gtgagatgac gtccgtccac gaggaggacc tggtcctcgg
    18781 cgcgctcgtc cggctgggca cccggctgga ctgcgccggc ttcggccggc tggacctgga
    18841 gggtccgcag gtgctgtggc tggtcgcggc gggcgccgtc gacctgttcg cggtggacgc
    18901 cgcgcagcag ggccactggc accacctcgg ccggctggag gcgggttcgc tgctgctcgg
    18961 cccggtcgcc ggaccgcagc acacactggt ggcccgtccg ctgcgcgact gcgtggtgca
    19021 ccgcatcggc ctgcgtgagc tgtaccagcc ggcgaccacg cagacctggt cgtacgacga
    19081 gtacggcaat ccgcagtacg tcccgccggc gacgagcccg ctggagcacg ccctcgccct
    19141 cggcgtgggc cgcagcctgt ccatcctgtt ccaggcgccg atggccaccg agcgggccgc
    19201 ggcgcccgcc gccgacgacg acgtgttctg gatgcaggta ccgccgggca gcgtgcagta
    19261 cggcgagctg tacggcgccg aggccgcggc cgacctgctg atggacccgg cgctgtggca
    19321 gagcatggtc gaccagcagt accgcctgct gaccacgctg gaccgctgga tcgagcagct
    19381 cgagcgcacc cacgagaccc ggaccgcgga gggcatcaag gccggtgagg cggtgcgcgc
    19441 ccgggccgac cggacgctgc tggcggcgat cggcaagccg tcggggcagc ggaccacggc
    19501 cgccgacgcg gacgcgacgt acgcggcgtg caggctggtc gcccgggccg cgggcatcgc
    19561 gctggccgag cccgcgcaca gcggtgcgga gagcgaccgg ctcgatccgg tggagcgggt
    19621 cgccgtcgcc tcccgggtgc gcacccgggc cgtccgtctc cagggccgct ggtggcggga
    19681 gaacgtcggg ccgctggtgg gccggcgggc gctgtccggg gcgccggtgg cgctgctctg
    19741 gcggcgcggc ggctatgtgg cggtgcatcc cggctccggg cgggagacgg ccgtggacaa
    19801 ggccaacgcc gaggagttcg agccgcgcgc ggtgatgttc taccggccgc tgcccgaacg
    19861 ccggctcagc ccgctgcggc tgatgcggtt ctgtctgcgg ggcacccgcg gcgacctgct
    19921 caacctgctg gccagcgggc tggtgacggt ggcgatcggg gcgctggtgc ccctggcgac
    19981 gggcaaggtg ctcggcgagt tcgtgccgcg cgcccagacc gaactgatcg cccaggtctg
    20041 cctgacggtg atgatcggcg gtgtcgtcgc ggcggcgttc atgctgctgc agaacctcac
    20101 catcctgcgg ctggagggcc ggatcgaggc caccctccag ccggcggtgt gggaccggct
    20161 gctgcggctg ccgacgacct tcttcaccga gcgttccacc ggcgagctgg cgagcgccgc
    20221 catgggcatc agcgcgatcc gtcggctgct ggcgggggtc ggcccgacgg tcgtccagtc
    20281 ggtgaccgtc ggcgcggtga acctggcgct gctgctgtgg ttcagcgtgc cgatggcgct
    20341 ggcggcgatc ggcatgctcg tcgtgatcgc cgcggtgttc ctggcgctcg ggctgtggca
    20401 ggtgcgctgg cagcggcggc tggtggtgct caccaacaag ctgaacaacc aggccttcca
    20461 gacgctgcgg ggcctgccca agctgcgggt cgccgcggcc gagaactacg cgtacgccgc
    20521 ctgggcggag cgtttcgcgc acagccgtga gctccagcag aaggcgggcc gcgtcaagaa
    20581 cctcaacgcc gtgctgggcg cggtctacct gccgctgtgc acgctgctga tgttcatgct
    20641 gctggcgggc ccggcgcgcg gctcgatgtc cgcggcggcg ttcctcacct tcagcacctc
    20701 ggtgaccatg ctgctgacct cggtgaccca gctcaccggc gcgttcgtct cggcggtggc
    20761 ggcgctgccg ctgttcgagg agatcaagcc ggtgctggag gcgacgccgg aggtgcgcac
    20821 ggccagcacc cggccgggtc cgctgtccgg ggcgatcgag gcgcggcggc tgtccttccg
    20881 gtacaccgac gacgggccgc tgatcctgga cgacgtgtcg ttcgaggtgc ggccgggcga
    20941 gttcgtggcg atcgtcggcc ccagcggctg cggcaagtcg a
//
