LOCUS       LN831790               21053 bp    DNA     linear   BCT 17-JUN-2020
DEFINITION  Streptomyces leeuwenhoekii strain C34 (= DSM 42122 = NRRL B-24963)
            genome assembly, chromosome: chromosome.
ACCESSION   LN831790
VERSION     LN831790.1
KEYWORDS    .
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-02-26 04:50:55
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4211122
            Orig. end    :: 4232175
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11053]"
                     /cutoff="5000"
                     /detection_rule="Trp_halogenase"
                     /neighbourhood="10000"
                     /product="halogenated"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11053
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="Trp_halogenase"
                     /neighbourhood="10000"
                     /product="halogenated"
                     /protocluster_number="1"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="Trp_halogenase"
                     /kind="single"
                     /product="halogenated"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="halogenated"
                     /region_number="29"
                     /rules="Trp_halogenase"
                     /tool="antismash"
     gene            867..2738
                     /gene="sle_35560"
     CDS             867..2738
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VZP1"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VZP1"
                     /gene="sle_35560"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 289; E-value: 1.2e-87)"
                     /gene_kind="transport"
                     /product="Iron import ATP-binding/permease protein IrtA"
                     /protein_id="CQR63017.1"
                     /transl_table=11
                     /translation="MATTEPVSALTDGTGRRTADGRTAQSEPNDKNQNSPVGHLPPGHR
                     LLMELLRPYRGRLVAVLVLQAVGALAGLAPLLAVIELGRELLTPGPADHGAVWTAVVCG
                     AAGLLVRILFTAAAGGIGHLVDGELNLSLRRQLAQRLGRLPLGWYAHHSSGEVNGVVQG
                     DVATLHHLIAHTPGEFTSAVVVPVASFGYLAWVDWRLTLVALIPVLLGLAVHLLLSTPE
                     RRRQGTAVGQAMGRIGASSVEFVQGISVVKTFGAAGRIHQRYRRAADDFADFFLGYVAD
                     SAGLASLSALVLSPPFVLLLVLTGGTLLIAEDSMPPVDLLPFLLLSVALTAPVAALGHG
                     MDNIHAAEQSADRIHRLLSVRPLPQPARPAVPHGDRVEYRGVGFAYDDGHPVLHDIDLI
                     LEPGTTTALVGPSGAGKSTLAQLLPRFFDPTHGTVLLGGVDIRDIPDEQLYQRVSFIFQ
                     DVRLLRATVAENIALAVPDASRSAIVAAARAAGLHERIESLPHGYDSVIGEDAGLSGGE
                     AQRLGIARALLIDAPVLVLDEAMSFADAKTEAEIRRALDVLCAGRTQLVIAHRLETITR
                     ADNIVVMEDGRIVESGTYRDLMAAGGTFAAMWRAQHGHGTDAQEGRH"
     gene            2738..4447
                     /gene="sle_35570"
     CDS             2738..4447
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VX85"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VX85"
                     /gene="sle_35570"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     251.3; E-value: 1.2e-76)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 295.7; E-value:
                     1.2e-89)"
                     /gene_kind="transport"
                     /product="Iron import ATP-binding/permease protein IrtB"
                     /protein_id="CQR63018.1"
                     /transl_table=11
                     /translation="MIRLLLRVLGESYGRPVRRTVALMSLRAVVEGLSYALLVPLLRAL
                     LGPHPADAWPWLGGFAAAFLLCAVLGYRSVLTGFRTGGELSRGLHHRLGDQLARLPLGW
                     FTPSRIGDVAGLTSRSVMQVMSVPAHRLGPLNDATFVPLTVVVVLFFFDWRLALAALVA
                     APLIAAVQRATARATAREDAERARRSDDASARVVEYVRAQPVLRAGGRTGERFRLLDEA
                     LHAQWRSERRAAVKGLPGIVGLSLTVQTVFTLVLVLGAYLALHGSIGAPSVLALLVLCA
                     RCVDPLLSLADLGGVMRASRGELERIDEVLREEPLPQPERPSVPADNSLELAEVTFRRG
                     GRTVLDGLSLRVEEGRRLAIVGSSGAGKTTLLQLAARFHDVDAGTVRLGGVDVRAIDGD
                     ELMSRLSIVFQDVYLFEGTIEENVRLGRPDATASDVRGAAAAARLDEVVARLPQGWDTQ
                     VGEGGAALSGGERQRVSIARALLKDAPVLLLDEATSALDPESERAVQEGLDRLMRGRTV
                     VMVAHRLHTVRDADSIALLEDGRIVESGTHQELLERDGKYAEFWKTATHQPA"
     misc_feature    2813..2815
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4561..5103
                     /gene="sle_35580"
     CDS             4561..5103
                     /NRPS_PKS="Domain: PP-binding (4-35). E-value: 2.5e-08.
                     Score: 26.2. Matches aSDomain:
                     nrpspksdomains_sle_35580_PP-binding.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR023213"
                     /db_xref="InterPro:IPR036736"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VR90"
                     /gene="sle_35580"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="Phenyloxazoline synthase MbtB"
                     /protein_id="CQR63019.1"
                     /sec_met_domain="PP-binding (E-value: 3e-06, bitscore:
                     26.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGTELTAADDDTDLFSLGLQSIQLMQLTNRINRVGGRTGFTELA
                     RDPRLTSWHRLLSSRTEKEGERPGPSPAPSPAPGPKPFPLTPVQQAYWIGRGDDRPLGG
                     VGCHAYLEIDAADVDPGRPGPNPQRPGTGPRDTGRTRYWAAFRTTRAGPTCPRSSPRTA
                     PSPTVSSTWPPTAWRPG"
     aSDomain        4573..4665
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sle_35580_PP-binding.1"
                     /evalue="2.50E-08"
                     /label="sle_35580_PP-binding.1"
                     /locus_tag="sle_35580"
                     /protein_end="35"
                     /protein_start="4"
                     /score="26.2"
                     /tool="antismash"
                     /translation="ELTAADDDTDLFSLGLQSIQLMQLTNRINRV"
     CDS_motif       4819..4848
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sle_35580_0001"
                     /evalue="1.90E-04"
                     /label="Cy1"
                     /locus_tag="sle_35580"
                     /protein_end="96"
                     /protein_start="86"
                     /score="13.6"
                     /tool="antismash"
                     /translation="PVQQAYWIGR"
     aSDomain        5088..6206
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sle_35590_AMP-binding.1"
                     /evalue="6.90E-72"
                     /label="sle_35590_AMP-binding.1"
                     /locus_tag="sle_35590"
                     /protein_end="373"
                     /protein_start="0"
                     /score="234.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="MASGLSQRGIAPGDRIVVQLPNGADMVVLCLALFRLGALPVFALP
                     AHRTAEITHLVESSGAVAYVCADRVLDCDHRELAQRILTRAGSLKHVLVAGDPGPFTAL
                     ADADADPVSLPPPDPSDVALFLLSGGTSGPPKLIPRTHADYAYQLRASAALCGVGRDSR
                     YLCALPMGHNFALACPGVLGTLRAGGTAVLAPAPTPDQCFPLIERARVSITSLVPPLVP
                     LWLDAAEWTDSDLSSLSLLQVGGSRLDPATAAQVPDRLRCTLQQVYGMAEGLLNFTRPD
                     DPEEVILHTQGRPLSPADEVRVIREDGADAGPGEVGELYTRGPYTLRGYYRAAEQNRTR
                     FTADGWYRSGDLVRRTAAGNLAVEGRTNDVVNR"
     gene            5088..6503
                     /gene="sle_35590"
     CDS             5088..6503
                     /NRPS_PKS="Domain: AMP-binding (0-373). E-value: 6.9e-72.
                     Score: 234.1. Matches aSDomain:
                     nrpspksdomains_sle_35590_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VTM6"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VTM6"
                     /gene="sle_35590"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     433.4; E-value: 1.6e-131)"
                     /gene_kind="biosynthetic-additional"
                     /product="2,3-dihydroxybenzoate-AMP ligase"
                     /protein_id="CQR63020.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-82, bitscore:
                     276.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASGLSQRGIAPGDRIVVQLPNGADMVVLCLALFRLGALPVFALP
                     AHRTAEITHLVESSGAVAYVCADRVLDCDHRELAQRILTRAGSLKHVLVAGDPGPFTAL
                     ADADADPVSLPPPDPSDVALFLLSGGTSGPPKLIPRTHADYAYQLRASAALCGVGRDSR
                     YLCALPMGHNFALACPGVLGTLRAGGTAVLAPAPTPDQCFPLIERARVSITSLVPPLVP
                     LWLDAAEWTDSDLSSLSLLQVGGSRLDPATAAQVPDRLRCTLQQVYGMAEGLLNFTRPD
                     DPEEVILHTQGRPLSPADEVRVIREDGADAGPGEVGELYTRGPYTLRGYYRAAEQNRTR
                     FTADGWYRSGDLVRRTAAGNLAVEGRTNDVVNRGGEKVPCQEVEEHLLADPRVTAAAVV
                     ALPHPLMGEQTCACVVLRDGEPELTLRQVQSVLRERGLAAYKVPDRLVVLQRMPLTGVG
                     KIDKRALRHHLAD"
     CDS_motif       6024..6110
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sle_35590_0001"
                     /evalue="6.40E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="sle_35590"
                     /protein_end="341"
                     /protein_start="312"
                     /score="18.6"
                     /tool="antismash"
                     /translation="PGEVGELYTRGPYTLRGYYRAAEQNRTRF"
     gene            complement(6584..7249)
                     /gene="sle_35600"
     CDS             complement(6584..7249)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W206"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR004111"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W206"
                     /gene="sle_35600"
                     /gene_functions="regulatory (smcogs) SMCOG1239:TetR family
                     transcriptional regulator (Score: 167.7; E-value: 5.4e-51)"
                     /gene_kind="regulatory"
                     /product="Transcriptional Regulator"
                     /protein_id="CQR63021.1"
                     /transl_table=11
                     /translation="MQPRTPRAGRTGRPPRLAREAILSAAQRILDEEGAENLSMRRLAK
                     EMSSTPMALYHYVRDKDELLLLLLEEHAAKFPRPDLPAEPRARLLASAQVLHDILVDCP
                     WIVEVVASDDLFAVSAMWIVENILDAAIECGMSPEDAVYAYRVIWYYTAGELTVRFNRE
                     RRHAHLDRPPHRDQITGLDPEEFPLLTMLGARWSELTTRDTHRRGLEAVVAGLLDQTT"
     gene            complement(7435..8148)
                     /gene="sle_35610"
     CDS             complement(7435..8148)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VZP5"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR004111"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VZP5"
                     /gene="sle_35610"
                     /gene_functions="regulatory (smcogs) SMCOG1239:TetR family
                     transcriptional regulator (Score: 165.9; E-value: 2.1e-50)"
                     /gene_kind="regulatory"
                     /product="Transcriptional Regulator"
                     /protein_id="CQR63022.1"
                     /transl_table=11
                     /translation="MRSSEAGTTGRKRMGRPSQLSQEAIIEAAQRIIDAEGDGSLSMRR
                     LARELSITPMALYHHVRDRDQLLRLLLETKARNLPRPSLPEDPRERLTAAAQLLHDVLA
                     DCPFLGEILTSDDLMTASCLWVIEAVLEAALACGFAVEEAVGLYRAVAHYTGGELLIRL
                     TRERHLAAHRDRPPYRARALATLQPQTHPRLCALADRWPALTSRDTHRAGLQALLDGFF
                     RTLDAGGAPAAAGPV"
     gene            8283..9818
                     /gene="sle_35620"
     CDS             8283..9818
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VX88"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VX88"
                     /gene="sle_35620"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 390.1; E-value:
                     1.8e-118)"
                     /gene_kind="transport"
                     /product="Cephamycin export protein CmcT"
                     /protein_id="CQR63023.1"
                     /transl_table=11
                     /translation="MSGTASNRGQALVAVALAQFMVTLDMTVVNVALPDMESGLGFDPA
                     QLPWVVNIYALFFGGFLLLGGRAADLYGQRRILLSGTWAFALASLAGGLAQEPWQMIAA
                     RAVQGVGAAVMAPAALAVLTLTQREGEERTRALGVYAAVAAVGGGAGVLVGGLLTEYAG
                     WRWVMLVNLPMALAVLLLALRSVPAGTFGNGRGRLDVIGAVLATGGVGLLILGMVRTDQ
                     LSWTSPTTILTLAVAVVLLVAFVLWEKYGPMTDPLIRLSLLTRRNVAGANLYMALLAAG
                     QLAVFYFLSLYLQRILKLGPAEAGAAFLPLCVIAMIAIQVTTRVLRRQLVGTKTLLVPA
                     GLIAAAGFAWCGMADASGSYLGDVLLPSVLAGLGVGIAFVPVTAAATVGLPPQEAGTAS
                     ALLNASRQVGSALGLAVLVTVATTRTDHRLAAGVSPDTAAVEGYSLGFVLAGGFLLLAV
                     LVAAFVLPRRPRPVAGQTPTAQQPGTGAPATIDGTGSGGTTSDITAGRMTPKS"
     misc_feature    8316..8318
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..11053)
                     /gene="sle_35630"
     CDS             complement(10001..11053)
                     /codon_start=1
                     /db_xref="InterPro:IPR006905"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VR95"
                     /gene="sle_35630"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     halogenated: Trp_halogenase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 360.2; E-value: 2.9e-109)"
                     /gene_kind="biosynthetic"
                     /product="Tryptophan 2-halogenase"
                     /protein_id="CQR63024.1"
                     /sec_met_domain="DAO (E-value: 1.5e-07, bitscore: 30.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 6.5e-25,
                     bitscore: 86.5, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSALFGVPDEYDVIVIGGGPAGATTAGLLAQRGRRVLVLDRERF
                     PRYHVGESLIPAFMRPMQEMGITERMDARGFERKYGGTLVWGNKQVPWNFSFIEGGAHE
                     YAFHTRRADLDALILDRARELGAFVIEDATVKEPVLVDGRVTGVRFALRGLDGLHEVRA
                     RLVVDASGQARVLGRRLTDVEWHEELRNVAVWTYFDNCERLPGDEYTNILIEGLDGGWF
                     WAIPIDKGTISVGYVTRSTTAGENGQSLEDLFHAERQRTTKLAKMLAGARQSAGFRTAR
                     DWSYHSNRFYGDGWVLVGDSAAFVDPLFSTGVALATLAGSTLAKILDRIVENPQIEEKA
                     LDRFQHVGAA"
     gene            11170..12228
                     /gene="sle_35640"
     CDS             11170..12228
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VTN0"
                     /gene="sle_35640"
                     /product="Hypothetical Protein sle_35640"
                     /protein_id="CQR63025.1"
                     /transl_table=11
                     /translation="MSGPFLGTQLASTGKCASRASVLRPSRQGGDVGTAHNPASSSSSA
                     WPCSRPGQRRARSDWLLPPDEAIGRELTPPSARVETISMAAWTSLFLRDVVPSLKSDHP
                     AGQPALPVAVDEKGQDLRSTATQLSRSPAVLHQWAPGSIRAGSYILRPVGSRGAARMMY
                     SALTREAPAGRCPITAPTRSAGILRSRRRHRTAVQADMVALPRDGVRGLDRGNAPEAEG
                     DLPSGGALAGLGGCRRMSSSAYRASSADGSRCAGVHTTSGRCGCAPGMTNGSPSPAPLT
                     TAAARCPSAPPTPTSSQPLITAFSVDKPAIARTGRSRSPSAHRRPATPPSDPAPQGQAD
                     RQLDPQDRFTQP"
     gene            12320..13195
                     /gene="sle_35650"
     CDS             12320..13195
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W207"
                     /gene="sle_35650"
                     /product="Hypothetical Protein sle_35650"
                     /protein_id="CQR63026.1"
                     /transl_table=11
                     /translation="MDQAGSGSGAWCRASQGGGGRHGEPWQPTTTRRWGSLPRERSRAW
                     GKGARPREPGLIQTRGPRPPSPRRPAHACLVDKRHSMNKHRERGMGDIVITMPPIPSVQ
                     LEHLRRCSSVREGGVEPPRPCGHWNLNPARLPIPPPAHWVCLPAPFLSARRLPTPRTLA
                     RPWRWIHIPAPGRPWSPPGRAPHAAPPSRRRSVHVSTSYRSLPSPQEPGGVHSRVRDTG
                     LRPPLRSWAEVRTAHFSTRSKRSAAGNVVRRRQASAGVGGRRREPAGVDTGRPGRQGEP
                     ADRPARGYDQ"
     gene            complement(12658..12741)
                     /gene="sle_35655"
     tRNA            complement(12658..12741)
                     /gene="sle_35655"
                     /product="tRNA-Leu"
     misc_feature    12803..12805
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13277..14143
                     /gene="sle_35660"
     CDS             13277..14143
                     /codon_start=1
                     /db_xref="InterPro:IPR000253"
                     /db_xref="InterPro:IPR008984"
                     /db_xref="InterPro:IPR022128"
                     /db_xref="InterPro:IPR032030"
                     /db_xref="InterPro:IPR042287"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VZQ0"
                     /gene="sle_35660"
                     /product="FHA Domain-Containing Protein"
                     /protein_id="CQR63027.1"
                     /transl_table=11
                     /translation="MGVLKKFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNAT
                     IWNRDRTVVPNDFIVELSTPDFERLSPYSGQLGDELAGMVRDYAKQQRYTFMGPIKVHL
                     EKADDLDTGLYRVRSRTLASSSSQQDPGAPAAPPAGRPGGYGYPPAAPAPPAGAPPMPS
                     APPPGAPAGRPGGYGYPPPASAPRPPAAAAGGRTRHWIEINGTRHQISRPTMVLGRSTD
                     ADVRIDDPGVSRRHCEIRTGTPSTIQDLGSTNGIVVDGQHTTRATLRDGSRIVVGSTTV
                     IYRQAEG"
     misc_feature    13308..13323
                     /note="TFBS match to LexA, Repressor of DNA damage
                     response, confidence: weak, score: 20.32"
                     /tool="antismash"
     gene            14154..14663
                     /gene="sle_35670"
     CDS             14154..14663
                     /codon_start=1
                     /db_xref="InterPro:IPR000253"
                     /db_xref="InterPro:IPR008984"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VX91"
                     /gene="sle_35670"
                     /product="FHA Domain-Containing Protein"
                     /protein_id="CQR63028.1"
                     /transl_table=11
                     /translation="MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGSRRD
                     AGRAQQAARQAPPPQRQQASGGRARRNAPTKLVVTEGTLTGTTVALQGQTITLGRAHDS
                     TIVLDDDYASSRHARIYPDRDGQWIVEDLGSTNGTYLDRTRLTTPTPIPLGAPIRIGKT
                     VIELRK"
     gene            14804..16369
                     /gene="sle_35680"
     CDS             14804..16369
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VRA0"
                     /db_xref="InterPro:IPR001932"
                     /db_xref="InterPro:IPR015655"
                     /db_xref="InterPro:IPR036457"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VRA0"
                     /gene="sle_35680"
                     /product="PP2C-family Ser/Thr phosphatase"
                     /protein_id="CQR63029.1"
                     /transl_table=11
                     /translation="MSLSLRFAAGSHRGMIREGNEDSGYAGPRLLAIADGMGGQAAGEV
                     ASSEVISTIVPLDDDVPGSDILTSLGTAVQRANDQLRQMVEDDPSLEGMGTTLTALLWT
                     GQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEANTHPQRSLLMRAL
                     GSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTLEDTLASYQGPQETVQELIQLAL
                     RGGGPDNITVIVADVLDLDTGDTLTGQLSDAPVVVGAVAENQHQIGDNGIMQTPAGRAA
                     GLGRHARGKGGGGGEFGPPGSGDTTGYIPAGDFADHGDGDFTKPHKNRRWLKSSFYTVL
                     ALAVIGGGLYGGWRWTQTQYYVGAKEGHVALYRGISQDLAWVSLSKVEKDHPEIELKYL
                     PPYQQKRVKATIAEGGLKNAQAKIEELSVQASACRKQAERRAAESESNAKTGEARAGGA
                     TGASPISFTSKATPAPDPTGSPSGAASAPSTSSPSPSTTAPTLSPGPSLSEEEQKVVSL
                     CGKQ"
     gene            16397..17842
                     /gene="sle_35690"
     CDS             16397..17842
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VTN4"
                     /db_xref="InterPro:IPR001182"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VTN4"
                     /gene="sle_35690"
                     /product="Probable cell division protein ftsW"
                     /protein_id="CQR63030.1"
                     /transl_table=11
                     /translation="MSSTNTPHSPAHHTSTIGAIGAPSRRNTELALLVFAVVIPVFAYA
                     NVGLAINDEVPAGLLSYGLGLGLLAGVGHLVVRKFAPYADPLLLPLATLLNGLGLVAIW
                     RLDQSELLQSIKQAGTAAPRQLLYTAMGIALFIAVVIFLKDHRVLQRYTYISMVGALFL
                     LLLPLVPGLGQNIYGAKIWISVAGFSIQPGEFAKIVLAVFFAGYLMVKRDALALASRRF
                     MGLYLPRGRDLGPILVVWAISILILVFETDLGTSLLFFGMFVIMLYVATERTSWIVFGL
                     LMSAAGAVGVASFEPHIQQRVDAWLDPMREYTLSRANQVGHSEQAMQALWAFGSGGTLG
                     TGWGQGHSDLIRFAANSDFILATFGEELGLAGVMALLLLYALIAERGVRTALAARDPFG
                     KLLAIGLSGAFALQVFVVAGGVMGLIPLTGMTMPFLAYGGSSVIANWALIGILLRISDT
                     ARRPAPAPAANPDAEMTQVVRPS"
     gene            17839..19311
                     /gene="sle_35700"
     CDS             17839..19311
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W209"
                     /db_xref="InterPro:IPR001460"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W209"
                     /gene="sle_35700"
                     /product="Penicillin-binding protein A"
                     /protein_id="CQR63031.1"
                     /transl_table=11
                     /translation="MNKPLRRIAIFCGLLILTLLIRDNWLQYVKADDLKNDEHNRRVAI
                     ARYASPRGDIIVDGKAITGHATTDGDFKYKRTYKDGAMWAPVTGYVSQVYGATQLEAID
                     DGILTGNDDRLFFRNTLDMITGKQKEGGNVVTTLNAAAQKAAYNGLKAQGGKGAVVALE
                     PSTGKILALASFPSYDPSTIAGDGASDGEAWQKLQKKNNPADPMLNRALREVYPPGSTF
                     KVVTAAAALEHGKYTDADAKTDTPLPWIMPGTTTPLKNEGNIPCEDATLRVALQYSCNT
                     VFGKIGADLGNEKMLETAKKFGFTEEQFTPVRSSASVFSDDMNDSQTALSSIGQFNTAA
                     TPLQMAMVASAVANNGTLMKPYMVDELQAPNLDTIEKTDPEEYSKPLSAENAQILQSMM
                     ETVVKDGTGKNAQIPGVTVGGKTGTAQHGVENSENPYAWFISYAKQSDNSSPVAVAVVV
                     EDENANRDDISGGGLAAPIAKSVMEAVIKSKK"
     gene            complement(19161..19562)
                     /gene="sle_35710"
     CDS             complement(19161..19562)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VZQ5"
                     /gene="sle_35710"
                     /product="Hypothetical Protein sle_35710"
                     /protein_id="CQR63032.1"
                     /transl_table=11
                     /translation="MVTYQPSPSVPTGTRVRPQTAVRAYRTRLALCDLAKAGQPIQDRY
                     RNVHRCDTDVSGVTYVRTLAARTYGVFRSRAVLRPLPRPHFLLLMTASITLFAMGAARP
                     PPEMSSRLAFSSSTTTATATGELLSLCLA"
ORIGIN
        1 cttcagccgg gccaacacgc tgaactccga ggcggtggtc gccggtctgg aggcggcgca
       61 ctgcttccaa atccacgtgg gcttcgagtc catgaacgac cagaccctga agaacatgag
      121 caagcgggtt tcggtgaaac agaaccggac ggcccacgac ctgctcagcc gcagcgagat
      181 caacgcctac gggctgttca tcgtcggata tccgggcgag accccgcaaa tgttccagga
      241 cacgcaggac ttcctcctgg aggagtacat cggtcacttc tccatggccc ggttcaccat
      301 caccgacgag aacatgccga tgtggcagga ccgggagaag ttccggatcg aggcggacaa
      361 tcccaacgat ccgggctcgg cctggtcgca catcggcatg gacagcgtcc gggcgggcga
      421 gctgctcacc gagaccctgg acaaggtccg gcgggccaac gaccgtgcgg tactgaagtt
      481 ctggcagcac aactaccagc actggctgct gccgaagcac gaccgcaaga ccaacctcgc
      541 cgtcgagaaa agcctggagc tgctcgccat ggcaccccgc gacttcactg atccgcagga
      601 gggggcgcac gaaatgcgca cccagctcga ccggttgcgt gcgctgggga tcgcgccggc
      661 ccccgaggag cgggagctgt gcctcgaccc gctgtgacgg acggctcgtg caccccctcc
      721 tgacgccttc gggtgccccc acgacgggtt gccgcccatt tcttatacgc gtatagtttc
      781 tgggtggagc ccagtcatga gcggttgccg atgcgggcgt gtgccgcgcg ggccgccgac
      841 ccggccttgg agggcgggag ttttctatgg ccacgacaga accggtgagt gcgctcaccg
      901 acggaaccgg ccgccgcacg gccgacggcc gcacggcaca gagcgagccg aacgacaaga
      961 accagaacag cccggtggga cacctcccac cggggcacag gctgctgatg gagttgctgc
     1021 gtccctaccg aggacggctc gtcgccgtcc tggtgctgca ggcggtgggc gccctggccg
     1081 gtctcgcccc gctgctcgcc gtgatcgaac tcggccgcga actgctcacc ccgggaccgg
     1141 ccgaccacgg tgccgtgtgg accgccgtgg tctgcggtgc cgcggggctg ctcgtacgaa
     1201 tcctgttcac cgcggcggcc ggcggcatcg gccacctcgt cgacggagag ctgaacctgt
     1261 cgctgcgcag gcaactggcc cagcgcctgg gacggctgcc cctcgggtgg tacgcgcacc
     1321 acagctcggg cgaggtgaac ggtgtggtgc agggcgacgt cgccaccctg caccatctga
     1381 tcgcccacac ccccggcgag ttcacctccg ccgtcgtcgt tcccgtcgcc tcgttcggct
     1441 acctcgcctg ggtggactgg cgcctgacgc tggtcgcgct gatccccgtc ctgctcggcc
     1501 tggcggtgca cctcctgctg tcgacgccgg agcgccgtcg ccagggcacg gccgtgggac
     1561 aggccatggg ccgtatcggc gcctcctccg tggagttcgt ccagggcatt tccgtggtca
     1621 agaccttcgg cgccgcgggc cggatccacc agcgctaccg tcgggccgcc gacgacttcg
     1681 ccgacttctt cctcgggtac gtcgccgaca gcgcgggact ggcctcgctg tccgctctcg
     1741 tcctgtcgcc gcccttcgtg ctgctgctcg tcctcaccgg aggcaccctg ctgatcgccg
     1801 aggactccat gccgcccgtc gacctcctgc ccttcctgct gctctccgtc gcgctgacgg
     1861 caccggtggc agcgctgggc cacggcatgg acaacatcca cgccgccgag cagtccgccg
     1921 accgcatcca ccggttgctc agcgtccgcc cgctgccgca gccggcccgc ccggccgtcc
     1981 cgcacgggga ccgggtggag taccgcggcg tcggcttcgc ctacgacgac ggccacccgg
     2041 tcctgcacga catcgacctc atcctggagc ccggcaccac caccgccctc gtgggtccct
     2101 ccggcgccgg caagtccacc ctcgcacaac tgctgccacg gttcttcgac ccgacgcacg
     2161 gcacggtcct gctcggcggt gtcgacatcc gcgacatccc cgacgagcag ctgtaccagc
     2221 gggtctcgtt catcttccag gacgtccggc tgctgcgcgc cacggtcgcc gagaacatcg
     2281 cgctggcggt gccggacgcc tcccgctccg cgatcgtcgc cgccgcacgc gcggccggcc
     2341 tgcacgagcg catcgagagc ctgccgcacg gctacgactc cgtgatcggg gaggacgccg
     2401 gcctgtccgg cggcgaggca cagcgcctgg gaatcgcccg cgcactgctc atcgacgcac
     2461 cggtgctcgt cctggacgag gccatgtcgt tcgccgacgc caagaccgag gccgagatcc
     2521 ggcgggccct ggacgtcctg tgcgcgggcc gcacccagtt ggtcatcgcg caccggctgg
     2581 agaccatcac ccgcgccgac aacatcgtcg tcatggagga cggtcgcatc gtggagagcg
     2641 gaacgtaccg ggacctcatg gccgcgggcg gcacgttcgc ggccatgtgg cgggcccagc
     2701 acggccacgg caccgacgca caggaaggac gccactgatg atccggctgc tcctgcgggt
     2761 cctgggcgag tcctatggcc gccccgtgcg tcgcaccgtc gccctgatgt cgttacgggc
     2821 cgtcgtggag ggtttgtcct acgccctgct cgtgccgctg ctgcgcgccc tgctggggcc
     2881 gcacccggcc gacgcctggc cgtggctggg cggtttcgcc gccgcgttcc tgctgtgcgc
     2941 cgtgctcggc taccgcagcg tgctgaccgg cttccgcacc ggcggagagc tctcccgcgg
     3001 actgcaccac cgtctcggcg accagctcgc ccgcctgccc ctgggctggt tcacgccctc
     3061 ccgcatcggg gacgtcgccg ggctgaccag ccgcagcgtg atgcaggtga tgtcggtgcc
     3121 cgcgcaccgg ctcggcccgc tcaacgacgc caccttcgtc ccccttaccg tcgtcgtggt
     3181 cctgttcttc ttcgactggc ggctggcact ggcggcgctc gtcgcggcac cgctgatcgc
     3241 cgcggtgcag cgcgccaccg cacgggccac ggcccgcgag gacgccgaac gcgcgcggcg
     3301 cagcgacgac gcctccgccc gggtggtgga gtacgtccgg gcgcagccgg tattgcgggc
     3361 cggcggccgc accggcgagc gcttccggct gctggacgag gccctgcacg cgcagtggcg
     3421 cagcgagcgg cgcgccgccg tcaaggggct gcccggcatc gtcggcctga gtctcaccgt
     3481 gcagacggtg ttcaccctcg tcctcgtcct cggcgcctac ctcgccctcc acggctccat
     3541 cggcgctccc tcggtcctcg ccctgctcgt gctgtgcgcc cgctgtgtcg atccgctgct
     3601 gtccctggcc gacctgggcg gcgtcatgcg ggcctcacgc ggtgagctgg aacgcatcga
     3661 cgaggtcctg cgggaggagc cgctgccgca gccggagcga ccaagtgtgc ccgcggacaa
     3721 cagccttgaa ctggcggagg tcaccttccg ccgcggcggc cgcaccgtcc tggacgggct
     3781 gagcctgagg gtggaggagg gcaggcggct ggcgatcgtc ggctcctccg gggcgggcaa
     3841 gacgacgctg ctgcagctcg ccgcgcggtt ccacgacgtg gacgccggta cggtccggct
     3901 cggcggggtc gacgtccgcg ccatcgacgg cgacgagctg atgtcccggc tgtccatcgt
     3961 cttccaggac gtctacctgt tcgagggcac catcgaggag aacgtgcgcc tcggccgtcc
     4021 cgatgccacg gcgtccgacg tgcgcggcgc ggccgccgcc gcgcggctcg acgaggtggt
     4081 ggccaggctg ccgcagggct gggacaccca ggtcggagag ggcggtgcgg cgctttccgg
     4141 cggtgagcgc cagcgggtgt ccatcgcccg cgccctgctg aaggacgccc ccgtgctgct
     4201 gctcgacgag gccacctcag ctctggaccc ggagagcgag cgggccgtcc aggagggcct
     4261 ggaccggctc atgcgcggcc gcaccgtcgt catggtcgcg caccggctgc acaccgtgcg
     4321 ggacgccgac agcatcgccc tcctggagga cggccgcatc gtggagtccg gcacccatca
     4381 ggaactgctc gaacgcgatg ggaagtacgc cgagttctgg aagaccgcca cacaccagcc
     4441 agcctgagag gaaccgaggt ggggatggca cgcaagggca cgtcgacagg ctcgtccggt
     4501 tgtacgggta cggggacttc cgcatggacg ccggaagccc tgcgcgccga ggtcgccgcg
     4561 atgctcggca ccgaactgac cgcggcagac gacgacaccg acctgttctc gttgggactg
     4621 cagtcgatcc agctgatgca gctcaccaac cggatcaacc gcgtcggcgg acggacaggc
     4681 ttcactgagc tggccaggga cccacggctc acctcctggc accggctgct gagcagccgc
     4741 acggagaagg aaggggagcg tcccgggccg tccccggcac cgtcccccgc accggggccg
     4801 aagccgttcc ccctcacgcc ggtccagcag gcgtactgga tcggccgggg cgacgaccgt
     4861 ccgctgggcg gcgtcgggtg ccacgcctac ctggagatcg atgcggcgga cgtcgacccc
     4921 ggccgccctg gcccgaatcc acagcggccc ggtaccgggc cgagggatac tggacggacg
     4981 aggtactggg ccgccttccg gacgacgcgg gccgggccga cctgcccgcg gtcgtcaccc
     5041 cggaccgcac cctcacccac ggtcagctcg acctggccgc cgaccgcttg gcgtccgggc
     5101 tgagccaacg gggcatcgcc cccggggacc gcatcgtcgt ccagctgccc aacggtgccg
     5161 acatggtcgt gctgtgtttg gccctgttcc ggctcggcgc cctgcccgtc ttcgcgctgc
     5221 cggcgcaccg caccgcggag atcacccatc tcgtggagtc ctccggggcg gttgcctacg
     5281 tctgcgcaga ccgggtcctg gactgcgacc accgggagct ggcccagcgg atactgaccc
     5341 gcgccggctc gctcaagcac gtcctggtgg ccggggaccc cggcccgttc accgcgctgg
     5401 cggacgccga cgccgacccg gtgtcgctgc cgccgcccga cccctcggac gtggcgctgt
     5461 tcctgctgtc cggaggcacc tcgggaccgc ccaagctcat cccgcgcacc cacgccgact
     5521 acgcctacca gctcagggcc agcgcggcgc tctgcggggt cgggcgggac agccggtacc
     5581 tgtgcgcgtt gcccatgggg cacaacttcg ctctggcctg ccccggcgtg ctcggcacgc
     5641 tccgggcggg cggtacggcg gtactcgcac cggcgcccac ccccgaccag tgcttcccgc
     5701 tcatcgagcg ggcgagggtg agcatcacct cgctcgtccc gccgctggtg ccgctgtggc
     5761 tggacgccgc cgagtggacc gacagcgacc tgtcgtccct gtccctgctg caggtggggg
     5821 gctcccggct cgaccccgcc accgccgcac aggtgccgga ccgcctccgg tgcaccctcc
     5881 agcaggtgta cggcatggcc gaaggcctgc tcaacttcac ccggccggat gacccggagg
     5941 aggtgatcct gcacacccag gggcgtccgc tgtctcccgc cgacgaggtc cgggtgatcc
     6001 gggaggacgg tgcggacgcc gggccgggcg aggtgggcga gctgtacacc cgcggcccgt
     6061 acaccctgcg tggttactac agggccgccg agcaaaaccg gacgaggttc actgcggacg
     6121 gctggtaccg cagcggtgac ctcgtgcgcc gcacggccgc gggcaacctc gcggtggagg
     6181 gccggaccaa cgacgtggtc aaccgcggcg gagagaaggt gccctgccag gaggtcgagg
     6241 agcatctgct ggcggaccca cgcgtcaccg ccgccgcggt cgtggcgctg ccgcacccac
     6301 tgatgggcga gcagacctgc gcgtgcgtgg tgctccgcga cggagagccg gagctgacgc
     6361 ttcgccaggt gcagagcgtc ctgcgagagc gcgggctcgc cgcgtacaag gtgcccgacc
     6421 gtctcgtcgt gttgcagcgg atgcctctca cgggtgtcgg caagatcgac aagagggcgc
     6481 tgcggcacca cctcgcggac tgacgacacg cccctcacgg gggccgcgga agagggctcg
     6541 gggcatccgc tccgagccct tcgccgcgtc ccgggccgat cggtcaggtc gtctggtcca
     6601 gcagccccgc gacgaccgcc tccagaccgc ggcggtgggt gtcccgggtg gtcagctcgc
     6661 tccagcgggc gcccagcatg gtcaggagcg ggaactcctc ggggtctagg ccggtgatct
     6721 ggtcgcggtg cggcggccga tccaggtgcg cgtggcggcg ctcccggttg aagcggacgg
     6781 tgagttcacc ggcggtgtag taccagatga cgcggtaggc gtagacggcg tcctcggggc
     6841 tcatcccgca ctcgatggcg gcgtccagga tgttctcgac gatccacatc gccgagacgg
     6901 cgaagaggtc gtcggaggcg accacctcga cgatccacgg gcaatccacc aggatgtcgt
     6961 gcagaacctg ggcggaggcg aggaggcggg cgcggggctc ggccggcagg tcgggccggg
     7021 gaaacttcgc ggcgtgctcc tcgaggagca gcagcaacag ctcgtccttg tcccgcacat
     7081 agtggtacaa ggccatgggc gtgctggaca tctccttggc gagccgacgc atggagaggt
     7141 tctccgcgcc ctcttcgtcc agaatgcgct gtgcggcgga caggatcgcc tcgcgcgcca
     7201 accggggcgg gcggccggtc ctgccggcgc ggggggttcg gggctgcatc cgtccatctt
     7261 ccgccacttc ccggcccggg cctatggggg attcgtacgt cgtacacggg aacgccacgg
     7321 cgtccggcgc gccgtcgtcg ttgtcgcccc gcccggccca ctcactgtcc cgtacgcgtc
     7381 tgggcgaatt ctggatctct tccgggccgg ccccggaagg cggcggcccg cccgtcagac
     7441 gggtccggcg gcggccggcg caccgcccgc gtcgagggtg cggaagaagc cgtcgaggag
     7501 cgcctgcagc ccggcccggt gcgtgtcgcg tgaggtgagc gcgggccagc ggtccgccag
     7561 ggcgcacagc cggggatggg tctgcggctg cagcgtggcc agtgcccgcg cccggtacgg
     7621 ggggcggtcg cggtgggccg ccaggtgccg ctcccgggtg aggcggatca gcagctcgcc
     7681 tccggtgtag tgggcgacgg cccggtagag gccgacggcc tcctccaccg cgaaaccgca
     7741 ggcgagtgcc gcctccagga ccgcttcgat gacccacagg caggaggcgg tcatcaagtc
     7801 gtcggaggtc aggatctcgc ccaggaacgg gcagtcggcc agcacgtcgt ggagcagctg
     7861 ggccgcggcc gtcagccgct cgcggggatc ctcgggcagc gacggccggg gcaggttccg
     7921 ggccttggtc tccagcagca gccgaaggag ctggtcccgg tcgcgtacgt ggtggtagag
     7981 cgccatcggc gtgatggaca gctcccgggc caagcgccgc atcgacaggc tgccgtcgcc
     8041 ctccgcgtcg atgatccgct gggccgcctc gatgatcgcc tcctgggaca gctgggaggg
     8101 ccgccccatc ctcttccggc ccgtggtgcc cgcttcgctc gaccgcatca gtccccacct
     8161 tccgcatgtg ccgtccgggc cggagcggat gacctccgac agcaccgggt gacaacggat
     8221 cggtcccggg ctagagttat cgtacgcgta cgtaatacgg gtaagaaaac tctggagggc
     8281 ggatgtccgg tacggcctcg aacagggggc aggcgttagt cgcagtcgcc ctcgcccagt
     8341 tcatggtcac cctcgacatg acagtcgtga acgtcgcgct gcccgacatg gaaagcggcc
     8401 tcggtttcga ccctgcccag ctgccgtggg tggtcaacat ctacgcactg ttcttcggcg
     8461 gcttcctgct gctcggcggc cgggcggcgg acctgtacgg ccagcggcgg atcctgctgt
     8521 ccgggacctg ggccttcgcc ctcgcctcgc tcgcgggcgg tctggcccag gagccgtggc
     8581 agatgatcgc cgcccgcgcg gtgcaggggg tgggcgcagc ggtgatggca ccggccgcgc
     8641 tggcggttct caccctcacc cagcgcgagg gcgaggagcg cacccgggcc ctcggtgtgt
     8701 acgccgcggt cgctgcggtc ggcggtggcg cgggcgtact ggtcggcggc ctgctcaccg
     8761 agtacgccgg ctggcgctgg gtgatgctgg tgaatctgcc gatggcgctc gcggtgctcc
     8821 tcctggccct gcgcagcgtc ccagccggca ccttcggcaa cggccggggc cggctcgacg
     8881 tcatcggcgc cgtcctcgcc acgggcggcg tggggttgct gatcctcggc atggtgcgca
     8941 ccgaccagct gtcctggacg tcgccgacga cgatcctcac gctggccgtc gccgtggtcc
     9001 tgctcgtcgc cttcgtcctg tgggagaagt acggcccgat gacggacccg ttgatccgac
     9061 tgtccctgct gacccggcgc aatgtcgccg gcgccaatct gtacatggcc ctgctggcgg
     9121 ccgggcagct cgcggtgttc tacttcctgt cgctgtacct gcaacggatc ctgaagctcg
     9181 ggccggccga ggcgggcgcc gccttcctgc ccctgtgcgt gatcgcgatg atcgcgatcc
     9241 aggtcaccac ccgtgtcctg cgcaggcagt tggtcggcac caagaccctg ctcgtgccgg
     9301 ccggcctgat cgccgcggcg ggattcgcct ggtgcggcat ggccgacgcc tccggcagct
     9361 acctgggaga cgtactgctg ccgtccgtgc tggccggcct cggggtgggc atcgccttcg
     9421 tcccggtgac ggcagcggcg accgtcggac tcccgccgca ggaggccggc acggcctcgg
     9481 ccctgctgaa cgcctcgcgg caggtcggca gcgccctcgg cctcgcggtg ctggtgaccg
     9541 tggcgaccac gcgcaccgac caccgcctgg ccgcgggcgt ctcccccgac acggccgcgg
     9601 tcgagggcta ctccctcggg ttcgtgctgg cgggagggtt cttgctgctg gccgtcctgg
     9661 tggcggcctt cgtactcccg cgccgtcccc ggcccgtcgc cgggcagacg ccgaccgcac
     9721 agcagcccgg taccggggcc cctgccacga tcgacggcac cgggtcgggc ggcacgacat
     9781 cggacatcac cgcgggccgg atgacgccga agtcgtgaac ggaactcgac tccatgcgca
     9841 ccgaaggggc gacggagtcg acgagcgcgg cggcggaggc ttccatcccc cgtcggcctc
     9901 cgccgccgcg tgttctccct gtgcacgcaa tgatattcgg ccaagcggag ggcgggaggt
     9961 tcagcggaaa ctgattaacg ggtatttccc gccctccgat tcaggccgca ccgacatgct
    10021 gaaaccggtc cagcgccttc tcctcgatct gcgggttctc aacgatgcgg tcgagaatct
    10081 tggccagggt gctgccggcg agcgtggcca gtgcgacccc ggtggagaac agcgggtcga
    10141 cgaaggcggc ggagtccccg accagcaccc agccgtcgcc gtagaaacgg ttgctgtggt
    10201 acgaccagtc acgcgccgtg cgaaaaccgg cggactgccg ggcgccggcg agcatcttcg
    10261 ccagcttcgt ggtgcgctgc cgctcggcgt ggaacaggtc ctccagtgac tggccgttct
    10321 caccggcggt ggtcgagcgc gtcacatagc cgacgctgat cgtgcccttg tcgatgggga
    10381 tggcccagaa ccagccgccg tccagaccct cgatgaggat gttggtgtac tcgtccccgg
    10441 gcagccgctc gcagttgtcg aaatacgtcc acaccgcgac gttgcgcagt tcctcgtgcc
    10501 actccacgtc ggtgagccgg cgtccgagca cacgggcctg tcccgaggcg tcgacgacca
    10561 gccgcgcccg cacctcatgc agcccgtcaa ggccgcgcag ggcgaagcgc acgccggtga
    10621 cccggccgtc caccaggacg ggctccttga cggtggcatc ctcgatcacg aaggcgccga
    10681 gctccctggc ccggtccagg atcagcgcgt ccaggtcggc ccgccgggtg tggaaggcgt
    10741 actcgtgcgc gccgccctca atgaacgaga aattccacgg cacctgcttg tttccccaga
    10801 cgagggtgcc gccgtacttc cgctcgaatc cgcgcgcatc catgcgctcg gttattccca
    10861 tttcctgcat ggggcgcatg aaggccggaa tgagggattc tccgacgtga tagcggggga
    10921 aacgctcacg gtccagaacg agaacacggc gaccgcgctg cgcgagaagc ccggcggtgg
    10981 tcgctccggc tggtccaccg ccgatgacga tcacgtcgta ttcatcaggg accccgaaaa
    11041 gagcggacga cattctggac ctccctagtg gctgtgtggt cacgttcgga agccggaaaa
    11101 cccctgcatc gctgtccgac cggaacgcgc ggccagtttg caggacccct tctgtaaggg
    11161 ctctgcacgt tgtctggacc cttcctgggc acacagctcg cgagcactgg aaagtgcgcc
    11221 tcgcgcgcat cggtcctgcg gccgtccagg cagggtggtg acgtaggaac ggcccacaac
    11281 ccggcctcca gttcctcctc tgcatggcct tgttctcgcc ctgggcagag acgggcgcga
    11341 tccgactggc tactgccacc ggacgaagcc atcggcaggg aactcacccc tccgtcagca
    11401 cgggtcgaga cgatctcgat ggctgcatgg acatcgctgt tcctccgtga tgtggtcccg
    11461 tcactcaagt cggaccaccc cgccgggcag ccggccctcc cagtagccgt cgatgagaag
    11521 gggcaggatc tcaggtccac ggcgacgcag ctgtcccgca gtccggccgt actccaccag
    11581 tgggcgccgg ggtccatcag ggcgggctcg tacatcctgc ggccggtcgg cagtcgcggt
    11641 gctgccagga tgatgtactc cgcgctcacc cgagaggcgc cagccgggag atgtccgatc
    11701 acggcgccga cacggagcgc cgggatcctt cgttcccggc gcagacatcg caccgcggtg
    11761 caggcggaca tggtcgcgct tccgcgcgat ggggtgagag ggctcgacag aggcaacgcg
    11821 ccggaggctg aaggtgacct gccgtcaggt ggtgctttgg ccgggctcgg tggttgcagg
    11881 cgtatgtcgt cgagtgctta ccgggcttcc tccgccgacg gttcgaggtg cgctggggtc
    11941 catacaacct ccggcaggtg tggttgcgct ccggggatga cgaatggctc gccgtcaccc
    12001 gcgcccttga ccacggcggc ggcccgttgc ccgtcggctc caccgacccc gacgtcgtcc
    12061 caacccctga tcaccgcctt ctccgtcgac aagccagcca tcgcccggac aggtaggagt
    12121 cgaagccctt cagcacatcg acgaccggcc acgccgccgt ccgacccggc gccgcagggc
    12181 caagccgacc ggcagctgga cccccaggac cgcttcaccc agccctgaga tattcatcac
    12241 agatggtgcc cagccagagc ggcccaacca aagatccaca acgcgaagcg ggccgccgaa
    12301 gaccacccag ggtctttcgt tggatcaggc cggatcaggg agcggggcct ggtgccgtgc
    12361 atcacaaggc ggaggagggc gccatggcga gccatggcaa ccgacgacaa cgcggcggtg
    12421 ggggtccctc ccgcgcgagc gaagccgagc gtgggggaag ggtgccaggc cccgcgagcc
    12481 cggcctgatc caaacgagag gccctagacc acctagccct cggcggcccg cccacgcatg
    12541 cctcgtagac aagcgtcaca gcatgaataa gcacagggaa agaggaatgg gcgacatcgt
    12601 catcacgatg ccgcccattc catcggtgca gctagagcac cttcgtcggt gctcctctgt
    12661 gcgcgagggg ggagttgaac ccccacgccc ttgcgggcac tggaacctga atccagcgcg
    12721 tctgcctatt ccgccacccg cgcattgggt gtgtcttccg gctccgttcc tttcggcccg
    12781 gcgccttccg acacccagaa cattagcacg cccgtggagg tggattcaca tccccgcccc
    12841 cgggcgcccc tggtcacccc cggggcgcgc cccgcacgcc gcgcctccgt ctcgacggag
    12901 gtccgttcac gtatcaacct cgtaccggtc cctcccgtct ccccaggagc cgggcggggt
    12961 ccacagccgg gtgcgggaca ctggtctgcg accgcctcta cgatcctggg cagaagtacg
    13021 gacagcacac ttctccacgc gttcgaagag gagcgccgca gggaacgtcg tcaggcgacg
    13081 gcaggcatcg gcgggagtcg gtgggcgtcg gcgggagccg gcgggcgtcg acaccggtcg
    13141 accgggccga cagggggaac cagccgatcg accggcgcgt ggatacgatc agtaagcagt
    13201 accaagtagg cagcacgcag gtaagcagta cgcggacagg cagagcacag ggcggcagcg
    13261 gcggaggagg tgccccatgg gagtcctgaa gaagttcgag cagcgtctcg aaggtctggt
    13321 caacggcacc ttcgccaagg tgttcaagtc cgaggtgcag cccgtggaga tcgcgggagc
    13381 gctccagcgg gagtgcgaca acaacgcgac catctggaac cgggaccgca cggtcgtccc
    13441 caacgacttc atcgtggagc tgagcacgcc ggacttcgag cggctcagcc cctactccgg
    13501 gcagctcggc gacgagctgg ccggcatggt gcgcgactac gccaagcagc agcgctacac
    13561 cttcatgggc cccatcaagg tccacctgga gaaggccgac gacctcgaca ccggcctgta
    13621 ccgcgtgcgc agccgtacgc tcgcctcctc cagcagccag caggaccccg gagcgcccgc
    13681 ggcccctccg gccgggcgcc ccggtggcta cggctacccg cccgccgcgc ccgcgccgcc
    13741 cgccggcgcc ccgcccatgc cgtccgcgcc gccgcccggc gccccggcgg ggcggcccgg
    13801 cggatacggc tacccaccgc ccgcgagcgc cccgcggccg ccggccgccg cggccggcgg
    13861 gcgcacccgc cactggatcg agatcaacgg cacccgccat cagatctccc gcccgacgat
    13921 ggtgctgggc cgcagcaccg acgccgacgt gcggatcgac gaccccggcg tgagccgccg
    13981 gcactgcgag atccggaccg gaacgccctc gacgatccag gatctcggat ccaccaacgg
    14041 catcgtggtg gacgggcagc acaccacccg cgctacgctc cgcgacggct cgcggatcgt
    14101 cgtgggcagc accaccgtta tctataggca agccgaaggg tgatccgggg gcaatgtcag
    14161 agctgaccct cacggtcatg cggctgggtt ttctggccgt actgtggctg ttcgtgatcg
    14221 tggccgtgca ggtcatccgc agcgatctgt tcggtacgcg cgtcacccag cgcgggtctc
    14281 gacgggacgc gggccgcgcg cagcaggccg cgcgccaggc gccgcccccg cagcgccagc
    14341 aggcgagcgg aggccgggcg cggcgcaacg ctcccaccaa gctggtggtg accgaaggca
    14401 cactcacggg cacgaccgtc gccctgcagg ggcagaccat caccctgggc cgggcccacg
    14461 actcgacgat cgtgctggac gacgactacg cctccagccg ccatgccagg atctacccgg
    14521 accgcgacgg ccagtggatc gtcgaggacc tgggctccac caacggcacc tatctggacc
    14581 ggacccggct gacgaccccc acgccgattc cgctgggcgc gccgatccgc atcggcaaga
    14641 ccgtcatcga gctgcggaag tagtgctacg tcatgaatga gcgcgagcgg agcgagcacg
    14701 cagcggcggt cccccgcgag gatcccggcg cgctcccgac cggagggtgg gcagtgtggc
    14761 tcgacacgac cggctgcatg cggagccgac gggcgaggtg cgcatgagtc tgtcactgcg
    14821 cttcgccgcc ggatcccaca ggggcatgat ccgggagggc aacgaggact ccgggtacgc
    14881 cggtccgcgc ctgctcgcca tcgccgacgg catgggcggc caggcggccg gcgaggtcgc
    14941 ctcctccgag gtgatctcca ccatcgtccc cctcgacgac gacgtgcccg gttccgacat
    15001 cctcacctcc ctcggcacgg ccgtccagcg ggccaacgac cagttgcggc agatggtgga
    15061 ggacgacccc agcctggagg gcatggggac caccctgacc gcgctgctgt ggaccgggca
    15121 gcggctcggg ctcgtccacg tcggcgactc gcgcgcgtac ctgctgcggg acggcgtgct
    15181 gacgcagatc acgcaggacc acacctgggt gcagcgcctg gtcgacgagg ggcgcatcac
    15241 cgaggaggag gcgaacaccc atccgcagcg gtcgctgctg atgcgggcgc tgggcagcgg
    15301 cgaccacgtc gagcccgacc tgtcgatccg cgaggtgcgc gccggtgacc ggtacctgat
    15361 ctgctccgac gggctgtccg gtgtcgtatc ccaccagacg ctggaggaca ccctcgccag
    15421 ctaccagggc ccccaggaga ccgtgcagga gctgatccag ctcgcgctgc gcggcggcgg
    15481 gcccgacaac atcaccgtca tcgtcgccga cgtcctggac ctggacaccg gcgacaccct
    15541 caccgggcag ctctccgacg ccccggtcgt ggtcggtgcc gtggccgaga accagcacca
    15601 gatcggcgac aacggcatca tgcagacccc ggcgggccgc gccgccggcc tcggccgcca
    15661 cgcgcgcggg aagggcggcg ggggcggcga gttcgggccg cccggcagcg gtgacacgac
    15721 gggctacatc ccggccgggg acttcgccga ccacggcgac ggcgacttca ccaagccgca
    15781 caagaaccgc aggtggctca agagctcctt ctacaccgtg ctggccctcg ccgtgatcgg
    15841 cggcgggctg tacggcggct ggcgctggac gcagacccag tactacgtcg gcgccaagga
    15901 agggcatgtc gcgctgtacc gggggatcag ccaggacctg gcctgggtgt cgctgtcgaa
    15961 ggtcgagaag gaccaccccg agatcgaact caagtacctg ccgccctacc agcagaagcg
    16021 ggtcaaggcg accatcgccg agggcggtct gaagaacgcc caggcgaaga tcgaagagct
    16081 gtcggtacag gcctccgcct gcaggaagca ggccgagcgg cgtgccgcag agagcgagag
    16141 caacgcgaag acgggcgagg cccgggccgg gggcgccacg ggggcctccc ccatctcctt
    16201 cacctccaag gccacgccgg ctccggaccc gacgggttcg ccgtcgggtg ccgcgtccgc
    16261 cccgtcgacg tcgtccccgt ctccgtccac gaccgcaccc actctcagcc ccggccccag
    16321 cctctcggag gaagagcaga aggtcgtctc gctgtgcggt aagcagtagg caagccgtga
    16381 gaggccctgt tacacgatga gcagtacgaa cacgccgcac tcgccggcgc accacacgtc
    16441 cacgatcggc gcgatcggcg cacccagccg ccgcaacacc gagctcgcac tgctggtgtt
    16501 cgccgtcgtc atcccggtct tcgcctacgc caacgtgggc ctggccatca acgacgaggt
    16561 gcccgcgggg ctgctgagct acgggctcgg cctcggcctg ctggccggcg tcggccacct
    16621 ggtcgtacgg aagttcgccc catacgcgga cccgctgttg ctgccgctgg ccacgctgct
    16681 gaacgggctc gggctggtcg ccatctggcg gctggaccag tccgaactgc tgcagtcgat
    16741 caagcaggcg ggaaccgcgg caccccggca gctgctgtac acggcgatgg gcatcgcgct
    16801 gttcatcgcg gtggtgatct tcctcaagga ccaccgcgtc ctccagcgct acacctacat
    16861 ctccatggtc ggcgcgctct tcctgctgct gctgccgctg gtcccgggcc tcggccagaa
    16921 catctacggc gccaagatct ggatctccgt cgcgggcttc tccatccagc ccggtgagtt
    16981 cgccaagatc gtgctggcgg tgttcttcgc gggctacctg atggtcaagc gggacgcgct
    17041 ggcgctggcg agccgccgct tcatggggct gtacctgccg cgcgggcgcg acctcggccc
    17101 gatcctcgtg gtctgggcga tctcgatcct gatcctggtc ttcgagaccg acctcggtac
    17161 ctcgctgctc ttcttcggca tgttcgtgat catgctgtac gtcgccaccg agcggaccag
    17221 ctggatcgtc ttcggtctgc tgatgtccgc cgccggcgcc gtcggcgtgg ccagcttcga
    17281 gccgcacatc cagcagcgcg tggacgcctg gctcgacccg atgcgcgagt acacgctctc
    17341 ccgcgccaac caggtcggcc actccgagca ggccatgcag gcgctgtggg cgttcggctc
    17401 cggcggcacc ctcggcaccg gctggggcca gggccactcc gacctgatcc ggttcgccgc
    17461 caactccgac ttcatcctcg ccaccttcgg cgaggagctg ggcctggccg gcgtgatggc
    17521 actgctgctg ctgtacgcgc tgatcgctga gcgcggcgtg cgcaccgccc tcgccgcccg
    17581 cgacccgttc ggcaagctgc tcgccatcgg tctgtccggc gccttcgccc tccaggtctt
    17641 cgtcgtcgcc ggcggtgtga tgggcctcat cccgctgacc ggtatgacga tgccgttcct
    17701 ggcgtacggc ggttcgtccg tcatcgccaa ctgggccctg atcggcatcc tgctgcgcat
    17761 cagcgacacc gcccgccgtc cggcgcccgc tcccgccgcc aaccccgacg ccgagatgac
    17821 ccaggtggtc cgcccgtcat gaacaagccc ctgcgccgga tcgcgatctt ctgcggcctg
    17881 ctgatcctca cgctgctcat ccgggacaac tggctccagt acgtcaaggc cgacgacctg
    17941 aagaacgacg agcacaaccg ccgcgtcgcc atcgcccggt acgccagccc gcgcggcgac
    18001 atcatcgtcg acggcaaggc catcacgggg cacgcgacga ccgacggcga cttcaagtac
    18061 aagcgcacct acaaggacgg cgcgatgtgg gcgccggtga ccgggtacgt ctcgcaggtc
    18121 tacggcgcca cccagctcga ggccatcgac gacggcatcc tcaccggcaa cgacgaccgg
    18181 ctcttcttcc gcaacaccct cgacatgatc acgggcaagc agaaggaggg cggcaacgtc
    18241 gtcaccaccc tcaacgccgc cgcgcagaag gccgcgtaca acggcctgaa ggcgcagggc
    18301 ggcaagggcg ccgtggtcgc cctggagccg tccaccggca agatcctggc gctggcctcc
    18361 ttcccgtcgt acgacccgtc gacgatcgcc ggcgacggcg cctcggacgg cgaggcgtgg
    18421 cagaagctcc agaagaagaa caacccggcc gacccgatgc tgaaccgggc gctgcgcgag
    18481 gtctacccgc ccggctccac cttcaaggtg gtcaccgccg cggcggccct ggagcacggc
    18541 aagtacacgg acgcggacgc caagaccgac accccgctgc cgtggatcat gccgggtacg
    18601 acgaccccgc tgaagaacga gggcaacatc ccctgcgagg acgccacctt gcgggtcgcc
    18661 ctccagtact cctgcaacac cgtcttcggc aagatcggcg ccgacctcgg caacgagaag
    18721 atgctggaga cggccaagaa gttcggtttc acggaggagc agttcacgcc ggtgcgctcc
    18781 agcgcctcgg tcttctccga cgacatgaac gactcgcaga ccgcgctgtc ctccatcggc
    18841 cagttcaaca cggcggccac cccgctgcag atggccatgg tcgcctcggc cgtcgccaac
    18901 aacggcacgc tgatgaagcc gtacatggtc gacgagctcc aggccccgaa cctcgacacc
    18961 atcgagaaga cggaccccga ggagtacagc aagccgctgt ccgcggagaa cgcgcagatc
    19021 ctccagtcga tgatggagac cgtcgtcaag gacggcaccg gcaagaacgc gcagatcccc
    19081 ggggtcaccg tcggcggcaa gaccggtacc gcccagcacg gcgtggagaa cagcgagaac
    19141 ccctacgcct ggttcatctc ctacgccaag cagagcgaca acagctcccc ggtcgccgtg
    19201 gccgtggtcg tcgaggacga gaacgccaac cgtgacgaca tctccggcgg cggcctggcg
    19261 gcgcccatcg cgaagagcgt gatggaggcc gtcatcaaga gcaagaagtg aggccgcggc
    19321 agcggccgga gcacggcgcg tgagcggaac accccgtacg tccgggcggc gagcgtccgc
    19381 acgtacgtga ctccgctcac gtccgtgtca catcggtgca cgttgcgata ccggtcctgt
    19441 atcggctgac cggctttggc caggtcacac aaagcgagcc gggtacggta ggcccggacg
    19501 gcagtctgcg gccgcacacg cgtgccggtc gggaccgacg gagagggctg gtaggtaacc
    19561 atggaagagc cgcgtcgcct cggcggccgg tacgagctgg gccaagtgct cggccgtggt
    19621 ggcatggcgg aggtctacct cggacatgac acccgcctcg gccgcaccgt ggcggtgaag
    19681 acgctgcgcg cggacctcgc gcgcgacccc accttccagg cccggttccg ccgggaggcc
    19741 cagtcggccg cctcgctcaa ccaccccgcg atcgtggcgg tctacgacac gggcgaggac
    19801 tacatcgacg gggtctccat cccctacatc gtcatggagt acgtcgacgg ctccaccctg
    19861 cgcgaactgc tgcacagcgg ccgcaagctg ctgccggagc gcgccatgga gatgaccatc
    19921 ggcatcctcc agggcctgga gtacgcccac cgcaacggca tcgtccaccg tgacatcaag
    19981 ccggccaacg tcatgctgac gcggggcggc caggtcaagg tgatggactt cggcatcgcc
    20041 cgcgccatgg gcgacgccgg catgacgatg acgcagacgg cggcggtcat cggcaccgcc
    20101 cagtacctct cgccggagca ggccaagggc gagcaggtcg acgcccgctc cgacctgtac
    20161 tccaccggct gcctgctgta cgagctgctg acggtccgtc cgcccttcgt cggcgactcc
    20221 ccggtcgcgg tggcctacca gcacgtccgg gaggagccgc aggcgccgag cgtcttcgac
    20281 cacgagatca cgcccgagat ggacgcgatc gtgctgaagg cgctggtcaa ggagccggac
    20341 taccgctatc agtcggccga cgagatgcgc gccgacatcg aggcgtgcct cgacgggcag
    20401 ccggtcgccg ccaccgcggc gatgggtgcg gcgggctacg gcggctactc cgacgaccac
    20461 cagacgacgg ccctgcgcgc cgacgccggc gggcacgggg gcgccacgac ggtgctgccg
    20521 ccgatgaacc cggacgacgg cggctacggc tacgacgacc gccccgaccg gcgccggcag
    20581 aagaagtcgt ccacctccac cgtcctgctg gtcctggcgg gcatcctcgt cctggtcggc
    20641 gccatcctga tcggcaagta cgcggtcggc aacggcgggg gcggcgacga ccaggtcgcg
    20701 gtgcccgacc tcgtcggcca gacgcaggag gcggccgggg acctgctgac caacgtcgac
    20761 ctgaaggtgg ggacggtcac gcgggagccc tgcgaggagc agcccaaggg caaggtctgc
    20821 gagcaggacc cggcccaggg ccgcgaggtc gacaagcaga ccacggtcaa cctggtggtc
    20881 tccacgggcg ccccgaaggt gacggtgccg agcgtgatcg gcctgagcct ggaggaggcc
    20941 cagtcgaagc tggagggcga cgactaccag ttcaaggtca agacggagga gcgcgagacc
    21001 tccgacaccc cgggcaccgt cctggaccag gacccggtca agggcaacga ggt
//
