LOCUS       LN831790               21877 bp    DNA     linear   BCT 17-JUN-2020
DEFINITION  Streptomyces leeuwenhoekii strain C34 (= DSM 42122 = NRRL B-24963)
            genome assembly, chromosome: chromosome.
ACCESSION   LN831790
VERSION     LN831790.1
KEYWORDS    .
SOURCE      Streptomyces leeuwenhoekii
  ORGANISM  Streptomyces leeuwenhoekii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-02-26 04:50:55
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 6314410
            Orig. end    :: 6336287
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21877
                     /aStool="rule-based-clusters"
                     /category="saccharide"
                     /contig_edge="False"
                     /core_location="[10000:11877]"
                     /cutoff="20000"
                     /detection_rule="minimum(2, [Alpha-amylase,
                     Alpha-amylase_C, Bac_transf, CBM_48, Capsule_synth,
                     DegT_DnrJ_EryC1, Epimerase_2, Glyco_tran_28_C,
                     Glyco_transf_28, Glyco_transf_8, Glyco_transf_8C,
                     Glyco_transf_9, Glycos_transf_1, Glycos_transf_2,
                     Glycos_transf_4, MannoseP_isomer, PIG-L, Poly_export,
                     Polysacc_synt, Polysacc_synt_2, RmlD_sub_bind, Wzy_C,
                     dTDP_sugar_isom])"
                     /neighbourhood="10000"
                     /product="saccharide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11877
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="minimum(2, [Alpha-amylase,
                     Alpha-amylase_C, Bac_transf, CBM_48, Capsule_synth,
                     DegT_DnrJ_EryC1, Epimerase_2, Glyco_tran_28_C,
                     Glyco_transf_28, Glyco_transf_8, Glyco_transf_8C,
                     Glyco_transf_9, Glycos_transf_1, Glycos_transf_2,
                     Glycos_transf_4, MannoseP_isomer, PIG-L, Poly_export,
                     Polysacc_synt, Polysacc_synt_2, RmlD_sub_bind, Wzy_C,
                     dTDP_sugar_isom])"
                     /neighbourhood="10000"
                     /product="saccharide"
                     /protocluster_number="1"
     cand_cluster    1..21877
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(2, [Alpha-amylase,
                     Alpha-amylase_C, Bac_transf, CBM_48, Capsule_synth,
                     DegT_DnrJ_EryC1, Epimerase_2, Glyco_tran_28_C,
                     Glyco_transf_28, Glyco_transf_8, Glyco_transf_8C,
                     Glyco_transf_9, Glycos_transf_1, Glycos_transf_2,
                     Glycos_transf_4, MannoseP_isomer, PIG-L, Poly_export,
                     Polysacc_synt, Polysacc_synt_2, RmlD_sub_bind, Wzy_C,
                     dTDP_sugar_isom])"
                     /kind="single"
                     /product="saccharide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21877
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="saccharide"
                     /region_number="41"
                     /rules="minimum(2, [Alpha-amylase, Alpha-amylase_C,
                     Bac_transf, CBM_48, Capsule_synth, DegT_DnrJ_EryC1,
                     Epimerase_2, Glyco_tran_28_C, Glyco_transf_28,
                     Glyco_transf_8, Glyco_transf_8C, Glyco_transf_9,
                     Glycos_transf_1, Glycos_transf_2, Glycos_transf_4,
                     MannoseP_isomer, PIG-L, Poly_export, Polysacc_synt,
                     Polysacc_synt_2, RmlD_sub_bind, Wzy_C, dTDP_sugar_isom])"
                     /tool="antismash"
     misc_feature    complement(618..627)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            1884..2858
                     /gene="sle_53870"
     CDS             1884..2858
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VWE0"
                     /db_xref="InterPro:IPR001126"
                     /db_xref="InterPro:IPR017961"
                     /db_xref="InterPro:IPR036775"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VWE0"
                     /gene="sle_53870"
                     /product="DNA polymerase IV"
                     /protein_id="CQR64844.1"
                     /transl_table=11
                     /translation="MTILCVRFQLPPMYEAALPRLLGMLEEFTPVVQALPPDGALADLR
                     GAERYFGRGAVELASVIRVRALALYGVDCVIGAAPGPMLARMALRDARPGATCVVPGDP
                     EGIAEFLAGKPVAALPGVGAATARTLCEYGLDTLGRVAAAPLSTLQRLVGAKTGRELRE
                     KAGGVDRGRVVPNGVSRSLAAERPFERDELDPDRHRRALLSAAEELGSRLRALDKVCRT
                     LTLTVRYADRSATTRSRTLPEPTAHSASLTRAVYGMYEALGLQRARVRALALRAEGLGP
                     AEQAAHQLTFDPVDEKVRRIEEVADRARAKFGPRAVMPGTLAA"
     gene            complement(2890..3909)
                     /gene="sle_53880"
     CDS             complement(2890..3909)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VYM4"
                     /db_xref="InterPro:IPR004302"
                     /db_xref="InterPro:IPR014756"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VYM4"
                     /gene="sle_53880"
                     /product="GlcNAc-binding protein A"
                     /protein_id="CQR64845.1"
                     /transl_table=11
                     /translation="MPARRTAAVAAAGIAPLVLTALAASPASAHGTMGDPVSRVAQCYA
                     EGAESPKSAACKAAVAAGGTQALYDWNGIRIGDAGGRHRELIPDGKLCSADSEEFKGLD
                     LARDDWPATSVTSGAHTFKYRVTAQHKGTFTVYVTKPGYDPARPLAWSDLDLEHPVATV
                     TDPVASGGFYTFSGSLPERSGKHLLYAIWQRSDSPEAFYSCSDVSFGGGATAGGGSAPA
                     PTASTPSGAQIEAGTGRSTIENHGHGDHDARTTADPAGGTGSTRTPAVGADAPDTGEGE
                     PAAAGANRAQAAGTELAETGGDGTTAYLAVGGAAALALGAAALFASARRRAVRTGHGR"
     gene            4097..4570
                     /gene="sle_53890"
     CDS             4097..4570
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W6J7"
                     /db_xref="InterPro:IPR000182"
                     /db_xref="InterPro:IPR016181"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W6J7"
                     /gene="sle_53890"
                     /product="Acetyltransferase"
                     /protein_id="CQR64846.1"
                     /transl_table=11
                     /translation="MIDHVAHQPVRPAVTEDVPAVKAVTDAAYHHYIERIGVVPQPMEA
                     DHAADVAAGKVFVTEEPGGGRVVGLVVVEARADHLFLDSIAVHPDAHGKGVGRRLLAFV
                     DAHARALGLPEVRLYTNAMMWENQKIYPKYGYEVVERRVDGPYDRVHYRKRLR"
     gene            complement(4611..4745)
                     /gene="sle_53900"
     CDS             complement(4611..4745)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W4S8"
                     /gene="sle_53900"
                     /product="Hypothetical Protein sle_53900"
                     /protein_id="CQR64847.1"
                     /transl_table=11
                     /translation="MRRVTVHKPLKKTDARRIREEADERPAGRPEIRKDIARTWWPDG"
     gene            4910..5593
                     /gene="sle_53910"
     CDS             4910..5593
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W276"
                     /db_xref="InterPro:IPR013216"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W276"
                     /gene="sle_53910"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 94.8; E-value: 1e-28)"
                     /gene_kind="biosynthetic-additional"
                     /product="Methyltransferase Type"
                     /protein_id="CQR64848.1"
                     /transl_table=11
                     /translation="MAPDTGEPGDGPVKQGAGGGGADSAAPRVDWDAAAAAFDDEPDHG
                     LRDADVRRAWSGRLRSWLPARPGDVLDLGCGTGSLSLLAAEQGHGVTGVDLSPAMLERA
                     RAKLAGHDAVFLTGDAALPPVGERCFDAVLVRHVLWTLPEPARVLRHWRSLLRPGGRLV
                     LVEGVWGSTAPVGIPADRLAALLAPLAGRTRVEHLSGDPALWGRAVDDERYAVVWSSPV
                     TRTTP"
     gene            complement(5648..5863)
                     /gene="sle_53920"
     CDS             complement(5648..5863)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VWE4"
                     /db_xref="InterPro:IPR016181"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VWE4"
                     /gene="sle_53920"
                     /product="Acetyltransferase"
                     /protein_id="CQR64849.1"
                     /transl_table=11
                     /translation="MTTAMTGTARAFRGRGLAKLVKNASLHRARAAGVTEAFTGNDTGN
                     GPMLAVNKWLGYEVCATEVRHARRLG"
     gene            6704..7078
                     /gene="sle_53930"
     CDS             6704..7078
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VYP9"
                     /db_xref="InterPro:IPR000524"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VYP9"
                     /gene="sle_53930"
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 76; E-value: 5.6e-23)"
                     /gene_kind="regulatory"
                     /product="GntR Family Transcriptional Regulator"
                     /protein_id="CQR64850.1"
                     /transl_table=11
                     /translation="MTLKIHVEDGVPPYEQVRAQISEQARSGALPVGYRLPTVRGLAES
                     LGLAANTVAKAYRALEADGVIETRGRNGTFVAAAGSAAERQLASAAQTYAERARRLGLG
                     QADALAAVRDALRAAYGTRE"
     gene            complement(7185..7955)
                     /gene="sle_53940"
     CDS             complement(7185..7955)
                     /codon_start=1
                     /db_xref="InterPro:IPR002763"
                     /db_xref="InterPro:IPR036520"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W6K0"
                     /gene="sle_53940"
                     /product="UPF0759 protein yecE"
                     /protein_id="CQR64851.1"
                     /transl_table=11
                     /translation="MTLYVGTSGWQYKDWRGVLYPEGCPIRRWLEEYAAGFATVESNNA
                     FYRLPSPETFAAWRERTPPDFVVAVKASRFLTHVKRLREPEEPVHRLLAHAAGLGDRLG
                     PVLLQLPPTLRADAELLDACLACFPPGVRVAVEPRHPSWWTPEVHEVLRARGAALCWAD
                     VLSRPVTPLWRTAGWGYVRFHQGRALPWPHYGRRALAAWAARVAAAWPEPADVYAYFNN
                     DPNAAAVRNAVSFAGLARAAGLTVTRTPGHLAPV"
     gene            complement(8034..9128)
                     /gene="sle_53950"
     CDS             complement(8034..9128)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W4T1"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR003959"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W4T1"
                     /gene="sle_53950"
                     /product="ATPase"
                     /protein_id="CQR64852.1"
                     /transl_table=11
                     /translation="MSANPHDALPIRLHVDDSDSPPDVVDALFLGRFATGEQPYSHAMN
                     IDRVRSGATLLPPGARVLRAARDDDRSATLAEGDGWTVLVSRWNRGADVTVTATSAELA
                     QKVLDQATDGAADEPEPQPENVTMGFWYVSPRRGPHRTTRQITAGTWEEVRPNYTAPVA
                     EAMDRLMKTSPEDIAGRLLLLHGPPGTGKTSALRTLARSWRDWCQVDCVLDPERLFSDV
                     GYLMDIAIGEEDAAGKGRWRLLLLEDCDELIRGEAKHTAGQALSRLLNLTDGLLGQGRN
                     VLVGVTTNEDLERLHPAVVRPGRCLARIEVGPLTRTEAVSWLGREEGVGRDGATLAELY
                     ALRRGTSPTALPEPRGGADAGLYL"
     gene            complement(9208..10008)
                     /gene="sle_53960"
     CDS             complement(9208..10008)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W281"
                     /db_xref="InterPro:IPR002509"
                     /db_xref="InterPro:IPR011330"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W281"
                     /gene="sle_53960"
                     /product="Putative polysaccharide deacetylase yxkH"
                     /protein_id="CQR64853.1"
                     /transl_table=11
                     /translation="MSEEPVPILMYHAVAAEPNDATRDLSVTPEAFAEQMAIVADRGRT
                     PVTTSELAAAWRSGRPLPDRPVLITFDDGYEGVHRHALPALAGHGFRATLFVSTGWLRG
                     PHDTGGALDTMLDWDQVRELAGAGVEIGGHSHSHPQLDQLDDERLRSELVRCQEIVAGQ
                     LGAAPVSFAYPYGYSDRRVRRAVREAGYAQALAVGNGTARRSQGPYALRRVTVRRGTGP
                     AAFERLIEGRAIARAFARDRALTKGYAVVRRARQVCGRVARARA"
     gene            complement(10001..11044)
                     /gene="sle_53970"
     CDS             complement(10001..11044)
                     /codon_start=1
                     /db_xref="InterPro:IPR001173"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VWE6"
                     /gene="sle_53970"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     saccharide: Glycos_transf_2"
                     /gene_kind="biosynthetic"
                     /product="Succinoglycan Biosynthesis Protein"
                     /protein_id="CQR64854.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 9.8e-22,
                     bitscore: 76.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPGVSVVICAYTEDRWEDLRAAVSSVRAQSHPALETLLVVDHN
                     EALRERLAAEYGEAGEVRVLANAGPRGLSAGRNTGIAASRGEVVAFLDDDAVAERDWLR
                     HFAEGYDDPRVMAVGGRTVPVWASGRRPAWFPEEFDWVVGCTYRGLPPGRVRVRNVLGG
                     NASFRRGAFDAAGGFATGIGRDGDKRPLGCEETELCIRLSRARPDAVLLIDDRAVIHHR
                     VPEAREHFAYFRTRTYAEGLSKALVARSVGADKGLESERRYATRVLPAGVARGLRDALL
                     ARPGGAGRAGAIVAGVLTAAGGYVVGSVRARRGGATFSVPPVPPVPPVTTGTRGLPATR
                     AEGDADV"
     gene            complement(11041..11877)
                     /gene="sle_53980"
     CDS             complement(11041..11877)
                     /codon_start=1
                     /db_xref="InterPro:IPR001173"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VYQ0"
                     /gene="sle_53980"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     saccharide: Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 193.5; E-value: 9.4e-59)"
                     /gene_kind="biosynthetic"
                     /product="Uncharacterized protein MJ1222"
                     /protein_id="CQR64855.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.7e-22,
                     bitscore: 78.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVLQPAAADQDPPSADPATAAGKYRPVSSHLAIAPPVSVVIPA
                     MNEAENLPYVFKTLPDWIHEVVLVDGNSTDRTVEVARELWPGVKVVEQRGRGKGDALIT
                     GFQACTGDIIVMVDADGSADGQEIVSYVCALVSGADFAKGSRFANGGGTDDMTLVRRLG
                     NAALCTVVNRKFGARYTDLCYGYNAFWRHCLDKIDLDCTGFEVETLMNIRVVKAGLKVQ
                     EIPSHEYLRIHGTSNLRAVRDGLRVLGVILRERSNRRALRARTPAPVIGTVRGKVS"
     misc_feature    12044..12059
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    12227..12247
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            12585..13391
                     /gene="sle_53990"
     CDS             12585..13391
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W6K3"
                     /db_xref="InterPro:IPR013830"
                     /db_xref="InterPro:IPR036514"
                     /db_xref="InterPro:IPR037460"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W6K3"
                     /gene="sle_53990"
                     /product="Lipase 1"
                     /protein_id="CQR64856.1"
                     /transl_table=11
                     /translation="MRRSRIAGFLASLLLATGTALAGTATAQASPTAVSGDYVALGDSY
                     SSGVGAGSYISSSGDCKRSTKAFPQLWAAAHAPSAFHFTACSGARTGDVLAGQLGPLGS
                     ATGLVSLSVGGNDAGFADVMTTCVLQSDSSCLSRINTARAYVDSTLPGQLDKVYTAIRD
                     RAPNARVIVLGYPRFYQLGTSCLGLSETKRKAINDASDHLNTAIAKRVADHGFTFGDVR
                     ATFTGHEICSGSAWLHSVNWLNIGESYHPTAAGQSGGYLPAFDRAA"
     misc_feature    complement(13829..13842)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(14038..14048)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            14043..14312
                     /gene="sle_54000"
     CDS             14043..14312
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W4T3"
                     /gene="sle_54000"
                     /product="Conserved Hypothetical Protein"
                     /protein_id="CQR64857.1"
                     /transl_table=11
                     /translation="MEQITVRSRARVPAITCGSSATSSRLDRHLAVLAGPAVPQRETVE
                     AMSLMRELTARDTAHDRSGRGARMRRVSLFAPLRRLRRSLFGGS"
     gene            complement(14647..15813)
                     /gene="sle_54010"
     CDS             complement(14647..15813)
                     /codon_start=1
                     /db_xref="InterPro:IPR041635"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W286"
                     /gene="sle_54010"
                     /product="Conserved Hypothetical Protein"
                     /protein_id="CQR64858.1"
                     /transl_table=11
                     /translation="MPGVTYEDTPPLADLMPWSVAPPRLGRDWPAGPDAASLKARWDAL
                     VTAEGPDREVLFQPTRSRTLHTAVGQLPGRTGGTERLARATGRCPEPVRVLRAPFDEQW
                     LIPDHRLIDAARPELWRVADERQVFVVETAGSAAGPPLLATSLLPLLGPGRVRPLHRRP
                     GGGEPNLAPGLLDHLAARHGRAPDPLDVLAWIVAAVRPGPRVPLTADPELWAHGVALGR
                     RALWLMRRDGERPKLPGGRRPYVRAPLPARPRALRYDAEEETLHLDEGRISPVPTDAWE
                     FEAGGVRVLEHWFAARTAAAEPGTLAAIRPAGWPQVWTSELLELITVLALLAEVREEIE
                     ELAVAETEPITTAELRAAGVLPVPGRARRPASVLDHLEEGPEGQFALL"
     gene            complement(15836..16585)
                     /gene="sle_54020"
     CDS             complement(15836..16585)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VWE8"
                     /db_xref="InterPro:IPR000524"
                     /db_xref="InterPro:IPR011663"
                     /db_xref="InterPro:IPR028978"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VWE8"
                     /gene="sle_54020"
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 175.5; E-value: 2.1e-53)"
                     /gene_kind="regulatory"
                     /product="HTH-type transcriptional repressor yvoA"
                     /protein_id="CQR64859.1"
                     /transl_table=11
                     /translation="MTSFAPDSLVLNRKLPLWYQVSQSLRASILGRSSRDPLRLPTEEQ
                     LAGHYGVSVLTMRQALKELEEEGLITRHRRRGTFIEPHARRGAPVRLLGSVDAIVAQQS
                     GMTTELLDHGSGPVPAEFAEYFPDLAETATYHRLRSDEKTGEPTNHARNWVRPELAARF
                     DPEDLARWPMTKVLRDVVKAGIGRITDTVEARLADPETARLLRIPLLSPILHYTGVTYD
                     TDGRVLDVAVIHYRGDRFSFTVTLDAT"
     gene            complement(16613..17929)
                     /gene="sle_54030"
     CDS             complement(16613..17929)
                     /codon_start=1
                     /db_xref="GOA:A0A0F7VYQ1"
                     /db_xref="InterPro:IPR005708"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="InterPro:IPR022950"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7VYQ1"
                     /gene="sle_54030"
                     /product="Homogentisate 1,2-dioxygenase"
                     /protein_id="CQR64860.1"
                     /transl_table=11
                     /translation="MSGDARKTAERLAYLTGFGNEHSSEAVPGALPEGRNSPQRAPLGL
                     YAEQLSGTAFTEPRAHNRRSWLYRIRPSAAHPAFTRADNGAIRTAPFTETVPDPNRLRW
                     NPLPEPPAGTDFLAGLWTLGGNGDAAQRTGVAVHLYHADASMDRVFSDADGELLIVPER
                     GGLLLRTEFGLLHAEPGHVALIPRGVRFRVELLDGTARGYVCENYGAPFRLPDLGPIGA
                     NGLANARDFRAPVAAYEDVEGPVEVVNKFCGNLWTARYDHSPLDVVAWHGNHVPYVYDL
                     RRFNVLGTVSYDHPDPSIFTVLTSPSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNV
                     MSEYMGLIEGAYDAKAEGFVPGGGSLHNMMSAHGPDRETFDRASAAELRPQKIDDGLAF
                     MFETRWPVTLTSQAARAGHLQQRYDDVWRGLERHFRPLH"
     gene            18218..18871
                     /gene="sle_54040"
     CDS             18218..18871
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W6K5"
                     /gene="sle_54040"
                     /product="Secreted Protein"
                     /protein_id="CQR64861.1"
                     /transl_table=11
                     /translation="MLAVCVLLPAGSAGCGAGDAREPARAHATASAAPVGELLDDTDAE
                     GRRYREVAAEHAPEVGVEVQPGTGGDWDIRLSVRNFRFSPPGTRAEARPGRGLAYLYLD
                     DGLVTRLRGPGHRLAARLVPRGTHHVTVRLHADDGTVWAVAGEPVENTADITVSGPRPT
                     AAEGPRPTAAEGPEPTAAERPGATGGERPGASTGEGPGATGAAGPGAVAARGAG"
     gene            18936..19556
                     /gene="sle_54050"
     CDS             18936..19556
                     /codon_start=1
                     /db_xref="GOA:A0A0F7W4T7"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR041674"
                     /db_xref="UniProtKB/TrEMBL:A0A0F7W4T7"
                     /gene="sle_54050"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 84.7; E-value: 1.8e-25)"
                     /gene_kind="regulatory"
                     /product="TetR Family Transcriptional Regulator"
                     /protein_id="CQR64862.1"
                     /transl_table=11
                     /translation="MRTVPHATSLRRAPVQRRSAERLARILDACADLLDEVGYEDLSTR
                     AVALRAGVPIGSVYRFFGNKRQMADALAQRNLERYTERVTERLSQAGGDAGWRAALDAV
                     LDEYLAMKRSAPGFSLVDFGNQIPVGARHTEPNHRVADRLTDLLSGHLGREPDEDLRRA
                     FLVAVETADTLVHLAFRVAPEGDEKIIEEARALLRAYLGRLLD"
ORIGIN
        1 tcggcgatgg cgcacgcggt cgccgaggtg gagcgggcga cgggggagcg gatcgacctg
       61 gacgcggtgc cggaggggga cccggcgacg tacgggctga tccgctccac cgagacgctg
      121 ggctgcttcc agatcgagtc gccgggccag cgggatctgg tcggacgact ccagccgagc
      181 accttccacg atctcgtcgt cgacatctcc ctcttccggc ccggcccggt cgccgccgac
      241 atggtgcggc cgttcatcga ggcacggcac gggcgggccc ccgtccgcta cccgcacccc
      301 ggcctggagg agccgctgcg ggagacgtac ggcgtcgtcg tcttccacga gcaggtcatc
      361 gacatcgtgc acctcatgac cggatgcggc cgcggcgagg cggaccgggt gcggcgcggg
      421 ctgtccgacc cggaatcgca ggggcggatc aaggtgtggt tcgcgcagca ggcggcggcg
      481 aacgggtacg acacggagac gatccggcgc acctgggaga tcgtcgaggc gttcggttcg
      541 tacggcttct gcaaggcgca cgcggtcgcc ttcgccgtgc ccacctacca gtcggcgtgg
      601 ctgaaggcgc accatccggc cgccttctac gccgggctgc tcacgcacga ccccggcatg
      661 taccccaagc ggctgctcct ggcggacgcg cggcggcgcg gggtgccgat cctgccgctg
      721 gacgtgaaca agtcgggggc cgcccaccgg atcgaactgg tgtctgaatc aaaggggacg
      781 cggaactggg ggctgcggct ggccctctcc gatgtgcacg gcatcagcga ggccgaggcg
      841 gcgcggatcg cggacgggca gccgtacgcc tccctgctcg acttctggga acgcgctcgg
      901 ccgagccgcc cgctcgccca gcgcctcgcc caggtcggcg cgctggacgc cttcggtgcc
      961 aaccgccgcg acctgcaact gcacctgacc gagctgcacc ggggctcccg cggcgcgggc
     1021 ggcggccaac tgccgctgtc cggcgggcgg aggacggctc cggccgggtt gcccgacctc
     1081 acctcggcgg agaggctgag cgccgagctg ggcgtgctgt cgatggacgc ctcgcgccat
     1141 ctgatggacg atcaccggac cttcctcgac gaactgggcg tggtcccggc gcggcggctg
     1201 cgcacggcgc gacacgggga gacggtgctg gtcgcgggcg ccaaggcggc cacccagaca
     1261 ccaccgatca ggtccggcag gcgagtcgtc ttcaccacgc tggacgacgg tacgggcctg
     1321 gtcgacctgg ccttcttcga cgactcccac gaggcgtgcg cccacaccgt cttccattcc
     1381 tggctgctgc tggtgcgcgg ggtggtgcag cgccgcggcc cgcgcagcct cagcgtggtg
     1441 ggctccgccg tctggaacct cgccgagctg ctggaggtgc gccgggagga gggcctggag
     1501 ggcgtcgcgg cccggctcgc cgagccgcgt ggcgacgggc ccgccccggg cgacggcgac
     1561 ggcccggcgc gtcggcggct ggccgggtcc gacggactgc ccgccccggc cggctccgcg
     1621 gcccgggacc cgatggagag cgcccggagc gagaggaacg gagagaacgg agagaacgga
     1681 aaggacggag agaacggaaa ggacggtaag ggaggaaagt acgagaaggc cgggaaggcc
     1741 gggaaggccg ggaaggagac gggggagcgc aggatccgca tgcccacggg gtacgagatg
     1801 cacccctggg ccgatctgcg ccccgcgggc gaagggcccg cggtgggaag gaagttgtgg
     1861 caccagagtc cggggagtgc gggatgacca ttctctgcgt acgtttccag ctaccgccga
     1921 tgtacgaggc ggccctgccc cgattgctgg ggatgctgga ggagttcacc ccggtcgtcc
     1981 aggccctgcc accggacggg gcactggccg acctgcgggg cgccgagcgg tacttcgggc
     2041 gcggcgcggt ggagctggcg tcggtgatcc gcgtccgcgc cctggcgctg tacggcgtcg
     2101 actgtgtgat cggcgcggcc cccgggccga tgctggcccg gatggcgctg cgggacgcca
     2161 ggcccggggc gacctgcgtg gtgcccgggg acccggaggg catcgcggag ttcctcgccg
     2221 gcaagcccgt cgccgcgctg cccggcgtgg gcgccgcgac cgcccgcacc ctgtgcgagt
     2281 acggcctcga caccctcggc cgggtcgccg ccgcacccct gtccacgctc cagcgcctgg
     2341 tcggcgcgaa gaccggccgt gagctgcgcg agaaggcagg gggcgtcgac cgcggccggg
     2401 tggtgccgaa cggcgtctcc cggtccctgg ccgccgaacg ccccttcgag cgggacgagc
     2461 tggacccgga ccggcaccgc cgtgccctgc tctcggccgc cgaggaactg gggtcccggc
     2521 tgcgcgccct ggacaaggtc tgccgcacgc tgaccctcac cgtgcgctac gccgaccggt
     2581 ccgccacgac ccgcagccgc accctgccgg agccgaccgc gcactcggcg tcgctcaccc
     2641 gggccgtgta cggcatgtac gaggcgctcg gcctgcagcg cgcccgggtc cgcgccctcg
     2701 ccctgcgcgc cgagggcctc ggccccgccg aacaggccgc ccaccagctc accttcgacc
     2761 cggtggacga gaaggtccgc cgcatcgagg aggtcgccga ccgcgcgcgg gccaagttcg
     2821 ggccgcgcgc ggtgatgccg gggacgctgg ccgcgtgacc ggccggcgtc agggcggccc
     2881 tttcgggggt cagcggccgt gtccggtgcg caccgcgcgt cggcgggccg aggcgaacag
     2941 cgccgccgcg cccagcgcca gtgcggcggc accgccgacg gcgaggtacg ccgtggtgcc
     3001 gtcaccgccg gtctcggcga gctccgtgcc ggcggcctgc gcccggttgg cgccggcggc
     3061 cgccggctcc ccctcgccgg tgtccggggc gtcggcgccg accgccgggg tccgggtgct
     3121 gccggtcccg ccggccgggt ccgcggtcgt acgggcgtcg tggtcgccgt ggccgtggtt
     3181 ctcgatcgtc gacctgccgg taccggcctc gatctgcgcg ccggacggcg tggacgccgt
     3241 cggtgccggg gcggagccgc cgcccgccgt ggcgccgccg ccgaaggaga cgtccgagca
     3301 ggagtagaac gcctccgggc tgtccgagcg ctgccagatc gcgtacagca ggtgcttgcc
     3361 ggaacgctcg ggaaggctgc cggagaaggt gtagaagccg ccggaggcga ccgggtcggt
     3421 gaccgtcgcc accgggtgct ccaggtcgag gtcggaccag gcgagcggcc gggccgggtc
     3481 gtagccgggc ttggtgacgt agacggtgaa cgtgcccttg tgctgggcgg tcacacggta
     3541 cttgaacgtg tgcgcgccgc tggtcacgct cgtcgcgggc cagtcgtcgc gggccaggtc
     3601 caggcccttg aactcctcgc tgtccgcgct gcacagcttg ccgtccggga tcagctcccg
     3661 gtgccggccg ccggcgtccc cgatgcggat gccgttccag tcgtacagcg cctgcgtccc
     3721 gccggccgcg accgccgcct tgcacgcggc cgacttcggg ctctcggcgc cctcggcgta
     3781 gcactgcgcg acccggctga ccgggtcgcc catcgtcccg tgcgcggacg ccggcgaggc
     3841 ggccagcgcg gtcaggacga gcggggcgat gccggcggcg gcgacggcgg ccgtgcggcg
     3901 tgcgggcatg gggaactcct cggaggacga cggtctgccg gatacgcggg ccgagcggcc
     3961 cgatctcgtg gggggggcga tcagcaagct agcccccggc gaccgggaaa tcgcctgcga
     4021 gaggcgggcg ggggagatcc ttatggccgc gttaaggaag agatcagact gccctcaggc
     4081 ggctaccgtt cggaccatga tcgaccacgt tgcccaccag ccggtcaggc cggccgtcac
     4141 cgaagacgta ccggcggtga aggccgtcac cgacgccgcg taccaccact acatcgagcg
     4201 catcggcgtg gtgccccagc ccatggaggc cgaccacgcg gccgacgtgg cggccgggaa
     4261 ggtgttcgtc accgaggaac ccggcggcgg gcgggtcgtc ggcctcgtcg tggtggaggc
     4321 ccgcgccgat cacctgttcc tggacagcat cgccgtccac cccgacgcgc acgggaaggg
     4381 cgtggggcgg cggctgctgg cgttcgtcga cgcgcacgcg cgtgcgctcg gcctgcccga
     4441 ggtgcggctc tacacgaacg cgatgatgtg ggagaaccag aagatctatc cgaagtacgg
     4501 ctacgaggtc gtcgaacgcc gtgtggacgg cccctacgac cgcgtccact accgcaagcg
     4561 gctgcgctga ccgcacgccg gaccctgggt cttcgttcgg atcagtccgg tcagccgtcc
     4621 ggccaccagg tgcgcgcgat gtccttgcgg atctccggac gcccggcggg gcgctcgtcg
     4681 gcctcctcgc ggatccggcg ggcgtcggtc ttcttcaggg gcttgtgcac ggtcacacgg
     4741 cgcatggcgg cctccttcga gggtccgccg cgttccgcgt tctcacggag gcggacccgt
     4801 tccccgaaca gttcctcatc gccgcacccg tgtcagtggc ggctgtcacg gccgggctgt
     4861 cagtggcggg tgtcaccctg ggcgcgtggt gaaacacgat ggcggcgcag tggcgccgga
     4921 taccggggag cccggtgacg gtcctgtgaa gcagggtgcc ggcgggggcg gcgccgactc
     4981 ggccgcgccc cgtgtcgact gggacgcggc ggcggcggcc ttcgacgacg agcccgatca
     5041 cggcctgcgc gacgcggacg tgcgccgggc gtggtccggc cggctgcgct cctggctgcc
     5101 cgcgcggccg ggcgacgtcc tcgacctggg ctgcggcacc ggcagcctgt cgctcctcgc
     5161 cgccgagcag ggacacggcg tcaccggcgt cgatctgtcc ccggcgatgc tggagcgggc
     5221 ccgggccaag ctcgccggac acgacgcggt gttcctgacc ggggacgcgg cgctgccccc
     5281 ggtgggggag cggtgcttcg acgccgtcct ggtacggcat gtgctgtgga cgctgcccga
     5341 gcccgcccgg gtgctgcggc actggcggtc actgctgcgc ccgggcgggc ggctggtgct
     5401 ggtggagggc gtgtggggga gcaccgcccc ggtcggcata ccggcggacc ggctcgccgc
     5461 cctcctcgcc ccgctcgccg ggcgcacgcg cgtggagcac ctgtcgggcg acccggcgct
     5521 gtgggggagg gcggtggacg acgagcggta cgcggtggtc tggtcctcgc cggtcacgcg
     5581 cacaaccccc tgacggaccg tcggccggtc cgccccggcc ggggcggcga ccggaccggg
     5641 cgccgggtca gccgagccgg cgggcatggc gcacctccgt ggcgcacacc tcgtacccga
     5701 gccacttgtt gacggcgagc atcgggccgt tgccggtgtc gttgcccgtg aacgcctccg
     5761 tgacgccggc cgcccgggcc cggtgcaggg aggcgttctt gacgagcttg gccaggccgc
     5821 ggccgcggaa ggcgcgggcg gtgccggtca tggcggtcgt catgacggaa ggcacggcgg
     5881 gggcagggtg gtcccgtcgg ccgggtgcgc ccgggagcgg ggagggtgcc gccgtcggtg
     5941 taggtcgcgg tgaaggcgac cgggcggcca ccggcgaccg ccaccgtcgt caggtccagg
     6001 ttcagcaggg ggtgtctcca ggtctcctcg acccaggctt cgtaatccgt gaactcggtg
     6061 tcgatgtcgc tcggttcgtc cgaggtcgtc tccgcgtcca gctcgaacag cggacgcggg
     6121 tcgtccgcga agtcggcggc ggtgcgcagc tcgacgcccg gcggaggcgg cgacagcggc
     6181 gggaggccgg cggccgcgag gtccaggcgg aggaagtggg ccgagcgccg gcggccgtag
     6241 ccgtgcgctt cggcgaaggc caggccggcc ggctcgtcca gcacccaggt gtacagggtc
     6301 gtcgccccct gaccggccag gtactcctcg gcggtgcgga ccagcagccc gccggcgccg
     6361 cgccggaggc ggtccgggcg tacgtagacg tcgaggaacc cctggccggg ctcggggctg
     6421 ccgtgggaga gccccgtccg agcggtgccg atcacctctc cgtcctcctc cgctaccagg
     6481 gaccgcaagc gggcgccggg gtgcgtgtgc gcgagggcgt gcaccacgga ctcgggcgtg
     6541 accagcatga acggcagggc gagacgccgg acccgggcga agccctccag atcggaggga
     6601 acgccggggc gcaggtcgcg cacgatcact gtcatgggcg cgcacgctac gcgggaacct
     6661 ctccgggcgc ctccggtttt cccgggtgcg ggacaatcgt cccgtgacct tgaagatcca
     6721 cgtcgaggac ggcgtaccgc cctacgagca ggtacgcgcg cagatctccg agcaggcccg
     6781 gtccggcgcg ctcccggtgg ggtaccggct gccgaccgtg cgggggctgg ccgagtcgct
     6841 ggggctcgcc gccaacacgg tcgccaaggc gtaccgcgcc ctggaggcgg acggggtgat
     6901 cgagacgcgg ggccgcaacg gcacgttcgt ggccgccgcg ggctcggccg ccgagcggca
     6961 gctcgcgtcc gccgcgcaga cctacgccga gcgggcccgg cggctcgggc tggggcaggc
     7021 cgacgcgctg gcggccgtac gggacgccct gcgggcggcg tacggaaccc gggagtaggg
     7081 tcttccgcct ggatcgggcc ggatcagggc gcggtgccgg gccccgcgag cccggtccgg
     7141 tccgagctgg aggccctggg gcgggagtgc ccgccgggcg cggctcagac gggcgccagg
     7201 tgccccggtg tgcgggtgac cgtcagcccc gccgcccgcg ccagcccggc gaagctcacc
     7261 gcgttgcgca ccgccgccgc gttcgggtcg ttgttgaagt acgcgtacac atcggccggc
     7321 tccggccagg cggcggcgac acgggccgcc caggccgcca gggcccgccg gccgtagtgc
     7381 ggccagggca gggcacggcc ctggtggaag cggacgtacc cccagccggc ggtgcgccac
     7441 agcggggtca cgggccggga cagcacgtcg gcccagcaca gcgcggcgcc ccgggcccgc
     7501 agcacctcgt gcacctcggg cgtccaccag gacggatggc ggggctccac cgcgacccgg
     7561 acgccgggcg ggaagcaggc gagacaggcg tccagcagct ccgcgtcggc gcgcagcgtg
     7621 ggcggcaact ggagcagcac cgggcccaga cggtcgccca gcccggcggc gtgggccagc
     7681 agccggtgca ccggctcctc cggctcccgc agccgcttga cgtgcgtcag gaagcggctc
     7741 gccttgaccg cgacgacgaa gtccggcggc gtgcgctccc gccaggccgc gaaggtctcc
     7801 ggggacggca gccggtagaa ggcgttgttg ctctccacgg tggcgaagcc cgccgcgtac
     7861 tcctccagcc accgccgtat gggacagccc tccgggtaca gcacgcctcg ccagtccttg
     7921 tactgccacc ccgacgttcc gacatacagg gtcatacgcc catcaaaaca ccggaagcga
     7981 ggcgggcgcc cgtcgccgtg aggcaccggc ggacgcgagc gccgcgcccg ccgtcacagg
     8041 tacaggcccg cgtccgcccc gccgcgcggt tccggcagcg ccgtcgggga ggtcccccgg
     8101 cgcagcgcgt acagctccgc cagggtcgcg ccgtcgcggc cgaccccctc ctcgcggccc
     8161 agccaggaca ccgcctcggt ccgggtcagg ggaccgacct cgatacgggc caggcagcgg
     8221 ccgggccgca cgacggccgg gtgcagacgc tccaggtcct cgttggtggt gacgcccacc
     8281 aggacgttgc ggccctggcc gagcagaccg tccgtcagat tcagcagacg ggacagggcc
     8341 tggccggcgg tgtgcttggc ctcgccgcgg atcagctcgt cgcagtcctc caggagcagc
     8401 agccgccagc ggcccttgcc cgccgcgtcc tcctcgccga tcgcgatgtc catcagatag
     8461 ccgacgtcgg agaagagccg ctccgggtcg agcacgcagt cgacctggca ccagtcccgc
     8521 caggaccggg ccagcgtcct gagggccgag gtcttgccgg tgcccggcgg gccgtgcagg
     8581 agcagcagcc ggcccgcgat gtcctcgggg gacgtcttca tcaggcggtc catcgcctcc
     8641 gcgaccggcg cggtgtagtt ggggcgcacc tcctcccagg tgcccgccgt gatctgccgg
     8701 gtggtgcggt gcggaccgcg gcgcggcgag acgtaccaga accccatcgt gacgttctcc
     8761 ggctgcggtt cgggctcgtc cgccgctccg tccgtcgcct ggtcgaggac cttctgcgcc
     8821 agttccgcgc tggtcgccgt caccgtgacg tcggcgcccc ggttccagcg ggagaccagc
     8881 accgtccagc cgtcgccctc ggcgagggtc gcgctgcggt cgtcgtcgcg ggcggcgcgc
     8941 agcacccgcg cgccgggcgg cagcagggtg gccccggacc gtacgcggtc gatgttcatc
     9001 gcgtgcgagt acggctgctc gcccgtcgcg aagcggccga ggaacagcgc gtcgacgacg
     9061 tcgggagggg agtcgctgtc gtcgacgtgg agccggatcg gcagcgcgtc gtgagggttg
     9121 gcagacatac cgccatgatc gggcacccgg ccgccgcatg cacccggttt ccggggtgcg
     9181 cgcggcgccg gcgccccggc cgccggctca ggcacgggcg cgtgcgacgc gcccgcacac
     9241 ctgccgggcc cggcgcacca cggcgtaccc cttcgtcagg gcccggtccc gggcgaaggc
     9301 acgggcgatc gcccgtccct cgatcagccg ctcgaacgcg gcgggcccgg tgccgcgccg
     9361 cacggtgacg cggcgcaggg cgtacggccc ctggctccgc cgtgccgtcc cgttgccgac
     9421 ggcgagtgcc tgcgcgtacc cggcctcgcg caccgcccgc cgcacccggc ggtcggagta
     9481 accgtacgga taggcgaacg agaccggcgc cgcgcccagt tggccggcga cgatctcctg
     9541 gcaccggacc agctcggagc gcagccgttc gtcgtcgagc tggtcgagct gcggatggct
     9601 gtggctgtgc ccgccgatct cgacgcccgc gccggccagt tccctgacct ggtcccagtc
     9661 gagcatggtg tccagggctc ctccggtgtc gtgcgggccg cgcagccacc cggtggagac
     9721 gaacagcgtg gcgcggaagc cgtgtccggc cagagcgggc agggcgtggc ggtgcacgcc
     9781 ctcgtagccg tcgtcgaagg tgatcagcac cgggcggtcg ggcagcgggc gcccggagcg
     9841 ccaggcggcg gccagctcgg acgtggtcac cggcgtgcgg ccccggtcgg cgacgatcgc
     9901 catctgctcg gcgaacgcct ccggcgtcac cgacagatca cgggtggcgt cgttcggttc
     9961 ggcggcgacc gcgtggtaca tgaggatcgg tacgggctcc tcagacatcg gcgtcccctt
    10021 cggcacgcgt cgccggcagg ccgcgtgttc ccgtggtcac cgggggcacc gggggcaccg
    10081 ggggcaccga gaacgtggcg cccccgcgcc gggcccgcac gctgcccacc acatagccgc
    10141 ccgccgccgt gagcaccccg gcgacgatcg cccccgcccg gcccgcaccg cccggccggg
    10201 ccagcagggc gtcgcgcagg ccgcgggcca ccccggccgg caggacccgg gtggcgtacc
    10261 ggcgctccga ctccagcccc ttgtccgcgc cgacactgcg cgccaccagg gccttggaca
    10321 gaccctcggc gtaggtgcgg gtgcggaagt aggcgaagtg ctcgcgggcc tcggggaccc
    10381 ggtggtggat caccgcccgg tcgtcgatga gcagcaccgc gtcgggccgg gcgcggctga
    10441 gccggatgca cagctcggtc tcctcgcacc ccagcggccg cttgtcgccg tcgcgcccga
    10501 tgccggtggc gaagccgccc gccgcgtcga aggcgccgcg gcggaaggag gcgttgccgc
    10561 cgaggacgtt gcgcacccgg acccggcccg gcggcaggcc ccggtaggtg cagcccacca
    10621 cccagtcgaa ctcctccggg aaccacgcgg gccggcggcc cgacgcccag accggcaccg
    10681 tgcgcccgcc gacggccatg acccgcgggt cgtcgtatcc ctcggcgaag tgccgcagcc
    10741 agtcgcgctc ggccacggcg tcgtcgtcga ggaaggcgac gacctccccg cgggaggccg
    10801 cgatgccggt gttgcggccg gccgacaggc cgcgggggcc cgcgttggcg agcacccgca
    10861 cctcgcccgc ctccccgtac tccgcggcca gccgctcccg gagcgcctcg ttgtggtcga
    10921 cgaccagcag ggtctccagc gccgggtggg actgcgcccg caccgaggag accgccgccc
    10981 gcaggtcctc ccagcggtcc tcggtgtagg cgcagatcac gacggagacg ccgggcgcgc
    11041 tcacgacacc ttcccccgga ccgtgccgat caccggtgcg ggcgtacggg cgcgcagggc
    11101 acggcggttg gaacgttccc ggaggatcac tccgagcacg cgcagcccgt cccgcacggc
    11161 ccgcagattg ctggtgccgt ggatgcggag gtactcgtgg ctcgggatct cctgcacctt
    11221 cagcccggcc ttgacgaccc ggatgttcat cagggtctcc acctcgaaac ccgtgcagtc
    11281 gaggtcgatc ttgtccaggc agtgccgcca gaacgcgttg tagccgtagc acaggtcggt
    11341 gtagcgggcg ccgaacttcc ggttgaccac cgtgcacagg gcggcgttgc cgagtctgcg
    11401 gacgagggtc atgtcgtcgg tgccgccgcc gttggcgaac cgggagccct tggcgaagtc
    11461 ggcacccgac accagggcac agacgtacga cacgatctcc tggccgtcgg cggagccgtc
    11521 cgcgtcgacc atcacgatga tgtcgccggt gcacgcctgg aacccggtga tcagcgcgtc
    11581 ccccttgccc ctgccgcgct gctcgacgac cttgacgccg ggccacagct ctcgggcgac
    11641 ctcgacggtg cggtccgtgg agttgccgtc cacgaggacg acttcgtgga tccagtccgg
    11701 cagtgtcttg aagacgtagg gcaggttctc cgcctcgttc atggcgggga tcaccacgct
    11761 caccggcggc gcgatggcca ggtgcgagga gacgggccgg tacttcccgg cggcggtggc
    11821 cgggtcggcg gacggcggat cctggtccgc ggccgccggt tgcagcactg agctcatggg
    11881 tctggtccct ctcgtccggt gggccgccca cccccgggcg gcccggctct gtgtccggtt
    11941 cgaaaggggg gttctcaccc acggcacgac ggaaatggcg ctccacccgt gccgggtgag
    12001 ccggcaaagc ctgccggtgc cggaaaacgg cagccgaccg cgcggcacgg cccggtcacc
    12061 tggtgcggtc accgggcacg gccccccccc ctgccgcgcg ccgcccgggt cgtcgcggcc
    12121 ccgagcccct cccctgaggc cgggtgccga tggaccggtg cgggtgaatt gtatgaaggt
    12181 attgacgctt gaacccgtat ggcaagccct ggaacgaggt ctcacatttt tatcggtttg
    12241 ccggtaatcg gccaaccgtt cgtagggtgc ggtcgggtcg tgtacctcga agccgcctct
    12301 gccgtcgtca ccatgacacc gtgtctgatc tttatgccgt catggacgtt catcgccgtt
    12361 catggccgtg catggcagag catggccgac tttgcccccc gaagtgtcgg atgccgggct
    12421 tcaatgtggc gtagctccgt acgcaccgtc aagacggggc ctgtgctgcg acactttttc
    12481 gttcaccttt gaaagttcgt agtcattctt ggcatgaaca cttcccgtca acacaaagcg
    12541 ttggtacgac ggttgaggca gagaccctgc taaagggagg ttccatgaga cgttcccgaa
    12601 ttgccggctt cctggcctcg ctcctcctcg ccaccggcac cgccctcgcc ggcaccgcga
    12661 cggcgcaggc atccccgacc gctgtatccg gcgactacgt ggccctcggc gactcctact
    12721 cctccggagt cggcgccggc agctacatct cctccagtgg tgactgcaag cgcagcacga
    12781 aggcgttccc ccagttgtgg gccgccgccc acgcaccctc ggcattccac ttcaccgcct
    12841 gctcgggcgc ccggacgggt gatgttctcg ccgggcagct cggcccgctc ggctccgcca
    12901 ccgggctggt ctccctgtcg gtcggcggca acgacgccgg tttcgccgac gtcatgacga
    12961 cctgtgtgct ccagtccgac agctcctgcc tgtcacgcat caacaccgcc cgggcgtacg
    13021 tcgactccac cctgcccgga cagctcgaca aggtgtacac ggccatccgc gaccgggctc
    13081 ccaacgcccg cgtcatcgtc ctcggctacc cccgcttcta ccagctcggc acttcctgtc
    13141 tcggcctgtc ggagaccaag cggaaggcga tcaacgacgc ctccgaccac ctgaacaccg
    13201 cgatcgccaa gcgcgtcgcc gaccacggct tcacgttcgg cgacgtacgt gccaccttca
    13261 ccggccatga gatctgctcc ggcagcgcgt ggctgcacag cgtcaactgg ctgaacatcg
    13321 gagagtcgta ccacccgacg gcggccggcc agtccggcgg ctacctgccg gcgttcgacc
    13381 gcgccgcctg agccaccgcc aggcgcgcgc cgacggcggc gcggaccgcg ggcggaagga
    13441 ggggaggcct ccctgccggg gagtcttccc ctccttccgt ttccctccct gccccgctcc
    13501 ccgtttcccg ctccgcttct ctctccttcc ctctccgttt tccttctccc gatctctccc
    13561 cgcgctcagg cgcgtgagat cgcccacgtt ccgctgtggg gatgacgccc gggcgcaggc
    13621 cggccgaccc gcccggccat ggcggcaggg agtgatcatt cccgcgccgc gggggcgtcc
    13681 ggtggccctc ttccggtggc cgcggcggcc cgccggacgc ccggctccac cggccggggc
    13741 gcgcccgcat cggtgggcga ccgcgcgacc tgggcttccg cggccgcgac atgcttcccc
    13801 ggcctccggg accgccaccc caccttggtg acgcagggtg accgatgcct tcggtggtca
    13861 ttcaccgaga tcctccggcc agcccgttgt ccaactcgcg ctggaacctg tcggattcgg
    13921 agagtaatcg tcaaccccct tgcggggaag gtgaatcccg cgaccgcgat acacgcgtgc
    13981 cgccccgggg cgatagggtt accctgcccg ggccgggtgg actcgtacgg gtggggagtg
    14041 acatggaaca gataacagtg cgcagcaggg cgagggtccc tgcgatcacc tgcgggagca
    14101 gcgcgaccag ctcgcgcctc gaccgccacc tcgcggtgct ggccggtccc gccgtcccgc
    14161 agcgggagac ggtcgaggcg atgtccctga tgcgtgaact caccgcgcgt gacaccgcgc
    14221 acgaccgcag cggcaggggt gcgcgaatgc gccgggtctc actcttcgcg ccgttgcgcc
    14281 ggctgcgccg ctcgctcttc ggcggtagct gaagcccgcg ctcgggtcgg tcacacctcc
    14341 cggcgtaccg ctgcgaccta gtcgtccgtc atccccacgg cacgcagcgg cgccccggtg
    14401 cccttccgag cgcgggcttg tgcccctttc tgcctgtccg gcttctccgt cttaccgctt
    14461 tccgtcttgc cgggctttct gccaccgccc ctccgctcgg cggcgacggc ttcccccccg
    14521 gcggcctccc ggatgcgagg ccgcttccgt gtttttccgc gcgtgcggcg gggtgcgggc
    14581 gcccgcccgc gccagaaacc ggccgccgcg gttccgcatg gctccgccgc gcgtgctccg
    14641 gccctcctac agcagcgcga actgcccctc cgggccctcc tccaggtggt ccagcaccga
    14701 ggccggccgc cgggcccgcc ccggcaccgg gagcactccc gccgcccgca gctccgccgt
    14761 cgtgatcggc tccgtctccg ccaccgccaa ctcctcgatc tcctcccgta cttcggcgag
    14821 cagggcgagc accgtgatca gctccagcag ctccgaggtc cagacctgcg gccacccggc
    14881 cgggcggatc gcggccagcg tgcccggctc ggccgcggcg gtccgggccg cgaaccagtg
    14941 ctccaggacc cgcaccccgc ccgcctcgaa ctcccaggcg tccgtcggca ccggggagat
    15001 acggccctcg tcgaggtgga gcgtctcctc ctccgcgtcg tagcgcaggg cccgcgggcg
    15061 ggccggcagc ggggcgcgga cgtaggggcg gcggccgccg ggcagcttcg gacgctcgcc
    15121 gtcgcgccgc atcagccaca gcgcgcggcg ccccagcgcg acaccgtggg cccacagctc
    15181 cgggtccgcg gtgagcggga cccgtgggcc gggacggacc gccgcgacga tccaggccag
    15241 gacgtccagc gggtccgggg cgcggccgtg ccgggcggcc agatggtcca ggagcccggg
    15301 ggccaggttg ggctccccgc cgcccgggcg gcggtggagc ggacggacgc ggccggggcc
    15361 cagcagcgga agcagcgagg tggccaggag cggcgggccg gcggcggagc cggccgtctc
    15421 cacgacgaag acctgccgct cgtccgccac ccgccacagc tccggccggg ccgcgtcgat
    15481 cagccggtgg tccgggatca gccactgctc gtcgaagggg gcgcgcagca cacgcaccgg
    15541 ctccgggcac cggcccgtgg cgcgcgccag ccgctccgtg cccccggtgc ggcccggcaa
    15601 ctgccccacc gccgtgtgca gcgtgcgcga ccgcgtcggc tggaagagga cctcgcggtc
    15661 gggcccctcc gccgtcacca aggcgtccca gcgggccttc agcgacgccg cgtccggacc
    15721 cgccggccag tcccggccga gccgcggcgg tgcgacggac cacggcatga ggtccgccag
    15781 cggcggagtg tcctcgtacg tcacgccggg catcgtacga cgctgcccgg gcgcgtcagg
    15841 tggcatccag cgtgaccgtg aaggagaagc ggtcgccccg gtaatggatg accgccacgt
    15901 ccagtacccg cccgtccgtg tcgtaggtga cgcccgtgta gtgcaggatc gggctgagca
    15961 gcgggatccg gagcagccgc gccgtctccg ggtccgccag ccgcgcctcc accgtgtccg
    16021 tgatacggcc gataccggct ttgacgacgt cccgcagcac cttggtcatc ggccagcggg
    16081 ccaggtcctc cgggtcgaag cgcgccgcca gttcgggacg gacccagttg cgggcgtggt
    16141 tggtcggctc accggtcttc tcgtcgctgc gcagccggtg gtacgtcgcc gtctcggcca
    16201 gatccgggaa gtactcggcg aactccgccg gcaccgggcc gctgccgtgg tccagcagtt
    16261 cggtcgtcat gccggactgc tgggccacga tcgcgtccac cgagcccagc agccgcaccg
    16321 gggcgccccg ccgggcgtgc ggctcgatga acgtgccgcg ccggcggtgg cgggtgatca
    16381 gcccctcctc ctccagttcc ttcagcgcct gccgcatggt gagcacgctc acgccgtagt
    16441 gaccggccag ttgctcctcg gtgggcaggc gcagcgggtc ccgggacgag cggcccagta
    16501 tggaggcgcg cagcgactgc gagacctggt accacagcgg cagcttgcgg ttcaggacga
    16561 gggagtccgg ggcgaaggag gtcacgaggc catccgtacc ggcaggcaag gatcagtgca
    16621 aggggcggaa gtgccgctcc aggccccgcc agacgtcgtc gtagcgctgt tgcaggtgtc
    16681 cggcgcgggc cgcctgcgag gtcagcgtca ccggccaccg cgtctcgaac atgaacgcca
    16741 gcccgtcgtc gatcttctgc ggccgcagct cggcggcgct cgcccggtcg aacgtctccc
    16801 ggtccggccc gtgcgccgac atcatgttgt gcagcgagcc gccgcccggc acgaagccct
    16861 ccgccttcgc gtcgtaggcg ccctcgatca ggcccatgta ctcgctcatc acgttccggt
    16921 ggaagtacgg cggccggaac gtgtcctcgc ccaccagcca gcgcggcgcg aagacgacga
    16981 agtcgacgcc cgccaggccc ggggtgtcgg agggggaggt cagcaccgtg aagatcgacg
    17041 ggtcggggtg gtcgtaggag acggtcccca gcacgttgaa ccggcgcagg tcgtagacgt
    17101 acggcacatg gttgccgtgc caggcgacca cgtcgagcgg tgagtggtcg taccgggcgg
    17161 tccacaggtt gccgcagaac ttgttcacga cctccaccgg gccctcgacg tcctcgtagg
    17221 cggcgaccgg cgcgcggaag tcccgcgcgt tggcgagccc gttggcgccg atcgggccga
    17281 ggtcggggag gcggaagggg gcgccgtagt tctcgcagac gtagccgcgg gccgtcccgt
    17341 ccagcagctc cacccggaag cggaccccgc gcgggatcag tgccacatgg cccggctcgg
    17401 cgtgcagcag gccgaactcg gtgcgcagca gcagccctcc gcgctccggg acgatgagca
    17461 gctcgccgtc ggcgtcgctg aagacccggt ccatggaggc gtcggcgtgg tacaggtgca
    17521 cggcgacgcc ggtgcgctgg gccgcgtccc cgttgccgcc gagcgtccac agacccgcga
    17581 ggaaatccgt cccggcgggc ggctcgggca gcgggttcca ccgcagccgg ttggggtcgg
    17641 gcaccgtctc ggtgaagggc gcggtgcgga tcgcgccgtt gtccgcccgg gtgaacgccg
    17701 ggtgcgcggc cgaggggcgg atccggtaca gccacgagcg ccggttgtgc gccctcggct
    17761 cggtgaacgc cgtgccgctg agctgctccg cgtacaggcc gaggggcgct cgctgcggcg
    17821 agttgcgccc ctcgggcagg gcgcccggca ccgcctccga gctgtgctcg ttgccgaaac
    17881 cggtgagata ggccagccgc tccgcggtct tccgcgcgtc cccgctcatg atcgctccct
    17941 cgccgtcaga tcccgcacgc ccactgattc ctatgcttca ccgtaggaat gggggcgcgt
    18001 gggcgcaaga ggtgtgcggc ggcccggcgg gaccgccccc gtccgggcgg gtggcggcag
    18061 ggccgttccg ggcgggtttc ggcgcatggg ggcgggttcc ggtcggtctc cgggactccg
    18121 ccggaaggcc gaccggaacc cgcccccagg aggatccgcg tccccggccc ggtgttctac
    18181 gctccccggc atgtcgtgga cacggagatc gcgtgccgtg ctcgcggtct gcgtcctgct
    18241 gccggccggg tccgcgggct gtggtgccgg cgacgctcgc gaaccggcgc gcgcacacgc
    18301 aaccgcgtcc gccgcgcccg tgggcgaact gctcgacgac accgacgcgg agggccggcg
    18361 ctaccgggag gtggccgccg agcacgctcc cgaggtcggc gtcgaggtgc agcccggcac
    18421 cggcggtgac tgggacatac ggctgtcggt ccgcaacttc cgcttctcgc cccccggtac
    18481 acgggccgaa gcgcggccgg gacgcggcct ggcctacctc tacctggacg acggtctcgt
    18541 cacccgcctg cgcggccccg gccaccggct cgccgcccgc ctcgtcccgc gcggcacaca
    18601 ccacgtcacc gtccgtctgc acgccgacga cggcacggtc tgggcggtgg cgggcgaacc
    18661 cgtcgagaac accgcggaca tcaccgtgtc ggggccgcga ccgaccgccg cggaagggcc
    18721 gcgaccgacc gccgcggagg ggccggagcc gaccgccgcc gagaggccgg gggcgaccgg
    18781 cggggagagg ccgggagcga gcaccggtga ggggcccggg gcgaccggcg cggcggggcc
    18841 cggagcggtc gcggcgcgcg gggcggggtg agtgccgcgg gcgcccggtt ccgcacccgc
    18901 cgtcacggtt caccggacgg cggcgggagg gcatcatgag gaccgtgccc cacgcgacat
    18961 cactccgccg cgcccccgtg cagcggcgca gtgccgaacg gctggcgagg atcctggacg
    19021 cctgcgccga tcttctggac gaggtcggct acgaggacct gagcacccgg gcggtggccc
    19081 tgcgcgccgg tgtgcccatc ggctcggtgt accgcttctt cggcaacaag cggcagatgg
    19141 ccgacgcgct cgcccagcgc aacctcgagc ggtacaccga gcgcgtgacc gagcgcctga
    19201 gccaggccgg cggtgacgcg ggctggcggg ccgcgctgga cgcggtgctc gacgagtacc
    19261 tggcgatgaa gcggtccgcg cccggcttct ccctcgtcga cttcggcaac cagataccgg
    19321 tgggcgcccg gcacaccgaa cccaaccacc gtgtcgccga ccggctcacc gacctgctct
    19381 ccggtcatct cggccgcgaa cccgacgagg acctgcgccg tgccttcctc gtcgccgtgg
    19441 agaccgccga taccctggtg cacctcgcct tccgggtcgc cccggagggc gacgagaaga
    19501 tcatcgagga ggcacgggcg ctgctgcggg cgtatctggg gcggttgctc gactgacgga
    19561 gcgggccttc gccgggcggg ccggatgtcg tccggtggtc cgggtgcccg tccggcggac
    19621 caggcgctcg tccggtggtc cgggtgcccg cccggcggac cagacgctcg tccggtggtc
    19681 cgggtgcccg tccggtgggc cgggtgttcg gcgccgaacc gggtgctcgg cggcgtcccg
    19741 gctgctccgc ggcgggccgg gcggctgccg accgccgccc gcccggccgg cggacggcgc
    19801 cccgccgccc gcgcgccctc cccggcgggc ataccgatcg gtatgctcgg cccgtgcccg
    19861 cgcgccaccg ccgcccccgg ggaggacccg tgtcccgcac cgccctgcgt atctgccccc
    19921 tgtgcgaggc cacctgcggc ctgaccctga cggtcgaggg gacccgcgtc accggcgccc
    19981 gcggtgaccg cgacgacgtg ttcagccagg ggttcgtctg ccccaagggc gcctcgttcg
    20041 gggccgtcga cgccgacccc gaccggctgc gcgcgcccct ggtccgccgg gacggcgtgc
    20101 tgcgcgagac cggctgggag gcggccttcg acgcggtggc cgccgggctg cggcccgtcg
    20161 tcgagcggta cggcccgcag tccgtcggcg tcgtcctcgg caaccccacc gtgcacacca
    20221 tggccggcgc cctctacccg cccgtcctgc tgagcgcgct cggcatccgc aacctgttca
    20281 ccgcctcgac gctcgaccag atgcccaagc acgtctccag cggcctgctc ttcggcgacg
    20341 ccaacgcgat ccccgtcccc gacctggacc gcaccgacca cctcctcctc atcggcgcca
    20401 accccctgga gtcaaacggg agtctgtgca ccgcgcccga cttccccggc cggctgaagg
    20461 ccctcaaggc ccgcggcggc accctgaccg tcgtcgaccc gcgccgcacc cgcaccgccc
    20521 gcctcgccga ccggcacatc gccccgcgcc ccggcaccga cgcgctgctg ctcgccgcga
    20581 tggcccacgt cctcttcgac gaggacctcg ccgacctcgg ggacctcgcc ccgcacgtcc
    20641 agggcgtcgc cgaactccgc acggccctgg ccgggttcac ccccgaggcc gtcgccgccg
    20701 cctgcgacgt ggacgcctcc ctcgtccgca ccctcgcccg ggaactcgcc gccgccccca
    20761 ccgccgccgt ctacggccgc atcggaagct gcaccgtccc ccacggcacc ctcgccagtt
    20821 ggctcgtgga cgtcctgaac atcctcaccg gcaacctcga ccgccccggc ggcgcgctgt
    20881 tcccgcaggc cgccaccgcc aggacgcccc gccccgccgg acccgggcgc ggcttcgccc
    20941 tcggccgctg gcgctcccgg gtgagcggac acccggaggc caagggggag ctgccgctgg
    21001 ccgccctcgc cgaggagatc gacaccgcca ccggcgaggg cacgcccctc cgcgcggtca
    21061 tcgccttcgc cgccaacccg gtgctctccg cacccgacgg cgaccggctc gccaaggccc
    21121 tggactccct cgacttcatg gtggccgtcg acccgtacct caacgagacc tcacgccacg
    21181 cgcacgtcgt gctgcccccg ccgccgcccg cgcagacccc gcaccacgac ttcgccttca
    21241 acaccctcgc cgtgcgcaac caggtccgct acacccgccc cgccgtccct ctcgaacccg
    21301 gccgcatggc cgagaccgag atcatggccc ggctggtcct cgccgcgacg ggccgccacg
    21361 gcgccgaccc gtccgccgtc gacgcgatgg tgatcgagca gagcctcgag gcggcggtgg
    21421 gggagccgca ctccccggtg cacggccgcg acccggggga actcgccgcc atgctgaccg
    21481 gcctggacgg ccccgagcgg cggctcgacc tgatgctgcg cctgggcccc tacggcgacg
    21541 gcttcggcgc ccggccggac gggctcaccc tggagaagct gctcgcgcac ccgcacggca
    21601 tcgacctcgg cccgctccgc ccccgcctgc cgcagccgct gaagaccagg agcggcaagg
    21661 tggagctgct gcccgggccg atcgccgacg acctgccccg cctgcgcgcc gccctggccg
    21721 agcgccccac cgggttcgtc ctggtcggcc gccgccatct gcgctccaac aacagctgga
    21781 tgcacaacat cccggccctc accggcggca ccaaccgctg caccctgcac atccaccccg
    21841 aggacgccgc ccgcctgggc gtacgggacg gggcacc
//
