RiPP-TIDE results


Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
precursor_groups_2166 30.46 +- 5.65 2 0 0 0 0.07 +- 0.12 2 6

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase

precursor_groups_906 57.96 +- 12.04 2 0 0 2 0.05 +- 0.10 2 9

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily

precursor_groups_239 614.62 +- 470.04 25 0 21 0 0.07 +- 0.11 25 26

TIGR01525 (25/25) heavy metal translocating P-type ATPase
PF04314 (25/25) Copper chaperone PCu(A)C
PF00702 (25/25) haloacid dehalogenase-like hydrolase
PF00403 (25/25) Heavy-metal-associated domain
PF00122 (25/25) E1-E2 ATPase
PF07690 (23/25) Major Facilitator Superfamily
PF05118 (21/25) Aspartyl/Asparaginyl beta-hydroxylase
TIGR01733 (19/25) amino acid adenylation domain
PF13193 (19/25) AMP-binding enzyme C-terminal domain
PF10862 (19/25) FcoT-like thioesterase domain
PF08545 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (19/25) Male sterility protein
PF02668 (19/25) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (19/25) Condensation domain
PF00550 (19/25) Phosphopantetheine attachment site
PF00501 (19/25) AMP-binding enzyme
TIGR01746 (18/25) thioester reductase domain
TIGR00747 (18/25) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF01497 (18/25) Periplasmic binding protein
PF01032 (18/25) FecCD transport family
PF00005 (18/25) ABC transporter
PF01965 (17/25) DJ-1/PfpI family
TIGR02937 (16/25) RNA polymerase sigma factor, sigma-70 family
PF08281 (16/25) Sigma-70, region 4
PF04542 (16/25) Sigma-70 region 2

precursor_groups_33088 240.43 +- 106.11 3 0 3 0 0.01 +- 0.02 3 4

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme

precursor_groups_8175 554.81 +- 177.49 10 0 0 0 0.02 +- 0.02 10 19

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family

precursor_groups_8171 414.92 +- 442.96 5 0 0 0 0.06 +- 0.12 5 7

PF13407 (5/5) Periplasmic binding protein domain
PF13377 (5/5) Periplasmic binding protein-like domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00005 (5/5) ABC transporter
PF05025 (4/5) RbsD / FucU transport protein family

precursor_groups_25857 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family

precursor_groups_48679 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_4581 280.13 +- 235.87 2 0 0 2 0.05 +- 0.16 2 7

PF14518 (2/2) Iron-containing redox enzyme
PF12704 (2/2) MacB-like periplasmic core domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF02687 (2/2) FtsX-like permease family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_1662 839.58 +- 460.42 22 20 2 22 0.02 +- 0.02 2 11

TIGR03891 (22/22) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (22/22) Lantibiotic biosynthesis dehydratase C-term
PF05147 (22/22) Lanthionine synthetase C-like protein
PF04738 (22/22) Lantibiotic dehydratase, N terminus
PF00005 (22/22) ABC transporter
TIGR03731 (21/22) lantibiotic, gallidermin/nisin family
PF02052 (18/22) Gallidermin
PF00486 (14/22) Transcriptional regulatory protein, C terminal
PF02518 (12/22) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (12/22) His Kinase A (phospho-acceptor) domain
PF00072 (12/22) Response regulator receiver domain

precursor_groups_41765 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III

precursor_groups_31630 43.41 +- 0.41 2 0 2 0 0.07 +- 0.09 2 5

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00905 (2/2) Penicillin binding protein transpeptidase domain
PF00266 (2/2) Aminotransferase class-V
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_81410 1580.73 +- 635.73 2 0 2 0 0.02 +- 0.04 2 14

PF13649 (2/2) Methyltransferase domain
PF05193 (2/2) Peptidase M16 inactive domain
PF03965 (2/2) Penicillinase repressor
PF01937 (2/2) Protein of unknown function DUF89
PF01475 (2/2) Ferric uptake regulator family
PF01435 (2/2) Peptidase family M48
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter

precursor_groups_60000 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_7743 516.00 +- 0.00 2 0 2 2 0.01 +- 0.00 2 7

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_20892 133.48 +- 31.64 2 0 0 0 0.04 +- 0.04 2 6

PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02899 (2/2) Phage integrase, N-terminal SAM-like domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain

precursor_groups_23858 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain

precursor_groups_4514 1001.47 +- 887.78 16 0 12 0 0.05 +- 0.18 16 18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase

precursor_groups_19376 140.89 +- 0.00 2 0 2 2 0.10 +- 0.08 2 12

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_44607 275.37 +- 49.63 2 0 0 0 0.02 +- 0.02 2 8

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16884 (2/2) N-terminal domain of oxidoreductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_46039 398.33 +- 178.68 3 0 0 0 0.02 +- 0.01 3 8

PF12697 (3/3) Alpha/beta hydrolase family
PF11723 (3/3) Homotrimeric ring hydroxylase
PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF00561 (3/3) alpha/beta hydrolase fold
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_6399 79.05 +- 17.93 5 0 0 0 0.08 +- 0.03 5 9

TIGR02133 (5/5) ribose 5-phosphate isomerase
PF16896 (5/5) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (5/5) Major Facilitator Superfamily
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF02734 (5/5) DAK2 domain
PF02733 (5/5) Dak1 domain
PF02502 (5/5) Ribose/Galactose Isomerase
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00121 (5/5) Triosephosphate isomerase

precursor_groups_9254 120.00 +- 0.00 2 0 0 0 0.10 +- 0.25 2 12

TIGR00229 (2/2) PAS domain S-box protein
PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (2/2) Animal haem peroxidase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01061 (2/2) ABC-2 type transporter
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (2/2) Universal stress protein family
PF00199 (2/2) Catalase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF08448 (1/2) PAS fold
PF00989 (1/2) PAS fold

precursor_groups_62683 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_19562 118.50 +- 53.50 2 0 0 0 0.05 +- 0.07 2 14

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat

precursor_groups_2 284.40 +- 250.53 6 0 5 1 0.05 +- 0.12 6 25

PF04149 (5/6) Domain of unknown function (DUF397)
TIGR01762 (4/6) chlorinating enzyme
TIGR01733 (4/6) amino acid adenylation domain
TIGR01509 (4/6) HAD hydrolase, family IA, variant 3
TIGR01444 (4/6) methyltransferase, FkbM family
TIGR00843 (4/6) benzoate transporter
PF16990 (4/6) Carbohydrate binding module (family 35)
PF13560 (4/6) Helix-turn-helix domain
PF13535 (4/6) ATP-grasp domain
PF13454 (4/6) FAD-NAD(P)-binding
PF13419 (4/6) Haloacid dehalogenase-like hydrolase
PF13193 (4/6) AMP-binding enzyme C-terminal domain
PF07691 (4/6) PA14 domain
PF06439 (4/6) Domain of Unknown Function (DUF1080)
PF05721 (4/6) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/6) Methyltransferase FkbM domain
PF03594 (4/6) Benzoate membrane transport protein
PF02771 (4/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/6) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/6) Fructose-bisphosphate aldolase class-II
PF00975 (4/6) Thioesterase domain
PF00892 (4/6) EamA-like transporter family
PF00550 (4/6) Phosphopantetheine attachment site
PF00501 (4/6) AMP-binding enzyme
PF00441 (4/6) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_1 922.65 +- 1480.94 16 0 5 5 0.03 +- 0.05 16 2

PF04149 (16/16) Domain of unknown function (DUF397)
PF13560 (8/16) Helix-turn-helix domain

precursor_groups_6306 257.74 +- 131.52 2 0 0 0 0.02 +- 0.10 2 15

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13560 (1/2) Helix-turn-helix domain
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF01580 (1/2) FtsK/SpoIIIE family
PF00436 (1/2) Single-strand binding protein family

precursor_groups_4 121.60 +- 155.04 4 0 0 0 0.05 +- 0.09 4 6

TIGR01509 (3/4) HAD hydrolase, family IA, variant 3
PF13419 (3/4) Haloacid dehalogenase-like hydrolase
PF08386 (3/4) TAP-like protein
PF04149 (3/4) Domain of unknown function (DUF397)
PF02388 (3/4) FemAB family
PF00561 (3/4) alpha/beta hydrolase fold

precursor_groups_353 456.93 +- 108.77 3 0 3 0 0.03 +- 0.03 3 6

TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF01959 (2/3) 3-dehydroquinate synthase II
PF01791 (2/3) DeoC/LacD family aldolase
PF01494 (2/3) FAD binding domain

precursor_groups_11212 795.64 +- 536.08 8 0 8 8 0.03 +- 0.08 8 12

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (8/8) SagB-type dehydrogenase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (8/8) Domain of unknown function (DUF4135)
PF03412 (8/8) Peptidase C39 family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00067 (8/8) Cytochrome P450
PF00005 (8/8) ABC transporter
PF00364 (6/8) Biotin-requiring enzyme
PF05147 (4/8) Lanthionine synthetase C-like protein

precursor_groups_31252 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain

precursor_groups_3707 1270.23 +- 755.78 18 2 16 18 0.02 +- 0.03 16 8

TIGR03897 (18/18) type 2 lantibiotic biosynthesis protein LanM
PF13575 (18/18) Domain of unknown function (DUF4135)
PF05147 (18/18) Lanthionine synthetase C-like protein
PF03412 (18/18) Peptidase C39 family
PF00664 (18/18) ABC transporter transmembrane region
PF00005 (18/18) ABC transporter
PF14867 (16/18) Lantibiotic alpha
PF12730 (15/18) ABC-2 family transporter protein

precursor_groups_46517 138.46 +- 43.67 3 0 0 0 0.03 +- 0.02 3 9

PF17291 (3/3) N-terminal domain of M60-like peptidases
PF13402 (3/3) Peptidase M60, enhancin and enhancin-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family

precursor_groups_41235 63.35 +- 11.31 3 0 0 0 0.05 +- 0.03 3 4

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family

precursor_groups_17587 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

precursor_groups_121 1363.95 +- 1630.95 4 0 4 4 0.04 +- 0.08 4 14

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF03704 (4/4) Bacterial transcriptional activator domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (4/4) ABC-2 type transporter
PF00881 (4/4) Nitroreductase family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00005 (4/4) ABC transporter
TIGR03892 (3/4) thiazolylpeptide-type bacteriocin precursor
TIGR01891 (3/4) amidohydrolase
PF01546 (3/4) Peptidase family M20/M25/M40
PF00296 (2/4) Luciferase-like monooxygenase

precursor_groups_34009 377.27 +- 142.73 2 0 0 0 0.02 +- 0.01 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00652 (2/2) Ricin-type beta-trefoil lectin domain

precursor_groups_21556 832.00 +- 254.75 5 0 0 5 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02441 (5/5) Flavoprotein

precursor_groups_18390 864.29 +- 155.78 3 0 3 3 0.01 +- 0.02 3 9

TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF01980 (3/3) tRNA-methyltransferase O
PF01494 (3/3) FAD binding domain
PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family

precursor_groups_44042 47.53 +- 2.00 2 0 0 0 0.06 +- 0.06 2 3

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I

precursor_groups_71616 195.00 +- 0.00 2 0 1 0 0.02 +- 0.00 2 10

TIGR00229 (2/2) PAS domain S-box protein
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_61212 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)

precursor_groups_3209 61.10 +- 12.21 3 0 1 0 0.05 +- 0.02 3 3

PF01292 (3/3) Prokaryotic cytochrome b561
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF07519 (2/3) Tannase and feruloyl esterase

precursor_groups_55307 481.90 +- 168.10 2 0 0 0 0.02 +- 0.02 2 6

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V

precursor_groups_83750 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family

precursor_groups_41801 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain

precursor_groups_36866 332.14 +- 118.84 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family

precursor_groups_545 287.08 +- 232.92 2 0 2 2 0.04 +- 0.10 2 7

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF06722 (2/2) Protein of unknown function (DUF1205)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain

precursor_groups_542 156.12 +- 66.54 2 0 1 0 0.07 +- 0.06 2 10

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF17900 (1/2) Peptidase M1 N-terminal domain
PF03814 (1/2) Potassium-transporting ATPase A subunit
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01433 (1/2) Peptidase family M1 domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00331 (1/2) Glycosyl hydrolase family 10
PF00293 (1/2) NUDIX domain

precursor_groups_11589 780.00 +- 260.00 6 0 0 6 0.01 +- 0.00 6 4

PF07690 (6/6) Major Facilitator Superfamily
PF04055 (6/6) Radical SAM superfamily
PF02441 (6/6) Flavoprotein
PF02310 (3/6) B12 binding domain

precursor_groups_11233 4608.81 +- 2021.19 2 0 2 0 0.02 +- 0.03 2 16

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01527 (2/2) Transposase
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13489 (1/2) Methyltransferase domain
PF00183 (1/2) Hsp90 protein
PF00069 (1/2) Protein kinase domain

precursor_groups_104 219.64 +- 53.64 11 0 0 0 0.04 +- 0.06 11 3

PF13545 (9/11) Crp-like helix-turn-helix domain
PF07228 (9/11) Stage II sporulation protein E (SpoIIE)
PF00027 (9/11) Cyclic nucleotide-binding domain

precursor_groups_4868 229.23 +- 30.77 3 1 1 0 0.01 +- 0.01 2 4

PF03412 (3/3) Peptidase C39 family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF00535 (2/3) Glycosyl transferase family 2

precursor_groups_17449 216.17 +- 107.83 2 0 0 0 0.04 +- 0.05 2 9

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)

precursor_groups_68315 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter

precursor_groups_70666 85.00 +- 45.00 2 0 0 0 0.03 +- 0.03 2 2

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_groups_23434 338.00 +- 182.00 2 0 0 0 0.02 +- 0.06 2 10

PF07291 (2/2) Methylamine utilisation protein MauE
PF00717 (2/2) Peptidase S24-like
PF00005 (2/2) ABC transporter
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10502 (1/2) Signal peptidase, peptidase S26
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (1/2) FAD binding domain
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00578 (1/2) AhpC/TSA family
PF00440 (1/2) Bacterial regulatory proteins, tetR family

precursor_groups_11906 183.10 +- 82.91 6 0 0 0 0.01 +- 0.01 6 1

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase

precursor_groups_78352 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_20733 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site

precursor_groups_77605 230.67 +- 116.00 2 0 0 0 0.02 +- 0.03 2 6

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_35663 122.11 +- 15.00 3 0 1 0 0.08 +- 0.21 3 9

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat

precursor_groups_15437 282.51 +- 110.62 6 0 0 0 0.01 +- 0.01 6 5

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family

precursor_groups_2281 800.06 +- 256.65 6 0 5 0 0.01 +- 0.01 6 11

PF17914 (6/6) HopA1 effector protein family
PF05193 (6/6) Peptidase M16 inactive domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00675 (6/6) Insulinase (Peptidase family M16)
PF13649 (5/6) Methyltransferase domain
PF13546 (5/6) DDE superfamily endonuclease
PF02441 (5/6) Flavoprotein
PF00005 (5/6) ABC transporter
TIGR00414 (3/6) serine--tRNA ligase
PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain
PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)

precursor_groups_10508 299.00 +- 23.50 2 0 0 0 0.05 +- 0.09 2 12

TIGR01764 (2/2) DNA binding domain, excisionase family
PF13411 (2/2) MerR HTH family regulatory protein
PF13245 (2/2) AAA domain
PF12728 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF12679 (2/2) ABC-2 family transporter protein
PF07739 (2/2) TipAS antibiotic-recognition domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF01551 (2/2) Peptidase family M23
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain

precursor_groups_5419 953.88 +- 214.88 4 0 0 4 0.01 +- 0.01 4 7

TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (4/4) Iron-sulfur cluster-binding domain
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (4/4) Radical SAM superfamily
PF01061 (4/4) ABC-2 type transporter
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter

precursor_groups_23648 167.66 +- 10.77 2 0 0 0 0.06 +- 0.03 2 9

TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter

precursor_groups_765 190.01 +- 103.85 17 0 17 16 0.04 +- 0.06 17 5

TIGR03975 (17/17) ribosomal peptide maturation radical SAM protein 1
PF07690 (17/17) Major Facilitator Superfamily
PF02310 (17/17) B12 binding domain
PF00326 (17/17) Prolyl oligopeptidase family
PF04055 (16/17) Radical SAM superfamily

precursor_groups_75057 2220.43 +- 119.57 2 0 0 0 0.01 +- 0.00 2 8

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein

precursor_groups_1137 203.30 +- 256.64 4 0 0 0 0.04 +- 0.05 4 2

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase

precursor_groups_45170 1548.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 17

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III

precursor_groups_40558 609.27 +- 165.86 3 0 3 0 0.01 +- 0.00 3 11

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase

precursor_groups_24923 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)

precursor_groups_20597 400.13 +- 221.16 3 0 1 0 0.05 +- 0.17 3 26

TIGR02100 (3/3) glycogen debranching enzyme GlgX
TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme
TIGR00377 (3/3) anti-anti-sigma factor
PF18085 (3/3) Maltokinase N-terminal cap domain
PF17124 (3/3) ThiJ/PfpI family-like
PF13614 (3/3) AAA domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13546 (3/3) DDE superfamily endonuclease
PF13466 (3/3) STAS domain
PF13460 (3/3) NAD(P)H-binding
PF13380 (3/3) CoA binding domain
PF11896 (3/3) Domain of unknown function (DUF3416)
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (3/3) EthD domain
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (3/3) DJ-1/PfpI family
PF01740 (3/3) STAS domain
PF00483 (3/3) Nucleotidyl transferase
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF00128 (3/3) Alpha amylase, catalytic domain

precursor_groups_22333 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6

precursor_groups_12158 2061.33 +- 765.80 7 0 0 0 0.01 +- 0.01 7 12

PF17874 (7/7) MalT-like TPR region
PF13560 (7/7) Helix-turn-helix domain
PF13393 (7/7) Histidyl-tRNA synthetase
PF05193 (7/7) Peptidase M16 inactive domain
PF03721 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (7/7) GlcNAc-PI de-N-acetylase
PF01370 (7/7) NAD dependent epimerase/dehydratase family
PF01061 (7/7) ABC-2 type transporter
PF00984 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (7/7) Insulinase (Peptidase family M16)
PF00005 (7/7) ABC transporter

precursor_groups_61591 306.43 +- 83.57 2 0 2 0 0.01 +- 0.00 2 7

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00155 (2/2) Aminotransferase class I and II

precursor_groups_6342 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_1450 759.98 +- 690.09 3 0 3 3 0.06 +- 0.20 3 6

PF06114 (3/3) IrrE N-terminal-like domain
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02687 (3/3) FtsX-like permease family
PF00082 (3/3) Subtilase family
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter

precursor_groups_14823 174.93 +- 114.89 6 0 0 0 0.03 +- 0.05 6 8

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase

precursor_groups_1355 178.94 +- 79.06 2 0 0 0 0.04 +- 0.07 2 5

PF00067 (2/2) Cytochrome P450
PF14534 (1/2) Domain of unknown function (DUF4440)
PF08002 (1/2) Protein of unknown function (DUF1697)
PF05922 (1/2) Peptidase inhibitor I9
PF00082 (1/2) Subtilase family

precursor_groups_45774 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain

precursor_groups_73507 1554.00 +- 6.00 2 0 2 0 0.01 +- 0.00 2 7

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter

precursor_groups_9108 117.34 +- 48.52 2 0 2 0 0.03 +- 0.04 2 4

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family

precursor_groups_64153 258.09 +- 86.03 2 0 0 2 0.03 +- 0.05 2 13

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter

precursor_groups_84823 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_78012 710.45 +- 47.26 2 0 2 2 0.03 +- 0.03 2 20

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (2/2) GAF domain
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)

precursor_groups_6043 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS

precursor_groups_70686 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase

precursor_groups_71289 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family

precursor_groups_1957 91.17 +- 58.33 18 0 0 0 0.03 +- 0.02 18 3

PF12833 (18/18) Helix-turn-helix domain
PF02311 (18/18) AraC-like ligand binding domain
PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)

precursor_groups_165 32.06 +- 9.93 8 0 0 0 0.07 +- 0.05 8 4

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_5606 65.80 +- 23.86 2 0 1 0 0.05 +- 0.06 2 8

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (1/2) Glycosyl hydrolase family 92

precursor_groups_79714 2072.00 +- 8.00 2 0 0 0 0.01 +- 0.00 2 7

PF08386 (2/2) TAP-like protein
PF07702 (2/2) UTRA domain
PF01380 (2/2) SIS domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_17666 49.71 +- 15.29 2 0 2 2 0.07 +- 0.08 2 6

PF14518 (2/2) Iron-containing redox enzyme
PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (2/2) Subtilase family

precursor_groups_1821 358.75 +- 32.16 2 0 0 0 0.01 +- 0.01 2 18

TIGR01558 (2/2) putative phage terminase, small subunit, P27 family
TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (2/2) Phage-related minor tail protein
PF05119 (2/2) Phage terminase, small subunit
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04586 (2/2) Caudovirus prohead serine protease
PF04542 (2/2) Sigma-70 region 2
PF03354 (2/2) Phage Terminase
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (2/2) Collagen triple helix repeat (20 copies)
PF01381 (2/2) Helix-turn-helix
PF00271 (2/2) Helicase conserved C-terminal domain

precursor_groups_68266 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_463 130.00 +- 70.00 2 0 0 0 0.04 +- 0.03 2 6

PF12833 (2/2) Helix-turn-helix domain
PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/2) mttA/Hcf106 family
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase

precursor_groups_462 509.83 +- 454.74 34 0 18 1 0.05 +- 0.15 34 15

TIGR01850 (34/34) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (34/34) RimK-like ATP-grasp domain
PF02779 (34/34) Transketolase, pyrimidine binding domain
PF01118 (34/34) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (34/34) Transketolase, thiamine diphosphate binding domain
TIGR00768 (30/34) alpha-L-glutamate ligase, RimK family
TIGR01902 (23/34) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (23/34) Peptidase family M20/M25/M40
PF01041 (23/34) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (23/34) Amino acid kinase family
PF07690 (18/34) Major Facilitator Superfamily
PF18603 (17/34) L-amino acid ligase C-terminal domain 2
PF18130 (17/34) ATP-grasp N-terminal domain
PF13535 (17/34) ATP-grasp domain
PF02780 (17/34) Transketolase, C-terminal domain

precursor_groups_9061 189.23 +- 42.98 2 0 0 0 0.02 +- 0.01 2 5

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_500 726.73 +- 607.66 2 0 1 1 0.08 +- 0.19 2 21

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/2) amidohydrolase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (1/2) Histidine kinase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03412 (1/2) Peptidase C39 family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (1/2) Peptidase family M20/M25/M40
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00877 (1/2) NlpC/P60 family
PF00664 (1/2) ABC transporter transmembrane region
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter

precursor_groups_265 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase

precursor_groups_44077 763.96 +- 609.16 2 0 2 1 0.05 +- 0.14 2 24

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03494 (2/2) salicylate synthase
TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR01443 (2/2) intein C-terminal splicing region
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (2/2) Pretoxin HINT domain
PF05593 (2/2) RHS Repeat
PF03704 (2/2) Bacterial transcriptional activator domain
PF02361 (2/2) Cobalt transport protein
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00425 (2/2) chorismate binding enzyme
PF00005 (2/2) ABC transporter
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region

precursor_groups_41937 915.56 +- 502.62 2 0 0 0 0.01 +- 0.01 2 8

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07722 (2/2) Peptidase C26
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_22977 3011.04 +- 331.81 2 0 2 2 0.01 +- 0.01 2 8

PF13649 (2/2) Methyltransferase domain
PF12730 (2/2) ABC-2 family transporter protein
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter

precursor_groups_4638 1058.04 +- 888.53 15 0 12 0 0.05 +- 0.18 15 18

TIGR01307 (15/15) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13535 (15/15) ATP-grasp domain
PF13480 (15/15) Acetyltransferase (GNAT) domain
PF13115 (15/15) YtkA-like
PF04389 (15/15) Peptidase family M28
PF02627 (15/15) Carboxymuconolactone decarboxylase family
PF01676 (15/15) Metalloenzyme superfamily
PF00664 (15/15) ABC transporter transmembrane region
PF00403 (15/15) Heavy-metal-associated domain
PF00275 (15/15) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (15/15) Aminotransferase class I and II
PF00117 (15/15) Glutamine amidotransferase class-I
PF00005 (15/15) ABC transporter
TIGR01525 (14/15) heavy metal translocating P-type ATPase
TIGR01356 (14/15) 3-phosphoshikimate 1-carboxyvinyltransferase
PF13549 (14/15) ATP-grasp domain
PF00702 (14/15) haloacid dehalogenase-like hydrolase
PF00122 (14/15) E1-E2 ATPase

precursor_groups_15205 169.73 +- 174.91 6 0 0 0 0.05 +- 0.09 6 10

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain

precursor_groups_62121 151.58 +- 28.42 2 0 0 0 0.02 +- 0.02 2 3

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme

precursor_groups_62573 376.25 +- 0.00 2 0 0 2 0.03 +- 0.03 2 20

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain

precursor_groups_53738 2291.55 +- 1062.45 2 0 0 0 0.01 +- 0.01 2 14

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF12146 (2/2) Serine aminopeptidase, S33
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (2/2) GH3 auxin-responsive promoter
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (2/2) Aconitase C-terminal domain
PF00330 (2/2) Aconitase family (aconitate hydratase)

precursor_groups_28574 274.58 +- 189.71 2 0 2 0 0.03 +- 0.05 2 10

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_2083 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family

precursor_groups_20660 144.72 +- 11.28 2 0 2 2 0.04 +- 0.04 2 3

PF13471 (2/2) Transglutaminase-like superfamily
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase

precursor_groups_1011 122.11 +- 96.49 3 0 0 0 0.03 +- 0.04 3 5

TIGR01840 (3/3) esterase, PHB depolymerase family
TIGR00666 (3/3) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (3/3) Protein of unknown function (DUF4232)
PF10503 (3/3) Esterase PHB depolymerase
PF02113 (3/3) D-Ala-D-Ala carboxypeptidase 3 (S13) family

precursor_groups_58650 454.25 +- 29.50 2 0 2 2 0.02 +- 0.02 2 13

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain

precursor_groups_5459 235.19 +- 41.40 6 0 1 0 0.02 +- 0.01 6 7

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF04488 (6/6) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (6/6) YbaB/EbfC DNA-binding family

precursor_groups_32866 197.39 +- 31.14 3 0 0 0 0.07 +- 0.11 3 15

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter

precursor_groups_10155 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2

precursor_groups_28226 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family

precursor_groups_85472 390.00 +- 0.00 2 0 1 0 0.01 +- 0.00 2 4

PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_918 213.47 +- 171.99 14 0 12 14 0.02 +- 0.02 14 4

PF04055 (14/14) Radical SAM superfamily
PF07690 (13/14) Major Facilitator Superfamily
PF02897 (12/14) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (12/14) Prolyl oligopeptidase family

precursor_groups_28782 253.73 +- 93.57 2 0 0 0 0.05 +- 0.06 2 11

PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF04909 (1/2) Amidohydrolase
PF04199 (1/2) Putative cyclase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_15497 1363.59 +- 571.41 2 0 0 0 0.01 +- 0.01 2 17

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter

precursor_groups_20405 235.76 +- 54.49 2 0 0 0 0.08 +- 0.12 2 11

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (2/2) Domain of unknown function (DUF4331)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00925 (2/2) GTP cyclohydrolase II
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00082 (2/2) Subtilase family

precursor_groups_37629 453.70 +- 99.16 2 0 0 0 0.03 +- 0.02 2 7

TIGR03296 (2/2) M6 family metalloprotease domain
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter

precursor_groups_1673 545.07 +- 292.47 24 0 24 24 0.04 +- 0.09 24 6

PF05147 (24/24) Lanthionine synthetase C-like protein
PF00664 (24/24) ABC transporter transmembrane region
PF00326 (24/24) Prolyl oligopeptidase family
PF00069 (24/24) Protein kinase domain
PF00005 (24/24) ABC transporter
PF04672 (23/24) S-adenosyl methyltransferase

precursor_groups_20705 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold

precursor_groups_72197 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_45090 194.50 +- 52.12 2 0 0 0 0.07 +- 0.08 2 15

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase

precursor_groups_8543 47.10 +- 5.79 3 0 0 0 0.06 +- 0.05 3 5

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02036 (3/3) SCP-2 sterol transfer family

precursor_groups_10436 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_42674 291.05 +- 29.25 2 0 0 0 0.08 +- 0.18 2 21

TIGR01928 (2/2) o-succinylbenzoate synthase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF12831 (2/2) FAD dependent oxidoreductase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (2/2) CoA-transferase family III
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01381 (2/2) Helix-turn-helix
PF01380 (2/2) SIS domain
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter

precursor_groups_84552 122.27 +- 27.73 2 0 2 0 0.02 +- 0.01 2 6

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family

precursor_groups_21947 420.25 +- 97.76 4 0 4 0 0.01 +- 0.00 4 6

PF03412 (4/4) Peptidase C39 family
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter

precursor_groups_14303 191.56 +- 72.66 4 0 0 0 0.07 +- 0.11 4 11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

precursor_groups_1009 1097.05 +- 1032.42 46 7 39 45 0.03 +- 0.09 39 7

PF13575 (45/46) Domain of unknown function (DUF4135)
PF05147 (45/46) Lanthionine synthetase C-like protein
TIGR03897 (44/46) type 2 lantibiotic biosynthesis protein LanM
PF03412 (44/46) Peptidase C39 family
PF00664 (44/46) ABC transporter transmembrane region
PF00005 (44/46) ABC transporter
PF14867 (43/46) Lantibiotic alpha

precursor_groups_48611 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase

precursor_groups_16355 383.81 +- 168.05 5 0 0 5 0.01 +- 0.03 5 7

TIGR00702 (5/5) YcaO-type kinase domain
PF18029 (5/5) Glyoxalase-like domain
PF13489 (5/5) Methyltransferase domain
PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (5/5) TfuA-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding

precursor_groups_40542 328.15 +- 104.38 2 0 2 0 0.07 +- 0.16 2 15

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain

precursor_groups_76415 96.37 +- 5.37 2 0 0 0 0.03 +- 0.04 2 4

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2

precursor_groups_42 40.24 +- 11.75 3 0 0 0 0.08 +- 0.17 3 3

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C

precursor_groups_42811 650.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 1

PF13367 (2/2) PrsW family intramembrane metalloprotease

precursor_groups_49 249.44 +- 156.55 16 8 7 10 0.05 +- 0.06 8 4

PF00005 (16/16) ABC transporter
PF00664 (14/16) ABC transporter transmembrane region
PF00069 (13/16) Protein kinase domain
PF05147 (9/16) Lanthionine synthetase C-like protein

precursor_groups_80550 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region

precursor_groups_51837 1068.75 +- 101.25 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_50833 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_15659 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain

precursor_groups_321 32.76 +- 4.10 2 0 0 0 0.06 +- 0.03 2 2

PF08007 (2/2) Cupin superfamily protein
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_6316 468.39 +- 239.31 3 0 0 0 0.03 +- 0.02 3 14

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13460 (3/3) NAD(P)H-binding
PF07690 (3/3) Major Facilitator Superfamily
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF01494 (3/3) FAD binding domain
PF00561 (3/3) alpha/beta hydrolase fold
TIGR00928 (2/3) adenylosuccinate lyase
PF13673 (2/3) Acetyltransferase (GNAT) domain
PF12800 (2/3) 4Fe-4S binding domain
PF01425 (2/3) Amidase
PF00486 (2/3) Transcriptional regulatory protein, C terminal
PF00206 (2/3) Lyase
PF00120 (2/3) Glutamine synthetase, catalytic domain
PF00072 (2/3) Response regulator receiver domain

precursor_groups_82367 322.38 +- 56.79 2 0 0 0 0.02 +- 0.02 2 6

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450

precursor_groups_5888 778.00 +- 2.83 3 0 0 3 0.01 +- 0.00 3 8

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)

precursor_groups_733 5756.47 +- 1500.30 3 0 3 3 0.01 +- 0.01 3 11

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00005 (3/3) ABC transporter
TIGR01189 (2/3) heme ABC exporter, ATP-binding protein CcmA
PF12698 (2/3) ABC-2 family transporter protein

precursor_groups_730 1147.46 +- 656.81 23 5 18 23 0.02 +- 0.04 18 8

TIGR03897 (23/23) type 2 lantibiotic biosynthesis protein LanM
PF13575 (23/23) Domain of unknown function (DUF4135)
PF05147 (23/23) Lanthionine synthetase C-like protein
PF03412 (22/23) Peptidase C39 family
PF00664 (22/23) ABC transporter transmembrane region
PF00005 (22/23) ABC transporter
TIGR03898 (20/23) type 2 lantibiotic, mersacidin/lichenicidin family
PF12679 (14/23) ABC-2 family transporter protein

precursor_groups_83733 4608.81 +- 2021.19 2 0 2 0 0.02 +- 0.03 2 16

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01527 (2/2) Transposase
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13489 (1/2) Methyltransferase domain
PF00183 (1/2) Hsp90 protein
PF00069 (1/2) Protein kinase domain

precursor_groups_2450 27.06 +- 5.19 2 0 0 0 0.09 +- 0.10 2 7

PF13516 (2/2) Leucine Rich repeat
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF14435 (1/2) SUKH-4 immunity protein
PF12796 (1/2) Ankyrin repeats (3 copies)
PF01738 (1/2) Dienelactone hydrolase family

precursor_groups_46115 186.14 +- 8.86 2 0 0 0 0.03 +- 0.04 2 6

PF13564 (2/2) DoxX-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (2/2) NADPH-dependent FMN reductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF18616 (1/2) CDI immunity proteins

precursor_groups_2515 339.13 +- 0.00 2 0 0 0 0.03 +- 0.01 2 8

TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1)
PF04679 (2/2) ATP dependent DNA ligase C terminal region
PF04675 (2/2) DNA ligase N terminus
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01068 (2/2) ATP dependent DNA ligase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_81827 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat

precursor_groups_9139 7843.20 +- 6508.80 2 0 2 2 0.05 +- 0.15 2 21

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (2/2) amidohydrolase
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (2/2) Histidine kinase
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03412 (2/2) Peptidase C39 family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (2/2) Peptidase family M20/M25/M40
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF14310 (1/2) Fibronectin type III-like domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain

precursor_groups_14447 122.10 +- 43.38 4 0 0 0 0.05 +- 0.04 4 12

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (4/4) amidohydrolase
TIGR00843 (4/4) benzoate transporter
PF13454 (4/4) FAD-NAD(P)-binding
PF13424 (4/4) Tetratricopeptide repeat
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (4/4) Peptidase family M20/M25/M40
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00931 (4/4) NB-ARC domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme

precursor_groups_429 687.94 +- 313.54 3 1 2 3 0.02 +- 0.02 2 11

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00069 (3/3) Protein kinase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
PF00494 (2/3) Squalene/phytoene synthase

precursor_groups_32192 365.31 +- 284.69 2 0 0 0 0.03 +- 0.05 2 3

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase

precursor_groups_427 3858.25 +- 1997.49 19 0 19 19 0.02 +- 0.06 19 7

TIGR03882 (19/19) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (19/19) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (19/19) Lantibiotic biosynthesis dehydratase C-term
PF02624 (19/19) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (19/19) Nitroreductase family
PF00005 (13/19) ABC transporter
PF05402 (10/19) Coenzyme PQQ synthesis protein D (PqqD)

precursor_groups_12981 276.85 +- 62.50 3 0 0 0 0.02 +- 0.02 3 5

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family

precursor_groups_132 112.76 +- 103.65 3 0 0 0 0.05 +- 0.07 3

No common domains found

precursor_groups_67117 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_48975 292.50 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family

precursor_groups_42689 1292.60 +- 296.28 2 0 2 2 0.03 +- 0.02 2 9

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (2/2) Lantibiotic alpha
PF13575 (2/2) Domain of unknown function (DUF4135)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13556 (1/2) PucR C-terminal helix-turn-helix domain

precursor_groups_45864 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter

precursor_groups_5499 174.02 +- 47.17 5 0 0 0 0.07 +- 0.10 5 7

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF12680 (5/5) SnoaL-like domain
PF07045 (5/5) Domain of unknown function (DUF1330)
PF01738 (5/5) Dienelactone hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00005 (5/5) ABC transporter

precursor_groups_26684 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter

precursor_groups_54637 69.96 +- 24.43 2 0 0 2 0.05 +- 0.09 2 11

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain

precursor_groups_12804 206.28 +- 77.96 4 0 0 0 0.09 +- 0.09 4 17

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (4/4) Alpha galactosidase A
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase

precursor_groups_56365 433.58 +- 275.92 2 0 0 0 0.04 +- 0.03 2 8

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter

precursor_groups_556 112.93 +- 162.01 47 4 40 47 0.04 +- 0.07 43 3

PF00733 (47/47) Asparagine synthase
PF13471 (46/47) Transglutaminase-like superfamily
PF05402 (46/47) Coenzyme PQQ synthesis protein D (PqqD)

precursor_groups_6671 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_13764 233.66 +- 123.26 4 0 0 0 0.02 +- 0.03 4 6

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family

precursor_groups_12543 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_5653 964.27 +- 325.73 2 0 0 0 0.01 +- 0.02 2 12

PF10502 (2/2) Signal peptidase, peptidase S26
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00899 (2/2) ThiF family
PF00717 (2/2) Peptidase S24-like
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF11271 (1/2) Porin PorA
PF07291 (1/2) Methylamine utilisation protein MauE
PF00440 (1/2) Bacterial regulatory proteins, tetR family

precursor_groups_75740 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain

precursor_groups_819 59.27 +- 22.81 4 0 4 0 0.04 +- 0.07 4 6

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain

precursor_groups_50706 129.50 +- 0.50 2 0 1 0 0.02 +- 0.00 2 5

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28

precursor_groups_62248 77.60 +- 25.60 2 0 0 0 0.03 +- 0.02 2 6

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase

precursor_groups_19855 277.22 +- 74.60 2 0 0 0 0.08 +- 0.08 2 22

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_64908 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_10742 114.31 +- 18.14 2 0 0 0 0.08 +- 0.04 2 5

PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00266 (2/2) Aminotransferase class-V

precursor_groups_2334 222.67 +- 78.34 11 0 0 0 0.03 +- 0.02 11 10

TIGR03930 (11/11) WXG100 family type VII secretion target
TIGR03920 (11/11) type VII secretion integral membrane protein EccD
TIGR03919 (11/11) type VII secretion protein EccB
PF15644 (11/11) Papain fold toxin 1, glutamine deamidase
PF08817 (11/11) WXG100 protein secretion system (Wss), protein YukD
PF07179 (11/11) SseB protein N-terminal domain
PF06013 (11/11) Proteins of 100 residues with WXG
PF05108 (11/11) Type VII secretion system ESX-1, transport TM domain B
PF02575 (11/11) YbaB/EbfC DNA-binding family
PF00652 (11/11) Ricin-type beta-trefoil lectin domain

precursor_groups_1282 192.97 +- 127.67 14 0 14 14 0.05 +- 0.03 14 13

TIGR04451 (14/14) lantipeptide, SCO0268 family
TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term
PF05147 (14/14) Lanthionine synthetase C-like protein
PF04738 (14/14) Lantibiotic dehydratase, N terminus
PF12802 (9/14) MarR family
PF12697 (9/14) Alpha/beta hydrolase family
PF02065 (9/14) Melibiase
PF01547 (9/14) Bacterial extracellular solute-binding protein
PF00528 (9/14) Binding-protein-dependent transport system inner membrane component
PF00480 (9/14) ROK family
PF02894 (8/14) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/14) Oxidoreductase family, NAD-binding Rossmann fold

precursor_groups_29741 336.40 +- 91.11 4 0 0 0 0.01 +- 0.01 4 4

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain

precursor_groups_1446 48.54 +- 0.65 2 0 0 0 0.08 +- 0.17 2 3

TIGR03296 (2/2) M6 family metalloprotease domain
PF09339 (2/2) IclR helix-turn-helix domain
PF03777 (2/2) ChpA-C

precursor_groups_21578 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_15041 226.53 +- 46.37 3 0 0 0 0.07 +- 0.11 3 11

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14224 (3/3) Domain of unknown function (DUF4331)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00925 (3/3) GTP cyclohydrolase II
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00082 (3/3) Subtilase family
PF02882 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

precursor_groups_50390 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_15049 2401.56 +- 1135.16 3 0 0 0 0.02 +- 0.01 3 13

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (3/3) ATP-grasp domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (3/3) Prephenate dehydrogenase
PF01613 (3/3) Flavin reductase like domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00106 (3/3) short chain dehydrogenase
PF18130 (2/3) ATP-grasp N-terminal domain

precursor_groups_52507 134.01 +- 78.72 2 0 2 2 0.06 +- 0.05 2 9

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF07591 (1/2) Pretoxin HINT domain
PF05593 (1/2) RHS Repeat

precursor_groups_9354 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_64010 117.00 +- 13.00 2 0 2 0 0.02 +- 0.01 2 4

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold

precursor_groups_36155 216.00 +- 44.00 2 0 0 0 0.01 +- 0.00 2 3

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain

precursor_groups_72354 69.81 +- 25.74 2 0 0 0 0.07 +- 0.06 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme

precursor_groups_2029 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_10969 877.59 +- 552.41 2 0 0 2 0.02 +- 0.06 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_39 50.96 +- 24.18 3 0 0 0 0.05 +- 0.03 3 3

PF13520 (3/3) Amino acid permease
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family

precursor_groups_585 93.44 +- 9.76 2 0 0 0 0.04 +- 0.07 2 5

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold

precursor_groups_1347 2220.43 +- 119.57 2 0 0 0 0.01 +- 0.00 2 8

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein

precursor_groups_14643 660.47 +- 112.74 7 0 7 0 0.01 +- 0.01 7 15

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_6914 73.12 +- 24.38 2 0 0 0 0.03 +- 0.02 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein

precursor_groups_10887 157.25 +- 62.23 4 0 2 0 0.07 +- 0.19 4 9

PF13191 (4/4) AAA ATPase domain
PF10502 (4/4) Signal peptidase, peptidase S26
PF07291 (4/4) Methylamine utilisation protein MauE
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter
PF02254 (3/4) TrkA-N domain
PF01242 (3/4) 6-pyruvoyl tetrahydropterin synthase
PF00664 (3/4) ABC transporter transmembrane region
PF13181 (2/4) Tetratricopeptide repeat

precursor_groups_9177 91.00 +- 39.00 2 0 0 0 0.03 +- 0.02 2 2

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase

precursor_groups_52435 1163.94 +- 693.66 2 0 0 0 0.02 +- 0.01 2 18

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (2/2) OsmC-like protein
PF02515 (2/2) CoA-transferase family III
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_20284 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family

precursor_groups_12012 858.49 +- 193.39 4 0 4 4 0.01 +- 0.00 4 11

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (4/4) HlyD family secretion protein
PF03412 (4/4) Peptidase C39 family
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter

precursor_groups_68571 24.72 +- 1.08 2 0 0 0 0.08 +- 0.08 2 4

PF10923 (2/2) P-loop Domain of unknown function (DUF2791)
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase

precursor_groups_1193 133.51 +- 85.83 9 0 0 0 0.03 +- 0.02 9 4

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like

precursor_groups_68779 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

precursor_groups_22154 1767.52 +- 216.09 3 0 1 3 0.01 +- 0.02 3 10

TIGR00702 (3/3) YcaO-type kinase domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF08007 (3/3) Cupin superfamily protein
PF07812 (3/3) TfuA-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00326 (3/3) Prolyl oligopeptidase family

precursor_groups_170 250.91 +- 0.64 2 0 1 0 0.07 +- 0.08 2 42

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00171 (2/2) Aldehyde dehydrogenase family
TIGR02258 (1/2) 2'-5' RNA ligase
TIGR00517 (1/2) acyl carrier protein
PF14310 (1/2) Fibronectin type III-like domain
PF13802 (1/2) Galactose mutarotase-like
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13377 (1/2) Periplasmic binding protein-like domain
PF08386 (1/2) TAP-like protein
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF07555 (1/2) beta-N-acetylglucosaminidase
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02838 (1/2) Glycosyl hydrolase family 20, domain 2
PF02834 (1/2) LigT like Phosphoesterase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01381 (1/2) Helix-turn-helix
PF01055 (1/2) Glycosyl hydrolases family 31
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00668 (1/2) Condensation domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00296 (1/2) Luciferase-like monooxygenase
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_174 500.84 +- 250.71 5 0 5 5 0.02 +- 0.05 5 11

TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM
PF13575 (5/5) Domain of unknown function (DUF4135)
PF13191 (5/5) AAA ATPase domain
PF05147 (5/5) Lanthionine synthetase C-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF00931 (5/5) NB-ARC domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13185 (4/5) GAF domain
PF08448 (4/5) PAS fold
PF07228 (4/5) Stage II sporulation protein E (SpoIIE)

precursor_groups_21393 152.71 +- 40.50 3 0 0 0 0.02 +- 0.01 3 3

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain

precursor_groups_10707 221.77 +- 79.53 9 0 0 0 0.05 +- 0.04 9 10

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (9/9) alpha/beta hydrolase fold
PF07690 (9/9) Major Facilitator Superfamily
PF03781 (9/9) Sulfatase-modifying factor enzyme 1
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (9/9) Phosphotriesterase family
PF01494 (9/9) FAD binding domain
PF00884 (9/9) Sulfatase
PF00753 (9/9) Metallo-beta-lactamase superfamily

precursor_groups_48835 1029.17 +- 97.50 2 0 2 0 0.01 +- 0.01 2 11

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_5265 2176.88 +- 2360.36 4 0 4 4 0.01 +- 0.01 4 8

TIGR03897 (4/4) type 2 lantibiotic biosynthesis protein LanM
PF14867 (4/4) Lantibiotic alpha
PF13575 (4/4) Domain of unknown function (DUF4135)
PF05147 (4/4) Lanthionine synthetase C-like protein
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF00296 (3/4) Luciferase-like monooxygenase

precursor_groups_2240 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

precursor_groups_2244 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix

precursor_groups_19605 157.71 +- 71.71 2 0 2 0 0.04 +- 0.08 2 9

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_450 27.25 +- 2.74 9 0 3 0 0.07 +- 0.09 9 6

PF13244 (9/9) Domain of unknown function (DUF4040)
PF12840 (9/9) Helix-turn-helix domain
PF04066 (9/9) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (9/9) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (9/9) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (9/9) Proton-conducting membrane transporter

precursor_groups_43009 109.51 +- 1.92 2 0 0 0 0.04 +- 0.03 2 6

PF04167 (2/2) Protein of unknown function (DUF402)
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00144 (2/2) Beta-lactamase
PF00082 (2/2) Subtilase family

precursor_groups_108 126.20 +- 2.80 2 0 1 0 0.05 +- 0.05 2 16

PF13088 (2/2) BNR repeat-like domain
TIGR03444 (1/2) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13641 (1/2) Glycosyltransferase like family 2
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13520 (1/2) Amino acid permease
PF11695 (1/2) Domain of unknown function (DUF3291)
PF04978 (1/2) Protein of unknown function (DUF664)
PF04264 (1/2) YceI-like domain
PF04248 (1/2) Domain of unknown function (DUF427)
PF04237 (1/2) YjbR
PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2)
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain

precursor_groups_6137 726.94 +- 148.59 6 0 0 0 0.02 +- 0.02 6 7

PF17914 (6/6) HopA1 effector protein family
PF13649 (6/6) Methyltransferase domain
PF05193 (6/6) Peptidase M16 inactive domain
PF02441 (6/6) Flavoprotein
PF00675 (6/6) Insulinase (Peptidase family M16)
PF00296 (6/6) Luciferase-like monooxygenase
PF00005 (6/6) ABC transporter

precursor_groups_513 297.75 +- 125.22 3 0 0 3 0.02 +- 0.03 3 10

TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF12706 (3/3) Beta-lactamase superfamily domain
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA

precursor_groups_31875 152.80 +- 39.15 3 0 0 0 0.03 +- 0.02 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family

precursor_groups_100 634.11 +- 416.96 8 0 5 8 0.05 +- 0.08 8 21

TIGR04364 (8/8) methyltransferase, FxLD system
TIGR04363 (8/8) FxLD family lantipeptide
TIGR03891 (8/8) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (8/8) Lantibiotic biosynthesis dehydratase C-term
PF05147 (8/8) Lanthionine synthetase C-like protein
PF04738 (8/8) Lantibiotic dehydratase, N terminus
PF01135 (8/8) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF05331 (7/8) Protein of unknown function (DUF742)
PF03259 (7/8) Roadblock/LC7 domain
PF03029 (7/8) Conserved hypothetical ATP binding protein
PF01427 (7/8) D-ala-D-ala dipeptidase
PF00293 (7/8) NUDIX domain
PF00196 (7/8) Bacterial regulatory proteins, luxR family
PF00005 (7/8) ABC transporter
PF02771 (5/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/8) Acyl-CoA dehydrogenase, middle domain
PF01590 (5/8) GAF domain
PF00723 (5/8) Glycosyl hydrolases family 15
PF00441 (5/8) Acyl-CoA dehydrogenase, C-terminal domain
PF13671 (4/8) AAA domain
PF02518 (4/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

precursor_groups_22572 473.90 +- 383.28 4 0 4 0 0.06 +- 0.20 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF13632 (4/4) Glycosyl transferase family group 2
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13191 (4/4) AAA ATPase domain
PF12710 (4/4) haloacid dehalogenase-like hydrolase
PF07690 (4/4) Major Facilitator Superfamily
PF04321 (4/4) RmlD substrate binding domain
PF01979 (4/4) Amidohydrolase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00459 (4/4) Inositol monophosphatase family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
TIGR00178 (3/4) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/4) Monomeric isocitrate dehydrogenase
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_1833 328.63 +- 21.56 3 0 3 3 0.03 +- 0.03 3 4

PF13471 (3/3) Transglutaminase-like superfamily
PF01546 (3/3) Peptidase family M20/M25/M40
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter

precursor_groups_298 359.72 +- 141.51 6 0 0 0 0.02 +- 0.04 6 6

PF07739 (6/6) TipAS antibiotic-recognition domain
PF07690 (6/6) Major Facilitator Superfamily
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF13411 (5/6) MerR HTH family regulatory protein
PF01551 (5/6) Peptidase family M23

precursor_groups_3023 325.00 +- 239.00 3 0 0 0 0.03 +- 0.08 3 3

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (3/3) SPFH domain / Band 7 family
PF00877 (3/3) NlpC/P60 family

precursor_groups_295 1775.87 +- 1261.12 4 0 3 4 0.04 +- 0.14 4 8

PF13649 (4/4) Methyltransferase domain
PF12730 (4/4) ABC-2 family transporter protein
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein

precursor_groups_26658 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II

precursor_groups_67341 447.87 +- 22.41 2 0 0 0 0.04 +- 0.02 2 16

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_5466 48.84 +- 15.40 2 0 0 0 0.09 +- 0.08 2 8

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain

precursor_groups_84495 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)

precursor_groups_84497 4695.60 +- 0.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01189 (2/2) heme ABC exporter, ATP-binding protein CcmA
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF12698 (2/2) ABC-2 family transporter protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter

precursor_groups_58293 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase

precursor_groups_2742 187.56 +- 79.93 4 0 0 0 0.03 +- 0.04 4 5

PF06628 (4/4) Catalase-related immune-responsive
PF01475 (4/4) Ferric uptake regulator family
PF00248 (4/4) Aldo/keto reductase family
PF00199 (4/4) Catalase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain

precursor_groups_48573 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_65596 175.06 +- 37.41 2 0 0 0 0.03 +- 0.04 2 9

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF07859 (2/2) alpha/beta hydrolase fold
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00459 (2/2) Inositol monophosphatase family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family

precursor_groups_11811 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain

precursor_groups_68952 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase

precursor_groups_7713 125.11 +- 36.14 2 0 0 0 0.05 +- 0.06 2 13

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain

precursor_groups_14797 47.52 +- 9.22 3 0 0 0 0.04 +- 0.05 3 3

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2

precursor_groups_69133 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family

precursor_groups_11727 272.98 +- 0.99 3 0 3 0 0.09 +- 0.18 3 11

TIGR03797 (3/3) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (3/3) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/3) Major Facilitator Superfamily
PF05013 (3/3) N-formylglutamate amidohydrolase
PF03412 (3/3) Peptidase C39 family
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF00664 (3/3) ABC transporter transmembrane region
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00005 (3/3) ABC transporter
PF13437 (2/3) HlyD family secretion protein

precursor_groups_73777 149.12 +- 39.59 2 0 0 0 0.06 +- 0.02 2 7

PF16353 (2/2) Domain of unknown function(DUF4981)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component

precursor_groups_49943 347.93 +- 153.74 2 0 2 2 0.05 +- 0.08 2 10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_639 398.21 +- 55.58 6 0 6 6 0.07 +- 0.08 6 12

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (6/6) SagB-type dehydrogenase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF13191 (6/6) AAA ATPase domain
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF03704 (6/6) Bacterial transcriptional activator domain
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (6/6) ABC-2 type transporter
PF00881 (6/6) Nitroreductase family
PF00486 (6/6) Transcriptional regulatory protein, C terminal
PF00005 (6/6) ABC transporter

precursor_groups_12109 150.50 +- 136.83 4 0 0 0 0.03 +- 0.02 4 3

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)

precursor_groups_61909 773.17 +- 20.67 2 0 0 0 0.01 +- 0.00 2 8

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_35315 582.00 +- 192.00 2 0 0 0 0.01 +- 0.01 2 10

PF13191 (2/2) AAA ATPase domain
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (2/2) Putative Ig domain
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (2/2) PA domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family

precursor_groups_25675 172.00 +- 60.81 3 0 0 0 0.01 +- 0.00 3 2

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase

precursor_groups_9823 404.91 +- 183.77 2 0 0 2 0.07 +- 0.11 2 18

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
TIGR01249 (1/2) prolyl aminopeptidase
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF07366 (1/2) SnoaL-like polyketide cyclase
PF04203 (1/2) Sortase domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01610 (1/2) Transposase
PF01381 (1/2) Helix-turn-helix
PF00672 (1/2) HAMP domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00561 (1/2) alpha/beta hydrolase fold
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00400 (1/2) WD domain, G-beta repeat
PF00072 (1/2) Response regulator receiver domain

precursor_groups_84405 1105.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 13

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_23621 394.50 +- 74.31 5 0 0 0 0.02 +- 0.03 5 6

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain

precursor_groups_4069 27.10 +- 6.92 3 0 0 0 0.08 +- 0.07 3 3

TIGR01249 (3/3) prolyl aminopeptidase
PF07470 (3/3) Glycosyl Hydrolase Family 88
PF00561 (3/3) alpha/beta hydrolase fold

precursor_groups_52985 91.60 +- 0.33 2 0 2 0 0.10 +- 0.29 2 17

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01842 (2/2) ACT domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00742 (2/2) Homoserine dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450

precursor_groups_1547 2852.98 +- 1813.19 13 8 5 13 0.01 +- 0.01 5 9

TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/13) Nitroreductase family
TIGR03605 (11/13) SagB-type dehydrogenase domain
PF04738 (10/13) Lantibiotic dehydratase, N terminus
PF00067 (8/13) Cytochrome P450
PF00440 (7/13) Bacterial regulatory proteins, tetR family

precursor_groups_16719 137.60 +- 68.80 2 0 0 0 0.06 +- 0.05 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_52076 139.98 +- 39.33 2 0 0 0 0.04 +- 0.04 2 6

PF07702 (2/2) UTRA domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03747 (2/2) ADP-ribosylglycohydrolase
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_50588 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

precursor_groups_71689 344.00 +- 0.00 2 0 0 0 0.03 +- 0.02 2 5

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_74379 3120.00 +- 0.00 2 0 0 0 0.01 +- 0.00 2 13

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_63001 105.74 +- 24.26 2 0 0 0 0.03 +- 0.03 2 3

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme

precursor_groups_1380 744.35 +- 495.10 3 0 2 3 0.02 +- 0.02 3 25

TIGR04504 (3/3) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (3/3) mycofactocin precursor
TIGR03967 (3/3) putative mycofactocin binding protein MftB
TIGR03966 (3/3) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (3/3) mycofactocin system glycosyltransferase
TIGR03964 (3/3) mycofactocin system creatininase family protein
TIGR03962 (3/3) mycofactocin radical SAM maturase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF04055 (3/3) Radical SAM superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01070 (3/3) FMN-dependent dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
PF17676 (2/3) LD-carboxypeptidase C-terminal domain
PF16861 (2/3) Carbamoyltransferase C-terminus
PF13489 (2/3) Methyltransferase domain
PF08242 (2/3) Methyltransferase domain
PF03129 (2/3) Anticodon binding domain
PF02543 (2/3) Carbamoyltransferase N-terminus
PF02016 (2/3) LD-carboxypeptidase N-terminal domain
PF01980 (2/3) tRNA-methyltransferase O
PF01041 (2/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/3) tRNA synthetase class II core domain (G, H, P, S and T)
PF00152 (2/3) tRNA synthetases class II (D, K and N)
PF00067 (2/3) Cytochrome P450

precursor_groups_25018 212.38 +- 67.73 3 0 3 3 0.04 +- 0.06 3 11

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450

precursor_groups_6246 1991.35 +- 896.21 5 0 5 0 0.02 +- 0.10 5 34

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter

precursor_groups_20824 1582.13 +- 391.36 2 0 2 0 0.03 +- 0.04 2 28

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10862 (2/2) FcoT-like thioesterase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (2/2) Sigma-70, region 4
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03929 (2/2) PepSY-associated TM region
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (2/2) DJ-1/PfpI family
PF01794 (2/2) Ferric reductase like transmembrane component
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter

precursor_groups_10459 128.12 +- 45.26 4 0 4 0 0.08 +- 0.18 4 20

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02127 (4/4) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (4/4) Thioesterase domain
PF00877 (4/4) NlpC/P60 family
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF12158 (2/4) Protein of unknown function (DUF3592)
PF01145 (2/4) SPFH domain / Band 7 family

precursor_groups_22684 618.09 +- 123.82 5 0 5 5 0.01 +- 0.02 5 15

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450

precursor_groups_37828 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III

precursor_groups_5898 203.13 +- 221.37 6 0 4 0 0.05 +- 0.10 6 6

PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (6/6) BFD-like [2Fe-2S] binding domain
PF02782 (6/6) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (6/6) FAD dependent oxidoreductase
PF00370 (6/6) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (4/6) NUDIX domain

precursor_groups_25793 694.47 +- 44.47 2 0 2 2 0.01 +- 0.00 2 9

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)

precursor_groups_76314 100.28 +- 9.84 2 0 0 0 0.06 +- 0.06 2 6

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter

precursor_groups_25791 685.57 +- 53.59 4 0 3 0 0.07 +- 0.22 4 19

TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (4/4) ATP-grasp domain
PF13535 (4/4) ATP-grasp domain
PF13480 (4/4) Acetyltransferase (GNAT) domain
PF13115 (4/4) YtkA-like
PF04389 (4/4) Peptidase family M28
PF02627 (4/4) Carboxymuconolactone decarboxylase family
PF01676 (4/4) Metalloenzyme superfamily
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00664 (4/4) ABC transporter transmembrane region
PF00403 (4/4) Heavy-metal-associated domain
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (4/4) Aminotransferase class I and II
PF00122 (4/4) E1-E2 ATPase
PF00117 (4/4) Glutamine amidotransferase class-I
PF00005 (4/4) ABC transporter
PF02222 (2/4) ATP-grasp domain

precursor_groups_63090 237.03 +- 98.37 2 0 0 0 0.02 +- 0.04 2 9

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family

precursor_groups_83681 702.33 +- 200.67 2 0 0 0 0.01 +- 0.00 2 12

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase

precursor_groups_56850 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_6965 216.00 +- 44.00 2 0 0 0 0.03 +- 0.04 2 4

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_9048 119.08 +- 0.00 2 0 0 0 0.03 +- 0.01 2 6

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family

precursor_groups_46472 300.06 +- 213.54 3 0 0 0 0.04 +- 0.05 3 7

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family

precursor_groups_2839 56.37 +- 16.27 3 0 0 0 0.08 +- 0.07 3 4

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07690 (3/3) Major Facilitator Superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00106 (3/3) short chain dehydrogenase

precursor_groups_10786 234.57 +- 34.56 3 0 0 0 0.01 +- 0.00 3 4

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03713 (3/3) Domain of unknown function (DUF305)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain

precursor_groups_72732 461.05 +- 11.67 2 0 0 0 0.04 +- 0.01 2 17

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain

precursor_groups_3163 322.50 +- 64.50 2 0 0 0 0.01 +- 0.00 2 7

PF17964 (1/2) Bacterial Ig domain
PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF04672 (1/2) S-adenosyl methyltransferase
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_2844 37.67 +- 9.91 8 0 0 0 0.06 +- 0.08 8 5

PF17866 (8/8) AAA lid domain
PF13229 (8/8) Right handed beta helix region
PF00652 (8/8) Ricin-type beta-trefoil lectin domain
PF00082 (8/8) Subtilase family
PF00004 (8/8) ATPase family associated with various cellular activities (AAA)

precursor_groups_50774 1057.64 +- 490.36 2 0 2 2 0.01 +- 0.02 2 9

TIGR04353 (2/2) PqqD family protein, HPr-rel-A system
PF13646 (2/2) HEAT repeats
PF13471 (2/2) Transglutaminase-like superfamily
PF13411 (2/2) MerR HTH family regulatory protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_77287 476.67 +- 43.33 2 0 0 0 0.01 +- 0.00 2 3

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_19328 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)

precursor_groups_1879 104.64 +- 38.90 15 0 0 0 0.06 +- 0.07 15 9

PF14158 (15/15) YndJ-like protein
PF13581 (15/15) Histidine kinase-like ATPase domain
PF13492 (15/15) GAF domain
PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (15/15) Domain of unknown function (DUF1990)
PF08447 (15/15) PAS fold
PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00149 (15/15) Calcineurin-like phosphoesterase

precursor_groups_47870 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain

precursor_groups_44302 260.13 +- 5.78 2 0 0 0 0.02 +- 0.01 2 11

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00326 (2/2) riboflavin biosynthesis protein RibD
PF13641 (2/2) Glycosyltransferase like family 2
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (2/2) RibD C-terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region

precursor_groups_40334 1659.14 +- 53.80 2 0 2 0 0.01 +- 0.01 2 10

PF13622 (2/2) Thioesterase-like superfamily
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00301 (2/2) Rubredoxin
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family

precursor_groups_1690 929.57 +- 1135.98 28 3 25 26 0.04 +- 0.11 25 8

PF03412 (27/28) Peptidase C39 family
PF00664 (27/28) ABC transporter transmembrane region
PF00005 (27/28) ABC transporter
TIGR03897 (26/28) type 2 lantibiotic biosynthesis protein LanM
PF13575 (26/28) Domain of unknown function (DUF4135)
PF05147 (26/28) Lanthionine synthetase C-like protein
PF14867 (23/28) Lantibiotic alpha
PF00296 (19/28) Luciferase-like monooxygenase

precursor_groups_13078 1151.39 +- 1025.31 5 1 1 4 0.05 +- 0.17 4 19

PF03176 (5/5) MMPL family
PF00550 (5/5) Phosphopantetheine attachment site
PF00202 (5/5) Aminotransferase class-III
TIGR03605 (4/5) SagB-type dehydrogenase domain
TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/5) Methyltransferase domain
PF07993 (4/5) Male sterility protein
PF03364 (4/5) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/5) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/5) Nitroreductase family
PF00698 (4/5) Acyl transferase domain
PF00196 (4/5) Bacterial regulatory proteins, luxR family
PF00109 (4/5) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/5) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/5) MOSC domain
PF01575 (3/5) MaoC like domain
PF00675 (3/5) Insulinase (Peptidase family M16)

precursor_groups_69987 895.44 +- 308.77 2 0 2 0 0.02 +- 0.03 2 15

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_19730 24.99 +- 2.38 2 0 0 0 0.08 +- 0.07 2 3

PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00457 (2/2) Glycosyl hydrolases family 11
PF00331 (2/2) Glycosyl hydrolase family 10

precursor_groups_7741 338.07 +- 45.25 7 0 1 0 0.09 +- 0.24 7 19

TIGR01902 (7/7) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (7/7) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (7/7) alpha-L-glutamate ligase, RimK family
PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF18130 (7/7) ATP-grasp N-terminal domain
PF13535 (7/7) ATP-grasp domain
PF08443 (7/7) RimK-like ATP-grasp domain
PF07690 (7/7) Major Facilitator Superfamily
PF02779 (7/7) Transketolase, pyrimidine binding domain
PF01546 (7/7) Peptidase family M20/M25/M40
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (7/7) Amino acid kinase family
PF00456 (7/7) Transketolase, thiamine diphosphate binding domain
PF00664 (6/7) ABC transporter transmembrane region
PF00005 (6/7) ABC transporter
PF13560 (5/7) Helix-turn-helix domain
PF10901 (5/7) Protein of unknown function (DUF2690)
PF01471 (5/7) Putative peptidoglycan binding domain

precursor_groups_32566 97.43 +- 4.08 3 0 0 0 0.02 +- 0.02 3 2

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)

precursor_groups_563 355.50 +- 160.50 4 2 2 4 0.03 +- 0.03 2 5

PF05147 (4/4) Lanthionine synthetase C-like protein
PF01061 (4/4) ABC-2 type transporter
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
TIGR01188 (2/4) daunorubicin resistance ABC transporter, ATP-binding protein

precursor_groups_566 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase

precursor_groups_568 387.98 +- 101.27 3 0 3 0 0.06 +- 0.09 3 23

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
PF01965 (2/3) DJ-1/PfpI family

precursor_groups_569 288.11 +- 28.11 2 0 1 1 0.03 +- 0.03 2 11

TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13471 (1/2) Transglutaminase-like superfamily
PF04235 (1/2) Protein of unknown function (DUF418)
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00005 (1/2) ABC transporter

precursor_groups_24085 125.56 +- 76.73 4 0 0 0 0.02 +- 0.01 4 4

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10977 (4/4) Protein of unknown function (DUF2797)
PF07398 (4/4) MDMPI C-terminal domain

precursor_groups_80972 2399.40 +- 696.60 2 0 0 0 0.01 +- 0.00 2 12

PF17914 (2/2) HopA1 effector protein family
PF09335 (2/2) SNARE associated Golgi protein
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00891 (2/2) O-methyltransferase domain
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_64989 183.91 +- 13.29 2 0 0 0 0.08 +- 0.06 2 18

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

precursor_groups_4804 196.89 +- 6.51 4 0 0 0 0.04 +- 0.15 4 16

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix

precursor_groups_83901 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_30428 332.84 +- 267.53 3 0 0 0 0.06 +- 0.12 3 18

TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II
PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07836 (3/3) DmpG-like communication domain
PF07690 (3/3) Major Facilitator Superfamily
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF01220 (3/3) Dehydroquinase class II
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (3/3) HMGL-like
PF00083 (3/3) Sugar (and other) transporter
TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain

precursor_groups_27291 186.44 +- 101.19 3 0 0 0 0.02 +- 0.02 3 7

PF16353 (3/3) Domain of unknown function(DUF4981)
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (3/3) Glycosyl hydrolases family 2

precursor_groups_69979 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA

precursor_groups_9908 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS

precursor_groups_75287 971.25 +- 3.75 2 0 0 0 0.01 +- 0.00 2 5

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_10458 320.07 +- 19.07 2 0 2 0 0.05 +- 0.02 2 18

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (2/2) Amidohydrolase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (2/2) Coenzyme A transferase
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF01965 (1/2) DJ-1/PfpI family

precursor_groups_86395 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450

precursor_groups_24883 73.19 +- 11.76 2 0 2 0 0.08 +- 0.08 2 14

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13560 (2/2) Helix-turn-helix domain
PF13478 (2/2) XdhC Rossmann domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00756 (2/2) Putative esterase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_10171 369.78 +- 5.91 3 0 0 0 0.07 +- 0.20 3 16

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF15648 (3/3) Restriction endonuclease fold toxin 5
PF13614 (3/3) AAA domain
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07811 (3/3) TadE-like protein
PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter

precursor_groups_81753 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter

precursor_groups_15593 303.16 +- 34.84 2 0 0 0 0.06 +- 0.10 2 19

TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14310 (2/2) Fibronectin type III-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (2/2) Peptidase_C39 like family
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF06684 (2/2) Amino acid synthesis
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF03547 (2/2) Membrane transport protein
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_10071 935.22 +- 296.60 9 0 7 9 0.01 +- 0.00 9 6

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase

precursor_groups_73123 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 7

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_30634 179.53 +- 21.38 2 0 2 0 0.08 +- 0.15 2 12

PF13641 (2/2) Glycosyltransferase like family 2
PF10823 (2/2) Protein of unknown function (DUF2568)
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (2/2) LysE type translocator
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00400 (2/2) WD domain, G-beta repeat
PF00067 (2/2) Cytochrome P450

precursor_groups_1298 137.11 +- 11.03 4 0 4 4 0.03 +- 0.04 4 3

PF13471 (4/4) Transglutaminase-like superfamily
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF00733 (4/4) Asparagine synthase

precursor_groups_1110 1141.85 +- 566.92 11 6 5 11 0.02 +- 0.02 5 4

PF13471 (11/11) Transglutaminase-like superfamily
PF05402 (11/11) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (11/11) Asparagine synthase
PF00005 (9/11) ABC transporter

precursor_groups_740 69.46 +- 4.96 2 0 0 0 0.04 +- 0.04 2 8

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF12802 (1/2) MarR family

precursor_groups_1501 323.00 +- 111.43 4 0 0 4 0.01 +- 0.00 4 10

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein

precursor_groups_44971 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase

precursor_groups_1057 247.62 +- 143.54 6 0 6 6 0.02 +- 0.03 6 4

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (5/6) Lantibiotic dehydratase, N terminus

precursor_groups_35030 215.00 +- 60.81 3 0 3 0 0.01 +- 0.01 3 3

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase

precursor_groups_18349 782.11 +- 340.79 6 0 0 0 0.01 +- 0.01 6 6

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein

precursor_groups_72835 462.83 +- 311.17 2 0 0 0 0.02 +- 0.04 2 6

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal

precursor_groups_45577 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal

precursor_groups_1592 252.97 +- 169.22 9 0 1 0 0.03 +- 0.07 9 5

PF07291 (9/9) Methylamine utilisation protein MauE
PF00717 (9/9) Peptidase S24-like
PF00005 (9/9) ABC transporter
PF10502 (6/9) Signal peptidase, peptidase S26
PF00578 (6/9) AhpC/TSA family

precursor_groups_42755 100.33 +- 20.27 3 0 0 0 0.02 +- 0.02 3 3

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme

precursor_groups_14774 63.45 +- 1.05 2 0 0 0 0.06 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_77109 21.30 +- 0.66 2 0 0 0 0.09 +- 0.13 2 5

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF07077 (2/2) Protein of unknown function (DUF1345)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase

precursor_groups_7824 134.38 +- 26.88 2 0 0 0 0.02 +- 0.01 2 5

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain

precursor_groups_5193 34.39 +- 12.89 2 0 2 0 0.09 +- 0.08 2 2

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator

precursor_groups_23 417.58 +- 443.50 3 0 0 0 0.02 +- 0.05 3 3

PF03965 (2/3) Penicillinase repressor
PF01435 (2/3) Peptidase family M48
PF00403 (2/3) Heavy-metal-associated domain

precursor_groups_26 338.56 +- 113.59 5 1 3 1 0.09 +- 0.18 4 11

PF03412 (5/5) Peptidase C39 family
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
TIGR03797 (4/5) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/5) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (4/5) HlyD family secretion protein
PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/5) Major Facilitator Superfamily
PF05013 (3/5) N-formylglutamate amidohydrolase
PF03055 (3/5) Retinal pigment epithelial membrane protein
PF00440 (3/5) Bacterial regulatory proteins, tetR family

precursor_groups_3158 34.67 +- 0.00 2 0 0 0 0.09 +- 0.12 2 5

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF11361 (2/2) Protein of unknown function (DUF3159)
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01522 (2/2) Polysaccharide deacetylase

precursor_groups_16507 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase

precursor_groups_3156 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2

precursor_groups_5697 196.34 +- 50.80 5 0 0 0 0.08 +- 0.07 5 10

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (5/5) hydrolase CocE/NonD family protein
PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family)
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00005 (5/5) ABC transporter
PF00296 (3/5) Luciferase-like monooxygenase

precursor_groups_59389 61.28 +- 3.22 2 0 0 0 0.05 +- 0.03 2 5

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme

precursor_groups_345 885.57 +- 176.07 4 0 1 0 0.01 +- 0.01 4 9

TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily
PF07690 (4/4) Major Facilitator Superfamily
PF03737 (4/4) Aldolase/RraA
PF03466 (4/4) LysR substrate binding domain
PF01361 (4/4) Tautomerase enzyme
PF00994 (4/4) Probable molybdopterin binding domain
PF00682 (4/4) HMGL-like
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_68668 38.91 +- 7.53 2 0 0 0 0.08 +- 0.05 2 4

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_groups_22163 437.99 +- 138.99 2 0 0 0 0.02 +- 0.10 2 18

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF12708 (1/2) Pectate lyase superfamily protein
PF12307 (1/2) Protein of unknown function (DUF3631)
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF05709 (1/2) Phage tail protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain

precursor_groups_76120 103.09 +- 21.09 2 0 0 0 0.06 +- 0.08 2 7

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_35953 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase

precursor_groups_41968 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter

precursor_groups_64500 100.71 +- 10.71 2 0 0 0 0.06 +- 0.04 2 3

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_16430 409.86 +- 183.82 5 0 5 0 0.02 +- 0.01 5 10

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

precursor_groups_78567 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

precursor_groups_63631 53.39 +- 20.89 2 0 0 0 0.05 +- 0.04 2 5

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase

precursor_groups_12692 968.17 +- 676.53 5 0 5 0 0.07 +- 0.11 5 28

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
TIGR01525 (5/5) heavy metal translocating P-type ATPase
TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10862 (5/5) FcoT-like thioesterase domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (5/5) Male sterility protein
PF07690 (5/5) Major Facilitator Superfamily
PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (5/5) Copper chaperone PCu(A)C
PF03929 (5/5) PepSY-associated TM region
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (5/5) DJ-1/PfpI family
PF01794 (5/5) Ferric reductase like transmembrane component
PF01497 (5/5) Periplasmic binding protein
PF01032 (5/5) FecCD transport family
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00403 (5/5) Heavy-metal-associated domain
PF00122 (5/5) E1-E2 ATPase
PF00005 (5/5) ABC transporter
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/5) Sigma-70, region 4
PF04542 (4/5) Sigma-70 region 2

precursor_groups_22188 43.48 +- 8.68 3 0 0 0 0.07 +- 0.05 3 9

PF13478 (3/3) XdhC Rossmann domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (3/3) XdhC and CoxI family
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_71012 194.00 +- 64.00 2 0 0 0 0.01 +- 0.01 2 3

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain

precursor_groups_119 75.88 +- 0.00 2 0 0 2 0.07 +- 0.07 2 14

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (2/2) pyruvate, phosphate dikinase
TIGR01255 (2/2) formate acetyltransferase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13411 (2/2) MerR HTH family regulatory protein
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (2/2) B12 binding domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (2/2) Glycine radical
PF00582 (2/2) Universal stress protein family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00106 (2/2) short chain dehydrogenase

precursor_groups_6108 87.16 +- 4.60 2 0 2 2 0.09 +- 0.18 2 12

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01292 (2/2) Prokaryotic cytochrome b561
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00188 (2/2) Cysteine-rich secretory protein family
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_11480 324.25 +- 46.50 3 0 3 0 0.01 +- 0.00 3 7

TIGR01746 (3/3) thioester reductase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00196 (3/3) Bacterial regulatory proteins, luxR family

precursor_groups_446 1399.85 +- 1431.38 62 0 8 0 0.02 +- 0.05 62 8

PF17914 (62/62) HopA1 effector protein family
PF02441 (61/62) Flavoprotein
PF00675 (61/62) Insulinase (Peptidase family M16)
PF05193 (59/62) Peptidase M16 inactive domain
PF00296 (57/62) Luciferase-like monooxygenase
PF00005 (55/62) ABC transporter
PF00664 (35/62) ABC transporter transmembrane region
PF13649 (33/62) Methyltransferase domain

precursor_groups_14492 164.69 +- 103.36 7 0 0 0 0.05 +- 0.04 7 11

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II

precursor_groups_39806 205.89 +- 16.36 2 0 0 0 0.06 +- 0.11 2 15

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (2/2) Domain of unknown function (DUF4380)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter

precursor_groups_22265 237.00 +- 29.70 3 0 3 0 0.01 +- 0.00 3 9

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12680 (3/3) SnoaL-like domain
PF08242 (3/3) Methyltransferase domain
PF07883 (3/3) Cupin domain
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme

precursor_groups_16466 273.59 +- 115.10 6 0 0 0 0.03 +- 0.01 6 7

PF07690 (6/6) Major Facilitator Superfamily
PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region
PF02538 (6/6) Hydantoinase B/oxoprolinase
PF01968 (6/6) Hydantoinase/oxoprolinase
PF01380 (6/6) SIS domain
PF01019 (6/6) Gamma-glutamyltranspeptidase
PF00294 (6/6) pfkB family carbohydrate kinase

precursor_groups_16970 592.86 +- 404.30 3 0 0 0 0.05 +- 0.08 3 7

PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF01551 (3/3) Peptidase family M23
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
PF12679 (2/3) ABC-2 family transporter protein

precursor_groups_41831 445.71 +- 74.29 2 0 2 0 0.01 +- 0.00 2 8

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

precursor_groups_114 276.73 +- 93.81 4 0 0 0 0.06 +- 0.07 4 16

TIGR01234 (2/4) ribulokinase
PF18029 (2/4) Glyoxalase-like domain
PF14200 (2/4) Ricin-type beta-trefoil lectin domain-like
PF11762 (2/4) L-arabinose isomerase C-terminal domain
PF07690 (2/4) Major Facilitator Superfamily
PF06964 (2/4) Alpha-L-arabinofuranosidase C-terminal domain
PF06772 (2/4) Bacterial low temperature requirement A protein (LtrA)
PF02782 (2/4) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/4) L-arabinose isomerase
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF00596 (2/4) Class II Aldolase and Adducin N-terminal domain
PF00561 (2/4) alpha/beta hydrolase fold
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
PF00370 (2/4) FGGY family of carbohydrate kinases, N-terminal domain
PF00296 (2/4) Luciferase-like monooxygenase
PF00106 (2/4) short chain dehydrogenase

precursor_groups_77189 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

precursor_groups_47289 358.87 +- 76.47 3 0 3 0 0.03 +- 0.03 3 16

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain

precursor_groups_64817 3194.97 +- 210.63 2 0 0 0 0.02 +- 0.01 2 13

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_23209 51.32 +- 24.99 3 0 0 0 0.05 +- 0.06 3 7

PF13424 (3/3) Tetratricopeptide repeat
PF07719 (3/3) Tetratricopeptide repeat
PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03413 (3/3) Peptidase propeptide and YPEB domain
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00348 (3/3) Polyprenyl synthetase

precursor_groups_48894 118.75 +- 11.25 2 0 0 0 0.08 +- 0.11 2 7

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (2/2) NMT1/THI5 like
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_27600 144.98 +- 11.02 2 0 0 0 0.09 +- 0.06 2 16

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A

precursor_groups_15312 166.79 +- 16.68 2 0 2 0 0.05 +- 0.06 2 10

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain

precursor_groups_15314 161.25 +- 96.75 2 0 0 0 0.02 +- 0.03 2 5

TIGR01840 (2/2) esterase, PHB depolymerase family
TIGR00666 (2/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (2/2) Protein of unknown function (DUF4232)
PF10503 (2/2) Esterase PHB depolymerase
PF02113 (2/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family

precursor_groups_67526 414.64 +- 27.64 2 0 0 0 0.01 +- 0.00 2 3

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00884 (2/2) Sulfatase

precursor_groups_8062 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter

precursor_groups_22919 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_624 260.57 +- 94.71 2 0 1 0 0.04 +- 0.05 2 10

PF12770 (2/2) CHAT domain
PF17866 (1/2) AAA lid domain
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF13229 (1/2) Right handed beta helix region
PF03756 (1/2) A-factor biosynthesis hotdog domain
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00082 (1/2) Subtilase family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

precursor_groups_4272 23.45 +- 0.00 2 0 0 0 0.09 +- 0.07 2 3

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/2) Methyltransferase domain
PF00753 (2/2) Metallo-beta-lactamase superfamily

precursor_groups_1627 148.42 +- 88.47 10 0 0 10 0.03 +- 0.02 10 3

PF13649 (10/10) Methyltransferase domain
PF07690 (10/10) Major Facilitator Superfamily
PF04055 (10/10) Radical SAM superfamily

precursor_groups_62305 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_1150 366.81 +- 92.54 7 0 7 7 0.07 +- 0.08 7 12

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF13191 (7/7) AAA ATPase domain
PF04738 (7/7) Lantibiotic dehydratase, N terminus
PF03704 (7/7) Bacterial transcriptional activator domain
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (7/7) ABC-2 type transporter
PF00881 (7/7) Nitroreductase family
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00005 (7/7) ABC transporter

precursor_groups_79452 372.32 +- 128.18 2 0 0 0 0.03 +- 0.03 2 9

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF02065 (2/2) Melibiase
PF01965 (2/2) DJ-1/PfpI family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_37210 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_19241 148.40 +- 67.91 5 0 0 0 0.02 +- 0.02 5 3

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold

precursor_groups_23731 734.34 +- 335.62 4 0 4 0 0.06 +- 0.06 4 28

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10862 (4/4) FcoT-like thioesterase domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (4/4) Sigma-70, region 4
PF07993 (4/4) Male sterility protein
PF07690 (4/4) Major Facilitator Superfamily
PF05118 (4/4) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (4/4) Sigma-70 region 2
PF04314 (4/4) Copper chaperone PCu(A)C
PF03929 (4/4) PepSY-associated TM region
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (4/4) DJ-1/PfpI family
PF01794 (4/4) Ferric reductase like transmembrane component
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00403 (4/4) Heavy-metal-associated domain
PF00122 (4/4) E1-E2 ATPase
PF00005 (4/4) ABC transporter

precursor_groups_1023 516.00 +- 129.00 2 0 2 2 0.01 +- 0.00 2 5

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (1/2) ABC transporter

precursor_groups_1534 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain

precursor_groups_1431 46.64 +- 3.06 3 0 0 0 0.06 +- 0.07 3 4

PF07730 (3/3) Histidine kinase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF13649 (2/3) Methyltransferase domain

precursor_groups_17315 116.33 +- 25.07 6 0 6 6 0.04 +- 0.04 6 4

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

precursor_groups_21458 137.60 +- 68.80 2 0 0 0 0.06 +- 0.05 2 8

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_43861 396.47 +- 171.88 3 0 0 0 0.01 +- 0.02 3 12

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain

precursor_groups_21455 303.45 +- 53.54 3 0 0 0 0.02 +- 0.01 3 8

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II

precursor_groups_63 217.46 +- 123.66 7 0 0 0 0.04 +- 0.04 7

No common domains found

precursor_groups_63015 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter

precursor_groups_61 412.74 +- 203.81 6 0 0 0 0.06 +- 0.19 6 16

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF00691 (6/6) OmpA family
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF07730 (5/6) Histidine kinase
PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00072 (5/6) Response regulator receiver domain
TIGR03177 (4/6) Flp pilus assembly protein CpaB
PF16976 (4/6) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/6) AAA domain
PF07811 (4/6) TadE-like protein
PF00437 (4/6) Type II/IV secretion system protein
PF15648 (3/6) Restriction endonuclease fold toxin 5
PF13231 (3/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00496 (3/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/6) ABC transporter

precursor_groups_13996 34.94 +- 12.33 2 0 0 0 0.07 +- 0.06 2 2

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF01872 (2/2) RibD C-terminal domain

precursor_groups_1870 187.80 +- 17.00 2 0 2 2 0.07 +- 0.08 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
TIGR03605 (1/2) SagB-type dehydrogenase domain
PF00931 (1/2) NB-ARC domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

precursor_groups_18839 142.22 +- 29.78 2 0 2 0 0.06 +- 0.03 2 8

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_9334 94.90 +- 28.28 4 0 0 0 0.04 +- 0.02 4 6

PF12697 (4/4) Alpha/beta hydrolase family
PF07729 (4/4) FCD domain
PF06684 (4/4) Amino acid synthesis
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00296 (4/4) Luciferase-like monooxygenase
PF00171 (4/4) Aldehyde dehydrogenase family

precursor_groups_30764 63.45 +- 1.05 2 0 0 0 0.06 +- 0.06 2 5

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_42885 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain

precursor_groups_83319 132.91 +- 39.09 2 0 0 0 0.05 +- 0.09 2 7

PF13581 (2/2) Histidine kinase-like ATPase domain
PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF02515 (2/2) CoA-transferase family III
PF01546 (2/2) Peptidase family M20/M25/M40
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase

precursor_groups_57593 1632.40 +- 187.60 2 0 2 2 0.01 +- 0.00 2 13

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_18 1139.50 +- 368.96 3 0 0 2 0.03 +- 0.12 3 5

PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF01636 (2/3) Phosphotransferase enzyme family
PF00196 (2/3) Bacterial regulatory proteins, luxR family

precursor_groups_6879 358.32 +- 74.43 10 0 6 0 0.06 +- 0.03 10 18

PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF08545 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF01144 (10/10) Coenzyme A transferase
PF00378 (10/10) Enoyl-CoA hydratase/isomerase
PF00196 (10/10) Bacterial regulatory proteins, luxR family
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00106 (10/10) short chain dehydrogenase
PF00005 (10/10) ABC transporter
TIGR00976 (9/10) hydrolase CocE/NonD family protein
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF12679 (9/10) ABC-2 family transporter protein
PF08530 (9/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (9/10) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (9/10) AMP-binding enzyme
PF04909 (8/10) Amidohydrolase
PF12697 (7/10) Alpha/beta hydrolase family

precursor_groups_4652 1090.53 +- 409.47 2 0 0 2 0.04 +- 0.03 2 31

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01590 (2/2) GAF domain
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (2/2) Glycosyl hydrolases family 15
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF13671 (1/2) AAA domain
PF13378 (1/2) Enolase C-terminal domain-like
PF13242 (1/2) HAD-hyrolase-like
PF10103 (1/2) Zincin-like metallopeptidase
PF09364 (1/2) XFP N-terminal domain
PF09363 (1/2) XFP C-terminal domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (1/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01300 (1/2) Telomere recombination

precursor_groups_17 441.98 +- 419.76 19 0 7 4 0.03 +- 0.06 19 2

PF13370 (13/19) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (10/19) Cytochrome P450

precursor_groups_1448 73.23 +- 29.66 4 0 0 0 0.05 +- 0.06 4 5

PF14534 (4/4) Domain of unknown function (DUF4440)
PF08002 (4/4) Protein of unknown function (DUF1697)
PF05922 (4/4) Peptidase inhibitor I9
PF00082 (4/4) Subtilase family
PF01323 (2/4) DSBA-like thioredoxin domain

precursor_groups_15 314.31 +- 204.63 20 0 19 0 0.06 +- 0.15 20 15

PF03621 (20/20) MbtH-like protein
PF00501 (19/20) AMP-binding enzyme
TIGR01733 (18/20) amino acid adenylation domain
PF13193 (18/20) AMP-binding enzyme C-terminal domain
PF00668 (18/20) Condensation domain
PF00550 (18/20) Phosphopantetheine attachment site
PF00975 (16/20) Thioesterase domain
TIGR01720 (13/20) non-ribosomal peptide synthase domain TIGR01720
TIGR03945 (11/20) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (11/20) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01188 (11/20) daunorubicin resistance ABC transporter, ATP-binding protein
PF02423 (11/20) Ornithine cyclodeaminase/mu-crystallin family
PF01061 (11/20) ABC-2 type transporter
PF00291 (11/20) Pyridoxal-phosphate dependent enzyme
PF00005 (11/20) ABC transporter

precursor_groups_3028 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme

precursor_groups_9053 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_7584 511.36 +- 133.14 5 0 2 0 0.04 +- 0.17 5 7

PF17914 (5/5) HopA1 effector protein family
PF02441 (5/5) Flavoprotein
PF01636 (5/5) Phosphotransferase enzyme family
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (4/5) ABC transporter
PF02897 (3/5) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (3/5) Prolyl oligopeptidase family

precursor_groups_22780 960.29 +- 332.05 5 0 0 0 0.02 +- 0.01 5 9

PF13649 (5/5) Methyltransferase domain
PF12698 (5/5) ABC-2 family transporter protein
PF02441 (5/5) Flavoprotein
PF00005 (5/5) ABC transporter
PF17914 (4/5) HopA1 effector protein family
PF01636 (4/5) Phosphotransferase enzyme family
PF00664 (4/5) ABC transporter transmembrane region
PF13732 (3/5) Domain of unknown function (DUF4162)
PF00196 (3/5) Bacterial regulatory proteins, luxR family

precursor_groups_82316 889.37 +- 45.01 2 0 2 0 0.06 +- 0.17 2 27

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00802 (2/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (2/2) GYF domain 2
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13421 (2/2) SPFH domain-Band 7 family
PF08281 (2/2) Sigma-70, region 4
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03824 (2/2) High-affinity nickel-transport protein
PF01070 (2/2) FMN-dependent dehydrogenase
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00067 (2/2) Cytochrome P450
TIGR01733 (1/2) amino acid adenylation domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/2) Male sterility protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme

precursor_groups_68599 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_150 243.84 +- 133.73 4 0 1 4 0.07 +- 0.08 4 8

TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01497 (2/4) Periplasmic binding protein
PF01032 (2/4) FecCD transport family

precursor_groups_68754 381.16 +- 102.59 2 0 0 0 0.02 +- 0.02 2 4

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family

precursor_groups_12312 593.52 +- 220.55 6 0 6 6 0.02 +- 0.04 6 10

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase

precursor_groups_16088 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain

precursor_groups_21277 1463.93 +- 1117.75 4 0 0 0 0.02 +- 0.01 4 14

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)

precursor_groups_78723 960.72 +- 458.28 2 0 2 0 0.02 +- 0.02 2 18

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_2140 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_2388 699.99 +- 270.33 3 0 3 0 0.07 +- 0.19 3 27

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (3/3) GYF domain 2
PF13421 (3/3) SPFH domain-Band 7 family
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF03824 (3/3) High-affinity nickel-transport protein
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
TIGR01733 (2/3) amino acid adenylation domain
PF13738 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF10862 (2/3) FcoT-like thioesterase domain
PF08545 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/3) Male sterility protein
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01070 (2/3) FMN-dependent dehydrogenase
PF00668 (2/3) Condensation domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
PF00067 (2/3) Cytochrome P450

precursor_groups_23252 68.37 +- 29.84 3 0 0 0 0.07 +- 0.06 3 8

TIGR00350 (3/3) cell envelope-related function transcriptional attenuator common domain
PF13399 (3/3) LytR cell envelope-related transcriptional attenuator
PF07859 (3/3) alpha/beta hydrolase fold
PF03816 (3/3) Cell envelope-related transcriptional attenuator domain
PF03807 (3/3) NADP oxidoreductase coenzyme F420-dependent
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00459 (3/3) Inositol monophosphatase family

precursor_groups_36304 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_574 693.83 +- 224.35 3 0 2 3 0.05 +- 0.16 3 23

TIGR04364 (3/3) methyltransferase, FxLD system
TIGR04363 (3/3) FxLD family lantipeptide
TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13581 (2/3) Histidine kinase-like ATPase domain
PF05331 (2/3) Protein of unknown function (DUF742)
PF04851 (2/3) Type III restriction enzyme, res subunit
PF04672 (2/3) S-adenosyl methyltransferase
PF03457 (2/3) Helicase associated domain
PF03259 (2/3) Roadblock/LC7 domain
PF03029 (2/3) Conserved hypothetical ATP binding protein
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF01636 (2/3) Phosphotransferase enzyme family
PF01590 (2/3) GAF domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/3) NUDIX domain
PF00271 (2/3) Helicase conserved C-terminal domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00005 (2/3) ABC transporter

precursor_groups_13665 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel

precursor_groups_32252 379.18 +- 103.46 3 0 3 0 0.08 +- 0.09 3 29

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (3/3) DJ-1/PfpI family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00501 (3/3) AMP-binding enzyme
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter

precursor_groups_274 770.06 +- 659.94 2 0 0 0 0.03 +- 0.05 2 15

PF00005 (2/2) ABC transporter
PF14903 (1/2) WG containing repeat
PF14435 (1/2) SUKH-4 immunity protein
PF10042 (1/2) Uncharacterized conserved protein (DUF2278)
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
PF05193 (1/2) Peptidase M16 inactive domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01937 (1/2) Protein of unknown function DUF89
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00950 (1/2) ABC 3 transport family
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_64854 246.49 +- 143.51 2 0 2 2 0.04 +- 0.15 2 8

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family

precursor_groups_48856 234.00 +- 26.00 2 0 0 0 0.01 +- 0.01 2 6

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family

precursor_groups_279 104.13 +- 69.20 2 0 0 0 0.08 +- 0.16 2 6

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin

precursor_groups_47384 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter

precursor_groups_13328 1552.41 +- 1036.67 5 0 5 0 0.02 +- 0.08 5 11

PF13622 (5/5) Thioesterase-like superfamily
PF07690 (5/5) Major Facilitator Superfamily
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00487 (5/5) Fatty acid desaturase
PF00301 (5/5) Rubredoxin
PF00067 (5/5) Cytochrome P450
PF12679 (4/5) ABC-2 family transporter protein
PF12146 (4/5) Serine aminopeptidase, S33
PF00005 (4/5) ABC transporter
PF00392 (3/5) Bacterial regulatory proteins, gntR family

precursor_groups_72506 195.60 +- 94.65 2 0 2 0 0.02 +- 0.02 2 6

PF12697 (2/2) Alpha/beta hydrolase family
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain

precursor_groups_10496 2158.41 +- 761.00 8 0 1 0 0.01 +- 0.01 8 12

PF13560 (8/8) Helix-turn-helix domain
PF13393 (8/8) Histidyl-tRNA synthetase
PF05193 (8/8) Peptidase M16 inactive domain
PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (8/8) GlcNAc-PI de-N-acetylase
PF01370 (8/8) NAD dependent epimerase/dehydratase family
PF01061 (8/8) ABC-2 type transporter
PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (8/8) Insulinase (Peptidase family M16)
PF00005 (8/8) ABC transporter
PF17874 (7/8) MalT-like TPR region

precursor_groups_1211 920.66 +- 794.45 2 0 0 0 0.02 +- 0.10 2 20

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF10145 (1/2) Phage-related minor tail protein
PF05065 (1/2) Phage capsid family
PF04851 (1/2) Type III restriction enzyme, res subunit
PF01580 (1/2) FtsK/SpoIIIE family
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01381 (1/2) Helix-turn-helix
PF01183 (1/2) Glycosyl hydrolases family 25
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain

precursor_groups_4654 359.93 +- 257.30 9 0 9 0 0.04 +- 0.07 9 10

TIGR01891 (9/9) amidohydrolase
TIGR01821 (9/9) 5-aminolevulinic acid synthase
PF16884 (9/9) N-terminal domain of oxidoreductase
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (9/9) Major Facilitator Superfamily
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (9/9) Peptidase family M20/M25/M40
PF00155 (9/9) Aminotransferase class I and II
PF00107 (9/9) Zinc-binding dehydrogenase

precursor_groups_7635 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS

precursor_groups_80912 1334.20 +- 95.80 2 0 0 0 0.02 +- 0.01 2 9

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF12698 (2/2) ABC-2 family transporter protein
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13732 (1/2) Domain of unknown function (DUF4162)
PF00196 (1/2) Bacterial regulatory proteins, luxR family

precursor_groups_84735 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat

precursor_groups_888 174.09 +- 18.88 3 0 0 0 0.07 +- 0.09 3 14

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2

precursor_groups_5445 48.47 +- 11.07 7 0 0 0 0.07 +- 0.10 7 5

PF03450 (7/7) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (7/7) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (7/7) [2Fe-2S] binding domain
PF01315 (7/7) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (7/7) FAD binding domain in molybdopterin dehydrogenase

Entry name Average score Number of operons Number of MIBiG operons Number of operons with antismash overlap Nr of operons with known RiPP domains Average COG score Nr of operons passed filter Common domains
jaccard_groups_437 1352.84 +- 864.00 2 0 0 0 0.01 +- 0.01 2 26

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
PF16177 (1/2) Acetyl-coenzyme A synthetase N-terminus
PF13607 (1/2) Succinyl-CoA ligase like flavodoxin domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13531 (1/2) Bacterial extracellular solute-binding protein
PF13380 (1/2) CoA binding domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07729 (1/2) FCD domain
PF07690 (1/2) Major Facilitator Superfamily
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02803 (1/2) Thiolase, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01575 (1/2) MaoC like domain
PF01494 (1/2) FAD binding domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00296 (1/2) Luciferase-like monooxygenase
PF00108 (1/2) Thiolase, N-terminal domain
PF00005 (1/2) ABC transporter

jaccard_groups_114 714.44 +- 930.96 4 0 2 0 0.03 +- 0.07 4 2

PF02983 (4/4) Alpha-lytic protease prodomain
PF00089 (4/4) Trypsin

jaccard_groups_2124 68.58 +- 37.00 4 0 0 0 0.05 +- 0.03 4 3

PF13520 (4/4) Amino acid permease
PF00202 (4/4) Aminotransferase class-III
PF00171 (4/4) Aldehyde dehydrogenase family

jaccard_groups_3027 52.65 +- 10.40 3 0 0 0 0.06 +- 0.07 3 5

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain

jaccard_groups_2120 447.92 +- 197.08 2 0 2 1 0.01 +- 0.01 2 8

PF07993 (2/2) Male sterility protein
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00334 (2/2) Nucleoside diphosphate kinase
PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family

jaccard_groups_6077 226.50 +- 31.50 2 0 0 0 0.01 +- 0.00 2 3

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase

jaccard_groups_3186 43.41 +- 0.41 2 0 2 0 0.07 +- 0.09 2 5

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00905 (2/2) Penicillin binding protein transpeptidase domain
PF00266 (2/2) Aminotransferase class-V
PF00171 (2/2) Aldehyde dehydrogenase family

jaccard_groups_1447 1179.64 +- 1207.20 3 0 3 0 0.05 +- 0.14 3 11

TIGR01830 (3/3) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12146 (3/3) Serine aminopeptidase, S33
PF07977 (3/3) FabA-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01323 (3/3) DSBA-like thioredoxin domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF02786 (2/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF00698 (2/3) Acyl transferase domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family

jaccard_groups_2909 479.19 +- 156.31 9 0 9 9 0.02 +- 0.01 9 7

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_3611 153.06 +- 34.46 4 0 4 0 0.06 +- 0.13 4 25

TIGR01762 (4/4) chlorinating enzyme
TIGR01733 (4/4) amino acid adenylation domain
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01444 (4/4) methyltransferase, FkbM family
TIGR00843 (4/4) benzoate transporter
PF16990 (4/4) Carbohydrate binding module (family 35)
PF13560 (4/4) Helix-turn-helix domain
PF13535 (4/4) ATP-grasp domain
PF13454 (4/4) FAD-NAD(P)-binding
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07691 (4/4) PA14 domain
PF06439 (4/4) Domain of Unknown Function (DUF1080)
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/4) Methyltransferase FkbM domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF03594 (4/4) Benzoate membrane transport protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain

jaccard_groups_4237 559.06 +- 431.39 3 0 1 3 0.02 +- 0.04 3 13

PF17676 (3/3) LD-carboxypeptidase C-terminal domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13280 (3/3) WYL domain
PF08279 (3/3) HTH domain
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF02016 (3/3) LD-carboxypeptidase N-terminal domain
PF00730 (3/3) HhH-GPD superfamily base excision DNA repair protein
PF00293 (3/3) NUDIX domain
PF00152 (3/3) tRNA synthetases class II (D, K and N)
PF00005 (3/3) ABC transporter
PF03372 (2/3) Endonuclease/Exonuclease/phosphatase family

jaccard_groups_177 52.32 +- 21.97 2 0 2 0 0.05 +- 0.02 2 2

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase

jaccard_groups_171 180.52 +- 200.37 17 0 3 0 0.03 +- 0.04 17 3

PF02868 (17/17) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (17/17) Thermolysin metallopeptidase, catalytic domain
PF07504 (15/17) Fungalysin/Thermolysin Propeptide Motif

jaccard_groups_172 131.15 +- 103.02 10 0 1 0 0.03 +- 0.04 10 3

PF11716 (10/10) Mycothiol maleylpyruvate isomerase N-terminal domain
TIGR03083 (9/10) uncharacterized Actinobacterial protein TIGR03083
PF07398 (6/10) MDMPI C-terminal domain

jaccard_groups_173 330.72 +- 274.50 18 0 18 0 0.05 +- 0.15 18 11

PF16197 (18/18) Ketoacyl-synthetase C-terminal extension
PF02801 (18/18) Beta-ketoacyl synthase, C-terminal domain
PF00668 (18/18) Condensation domain
PF00550 (18/18) Phosphopantetheine attachment site
PF00109 (18/18) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (17/18) amino acid adenylation domain
PF13193 (17/18) AMP-binding enzyme C-terminal domain
PF00698 (17/18) Acyl transferase domain
PF00501 (17/18) AMP-binding enzyme
PF00975 (15/18) Thioesterase domain
PF07690 (10/18) Major Facilitator Superfamily

jaccard_groups_6305 121.07 +- 15.52 2 0 0 0 0.03 +- 0.05 2 8

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase

jaccard_groups_2973 375.44 +- 131.77 2 0 2 0 0.09 +- 0.21 2 34

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF00857 (1/2) Isochorismatase family

jaccard_groups_2691 259.00 +- 1.00 2 0 1 0 0.01 +- 0.00 2 4

PF13243 (2/2) Squalene-hopene cyclase C-terminal domain
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00348 (1/2) Polyprenyl synthetase
PF00293 (1/2) NUDIX domain

jaccard_groups_489 259.00 +- 1.00 2 0 0 0 0.01 +- 0.00 2 3

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

jaccard_groups_642 315.42 +- 243.98 35 0 2 0 0.03 +- 0.04 35 8

TIGR03920 (35/35) type VII secretion integral membrane protein EccD
TIGR03919 (35/35) type VII secretion protein EccB
PF08817 (35/35) WXG100 protein secretion system (Wss), protein YukD
PF05108 (35/35) Type VII secretion system ESX-1, transport TM domain B
PF02575 (34/35) YbaB/EbfC DNA-binding family
PF06013 (29/35) Proteins of 100 residues with WXG
TIGR03930 (26/35) WXG100 family type VII secretion target
PF07179 (20/35) SseB protein N-terminal domain

jaccard_groups_2674 131.54 +- 3.07 2 0 0 0 0.09 +- 0.06 2 10

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS

jaccard_groups_2676 260.26 +- 108.12 9 0 9 9 0.05 +- 0.03 9 13

TIGR04451 (9/9) lantipeptide, SCO0268 family
TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF12802 (9/9) MarR family
PF12697 (9/9) Alpha/beta hydrolase family
PF05147 (9/9) Lanthionine synthetase C-like protein
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF02065 (9/9) Melibiase
PF01547 (9/9) Bacterial extracellular solute-binding protein
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00480 (9/9) ROK family
PF02894 (8/9) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/9) Oxidoreductase family, NAD-binding Rossmann fold

jaccard_groups_5583 129.86 +- 93.00 2 0 0 0 0.05 +- 0.10 2 3

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

jaccard_groups_4356 777.00 +- 3.00 2 0 0 0 0.01 +- 0.00 2 8

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450

jaccard_groups_2472 1010.92 +- 468.30 4 0 0 4 0.03 +- 0.04 4 25

TIGR03812 (4/4) tyrosine decarboxylase MnfA
PF17755 (4/4) UvrA DNA-binding domain
PF16861 (4/4) Carbamoyltransferase C-terminus
PF16169 (4/4) Domain of unknown function (DUF4872)
PF14399 (4/4) Butirosin biosynthesis protein H, N-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (4/4) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (4/4) DNA alkylation repair enzyme
PF08241 (4/4) Methyltransferase domain
PF04879 (4/4) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (4/4) Radical SAM superfamily
PF03241 (4/4) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (4/4) Carbamoyltransferase N-terminus
PF02310 (4/4) B12 binding domain
PF02195 (4/4) ParB-like nuclease domain
PF01613 (4/4) Flavin reductase like domain
PF01568 (4/4) Molydopterin dinucleotide binding domain
PF01061 (4/4) ABC-2 type transporter
PF00805 (4/4) Pentapeptide repeats (8 copies)
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00384 (4/4) Molybdopterin oxidoreductase
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (4/4) ABC transporter
PF00501 (3/4) AMP-binding enzyme

jaccard_groups_5613 135.53 +- 39.47 2 0 0 0 0.06 +- 0.09 2 9

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase

jaccard_groups_289 586.17 +- 706.86 6 0 0 0 0.02 +- 0.03 6 6

TIGR03930 (6/6) WXG100 family type VII secretion target
PF06013 (6/6) Proteins of 100 residues with WXG
TIGR03921 (5/6) type VII secretion-associated serine protease mycosin
PF05108 (5/6) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/6) Subtilase family
TIGR03919 (4/6) type VII secretion protein EccB

jaccard_groups_5572 533.02 +- 31.35 2 0 0 0 0.01 +- 0.00 2 9

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal

jaccard_groups_795 339.13 +- 0.00 2 0 0 0 0.03 +- 0.01 2 8

TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1)
PF04679 (2/2) ATP dependent DNA ligase C terminal region
PF04675 (2/2) DNA ligase N terminus
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01068 (2/2) ATP dependent DNA ligase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase

jaccard_groups_4775 763.96 +- 609.16 2 0 2 1 0.05 +- 0.14 2 24

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03494 (2/2) salicylate synthase
TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR01443 (2/2) intein C-terminal splicing region
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (2/2) Pretoxin HINT domain
PF05593 (2/2) RHS Repeat
PF03704 (2/2) Bacterial transcriptional activator domain
PF02361 (2/2) Cobalt transport protein
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00425 (2/2) chorismate binding enzyme
PF00005 (2/2) ABC transporter
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region

jaccard_groups_5270 344.00 +- 86.00 2 0 0 0 0.01 +- 0.01 2 7

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain

jaccard_groups_1652 427.40 +- 123.00 2 0 2 0 0.03 +- 0.03 2 6

TIGR03892 (2/2) thiazolylpeptide-type bacteriocin precursor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme

jaccard_groups_3940 1767.52 +- 216.09 3 0 1 3 0.01 +- 0.02 3 10

TIGR00702 (3/3) YcaO-type kinase domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF08007 (3/3) Cupin superfamily protein
PF07812 (3/3) TfuA-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00326 (3/3) Prolyl oligopeptidase family

jaccard_groups_594 215.75 +- 52.67 4 0 0 0 0.02 +- 0.04 4 3

TIGR03086 (4/4) TIGR03086 family protein
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF01814 (2/4) Hemerythrin HHE cation binding domain

jaccard_groups_4857 152.80 +- 39.15 3 0 0 0 0.03 +- 0.02 3 7

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family

jaccard_groups_5054 224.43 +- 53.86 3 0 0 0 0.03 +- 0.04 3 6

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family

jaccard_groups_5724 766.32 +- 13.68 2 0 2 0 0.01 +- 0.00 2 13

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

jaccard_groups_50 561.62 +- 388.29 2 0 0 0 0.01 +- 0.01 2 12

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13185 (1/2) GAF domain
PF12770 (1/2) CHAT domain
PF07905 (1/2) Purine catabolism regulatory protein-like family
PF07690 (1/2) Major Facilitator Superfamily
PF01872 (1/2) RibD C-terminal domain
PF01047 (1/2) MarR family
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family

jaccard_groups_52 45.69 +- 30.15 4 0 1 0 0.07 +- 0.09 4 5

TIGR01525 (4/4) heavy metal translocating P-type ATPase
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00122 (4/4) E1-E2 ATPase
PF04314 (3/4) Copper chaperone PCu(A)C
PF00403 (3/4) Heavy-metal-associated domain

jaccard_groups_55 162.82 +- 79.43 8 0 0 0 0.03 +- 0.03 8 2

PF08240 (8/8) Alcohol dehydrogenase GroES-like domain
PF00107 (8/8) Zinc-binding dehydrogenase

jaccard_groups_946 223.40 +- 135.81 3 0 2 0 0.03 +- 0.04 3 7

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF18130 (2/3) ATP-grasp N-terminal domain
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00155 (2/3) Aminotransferase class I and II

jaccard_groups_866 47.52 +- 9.22 3 0 0 0 0.04 +- 0.05 3 3

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2

jaccard_groups_948 1680.69 +- 1143.93 5 0 3 5 0.04 +- 0.12 5 8

PF13649 (5/5) Methyltransferase domain
PF00465 (5/5) Iron-containing alcohol dehydrogenase
PF00202 (5/5) Aminotransferase class-III
PF00005 (5/5) ABC transporter
PF12730 (4/5) ABC-2 family transporter protein
PF00296 (4/5) Luciferase-like monooxygenase
PF00069 (4/5) Protein kinase domain
PF05147 (3/5) Lanthionine synthetase C-like protein

jaccard_groups_864 1319.20 +- 1319.09 76 0 14 0 0.02 +- 0.04 76 9

PF17914 (75/76) HopA1 effector protein family
PF02441 (74/76) Flavoprotein
PF00675 (71/76) Insulinase (Peptidase family M16)
PF00005 (68/76) ABC transporter
PF05193 (67/76) Peptidase M16 inactive domain
PF00296 (61/76) Luciferase-like monooxygenase
PF13649 (43/76) Methyltransferase domain
PF00664 (42/76) ABC transporter transmembrane region
PF01636 (40/76) Phosphotransferase enzyme family

jaccard_groups_3200 400.13 +- 221.16 3 0 1 0 0.05 +- 0.17 3 26

TIGR02100 (3/3) glycogen debranching enzyme GlgX
TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme
TIGR00377 (3/3) anti-anti-sigma factor
PF18085 (3/3) Maltokinase N-terminal cap domain
PF17124 (3/3) ThiJ/PfpI family-like
PF13614 (3/3) AAA domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13546 (3/3) DDE superfamily endonuclease
PF13466 (3/3) STAS domain
PF13460 (3/3) NAD(P)H-binding
PF13380 (3/3) CoA binding domain
PF11896 (3/3) Domain of unknown function (DUF3416)
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (3/3) EthD domain
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (3/3) DJ-1/PfpI family
PF01740 (3/3) STAS domain
PF00483 (3/3) Nucleotidyl transferase
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF00128 (3/3) Alpha amylase, catalytic domain

jaccard_groups_219 238.29 +- 148.71 2 0 2 0 0.03 +- 0.04 2 6

PF17900 (2/2) Peptidase M1 N-terminal domain
PF01433 (2/2) Peptidase family M1 domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00293 (1/2) NUDIX domain
PF00067 (1/2) Cytochrome P450

jaccard_groups_216 135.76 +- 125.47 4 0 0 0 0.04 +- 0.03 4 6

PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF07690 (3/4) Major Facilitator Superfamily
PF05721 (2/4) Phytanoyl-CoA dioxygenase (PhyH)
PF00378 (2/4) Enoyl-CoA hydratase/isomerase

jaccard_groups_212 129.71 +- 150.27 3 0 0 0 0.07 +- 0.07 3 3

PF00753 (3/3) Metallo-beta-lactamase superfamily
PF13370 (2/3) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/3) Methyltransferase domain

jaccard_groups_3386 273.84 +- 106.57 7 0 1 0 0.03 +- 0.01 7 7

PF07690 (7/7) Major Facilitator Superfamily
PF05378 (7/7) Hydantoinase/oxoprolinase N-terminal region
PF02538 (7/7) Hydantoinase B/oxoprolinase
PF01968 (7/7) Hydantoinase/oxoprolinase
PF01380 (7/7) SIS domain
PF01019 (7/7) Gamma-glutamyltranspeptidase
PF00294 (7/7) pfkB family carbohydrate kinase

jaccard_groups_3382 111.05 +- 61.85 5 0 0 0 0.05 +- 0.05 5 8

TIGR00350 (5/5) cell envelope-related function transcriptional attenuator common domain
PF13399 (5/5) LytR cell envelope-related transcriptional attenuator
PF07859 (5/5) alpha/beta hydrolase fold
PF03816 (5/5) Cell envelope-related transcriptional attenuator domain
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF01258 (5/5) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (5/5) D-alanyl-D-alanine carboxypeptidase
PF00459 (5/5) Inositol monophosphatase family

jaccard_groups_6289 1942.50 +- 7.50 2 0 0 0 0.01 +- 0.00 2 12

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter

jaccard_groups_3720 427.75 +- 162.91 4 0 0 0 0.02 +- 0.01 4 8

PF11723 (4/4) Homotrimeric ring hydroxylase
PF02900 (4/4) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (4/4) Peptidase family M20/M25/M40
PF00561 (4/4) alpha/beta hydrolase fold
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF12697 (3/4) Alpha/beta hydrolase family
PF00175 (3/4) Oxidoreductase NAD-binding domain

jaccard_groups_6235 2080.00 +- 260.00 2 0 2 2 0.01 +- 0.00 2 11

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF02597 (2/2) ThiS family
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF02310 (2/2) B12 binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

jaccard_groups_3370 332.84 +- 267.53 3 0 0 0 0.06 +- 0.12 3 18

TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II
PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07836 (3/3) DmpG-like communication domain
PF07690 (3/3) Major Facilitator Superfamily
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF01220 (3/3) Dehydroquinase class II
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (3/3) HMGL-like
PF00083 (3/3) Sugar (and other) transporter
TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain

jaccard_groups_3371 68.23 +- 18.44 2 0 1 0 0.05 +- 0.04 2 6

TIGR00345 (2/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF02554 (2/2) Carbon starvation protein CstA
PF02374 (2/2) Anion-transporting ATPase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4

jaccard_groups_500 34.39 +- 12.89 2 0 2 0 0.09 +- 0.08 2 2

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator

jaccard_groups_509 390.00 +- 0.00 3 0 2 0 0.01 +- 0.00 3 4

PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (3/3) Flavin reductase like domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase

jaccard_groups_1276 24.19 +- 0.00 2 0 0 0 0.08 +- 0.03 2 2

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme

jaccard_groups_767 151.70 +- 47.50 3 0 0 0 0.07 +- 0.10 3 7

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
PF09995 (2/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF05719 (2/3) Golgi phosphoprotein 3 (GPP34)

jaccard_groups_761 729.04 +- 362.80 9 0 5 9 0.05 +- 0.11 9 19

TIGR04364 (9/9) methyltransferase, FxLD system
TIGR04363 (9/9) FxLD family lantipeptide
TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF05331 (9/9) Protein of unknown function (DUF742)
PF05147 (9/9) Lanthionine synthetase C-like protein
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF03259 (9/9) Roadblock/LC7 domain
PF03029 (9/9) Conserved hypothetical ATP binding protein
PF01135 (9/9) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (9/9) NUDIX domain
PF00196 (9/9) Bacterial regulatory proteins, luxR family
PF00005 (9/9) ABC transporter
PF02771 (7/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (7/9) Acyl-CoA dehydrogenase, middle domain
PF01590 (7/9) GAF domain
PF01427 (7/9) D-ala-D-ala dipeptidase
PF00441 (7/9) Acyl-CoA dehydrogenase, C-terminal domain
PF00723 (5/9) Glycosyl hydrolases family 15

jaccard_groups_763 1162.04 +- 959.64 85 28 57 84 0.03 +- 0.08 57 7

PF00005 (85/85) ABC transporter
PF13575 (84/85) Domain of unknown function (DUF4135)
PF05147 (84/85) Lanthionine synthetase C-like protein
PF00664 (84/85) ABC transporter transmembrane region
PF03412 (83/85) Peptidase C39 family
TIGR03897 (79/85) type 2 lantibiotic biosynthesis protein LanM
PF14867 (43/85) Lantibiotic alpha

jaccard_groups_139 331.74 +- 178.03 5 0 3 0 0.02 +- 0.02 5 8

PF02780 (5/5) Transketolase, C-terminal domain
PF00676 (5/5) Dehydrogenase E1 component
PF00364 (5/5) Biotin-requiring enzyme
PF00198 (5/5) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PF02779 (4/5) Transketolase, pyrimidine binding domain
PF08545 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (3/5) Phosphopantetheine attachment site

jaccard_groups_1879 1882.17 +- 1757.83 2 0 0 0 0.05 +- 0.07 2 17

PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13802 (1/2) Galactose mutarotase-like
PF08244 (1/2) Glycosyl hydrolases family 32 C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01833 (1/2) IPT/TIG domain
PF01055 (1/2) Glycosyl hydrolases family 31
PF00754 (1/2) F5/8 type C domain
PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain

jaccard_groups_6462 50.96 +- 10.96 2 0 0 0 0.06 +- 0.07 2 4

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

jaccard_groups_3129 864.29 +- 155.78 3 0 3 3 0.01 +- 0.02 3 9

TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF01980 (3/3) tRNA-methyltransferase O
PF01494 (3/3) FAD binding domain
PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family

jaccard_groups_3796 214.87 +- 119.93 4 0 0 0 0.02 +- 0.03 4 4

PF05901 (4/4) Excalibur calcium-binding domain
PF01738 (4/4) Dienelactone hydrolase family
PF00293 (4/4) NUDIX domain
PF00067 (2/4) Cytochrome P450

jaccard_groups_6512 101.28 +- 23.28 2 0 0 2 0.05 +- 0.10 2 8

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)

jaccard_groups_2010 142.50 +- 52.50 2 0 0 0 0.05 +- 0.07 2 18

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00392 (2/2) Bacterial regulatory proteins, gntR family
TIGR00791 (1/2) transporter, gluconate:H+ symporter (GntP) family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13407 (1/2) Periplasmic binding protein domain
PF13185 (1/2) GAF domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01614 (1/2) Bacterial transcriptional regulator
PF00775 (1/2) Dioxygenase

jaccard_groups_3159 284.37 +- 95.70 5 0 1 0 0.03 +- 0.05 5 8

PF12833 (5/5) Helix-turn-helix domain
PF02774 (5/5) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (5/5) DJ-1/PfpI family
PF01118 (5/5) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (5/5) Amino acid kinase family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00171 (5/5) Aldehyde dehydrogenase family
PF00465 (4/5) Iron-containing alcohol dehydrogenase

jaccard_groups_2206 139.29 +- 9.29 2 0 0 0 0.03 +- 0.02 2 7

PF13460 (2/2) NAD(P)H-binding
PF00561 (2/2) alpha/beta hydrolase fold
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01494 (1/2) FAD binding domain

jaccard_groups_1473 113.82 +- 0.00 2 0 0 0 0.08 +- 0.05 2 6

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF04203 (1/2) Sortase domain

jaccard_groups_1478 1029.59 +- 549.79 5 2 3 5 0.03 +- 0.03 3 10

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (5/5) ABC-2 type transporter
PF00733 (5/5) Asparagine synthase
PF00005 (5/5) ABC transporter
TIGR01188 (3/5) daunorubicin resistance ABC transporter, ATP-binding protein
PF13462 (3/5) Thioredoxin
PF07730 (3/5) Histidine kinase
PF00196 (3/5) Bacterial regulatory proteins, luxR family
PF00072 (3/5) Response regulator receiver domain

jaccard_groups_997 144.69 +- 113.31 2 0 0 0 0.04 +- 0.06 2 5

PF18593 (2/2) CdiI immunity protein
PF18431 (2/2) Bacterial CdiA-CT RNAse A domain
PF13560 (2/2) Helix-turn-helix domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF04149 (2/2) Domain of unknown function (DUF397)

jaccard_groups_994 250.84 +- 78.71 6 0 0 0 0.03 +- 0.11 6 16

TIGR01558 (6/6) putative phage terminase, small subunit, P27 family
TIGR01554 (6/6) phage major capsid protein, HK97 family
TIGR01543 (6/6) phage prohead protease, HK97 family
TIGR01537 (6/6) phage portal protein, HK97 family
PF10145 (6/6) Phage-related minor tail protein
PF05119 (6/6) Phage terminase, small subunit
PF05065 (6/6) Phage capsid family
PF04860 (6/6) Phage portal protein
PF04586 (6/6) Caudovirus prohead serine protease
PF03354 (6/6) Phage Terminase
PF01510 (6/6) N-acetylmuramoyl-L-alanine amidase
PF01381 (6/6) Helix-turn-helix
PF16945 (4/6) Putative lactococcus lactis phage r1t holin
PF13229 (4/6) Right handed beta helix region
PF01476 (4/6) LysM domain
PF01464 (4/6) Transglycosylase SLT domain

jaccard_groups_5913 647.50 +- 2.50 2 0 0 0 0.01 +- 0.00 2 10

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family

jaccard_groups_993 66.40 +- 35.34 2 0 1 0 0.06 +- 0.08 2 13

PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF16259 (1/2) Domain of unknown function (DUF4913)
PF13649 (1/2) Methyltransferase domain
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF12307 (1/2) Protein of unknown function (DUF3631)
PF08239 (1/2) Bacterial SH3 domain
PF01555 (1/2) DNA methylase

jaccard_groups_4482 1855.31 +- 282.62 3 0 3 0 0.04 +- 0.15 3 33

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter

jaccard_groups_4093 886.61 +- 688.91 3 0 0 0 0.03 +- 0.01 3 18

TIGR03561 (3/3) peroxiredoxin, Ohr subfamily
PF13649 (3/3) Methyltransferase domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF09339 (3/3) IclR helix-turn-helix domain
PF09084 (3/3) NMT1/THI5 like
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF02566 (3/3) OsmC-like protein
PF01614 (3/3) Bacterial transcriptional regulator
PF01546 (3/3) Peptidase family M20/M25/M40
PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
PF04199 (2/3) Putative cyclase
PF03972 (2/3) MmgE/PrpD family
PF03328 (2/3) HpcH/HpaI aldolase/citrate lyase family
PF02515 (2/3) CoA-transferase family III
PF01979 (2/3) Amidohydrolase family

jaccard_groups_4722 146.32 +- 79.43 2 0 0 2 0.04 +- 0.06 2 7

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family

jaccard_groups_5898 600.85 +- 188.32 2 0 0 0 0.03 +- 0.04 2 20

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00738 (2/2) Rrf2 family protein
PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13743 (2/2) Thioredoxin
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02082 (2/2) Transcriptional regulator
PF01613 (2/2) Flavin reductase like domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00384 (2/2) Molybdopterin oxidoreductase
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13427 (1/2) Domain of unknown function (DUF4111)
PF12146 (1/2) Serine aminopeptidase, S33
PF08386 (1/2) TAP-like protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01909 (1/2) Nucleotidyltransferase domain

jaccard_groups_1054 156.96 +- 65.90 2 0 0 0 0.02 +- 0.03 2 4

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel

jaccard_groups_1976 100.79 +- 5.13 2 0 0 0 0.06 +- 0.07 2 14

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter

jaccard_groups_2336 40.24 +- 11.75 3 0 0 0 0.08 +- 0.17 3 3

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C

jaccard_groups_1114 241.84 +- 175.07 6 0 0 0 0.05 +- 0.05 6 10

PF16353 (6/6) Domain of unknown function(DUF4981)
PF02929 (6/6) Beta galactosidase small chain
PF02837 (6/6) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (6/6) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (4/6) Glycosyl hydrolases family 2
PF13385 (3/6) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/6) Uncharacterized protein conserved in bacteria (DUF2236)
PF01547 (3/6) Bacterial extracellular solute-binding protein
PF01074 (3/6) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component

jaccard_groups_2849 98.93 +- 27.86 3 0 3 0 0.05 +- 0.05 3 6

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family

jaccard_groups_4006 502.26 +- 347.48 5 0 5 0 0.05 +- 0.18 5 17

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

jaccard_groups_1505 104.64 +- 38.90 15 0 0 0 0.06 +- 0.07 15 9

PF14158 (15/15) YndJ-like protein
PF13581 (15/15) Histidine kinase-like ATPase domain
PF13492 (15/15) GAF domain
PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (15/15) Domain of unknown function (DUF1990)
PF08447 (15/15) PAS fold
PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00149 (15/15) Calcineurin-like phosphoesterase

jaccard_groups_618 32.06 +- 9.93 8 0 0 0 0.07 +- 0.05 8 4

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase

jaccard_groups_610 172.00 +- 34.40 2 0 0 0 0.02 +- 0.03 2 5

PF00891 (2/2) O-methyltransferase domain
PF16864 (1/2) Dimerisation domain
PF13649 (1/2) Methyltransferase domain
PF05090 (1/2) Vitamin K-dependent gamma-carboxylase
PF01212 (1/2) Beta-eliminating lyase

jaccard_groups_616 226.60 +- 172.94 7 3 3 0 0.03 +- 0.04 4 5

PF13649 (7/7) Methyltransferase domain
PF00005 (7/7) ABC transporter
PF12697 (5/7) Alpha/beta hydrolase family
PF13450 (4/7) NAD(P)-binding Rossmann-like domain
PF00664 (4/7) ABC transporter transmembrane region

jaccard_groups_2522 637.59 +- 4.54 2 0 0 0 0.03 +- 0.02 2 14

TIGR00928 (2/2) adenylosuccinate lyase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13460 (2/2) NAD(P)H-binding
PF12800 (2/2) 4Fe-4S binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01494 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00072 (2/2) Response regulator receiver domain

jaccard_groups_5316 182.05 +- 34.62 2 0 0 0 0.02 +- 0.02 2 6

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase

jaccard_groups_4266 179.53 +- 21.38 2 0 2 0 0.08 +- 0.15 2 12

PF13641 (2/2) Glycosyltransferase like family 2
PF10823 (2/2) Protein of unknown function (DUF2568)
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (2/2) LysE type translocator
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00400 (2/2) WD domain, G-beta repeat
PF00067 (2/2) Cytochrome P450

jaccard_groups_61 94.60 +- 8.60 2 0 1 0 0.02 +- 0.02 2 4

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF18029 (1/2) Glyoxalase-like domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00156 (1/2) Phosphoribosyl transferase domain

jaccard_groups_5094 154.25 +- 11.20 2 0 2 0 0.05 +- 0.16 2 19

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family

jaccard_groups_18 38.61 +- 19.66 3 0 0 0 0.07 +- 0.07 3 4

PF00271 (3/3) Helicase conserved C-terminal domain
PF00270 (3/3) DEAD/DEAH box helicase
PF10923 (2/3) P-loop Domain of unknown function (DUF2791)
PF09848 (2/3) Uncharacterized conserved protein (DUF2075)

jaccard_groups_19 138.16 +- 77.48 8 1 3 0 0.05 +- 0.10 7 5

PF07228 (7/8) Stage II sporulation protein E (SpoIIE)
PF08448 (6/8) PAS fold
TIGR00229 (5/8) PAS domain S-box protein
PF13581 (5/8) Histidine kinase-like ATPase domain
PF13185 (4/8) GAF domain

jaccard_groups_14 412.84 +- 268.06 10 0 2 1 0.03 +- 0.04 10 6

PF13377 (10/10) Periplasmic binding protein-like domain
PF00356 (10/10) Bacterial regulatory proteins, lacI family
PF00528 (7/10) Binding-protein-dependent transport system inner membrane component
PF02065 (6/10) Melibiase
PF00266 (6/10) Aminotransferase class-V
PF13416 (5/10) Bacterial extracellular solute-binding protein

jaccard_groups_1609 164.29 +- 96.60 9 0 0 0 0.05 +- 0.04 9 11

TIGR03217 (9/9) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (9/9) acetaldehyde dehydrogenase (acetylating)
PF13621 (9/9) Cupin-like domain
PF09290 (9/9) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (9/9) DmpG-like communication domain
PF07690 (9/9) Major Facilitator Superfamily
PF03328 (9/9) HpcH/HpaI aldolase/citrate lyase family
PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (9/9) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (9/9) HMGL-like
PF00155 (9/9) Aminotransferase class I and II

jaccard_groups_16 107.91 +- 40.97 3 0 0 0 0.05 +- 0.04 3 2

PF03466 (3/3) LysR substrate binding domain
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_1975 343.46 +- 204.82 9 0 7 8 0.02 +- 0.04 9 6

PF13191 (9/9) AAA ATPase domain
PF00211 (9/9) Adenylate and Guanylate cyclase catalytic domain
PF00082 (9/9) Subtilase family
PF13185 (8/9) GAF domain
PF04055 (8/9) Radical SAM superfamily
PF14518 (5/9) Iron-containing redox enzyme

jaccard_groups_10 281.67 +- 272.44 6 0 2 1 0.04 +- 0.08 6 5

PF03704 (5/6) Bacterial transcriptional activator domain
PF00486 (5/6) Transcriptional regulatory protein, C terminal
PF00931 (4/6) NB-ARC domain
PF13424 (3/6) Tetratricopeptide repeat
PF00082 (3/6) Subtilase family

jaccard_groups_11 230.60 +- 200.58 12 0 3 2 0.05 +- 0.09 12 5

PF02518 (12/12) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (12/12) His Kinase A (phospho-acceptor) domain
PF00486 (12/12) Transcriptional regulatory protein, C terminal
PF00072 (12/12) Response regulator receiver domain
PF00672 (11/12) HAMP domain

jaccard_groups_3908 1645.66 +- 1357.34 2 0 2 1 0.05 +- 0.19 2 38

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
TIGR00761 (2/2) acetylglutamate kinase
PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF05977 (2/2) Transmembrane secretion effector
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR02039 (1/2) sulfate adenylyltransferase, small subunit
TIGR02034 (1/2) sulfate adenylyltransferase, large subunit
TIGR00455 (1/2) adenylyl-sulfate kinase
PF18029 (1/2) Glyoxalase-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01583 (1/2) Adenylylsulphate kinase
PF01507 (1/2) Phosphoadenosine phosphosulfate reductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00326 (1/2) Prolyl oligopeptidase family
PF00009 (1/2) Elongation factor Tu GTP binding domain

jaccard_groups_1501 120.00 +- 0.00 2 0 0 0 0.10 +- 0.25 2 12

TIGR00229 (2/2) PAS domain S-box protein
PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (2/2) Animal haem peroxidase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01061 (2/2) ABC-2 type transporter
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (2/2) Universal stress protein family
PF00199 (2/2) Catalase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF08448 (1/2) PAS fold
PF00989 (1/2) PAS fold

jaccard_groups_5008 765.63 +- 127.45 2 0 1 0 0.01 +- 0.01 2 8

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site

jaccard_groups_5003 650.00 +- 0.00 2 0 0 0 0.02 +- 0.00 2 6

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase

jaccard_groups_4865 738.11 +- 238.15 3 0 3 0 0.01 +- 0.01 3 13

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase

jaccard_groups_1232 71.67 +- 26.71 5 0 0 0 0.06 +- 0.07 5 4

PF14534 (5/5) Domain of unknown function (DUF4440)
PF08002 (5/5) Protein of unknown function (DUF1697)
PF05922 (5/5) Peptidase inhibitor I9
PF00082 (5/5) Subtilase family

jaccard_groups_3541 108.35 +- 37.40 3 0 1 0 0.09 +- 0.06 3 5

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

jaccard_groups_3340 371.41 +- 284.77 6 0 0 0 0.03 +- 0.08 6 16

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain

jaccard_groups_6243 107.29 +- 28.50 2 0 2 2 0.04 +- 0.04 2 10

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain

jaccard_groups_4892 1018.46 +- 114.56 3 0 0 3 0.01 +- 0.00 3 9

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain

jaccard_groups_800 90.32 +- 12.32 2 0 1 0 0.03 +- 0.02 2 5

PF14759 (2/2) Reductase C-terminal
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF14518 (1/2) Iron-containing redox enzyme
PF00083 (1/2) Sugar (and other) transporter

jaccard_groups_4890 1430.00 +- 130.00 2 0 2 2 0.01 +- 0.00 2 16

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain

jaccard_groups_4895 151.88 +- 91.88 2 0 0 0 0.04 +- 0.05 2 11

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF13333 (1/2) Integrase core domain
PF13276 (1/2) HTH-like domain
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain

jaccard_groups_677 115.84 +- 70.48 5 0 3 5 0.03 +- 0.05 5 3

PF13537 (5/5) Glutamine amidotransferase domain
PF00733 (5/5) Asparagine synthase
PF00171 (3/5) Aldehyde dehydrogenase family

jaccard_groups_546 169.85 +- 94.28 4 0 3 0 0.04 +- 0.04 4 3

PF03033 (4/4) Glycosyltransferase family 28 N-terminal domain
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00756 (3/4) Putative esterase

jaccard_groups_269 271.71 +- 249.02 8 0 1 0 0.04 +- 0.07 8 3

PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family)
TIGR00976 (6/8) hydrolase CocE/NonD family protein

jaccard_groups_402 569.24 +- 406.57 4 0 2 0 0.05 +- 0.06 4 5

PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF08533 (3/4) Beta-galactosidase C-terminal domain
PF01547 (3/4) Bacterial extracellular solute-binding protein

jaccard_groups_6019 1040.00 +- 0.00 2 0 0 2 0.01 +- 0.00 2 6

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)

jaccard_groups_2069 77.88 +- 16.58 6 0 0 0 0.08 +- 0.04 6 9

TIGR02133 (6/6) ribose 5-phosphate isomerase
PF16896 (6/6) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (6/6) Major Facilitator Superfamily
PF03807 (6/6) NADP oxidoreductase coenzyme F420-dependent
PF02734 (6/6) DAK2 domain
PF02733 (6/6) Dak1 domain
PF02502 (6/6) Ribose/Galactose Isomerase
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00121 (6/6) Triosephosphate isomerase

jaccard_groups_2068 249.70 +- 143.29 3 0 0 0 0.05 +- 0.05 3 18

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain

jaccard_groups_2064 359.93 +- 257.30 9 0 9 0 0.04 +- 0.07 9 10

TIGR01891 (9/9) amidohydrolase
TIGR01821 (9/9) 5-aminolevulinic acid synthase
PF16884 (9/9) N-terminal domain of oxidoreductase
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (9/9) Major Facilitator Superfamily
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (9/9) Peptidase family M20/M25/M40
PF00155 (9/9) Aminotransferase class I and II
PF00107 (9/9) Zinc-binding dehydrogenase

jaccard_groups_3164 378.11 +- 182.20 6 0 6 0 0.02 +- 0.03 6 10

PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00348 (6/6) Polyprenyl synthetase
PF00106 (6/6) short chain dehydrogenase
PF00743 (5/6) Flavin-binding monooxygenase-like
TIGR01534 (4/6) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

jaccard_groups_3690 215.27 +- 98.42 5 0 5 4 0.04 +- 0.05 5 11

TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family
PF10025 (5/5) Uncharacterized conserved protein (DUF2267)
PF08281 (5/5) Sigma-70, region 4
PF04542 (5/5) Sigma-70 region 2
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00067 (5/5) Cytochrome P450
TIGR03975 (4/5) ribosomal peptide maturation radical SAM protein 1
PF07690 (4/5) Major Facilitator Superfamily
PF04055 (4/5) Radical SAM superfamily
PF02310 (4/5) B12 binding domain
PF00326 (4/5) Prolyl oligopeptidase family

jaccard_groups_3647 447.82 +- 139.46 3 0 1 0 0.06 +- 0.21 3 11

PF17914 (3/3) HopA1 effector protein family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02441 (3/3) Flavoprotein
PF01636 (3/3) Phosphotransferase enzyme family
PF00326 (3/3) Prolyl oligopeptidase family
PF00296 (3/3) Luciferase-like monooxygenase
PF07730 (2/3) Histidine kinase
PF01061 (2/3) ABC-2 type transporter
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
PF00005 (2/3) ABC transporter

jaccard_groups_104 29.41 +- 3.34 3 0 0 0 0.08 +- 0.06 3 3

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00106 (2/3) short chain dehydrogenase

jaccard_groups_3587 187.56 +- 79.93 4 0 0 0 0.03 +- 0.04 4 5

PF06628 (4/4) Catalase-related immune-responsive
PF01475 (4/4) Ferric uptake regulator family
PF00248 (4/4) Aldo/keto reductase family
PF00199 (4/4) Catalase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain

jaccard_groups_6495 64.13 +- 5.87 2 0 0 0 0.06 +- 0.13 2 8

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA

jaccard_groups_3568 491.70 +- 429.24 5 0 0 0 0.02 +- 0.05 5 12

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase

jaccard_groups_163 146.25 +- 113.75 2 0 0 0 0.03 +- 0.05 2 4

PF05685 (2/2) Putative restriction endonuclease
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF04149 (1/2) Domain of unknown function (DUF397)
PF00583 (1/2) Acetyltransferase (GNAT) family

jaccard_groups_2368 94.90 +- 28.28 4 0 0 0 0.04 +- 0.02 4 6

PF12697 (4/4) Alpha/beta hydrolase family
PF07729 (4/4) FCD domain
PF06684 (4/4) Amino acid synthesis
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00296 (4/4) Luciferase-like monooxygenase
PF00171 (4/4) Aldehyde dehydrogenase family

jaccard_groups_160 258.67 +- 0.94 3 0 0 0 0.01 +- 0.00 3 2

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family

jaccard_groups_1491 1089.57 +- 871.67 7 0 7 0 0.01 +- 0.00 7 6

PF03412 (7/7) Peptidase C39 family
PF00668 (7/7) Condensation domain
PF00664 (7/7) ABC transporter transmembrane region
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00005 (7/7) ABC transporter

jaccard_groups_165 144.63 +- 101.54 4 0 2 1 0.04 +- 0.04 4 7

TIGR03026 (4/4) nucleotide sugar dehydrogenase
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/4) Major Facilitator Superfamily
PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase

jaccard_groups_3769 240.97 +- 100.44 3 0 3 0 0.02 +- 0.02 3 6

PF12697 (3/3) Alpha/beta hydrolase family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00313 (3/3) 'Cold-shock' DNA-binding domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00069 (3/3) Protein kinase domain

jaccard_groups_2360 197.13 +- 83.31 2 0 0 0 0.02 +- 0.02 2 11

PF12833 (2/2) Helix-turn-helix domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
TIGR03446 (1/2) mycothiol conjugate amidase Mca
PF07859 (1/2) alpha/beta hydrolase fold
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01494 (1/2) FAD binding domain

jaccard_groups_1785 273.52 +- 225.37 4 0 0 0 0.03 +- 0.07 4 3

PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (4/4) SPFH domain / Band 7 family
PF00877 (4/4) NlpC/P60 family

jaccard_groups_2807 154.14 +- 79.86 2 0 0 0 0.02 +- 0.03 2 9

PF13602 (2/2) Zinc-binding dehydrogenase
PF13564 (2/2) DoxX-like family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13460 (1/2) NAD(P)H-binding
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)

jaccard_groups_2804 419.05 +- 139.95 3 0 0 0 0.01 +- 0.00 3 9

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain

jaccard_groups_1424 383.25 +- 193.13 12 0 2 0 0.02 +- 0.06 12 5

PF07291 (12/12) Methylamine utilisation protein MauE
PF00717 (12/12) Peptidase S24-like
PF00005 (12/12) ABC transporter
PF00578 (9/12) AhpC/TSA family
PF10502 (6/12) Signal peptidase, peptidase S26

jaccard_groups_1397 799.92 +- 505.57 9 0 9 9 0.02 +- 0.07 9 11

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
TIGR03604 (9/9) thiazole/oxazole-forming peptide maturase, SagD family component
PF03412 (9/9) Peptidase C39 family
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (9/9) Nitroreductase family
PF00664 (9/9) ABC transporter transmembrane region
PF00005 (9/9) ABC transporter
PF13575 (8/9) Domain of unknown function (DUF4135)
PF00067 (8/9) Cytochrome P450
PF00364 (6/9) Biotin-requiring enzyme

jaccard_groups_5864 80.77 +- 3.37 2 0 0 0 0.06 +- 0.08 2 8

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

jaccard_groups_1544 41.61 +- 0.00 2 0 2 0 0.10 +- 0.09 2 4

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (2/2) Major Facilitator Superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450

jaccard_groups_719 282.54 +- 181.38 8 0 0 0 0.03 +- 0.05 8 6

PF07739 (8/8) TipAS antibiotic-recognition domain
PF07228 (8/8) Stage II sporulation protein E (SpoIIE)
PF13411 (7/8) MerR HTH family regulatory protein
PF07690 (6/8) Major Facilitator Superfamily
PF01551 (6/8) Peptidase family M23
PF00291 (6/8) Pyridoxal-phosphate dependent enzyme

jaccard_groups_8 552.00 +- 588.46 44 13 29 31 0.03 +- 0.05 31 6

PF00005 (44/44) ABC transporter
PF00664 (41/44) ABC transporter transmembrane region
PF00069 (38/44) Protein kinase domain
PF05147 (30/44) Lanthionine synthetase C-like protein
PF00326 (25/44) Prolyl oligopeptidase family
PF04672 (23/44) S-adenosyl methyltransferase

jaccard_groups_9 133.85 +- 102.99 5 0 2 2 0.03 +- 0.04 5 1

PF00069 (5/5) Protein kinase domain

jaccard_groups_4 163.62 +- 122.15 7 1 1 0 0.04 +- 0.05 6 1

PF07690 (7/7) Major Facilitator Superfamily

jaccard_groups_5 171.61 +- 154.50 3 0 1 0 0.07 +- 0.12 3 3

PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family

jaccard_groups_2 376.95 +- 80.35 5 0 0 1 0.01 +- 0.00 5 1

PF00440 (5/5) Bacterial regulatory proteins, tetR family

jaccard_groups_3 243.73 +- 166.49 19 0 1 0 0.03 +- 0.08 19 3

PF07730 (19/19) Histidine kinase
PF00196 (19/19) Bacterial regulatory proteins, luxR family
PF00072 (19/19) Response regulator receiver domain

jaccard_groups_3864 150.05 +- 8.21 2 0 0 0 0.09 +- 0.23 2 24

TIGR03144 (2/2) cytochrome c-type biogenesis protein CcsB
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF07690 (2/2) Major Facilitator Superfamily
PF05140 (2/2) ResB-like family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF01758 (2/2) Sodium Bile acid symporter family
PF01578 (2/2) Cytochrome C assembly protein
PF01545 (2/2) Cation efflux family
PF01252 (2/2) Signal peptidase (SPase) II
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase
TIGR01573 (1/2) CRISPR-associated endonuclease Cas2
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF13411 (1/2) MerR HTH family regulatory protein
PF12833 (1/2) Helix-turn-helix domain
PF10825 (1/2) Protein of unknown function (DUF2752)
PF09827 (1/2) CRISPR associated protein Cas2
PF02630 (1/2) SCO1/SenC
PF00795 (1/2) Carbon-nitrogen hydrolase

jaccard_groups_2565 345.37 +- 304.63 2 0 0 0 0.02 +- 0.03 2 6

PF00082 (2/2) Subtilase family
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13191 (1/2) AAA ATPase domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF03704 (1/2) Bacterial transcriptional activator domain

jaccard_groups_293 149.38 +- 100.19 8 0 0 0 0.02 +- 0.02 8 4

PF14759 (7/8) Reductase C-terminal
PF13370 (7/8) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (7/8) Pyridine nucleotide-disulphide oxidoreductase
PF00903 (5/8) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

jaccard_groups_5605 705.83 +- 204.17 2 0 0 0 0.01 +- 0.01 2 7

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family

jaccard_groups_69 42.23 +- 13.81 3 0 1 0 0.06 +- 0.04 3 2

PF00248 (3/3) Aldo/keto reductase family
PF08007 (2/3) Cupin superfamily protein

jaccard_groups_1160 605.32 +- 462.85 23 0 23 0 0.07 +- 0.11 23 23

TIGR01733 (23/23) amino acid adenylation domain
PF13193 (23/23) AMP-binding enzyme C-terminal domain
PF10862 (23/23) FcoT-like thioesterase domain
PF08545 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (23/23) Male sterility protein
PF07690 (23/23) Major Facilitator Superfamily
PF05118 (23/23) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (23/23) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (23/23) Condensation domain
PF00550 (23/23) Phosphopantetheine attachment site
PF00501 (23/23) AMP-binding enzyme
TIGR01746 (22/23) thioester reductase domain
TIGR01525 (22/23) heavy metal translocating P-type ATPase
TIGR00747 (22/23) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF04314 (22/23) Copper chaperone PCu(A)C
PF00702 (22/23) haloacid dehalogenase-like hydrolase
PF00403 (22/23) Heavy-metal-associated domain
PF00122 (22/23) E1-E2 ATPase
PF01497 (21/23) Periplasmic binding protein
PF01032 (21/23) FecCD transport family
PF00005 (21/23) ABC transporter
PF01965 (19/23) DJ-1/PfpI family

jaccard_groups_22 134.76 +- 86.38 2 0 0 0 0.04 +- 0.07 2 3

PF12802 (2/2) MarR family
PF01965 (2/2) DJ-1/PfpI family
PF00069 (2/2) Protein kinase domain

jaccard_groups_4291 227.25 +- 162.75 2 0 0 0 0.03 +- 0.05 2 7

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10

jaccard_groups_199 250.40 +- 9.60 2 0 0 0 0.02 +- 0.02 2 4

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

jaccard_groups_222 1424.71 +- 886.93 4 0 0 0 0.02 +- 0.05 4 9

PF07811 (4/4) TadE-like protein
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF13400 (3/4) Putative Flp pilus-assembly TadE/G-like
PF08666 (3/4) SAF domain
PF01476 (3/4) LysM domain
PF14081 (2/4) Domain of unknown function (DUF4262)
PF03704 (2/4) Bacterial transcriptional activator domain
PF01381 (2/4) Helix-turn-helix

jaccard_groups_2414 122.10 +- 43.38 4 0 0 0 0.05 +- 0.04 4 12

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (4/4) amidohydrolase
TIGR00843 (4/4) benzoate transporter
PF13454 (4/4) FAD-NAD(P)-binding
PF13424 (4/4) Tetratricopeptide repeat
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (4/4) Peptidase family M20/M25/M40
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00931 (4/4) NB-ARC domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme

jaccard_groups_5043 760.47 +- 374.44 3 0 0 0 0.04 +- 0.12 3 26

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III

jaccard_groups_60 278.98 +- 192.79 15 1 0 1 0.02 +- 0.04 14 1

PF00082 (15/15) Subtilase family

jaccard_groups_5049 388.00 +- 128.00 2 0 0 0 0.01 +- 0.00 2 6

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family

jaccard_groups_25 108.15 +- 115.79 8 0 0 0 0.06 +- 0.06 8 5

PF05331 (8/8) Protein of unknown function (DUF742)
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF00067 (8/8) Cytochrome P450
PF04149 (6/8) Domain of unknown function (DUF397)

jaccard_groups_26 115.49 +- 100.95 3 0 0 0 0.04 +- 0.04 3 1

PF00293 (3/3) NUDIX domain

jaccard_groups_21 325.60 +- 323.07 3 0 0 0 0.03 +- 0.08 3 6

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
TIGR01443 (2/3) intein C-terminal splicing region
PF13385 (2/3) Concanavalin A-like lectin/glucanases superfamily
PF07591 (2/3) Pretoxin HINT domain
PF05593 (2/3) RHS Repeat

jaccard_groups_23 135.79 +- 170.09 4 0 0 0 0.07 +- 0.12 4 4

PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (3/4) Major Facilitator Superfamily

jaccard_groups_4226 444.94 +- 356.18 4 0 0 0 0.03 +- 0.04 4 6

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter

jaccard_groups_3896 821.14 +- 717.35 4 0 0 0 0.05 +- 0.15 4 21

TIGR01928 (4/4) o-succinylbenzoate synthase
TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (4/4) LD-carboxypeptidase C-terminal domain
PF13378 (4/4) Enolase C-terminal domain-like
PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02016 (4/4) LD-carboxypeptidase N-terminal domain
PF01546 (4/4) Peptidase family M20/M25/M40
PF01380 (4/4) SIS domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (4/4) ABC transporter
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF12831 (3/4) FAD dependent oxidoreductase
PF07883 (3/4) Cupin domain
PF07690 (3/4) Major Facilitator Superfamily
PF02515 (3/4) CoA-transferase family III
PF01381 (3/4) Helix-turn-helix
PF00701 (3/4) Dihydrodipicolinate synthetase family
PF00378 (3/4) Enoyl-CoA hydratase/isomerase
PF00171 (3/4) Aldehyde dehydrogenase family

jaccard_groups_29 162.56 +- 163.90 7 0 0 0 0.03 +- 0.04 7 1

PF00583 (7/7) Acetyltransferase (GNAT) family

jaccard_groups_349 258.00 +- 0.00 2 0 0 0 0.01 +- 0.01 2 5

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (1/2) Polysaccharide deacetylase
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01145 (1/2) SPFH domain / Band 7 family
PF00877 (1/2) NlpC/P60 family

jaccard_groups_178 362.00 +- 154.00 2 0 2 0 0.01 +- 0.01 2 2

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

jaccard_groups_3030 124.21 +- 42.94 2 0 2 0 0.06 +- 0.06 2 13

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01756 (2/2) Acyl-CoA oxidase
PF00550 (2/2) Phosphopantetheine attachment site
PF00294 (2/2) pfkB family carbohydrate kinase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12840 (1/2) Helix-turn-helix domain
PF10400 (1/2) Virulence activator alpha C-term
PF03551 (1/2) Transcriptional regulator PadR-like family
PF01497 (1/2) Periplasmic binding protein
PF00005 (1/2) ABC transporter

jaccard_groups_1341 234.18 +- 83.20 3 0 0 0 0.08 +- 0.09 3 11

TIGR01234 (3/3) ribulokinase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF11762 (3/3) L-arabinose isomerase C-terminal domain
PF06964 (3/3) Alpha-L-arabinofuranosidase C-terminal domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (3/3) L-arabinose isomerase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF18029 (2/3) Glyoxalase-like domain

jaccard_groups_1268 97.17 +- 73.63 3 0 0 0 0.05 +- 0.04 3 6

PF00106 (3/3) short chain dehydrogenase
PF12833 (2/3) Helix-turn-helix domain
PF12625 (2/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/3) mttA/Hcf106 family
PF00743 (2/3) Flavin-binding monooxygenase-like
PF00171 (2/3) Aldehyde dehydrogenase family

jaccard_groups_5131 516.00 +- 0.00 2 0 2 0 0.01 +- 0.00 2 4

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat

jaccard_groups_6119 292.50 +- 0.00 2 0 0 0 0.01 +- 0.00 2 3

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family

jaccard_groups_3009 387.00 +- 271.72 2 0 0 2 0.04 +- 0.03 2 29

TIGR04050 (2/2) AIR synthase-related protein, MSMEG_0567 C-terminal family
TIGR04047 (2/2) glycosyltransferase, MSMEG_0565 family
TIGR04046 (2/2) flavin-dependent oxidoreductase, MSMEG_0569 family
TIGR04045 (2/2) putative N-acetyltransferase, MSMEG_0567 N-terminal domain family
TIGR04044 (2/2) MSMEG_0572 family protein
TIGR04043 (2/2) radical SAM protein, MSMEG_0568 family
TIGR04042 (2/2) MSMEG_0570 family protein
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13439 (2/2) Glycosyltransferase Family 4
PF04909 (2/2) Amidohydrolase
PF04055 (2/2) Radical SAM superfamily
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF02635 (2/2) DsrE/DsrF-like family
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00534 (2/2) Glycosyl transferases group 1
TIGR01910 (1/2) peptidase, ArgE/DapE family
PF18029 (1/2) Glyoxalase-like domain
PF16990 (1/2) Carbohydrate binding module (family 35)
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01546 (1/2) Peptidase family M20/M25/M40
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family

jaccard_groups_3413 260.72 +- 115.49 7 0 0 0 0.01 +- 0.01 7 5

TIGR02532 (7/7) prepilin-type N-terminal cleavage/methylation domain
PF07963 (7/7) Prokaryotic N-terminal methylation motif
PF06750 (7/7) Bacterial Peptidase A24 N-terminal domain
PF03551 (7/7) Transcriptional regulator PadR-like family
PF01478 (7/7) Type IV leader peptidase family

jaccard_groups_4315 1556.00 +- 516.03 4 0 0 0 0.01 +- 0.00 4 7

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family

jaccard_groups_3003 1355.01 +- 1011.49 7 0 6 0 0.03 +- 0.08 7 10

PF13622 (7/7) Thioesterase-like superfamily
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00487 (7/7) Fatty acid desaturase
PF00301 (7/7) Rubredoxin
PF00067 (7/7) Cytochrome P450
PF07690 (6/7) Major Facilitator Superfamily
PF12146 (5/7) Serine aminopeptidase, S33
PF12679 (4/7) ABC-2 family transporter protein
PF00005 (4/7) ABC transporter

jaccard_groups_6202 571.90 +- 331.10 2 0 0 0 0.02 +- 0.03 2 9

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family

jaccard_groups_537 40.72 +- 12.05 2 0 0 0 0.06 +- 0.14 2 6

PF13641 (2/2) Glycosyltransferase like family 2
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF18616 (1/2) CDI immunity proteins
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_3091 1255.97 +- 999.97 4 0 4 0 0.03 +- 0.06 4 33

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain

jaccard_groups_533 69.67 +- 7.31 3 0 0 0 0.03 +- 0.03 3 2

PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00067 (2/3) Cytochrome P450

jaccard_groups_4218 516.00 +- 258.00 2 0 0 0 0.02 +- 0.03 2 3

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

jaccard_groups_538 717.07 +- 434.19 8 0 0 0 0.03 +- 0.03 8 5

PF13416 (8/8) Bacterial extracellular solute-binding protein
PF08402 (8/8) TOBE domain
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
PF00962 (4/8) Adenosine/AMP deaminase

jaccard_groups_17 103.93 +- 69.03 9 0 0 1 0.04 +- 0.05 9 2

PF07702 (9/9) UTRA domain
PF00392 (9/9) Bacterial regulatory proteins, gntR family

jaccard_groups_459 261.23 +- 64.11 5 0 0 0 0.01 +- 0.01 5 6

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold

jaccard_groups_755 275.25 +- 17.25 2 0 1 0 0.01 +- 0.00 2 10

TIGR00231 (2/2) small GTP-binding protein domain
PF14492 (2/2) Elongation Factor G, domain II
PF03764 (2/2) Elongation factor G, domain IV
PF00679 (2/2) Elongation factor G C-terminus
PF00009 (2/2) Elongation factor Tu GTP binding domain
PF16864 (1/2) Dimerisation domain
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF01494 (1/2) FAD binding domain
PF00891 (1/2) O-methyltransferase domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)

jaccard_groups_1869 365.99 +- 130.08 14 0 8 0 0.06 +- 0.03 14 18

PF13561 (14/14) Enoyl-(Acyl carrier protein) reductase
PF08545 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (14/14) Beta-ketoacyl synthase, C-terminal domain
PF00378 (14/14) Enoyl-CoA hydratase/isomerase
PF00109 (14/14) Beta-ketoacyl synthase, N-terminal domain
PF00106 (14/14) short chain dehydrogenase
TIGR00976 (13/14) hydrolase CocE/NonD family protein
PF13193 (13/14) AMP-binding enzyme C-terminal domain
PF08530 (13/14) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (13/14) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (13/14) Coenzyme A transferase
PF00501 (13/14) AMP-binding enzyme
PF00196 (13/14) Bacterial regulatory proteins, luxR family
PF00005 (13/14) ABC transporter
PF04909 (12/14) Amidohydrolase
PF12679 (10/14) ABC-2 family transporter protein
PF12697 (9/14) Alpha/beta hydrolase family

jaccard_groups_128 110.12 +- 103.02 10 0 2 0 0.04 +- 0.05 10 1

PF01872 (10/10) RibD C-terminal domain

jaccard_groups_127 154.80 +- 0.00 2 0 0 0 0.02 +- 0.01 2 5

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6

jaccard_groups_2734 595.57 +- 149.62 4 0 4 0 0.01 +- 0.00 4 17

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)

jaccard_groups_2138 57.64 +- 2.36 2 0 0 0 0.07 +- 0.09 2 4

PF04203 (2/2) Sortase domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family

jaccard_groups_122 269.82 +- 196.36 3 0 0 0 0.04 +- 0.06 3 2

PF11706 (3/3) CGNR zinc finger
PF07336 (3/3) Putative stress-induced transcription regulator

jaccard_groups_4359 73.12 +- 24.38 2 0 0 0 0.03 +- 0.02 2 3

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein

jaccard_groups_1295 60.20 +- 25.80 2 0 0 0 0.03 +- 0.04 2 3

PF04231 (2/2) Endonuclease I
PF11239 (1/2) Protein of unknown function (DUF3040)
PF10706 (1/2) Aminoglycoside-2''-adenylyltransferase

jaccard_groups_2927 622.29 +- 125.90 3 0 3 0 0.01 +- 0.02 3 9

TIGR01250 (3/3) proline-specific peptidase
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (3/3) B12 binding domain
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450

jaccard_groups_1740 228.06 +- 94.91 4 0 0 0 0.06 +- 0.09 4 14

PF18565 (4/4) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (4/4) Domain of unknown function (DUF4982)
PF14310 (4/4) Fibronectin type III-like domain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00703 (4/4) Glycosyl hydrolases family 2
PF17390 (3/4) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/4) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/4) alpha/beta hydrolase fold
PF05592 (3/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain

jaccard_groups_1465 83.73 +- 28.80 3 0 0 0 0.05 +- 0.05 3 5

PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00501 (3/3) AMP-binding enzyme

jaccard_groups_984 274.59 +- 266.03 15 0 0 14 0.03 +- 0.05 15 3

PF07690 (15/15) Major Facilitator Superfamily
PF04055 (14/15) Radical SAM superfamily
PF13649 (11/15) Methyltransferase domain

jaccard_groups_3631 516.88 +- 343.12 2 0 2 0 0.04 +- 0.11 2 19

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II

jaccard_groups_150 137.60 +- 34.40 2 0 0 0 0.02 +- 0.01 2 3

PF04672 (2/2) S-adenosyl methyltransferase
TIGR03296 (1/2) M6 family metalloprotease domain
PF13649 (1/2) Methyltransferase domain

jaccard_groups_5491 961.71 +- 70.29 2 0 2 0 0.01 +- 0.00 2 8

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase

jaccard_groups_2218 454.73 +- 318.28 6 0 0 0 0.05 +- 0.08 6 7

PF13411 (6/6) MerR HTH family regulatory protein
PF07739 (6/6) TipAS antibiotic-recognition domain
PF03033 (6/6) Glycosyltransferase family 28 N-terminal domain
PF01551 (6/6) Peptidase family M23
PF00392 (6/6) Bacterial regulatory proteins, gntR family
PF00005 (6/6) ABC transporter
PF12679 (5/6) ABC-2 family transporter protein

jaccard_groups_2357 138.29 +- 11.26 2 0 2 0 0.06 +- 0.16 2 22

TIGR02412 (2/2) aminopeptidase N
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (2/2) ERAP1-like C-terminal domain
PF09334 (2/2) tRNA synthetases class I (M)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02274 (2/2) Amidinotransferase
PF01433 (2/2) Peptidase family M1 domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00550 (2/2) Phosphopantetheine attachment site
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF17900 (1/2) Peptidase M1 N-terminal domain
PF03466 (1/2) LysR substrate binding domain
PF02195 (1/2) ParB-like nuclease domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_5496 155.40 +- 85.40 2 0 0 0 0.04 +- 0.04 2 6

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family

jaccard_groups_2608 1607.67 +- 212.33 2 0 2 0 0.01 +- 0.00 2 31

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region

jaccard_groups_393 101.79 +- 64.37 20 0 0 0 0.03 +- 0.02 20 3

PF12833 (20/20) Helix-turn-helix domain
PF02311 (20/20) AraC-like ligand binding domain
PF00150 (19/20) Cellulase (glycosyl hydrolase family 5)

jaccard_groups_2851 45.39 +- 2.39 2 0 2 0 0.04 +- 0.04 2 7

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat

jaccard_groups_2323 87.16 +- 61.05 3 0 0 0 0.04 +- 0.08 3 4

PF03965 (3/3) Penicillinase repressor
PF01435 (3/3) Peptidase family M48
PF00403 (3/3) Heavy-metal-associated domain
PF00877 (2/3) NlpC/P60 family

jaccard_groups_2321 388.80 +- 1.47 5 0 0 0 0.01 +- 0.00 5 3

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)

jaccard_groups_1046 301.58 +- 214.44 4 0 4 4 0.07 +- 0.15 4 13

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF05147 (4/4) Lanthionine synthetase C-like protein
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
TIGR03558 (2/4) luciferase family oxidoreductase, group 1
PF13649 (2/4) Methyltransferase domain
PF01292 (2/4) Prokaryotic cytochrome b561
PF00196 (2/4) Bacterial regulatory proteins, luxR family
PF00188 (2/4) Cysteine-rich secretory protein family
PF00174 (2/4) Oxidoreductase molybdopterin binding domain
PF00072 (2/4) Response regulator receiver domain

jaccard_groups_1045 608.93 +- 519.61 5 0 4 1 0.03 +- 0.05 5 11

TIGR03945 (5/5) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (5/5) amino acid adenylation domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
TIGR03944 (4/5) 2,3-diaminopropionate biosynthesis protein SbnB
PF00975 (4/5) Thioesterase domain
PF02668 (3/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (3/5) Condensation domain

jaccard_groups_628 28.77 +- 5.25 10 0 3 0 0.07 +- 0.09 10 6

PF13244 (10/10) Domain of unknown function (DUF4040)
PF04066 (10/10) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (10/10) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (10/10) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (10/10) Proton-conducting membrane transporter
PF12840 (9/10) Helix-turn-helix domain

jaccard_groups_2516 118.50 +- 53.50 2 0 0 0 0.05 +- 0.07 2 14

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat

jaccard_groups_302 291.55 +- 224.45 2 0 0 0 0.03 +- 0.06 2 1

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

jaccard_groups_300 2363.38 +- 2722.61 59 9 49 59 0.03 +- 0.08 50 9

TIGR03882 (59/59) bacteriocin biosynthesis cyclodehydratase domain
PF02624 (59/59) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR03604 (58/59) thiazole/oxazole-forming peptide maturase, SagD family component
PF00881 (58/59) Nitroreductase family
PF14028 (57/59) Lantibiotic biosynthesis dehydratase C-term
PF00005 (41/59) ABC transporter
PF04738 (40/59) Lantibiotic dehydratase, N terminus
PF01061 (33/59) ABC-2 type transporter
TIGR03605 (30/59) SagB-type dehydrogenase domain

jaccard_groups_78 154.21 +- 58.34