eQTL visualization and investigation

Choose an experiment:	Type	Traits	Cross	Sample	Publication	Download
Gutteling_2007b	phenotype	18	N2 x CB4856		Mapping phenotypic plasticity and genotype-environment inte…	LOD scores Markers Map Expression data
Bendesky_2011	phenotype	1	N2 x CB4856		Catecholamine receptor polymorphisms affect decision-making…	LOD scores Markers Map Expression data
Stastna_2015	phenotype	2	N2 x CB4856		Genotype-dependent lifespan effects in peptone deprived Cae…	LOD scores Markers Map Expression data
Elvin_2011	phenotype	108	N2 x CB4856		A fitness assay for comparing RNAi effects across multiple …	LOD scores Markers Map Expression data
Zhu_2015	phenotype	15	N2 x CB4856		Compatibility between mitochondrial and nuclear genomes cor…	LOD scores Markers Map Expression data
Nakad_2016	phenotype	24	N2 x CB4856		Contrasting invertebrate immune defense behaviors caused by…	LOD scores Markers Map Expression data
Glater_2014	phenotype	2	N2 x CB4856		Multigenic natural variation underlies Caenorhabditis elega…	LOD scores Markers Map Expression data
Gutteling_2007a	phenotype	6	N2 x CB4856		Environmental influence on the genetic correlations between…	LOD scores Markers Map Expression data
Vinuela_Snoek_etal_2010_reproductive	eQTL	16532	N2 x CB4856	L4 (40 h), adult (96 h), old (214 h)	Genome-wide gene expression regulation as a function of gen…	LOD scores Markers Map Expression data
Zdraljevic_2017	phenotype	2	N2 x CB4856		Natural variation in a single amino acid substitution under…	LOD scores Markers Map Expression data
Harvey_2009	phenotype	2	N2 x DR1350		Non-dauer larval dispersal in Caenorhabditis elegans	LOD scores Markers Map Expression data
Vinuela_Snoek_etal_2010_juvenile	eQTL	16532	N2 x CB4856	L4 (40 h), adult (96 h), old (214 h)	Genome-wide gene expression regulation as a function of gen…	LOD scores Markers Map Expression data
Rodriguez_2012	phenotype	9	N2 x CB4856		Genetic variation for stress-response hormesis in C. elega…	LOD scores Markers Map Expression data
Schmid_2015	phenotype	2	MT2124 × CB4856		Systemic regulation of RAS/MAPK signaling by the serotonin …	LOD scores Markers Map Expression data
Snoek_2019	phenotype	21	JU1511 × JU1926 × JU1931 × JU1941		A multi-parent recombinant inbred line population of C. el…	LOD scores Markers Map Expression data
Snoek_Sterken_etal_2017_hs	eQTL	20554	N2 x CB4856	L4	Contribution of trans regulatory eQTL to cryptic genetic va…	LOD scores Markers Map Expression data
Li_etal_2006_16celcius	eQTL	16532	N2 x CB4856	L3	Mapping determinants of gene expression plasticity by genet…	LOD scores Markers Map Expression data
Vinuela_Snoek_etal_2010_old	eQTL	16532	N2 x CB4856	L4 (40 h), adult (96 h), old (214 h)	Genome-wide gene expression regulation as a function of gen…	LOD scores Markers Map Expression data
Snoek_Sterken_etal_2017_rec	eQTL	20554	N2 x CB4856	L4	Contribution of trans regulatory eQTL to cryptic genetic va…	LOD scores Markers Map Expression data
Bendesky_2012	phenotype	2	N2 x CB4856		Long-range regulatory polymorphisms affecting a GABA recept…	LOD scores Markers Map Expression data
Harvey_2008	phenotype	26	N2 x DR1350		Quantitative genetic analysis of life-history traits of Cae…	LOD scores Markers Map Expression data
Vinuela_2010	phenotype	2	N2 x CB4856		Genome-wide gene expression regulation as a function of gen…	LOD scores Markers Map Expression data
Li_etal_2006_24celcius	eQTL	16532	N2 x CB4856	L3	Mapping determinants of gene expression plasticity by genet…	LOD scores Markers Map Expression data
Large_2016	phenotype	5	LSJ2 x CX12311		Selection on a subunit of the nurf chromatin remodeler modi…	LOD scores Markers Map Expression data
Evans_Brady_2018	phenotype	384	N2 x CB4856		Common loci underlie natural variation in diverse toxin res…	LOD scores Markers Map Expression data
Andersen_2015	phenotype	34	N2 x CB4856		A powerful new quantitative genetics platform, combining Ca…	LOD scores Markers Map Expression data
Snoek_Sterken_etal_2017_ct	eQTL	20554	N2 x CB4856	L4	Contribution of trans regulatory eQTL to cryptic genetic va…	LOD scores Markers Map Expression data
Singh_2016	phenotype	10	N2 x CB4856		Natural genetic variation influences protein abundances in …	LOD scores Markers Map Expression data
Andersen_2014	phenotype	7	N2 x CB4856		A variant in the neuropeptide receptor npr-1 is a major det…	LOD scores Markers Map Expression data
Lee_2017	phenotype	1	N2 x CB4856		The genetic basis of natural variation in a phoretic behavi…	LOD scores Markers Map Expression data
Snoek_Orbidans_2014	phenotype	4	N2 x CB4856		Widespread genomic incompatibilities in Caenorhabditis eleg…	LOD scores Markers Map Expression data
Balla_2015	phenotype	1	N2 x CB4856		A wild C. elegans strain has enhanced epithelial immunity t…	LOD scores Markers Map Expression data
McGrath_2009	phenotype	2	N2 x CB4856		Quantitative mapping of a digenic behavioral trait implicat…	LOD scores Markers Map Expression data
Noble_2015	phenotype	5	QG5 x QX1199		Natural variation in plep-1 causes male-male copulatory beh…	LOD scores Markers Map Expression data
Rockman_etal_2010	eQTL	16476	N2 × CB4856	Young adult (60 h)	Selection at linked sites shapes heritable phenotypic varia…	LOD scores Markers Map Expression data
Li_etal_2010	eQTL	24455	N2 × CB4856	Late L3	Global genetic robustness of the alternative splicing machi…	LOD scores Markers Map Expression data
Sterken_etal_2017	eQTL	18447	MT2124 × CB4856	Adult (72 h)	Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis e…	LOD scores Markers Map Expression data
Rockman_Kruglyak_2009	phenotype	7	N2 x CB4856		Recombinational Landscape and Population Genomics of Caenor…	LOD scores Markers Map Expression data
Kammenga_2007	phenotype	1	N2 × CB4856		A C. elegans wild-type defies the temperature-size rule owi…	LOD scores Markers Map Expression data
Gao_Sterken_2018	phenotype	378	N2 x CB4856		Natural genetic variation in C. elegans identified genomic …	LOD scores Markers Map Expression data
Greene_2016	phenotype	2	MY14 x CX12311		Balancing selection shapes density-dependent foraging behav…	LOD scores Markers Map Expression data
Duveau_2012	phenotype	3	JU605 x JU606		Role of Pleiotropy in the evolution of a cryptic developmen…	LOD scores Markers Map Expression data
Gaertner_2012	phenotype	5	N2 x CB4856		A complex epistatic network underlies natural variation in …	LOD scores Markers Map Expression data
Snoek_2021	eQTL	11661	JU1511 × JU1926 × JU1931 × JU1941			LOD scores Markers Map Expression data

Getting started

To view all eQTL profiles for a certain gene, type its name or ID in the text box and click the Search button.

To see a cis-trans plot with all eQTL peaks for a certain experiment, click on the experiment name.

You can search with a keyword to find genes and gene ontology (GO) categories.

Select the examples menu to see some example analysis with WormQTL 2.

Find correlating eQTL profiles

Show all genes for which the eQTL profile correlates with that of the query gene above the set cut-off, in the selected experiment.

Strongly correlating eQTL profiles could indicate that the genes are regulated by the same loci.

Query per locus

Show the eQTL profiles of genes with a LOD score above the threshold at the selected locus in the selected experiment.

A locus can be a marker, a gene name, gene id or a genomic position (i.e. 2:11095452).

What is WormQTL 2?

WormQTL 2 is the C.elgans workbench and database for eQTL analysis.

It allows easy access to the data of all published Caenorhabditis elegans genetical genomics experiments.

WormQLT2 was modelled after AraQTL (the arabidopsis eQTL resource).

A paper describing WormQTL2 was published in Database:
WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans

What is an eQTL?

An eQTL is a genetic locus that was shown to affect the expression of the current gene.

eQTLs are the result of combining genomics with genetics, in "genetical genomics" Jansen and Nap Trends in Genetics 17(7):388-91 (2001)